Abstracts tagged "Muscle Function"

Abstract Number: 1079 • ACR Convergence 2024
Early Recognition of Myositis: Time Correlation Between Transaminases and Inflammatory Myopathy in a Community-Based Rheumatology Practice
Anjali nidhaan, Shannon Iriza, Abbie West, Michael martin and Gauri Pethe, prisma health, columbia, SC
Background/Purpose: Recognizing muscle breakdown as a potential cause of elevated transaminases is crucial in the primary care setting to facilitate early referral to rheumatology for…
Abstract Number: 1182 • ACR Convergence 2024
Assessing Male Pelvic Floor Contractions Using a Novel External Pressure Device and Ultrasound
Benedetto Giardulli¹, Mirko Job¹, Filippo Recenti¹, Gaia Leuzzi¹, Alessandro Muda², Ottavia Buccarella¹ and Marco Testa¹, ¹University of Genova, Savona, Italy, ²Lavagna Hospital - Radiology Dept., Genova, Italy
Background/Purpose: Men with rheumatic and musculoskeletal diseases (RMD) often experience sexual dysfunctions such as pelvic floor pain and erectile dysfunctions, which affect their sexual well-being.…
Abstract Number: 2061 • ACR Convergence 2024
Associations Between Intramyocellular Lipid and Muscle Function in Patients with Osteoarthritis
Rachel Gillcrist¹, Marianna Olave², Ryan Armbruster³ and Joshua Baker⁴, ¹Corporal Michael J. Crescenz VA Medical Center, Philadelphia, ²Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, ⁴Department of Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA
Background/Purpose: Intramyocellular lipids (IMCL), stored within lipid droplets in skeletal muscle cells, serve as an important metabolic fuel source during exercise. Endurance athletes have demonstrated higher…
Abstract Number: 2670 • ACR Convergence 2024
Sera from Patients with Idiopathic Inflammatory Myopathy Induces Muscle Weakness, Mitochondrial Dysfunction and Induction of Cytokines in Isolated Skeletal Muscle
Cecilia Leijding¹, Suchada Kaewin², Kristofer Andreasson¹, Tomas Schiffer¹, Angeles Galindo-Feria³, Begum Horuluoglu¹, Mattias Carlstrom¹, Stefano Gastaldello¹, Helene Alexanderson⁴, Ingrid Lundberg⁵ and Daniel Andersson⁶, ¹Karolinska Institutet, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, ³Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Karolinska University Hospital, Stockholm, Sweden, ⁵Karolinska Universitetssjukhuset, Karolinska Institutet, Stockholm, Sweden, ⁶Karolinska Institutet, Solna, Sweden
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune inflammatory muscle disorders characterized by symmetrical skeletal muscle weakness and accelerated fatigue. Although signs…
Abstract Number: 0560 • ACR Convergence 2024
Association Between a Self-Report Screening Tool for Sarcopenia (SARC-F) and Disease Activity, Muscle Strength and Muscle Power Measures, Patient-Reported Outcomes and Body Composition in Patients with Spondyloarthritides
Iuliia Kononenko¹, Marius Bedei², Bjoern Buehring³, Xenofon Baraliakos⁴ and Uta Kiltz⁵, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr University Bochum, Germany, Bochum, Germany, ²Rheumazentrum Ruhrgebiet Herne, Ruhr University Bochum, Germany, Herne, Germany, ³Bergisches Rheuma-Zentrum, Wuppertal, Germany, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵Rheumazentrum Ruhrgebiet Herne, Ruhr-University, D-44649 Herne, Germany
Background/Purpose: The SARC-F is a self-report screening tool for sarcopenia (Sar) used to identify individuals at risk for poor functional outcomes [1]. The aim of this study was…
Abstract Number: 0684 • ACR Convergence 2024
The Diagnostic Accuracy of Ultrasound for Low Muscle Mass in Women with Systemic Sclerosis
Lucas Dória¹, Vanessa Hax², André Mallmann², Rafaela Santo³, Leonardo Santos², Stephanie Pilotti², Daniel Moraes², Isabella Boening², Pedro Glanze², ODIRLEI MONTICIELO¹, Ricardo Xavier⁴ and Rafael Chakr⁵, ¹Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil, ²Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil, ³Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania, Porto Alegre, Rio Grande do Sul, Brazil, ⁴Universidade Federal do Rio Grande do Sul, Porto Alegre/RS, Rio Grande do Sul, Brazil, ⁵Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Background/Purpose: Patients with systemic sclerosis (SSc) often experience body composition changes, including low muscle mass (myopenia), associated with physical disability, hospitalization and death. Our purpose…
Abstract Number: 0302 • ACR Convergence 2023
Remission in Anti-HMGCR Positive Immune-mediated Necrotizing Myopathy Without the Use of Glucocorticoids: A Multicentric Study of 24 Patients
David Martinez-Lopez¹, Cristina Corrales Selaya², Diana Prieto-Peña², Piotr Szczesny³, Antonella Notarnicola⁴, Ricardo Blanco⁵, Ingrid Lundberg⁶ and Maryam Dastmalchi⁶, ¹Hospital de Sierrallana, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla, Santander, Spain, ³Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland; Department of Neurology, Medical University of Warsaw, Warsaw, Poland, ⁴Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁵Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁶Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Gastroenterology, Dermatotology, Rhematology, Karolinska Universitetssjukhuset, Stockholm, Sweden
Background/Purpose: Statin-induced immune mediated necrotizing myopathy (IMNM) is a subtype of inflammatory myopathy associated with anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies. This condition is characterized by progressive…
Abstract Number: 1147 • ACR Convergence 2023
Blood-Based Biomarkers of Inflammation and Tissue Remodeling Can Discriminate Between Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis and Are Associated with Hand Function
Helena Port I Linares¹, Birte Coppers², Sara Bayat², Godonou Elie-Tino², Larissa Valor-Mendez², David Simon², Filippo Fagni², Giulia Corte², Anne-Christine Bay-Jensen³, Koray Tascilar², Axel Hueber⁴, Verena Schoenau², Michael Sticherling⁵, Simon Heinrich⁶, Daniela Bohr², Georg Schett⁷, Arnd Kleyer⁸, Sigrid Leyendecker⁶, Signe Holm Nielsen³ and Anna-Maria Liphardt⁹, ¹Nordic Bioscience A/S / University of Copenhagen, Copenhagen, Denmark, ²Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology / Deutsches Zentrum Immuntherapie, Erlangen, Germany, ³Nordic Bioscience, Herlev, Denmark, ⁴Division of Rheumatology, Klinikum Nürnberg, Paracelsus Medical University / Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Nürnberg, Germany, ⁵Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, ⁶Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Institute of Applied Dynamics, Erlangen, Germany, ⁷Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ⁸University Hospital Erlangen, Erlangen, Germany, ⁹Friedrich-Alexander-University Erlangen-Nuremberg, Internal Medicine 3 - Rheumatology and Immunology, University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Inflammatory musculoskeletal diseases including rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are characterized by physical function impairment due to progressive inflammatory and structural changes.…
Abstract Number: 1177 • ACR Convergence 2023
Anti-HMGCR Autoantibody Levels in the Follow-up of Statin-induced Immune-mediated Necrotizing Myopathy: Multicentric Study of 24 Patients
David Martinez-Lopez¹, Cristina Corrales Selaya², Diana Prieto-Peña², Piotr Szczesny³, Antonella Notarnicola⁴, Marcos Lopez-Hoyos⁵, Ricardo Blanco⁶, Ingrid Lundberg⁷ and Maryam Dastmalchi⁷, ¹Hospital de Sierrallana, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla, Santander, Spain, ³Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland; Department of Neurology, Medical University of Warsaw, Warsaw, Poland, ⁴Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁵Marques de Valdecilla University Hospital-IDIVAL, Santander, Spain, ⁶Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁷Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Gastroenterology, Dermatotology, Rhematology, Karolinska Universitetssjukhuset, Stockholm, Sweden
Background/Purpose: Statin-induced immune-mediated necrotizing myopathy (IMNM) is associated with anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies. It is characterized by elevated creatine kinase (CK) levels, and severe muscle…
Abstract Number: 1789 • ACR Convergence 2023
Microtrauma Exacerbates Arthritis and Enthesitis in Curdlan-administered SKG Mice by Inducing FGF16 Expresssion
Seung Hoon Lee¹, Chanhyeok Jeon¹, Sungsin Jo¹ and Tae-Hwan Kim², ¹Hanyang University Institute for Rheumatology Research, Seoul, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Microtrauma might be considered a crucial of various environmental factors in AS, but there is still unknown whether microtrauma has a direct/indirect role in…
Abstract Number: 1957 • ACR Convergence 2023
Non-Linear Mendelian Randomization Analyses Support a Role for Low Vitamin D Status in Sarcopenia Risk
Tingting Sha¹, Yilun Wang², Yuqing Zhang³, Nancy Lane⁴, Changjun Li⁵, Jie Wei⁶, Chao Zeng² and Guanghua Lei², ¹Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China, ²Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ³Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, ⁴University of California, Hillsborough, CA, ⁵National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China, ⁶Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Vitamin D deficiency is commonly associated with sarcopenia; however, the latest International Clinical Practice Guidelines for Sarcopenia do not recommend vitamin D supplementation for…
Abstract Number: 1971 • ACR Convergence 2023
Muscle Pathology in Patients with Primary Biliary Cholangitis
Jose Cesar Milisenda¹, Iago Pinal-Fernandez², Katherine Pak², Maria Casal-Dominguez³, Yaiza Duque-Jaimez⁴, Gloria Garrabou¹, Sandra Muñoz-Braceras⁵, Mariona Guitart-Manpel¹, Jose Jiram Torres-Ruiz⁵, Ester Tobias⁴, Maria Dolores Cano⁴, Iban Aldecoa⁴, Josep Maria Grau¹ and Andrew Mammen³, ¹Muscle Research Unit, Internal Medicine Service, Hospital Clinic, Barcelona, Spain, ²National Institutes of Health, Bethesda, MD, ³NIH, Bethesda, MD, ⁴Hospital Clínic de Barcelona, Barcelona, Spain, ⁵Muscle Disease Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease that primarily affects middle-aged women. It is characterized by elevated serum alkaline phosphatase levels,…
Abstract Number: 2467 • ACR Convergence 2023
Quadriceps Muscle Fat Composition but Not Muscle Energetics Is Associated with Knee Osteoarthritis: Initial Results from the Study of Muscle, Mobility, and Aging
Giovanna Distefano¹, Daniel Evans², Peggy Cawthon², John Lynch², Thomas Link², Philip Kramer³, Stephanie Harrison², Bret Goodpaster⁴, Jane Cauley⁵, Theresa Mau², Paul Coen⁴, Lauren Sparks⁴ and Nancy Lane⁶, ¹AventisHealth, Orlando, FL, ²University of California San Francisco, San Francisco, CA, ³Wake Forest, Winston-Salem, NC, ⁴Aventis Health, Orlando, FL, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶University of California, Hillsborough, CA
Background/Purpose: Osteoarthritis (OA) remains the most common cause of joint pain and disability with age, and to date, effective treatments to reduce pain and slow…
Abstract Number: 1233 • ACR Convergence 2022
Ultrasound Is Reliable in the Assessment of Muscle Echogenicity in Patients with Rheumatic Diseases: Results of a Multicenter International Web-based Study
Andrea Di Matteo¹, Erica Moscioni², Maria Giovanna Lommano¹, Edoardo Cipolletta¹, Gianluca Smerilli¹, Sonia Farah¹, Carla Airoldi³, Sibel Aydin⁴, Becciolini Andrea⁵, Karina Bonfiglioli⁶, Marina Carotti⁷, Greta Carrara⁸, Tomas Cazenave⁹, Davide Corradini¹⁰, Micaela Ana Cosatti¹¹, Juan Josè de Agustin¹², Giulia Maria Destro Castaniti¹³, Marco Di Carlo¹, Eleonora Di Donato⁵, Luca Di geso¹⁴, Ashley Elliott¹⁵, Daniela Fodor¹⁶, Francesca Francioso¹, Alessandra Gabba¹⁷, Cristina Hernández-Díaz¹⁸, Rudolf Horvath¹⁹, Jana Hurnakova¹⁹, Diogo Jesus²⁰, Josefina Marin²¹, Maria Victoria Martire²², Riccardo Mashadi-Mirza²³, Marco Massarotti²⁴, Alice Andreea Musca²⁵, Jagdish Nair²⁶, Tadashi Okano²⁷, Ioannis Papalopoulos²⁸, Javier Eduardo Rosa²¹, Marcos Rosemffet²⁹, João Rovisco³⁰, Davide Rozza⁸, Fausto Salaffi¹, Crescenzio Scioscia³¹, Carlo Alberto Scirè⁸, Maria-Magdalena Tamas³², Shun Tanimura³³, Lucio Ventura-Rios¹⁸, Catalina Villota-Eraso³⁴, Orlando Villota³⁵, Paraksevi V Voulgari³⁶, Florentin Ananu Vreju³⁷, Gentiana Vukatana³⁷, Johana Zacariaz Hereter²¹, Anna Zanetti⁸, Walter Grassi¹ and Emilio Filippucci¹, ¹Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Italy, ²Polytechnic University of Marche, Jesi, Italy, ³Hospital Provincial, Rosario, Argentina, ⁴University of Ottawa, Rheumatology, Ottawa, Canada, Ottawa, ON, Canada, ⁵Department of Medicine, Internal Medicine and Rheumatology Unit, Azienda Ospedaliero Universitaria di Parma, Parma, Italy, ⁶Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁷Department of Radiology, Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy, ⁸Epidemiology Unit, Italian Society of Rheumatology, Milano, Italy, ⁹Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ¹⁰Rheumatology Unit, University Clinic AOU Cagliari, Cagliari, Italy, ¹¹CEMIC, Centro de educación médica e investigaciones médicas "Norberto Quirno", Buenos Aires, Argentina, ¹²Vall D'hebron University Hospital, Barcelona, Spain, ¹³Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology section, University of Palermo, Palermo, Italy, ¹⁴Ospedale Madonna del Soccorso, Department of Internal Medicine, San Benedetto del Tronto, Italy, ¹⁵Centre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom, ¹⁶2nd Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania, ¹⁷Local Health Unit (ASL), Oristano, Italy, ¹⁸Division de Reumatologia. Instituto Nacional de Rehabilitacion "Luis Guillermo Ibarra Ibarra", Ciudad de México, Mexico, ¹⁹Department of Paediatric and Adult Rheumatology, University Hospital Motol, Prague, Czech Republic, ²⁰Rheumatology Department, Centro Hospitalar de Leiria, Leira, Portugal, ²¹Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²²San Roque Hospital, La Plata, Buenos Aires, Argentina, ²³Radiology Department, A.O. Ospedali Riuniti Marche Nord, Pesaro, Italy, ²⁴Department of Rheumatology, University Hospitals Dorset NHS Foundation Trust, Christchurch Hospital, Christchurch, United Kingdom, ²⁵Department of Rheumatology - Colentina Clinical Hospital, Bucharest, Romania, ²⁶Rheumatology, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom, ²⁷Department of Orthopedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, ²⁸Department of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece, ²⁹Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Capital Federal, Argentina, ³⁰Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ³¹Department of Emergency and Organ Transplantations-Rheumatology Unit, University of Bari "Aldo Moro", Bari, Italy, ³²Department of Rheumatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania, ³³Rheumatology Department, Hokkaido Medical Center for Rheumatic Diseases, Sapporo, Japan, ³⁴IPS Servicio integral de reumatología e inmunología Dr Orlando Villota, Pasto, Colombia, ³⁵Division of Rheumatology, Fundación Hospital San Pedro, Pasto, Colombia, ³⁶Department of Rheumatology, School of Health Science, Faculty of Medicine, University of Ioannina, Ioannina, Greece, ³⁷Rheumatology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania, ³⁷Rheumatology Unit; IRCCS Policlinico S. Orsola Malpighi, Bologna, Italy
Background/Purpose: Studies have showed that an increased ultrasound (US) muscle echogenicity indicating fatty replacement/fibrosis of muscle tissue may represent an early indicator of muscle involvement associated…
Abstract Number: 1886 • ACR Convergence 2022
Statin-induced Immune-mediated Miopathy: Treatment with Glucocorticoid-free Protocols and Role of Muscle Biopsy in the Follow-up
David Martínez-López¹, Piotr Szczęsny², Inger Nennesmo³, Karina Gheorghe⁴, Antonella Notarnicola⁵, Helene Alexanderson⁶, Ingrid Lundberg⁷ and Maryam Dastmalchi⁸, ¹Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland. Department of Neurology, Medical University of Warsaw, Warsaw, Poland, ³Department of Pathology, Karolinska University Hospital,Pathology, Karolinska University Hospital., Stockholm, Sweden, ⁴Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet. Rheumatology, Karolinska University Hospital Stockholm, Sweden. Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁵Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁶Karolinska Institutet, Stockholm, Sweden, ⁷Karolinska Universitetssjukhuset, Karolinska Institutet, Stockholm, Sweden, ⁸Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Statin-induced immune mediated necrotizing myopathy (IMNM) is a recently identified autoimmune condition associated with anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, characterized by progressive muscle weakness leading…

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