Abstracts tagged "MRI"

Abstract Number: 657 • 2018 ACR/ARHP Annual Meeting
First Validation of Consensus Definitions for MRI Lesions in the Sacroiliac Joint By the Assessments in Spondyloarthritis International Society MRI Group
Walter P. Maksymowych^1,2, Ulrich Weber³, Susanne J Pedersen⁴, Xenofon Baraliakos⁵, Pedro Machado⁶, Joachim Sieper⁷, Denis Poddubnyy⁷, Stephanie Wichuk¹, Joel Paschke², Robert G. Lambert¹ and Mikkel Østergaard⁴, ¹University of Alberta, Edmonton, AB, Canada, ²CaRE Arthritis, Edmonton, AB, Canada, ³University of Southern Denmark, Odense, Denmark, ⁴COPECARE University of Copenhagen, Copenhagen, Denmark, ⁵Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁶University College London, London, United Kingdom, ⁷Charité Universitätsmeidzin Berlin, Berlin, Germany
Background/Purpose: The diversity of MRI lesions in the sacroiliac joints of patients with axial spondyloarthritis (axSpA) has only recently been appreciated and consistent terminology, descriptions,…
Abstract Number: 1496 • 2018 ACR/ARHP Annual Meeting
Sex Differences in the Achievement of Clinical Remission and Low MRI Synovitis Scores in Rheumatoid Arthritis
Joshua Baker¹, Mikkel Østergaard², Carson Maynard³, Michael D. George⁴, Daniel Baker⁵ and Philip G. Conaghan⁶, ¹Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, ²Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ³Rheumatology, University of Pennsylvania, Philadlphia, PA, ⁴Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵Johnson & Johnson, Spring House, PA, ⁶University of Leeds, Leeds, UK, Leeds, United Kingdom
Background/Purpose: Several prior studies have demonstrated poor clinical responses and reduced likelihood of achievement of remission among women with rheumatoid arthritis (RA). We aimed to…
Abstract Number: 14L • 2017 ACR/ARHP Annual Meeting
Miv-711, a Novel Cathepsin K Inhibitor Demonstrates Evidence of Osteoarthritis Structure Modification: Results from a 6 Month Randomized Double-Blind Placebo-Controlled Phase IIA Trial
Philip G. Conaghan¹, Michael A Bowes², Sarah R. Kingsbury¹, Alan Brett², Gwenael Guillard², Åsa Jansson³, Cecilia Wadell³, Richard Bethell³ and John Öhd³, ¹University of Leeds, Leeds, United Kingdom, ²Imorphics Ltd, Manchester, United Kingdom, ³Medivir AB, Huddinge, Sweden

Background/Purpose: The need for drugs that achieve structure modification in OA is imminent but their development has been burdened by the need for large, long…
Abstract Number: 586 • 2017 ACR/ARHP Annual Meeting
Validation of Online Calibration Modules for the Spondyloarthritis Research Consortium of Canada MRI Scores Based on Real-Time Experiential Learning
Matthew Maksymowych¹, Hanne Boutrup², Jonathan Cheah³, Riccardo Guglielmi⁴, Eric Heffernan⁵, Jacob Jaremko¹, Mats-Peter Johansson⁶, Simon Krabbe⁷, Georg Kroeber⁸, Fardina Malik⁹, Susanne Juhl Pedersen⁷, Sander Shafer⁶, Ulrich Weber¹⁰, Pam Weiss¹¹, Brian Trinh¹², Joel Paschke¹³ and Robert G. Lambert¹⁴, ¹Radiology, University of Alberta, Edmonton, AB, Canada, ²University of Copenhagen, Copenhagen, Denmark, ³Medicine, Hospital for Special Surgery, New York, NY, ⁴Radiology, Ente Ospedaliero Cantonale, Lugano, Switzerland, ⁵Radiology, St. Vincent's University Hospital, Dublin, Ireland, ⁶Rheumatology, Gentofte Hospital, Copenhagen, Denmark, ⁷Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, ⁸University of Southern Denmark, Odense, Denmark, ⁹Medicine- Rheumatology, Weill Cornell Medical College, New York, NY, ¹⁰Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, ¹¹Pediatrics, Children's Hospital Philadelphia, Philadelphia, PA, ¹²CARE Arthritis, EDMONTON, AB, Canada, ¹³CARE Arthritis, Edmonton, AB, Canada, ¹⁴University of Alberta, Edmonton, AB, Canada
Background/Purpose: The appropriate use of imaging-based scoring instruments is usually an ad hoc process based on passive learning from published manuscripts. Moreover, most instruments lack…
Abstract Number: 1996 • 2017 ACR/ARHP Annual Meeting
Changes in Cartilage Matrix Measured By MR T1ρ Are Correlated with Changes in Bone Erosion Volume Measured By HR-pQCT Three Months after MTX and Anti-TNF Treatment in Patients with Rheumatoid Arthritis: A Multi-Modality Imaging Study
Tomohiro Shimizu^1,2,3, Kenji Mamoto¹, Ursula Heilmeier¹, Matthew Tanaka¹, Andrew J Burghardt¹, Thomas Link¹, Jonathan Graf⁴, John B. Imboden Jr.⁵ and Xiaojuan Li⁶, ¹Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California, San Francisco, San Francisco, CA, ²Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, ³Department of Orthopaedic Surgery, Hokkaido University, Sapporo, Japan, ⁴Department of Medicine, Division of Rheumatology Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, ⁵Medicine, University of California, San Francisco, San Francisco, CA, ⁶Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA
Background/Purpose: MR-based T1rho relaxation time mapping allows non-invasive quantification of early cartilage deterioration, while high-resolution peripheral quantitative computed tomography (HR-pQCT) can detect early changes in…
Abstract Number: 587 • 2017 ACR/ARHP Annual Meeting
Detection of Structural Lesions on T1 Weighted MRI Versus Radiography of the Sacroiliac Joints in Early Axial Spa: 2-Year Data
Walter P. Maksymowych¹, Pascal Claudepierre², Manouk de Hooge³, Robert G. Lambert⁴, Robert B.M. Landewé⁵, Anna Molto⁶, Désirée van der Heijde³, Jack F Bukowski⁷, Heather Jones⁸, Isabelle Logeart⁹, Lisa Marshall⁸, Ronald Pedersen¹⁰, Annette Szumski¹¹, Bonnie Vlahos¹² and Maxime Dougados¹³, ¹Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ²Universite Paris Est Creteil, Paris, France, ³Leiden University Medical Center, Leiden, Netherlands, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, ⁶Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ⁷Clinical Affairs, Pfizer, Collegeville, PA, ⁸Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, ⁹Medical Affairs, Pfizer, France, Paris, France, ¹⁰Department of Biostatistics, Pfizer, Collegeville, PA, ¹¹inVentiv Health, Princeton, NJ, ¹²Clinical Sciences, Pfizer, Collegeville, PA, ¹³Hopital Cochin, Paris Descartes University, Paris, France
Background/Purpose: At the SI joint (SIJ) level, several methods exist for evaluating structural damage, e.g., MRI, CT scan, radiographs. In EMBARK (NCT01258738) and DESIR (NCT01648907),…
Abstract Number: 2000 • 2017 ACR/ARHP Annual Meeting
MRI Contributes to Accurate and Early Diagnosis of Non-Radiographic HLA-B27 Negative Axial Spondyloarthritis
Chun-Chi Lu¹, Guo-Shu Hunag², Tony Szu-Hsien Lee³, En Chao⁴, Hsiang-Cheng Chen², Shi-Jye Chu², Feng-Cheng Liu², San-Yuan Kao², Tsung-Yun Hou², Chen-Hung Chen⁵, Sin-Yi Lyu⁶ and Deh-Ming Chang⁷, ¹University of Washington; Tri-Service General Hopsital, National Defense Medical Center, Seattle, WA, ²Tri-Service General Hopsital, National Defense Medical Center, Taipei, Taiwan, ³National Taiwan Normal University, Taipei, Taiwan, ⁴Tri-Service General Hospital Songshan branch, National Defense Medical Center, Taipei, Taiwan, ⁵Taipei Tzu Chi Hospital, Taipei, Taiwan, ⁶Taoyuan General Hospital, Ministry of Health and Welfare, Taipei, Taiwan, ⁷Tri-Service General Hospital, National Defense Medical Center; Taipei Veteran General Hospital, Taipei, Taiwan
Background/Purpose: According to the ASAS classification criteria for axial spondyloarthritis (SpA), the presence of structure changes of sacroiliac (SI) joints such as sclerosis, bone erosion,…
Abstract Number: 588 • 2017 ACR/ARHP Annual Meeting
Inflammatory Lesions of the Sacroiliac Joints, but Not of the Spine, Are of High Utility for Recent Onset Axial Spondyloarthritis Recognition
Anna Molto¹, Laure Gossec², Violaine Foltz², Romain Beaufort³, Jean Denis Laredo⁴, Pascal Richette⁵, Philippe Dieude⁶, Philippe Goupille⁷, Antoine Feydy⁸ and Maxime Dougados⁹, ¹Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³Private Practice,, Paris, France, ⁴Radiology Department, Lariboisière Hospital, Paris, France, ⁵Rheumatology Department, Université Paris Diderot, Paris, France, ⁶Université Paris-Diderot, Paris, France, ⁷Université François-Rabelais, Tours, France, ⁸Univ. Paris Descartes, PRES Sorbonne Paris Cité, Service de radiologie B, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, Paris, France, ⁹Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: only scarce data are available regarding the prevalence of MRI inflammatory lesions of the sacroiliac joints (SIJ) or the spine suggestive of axial Spondyloarthritis…
Abstract Number: 2001 • 2017 ACR/ARHP Annual Meeting
Prevalence of Inflammatory Posterior Arch Abnormalities on Lumbar Spine MRI in Spondyloarthritis Patients Compared to Low Back Pain Patients
Helene Braun¹, Clement Geniez¹, Yannick Degboe², Arnaud Constantin³, Alain Cantagrel⁴, Delphine Nigon⁵, Marie Faruch-Bilfeld¹ and Adeline Ruyssen-Witrand⁴, ¹Purpan Hospital, Toulouse, France, ²Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France, ³Purpan Hospital, toulouse, France, ⁴Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, ⁵CHU Purpan, Toulouse, France
Background/Purpose: To compare the prevalence of inflammatory posterior arch abnormalities (IPAA) on lumbar spine MRI between spondyloarthritis patients (SpA) and low back pain patients (LBP).…
Abstract Number: 589 • 2017 ACR/ARHP Annual Meeting
Erosions at the Sacroiliac Joints and Fatty Lesions at the Spine Are the Most Discriminant Lesions for Recent Onset Axial Spondyloarthritis Recognition
Anna Molto¹, Laure Gossec², Violaine Foltz², Romain Beaufort³, Jean Denis Laredo⁴, Pascal Richette⁵, Philippe Dieude⁶, Philippe Goupille⁷, Antoine Feydy⁸ and Maxime Dougados⁹, ¹Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³Private Practice,, Paris, France, ⁴Radiology Department, Lariboisière Hospital, Paris, France, ⁵Rheumatology Department, Université Paris Diderot, Paris, France, ⁶Université Paris-Diderot, Paris, France, ⁷Department of Rheumatology, CHRU de Tours; and Université François-Rabelais de Tours, Tours, France, ⁸Univ. Paris Descartes, PRES Sorbonne Paris Cité, Service de radiologie B, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, Paris, France, ⁹Paris, Paris, France
Background/Purpose: only scarce data are available regarding the prevalence of MRI structural lesions of the sacroiliac joints (SIJ) or the spine suggestive of axial Spondyloarthritis…
Abstract Number: 2038 • 2017 ACR/ARHP Annual Meeting
Radiological Changes Measured By MRI and High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) Show Correlation with Michigan Hand Outcome Questionnaire (MHQ) in Rheumatoid Arthritis Patients
Ana Cruz¹, Tomohiro Shimizu², Matthew Tanaka³, Kenji Mamoto³, Andrew J Burghardt³, Ursula Heilmeier³, Thomas Link³, Jonathan Graf⁴, John B. Imboden Jr.⁵ and Xiaojuan Li⁶, ¹University of California, San Francisco, San Francisco, CA, ²Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California, San Francisco, SAN FRANCISCO, CA, ³Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, University of California, San Francisco, San Francisco, CA, ⁴Department of Medicine, Division of Rheumatology Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, ⁵Medicine, University of California, San Francisco, San Francisco, CA, ⁶Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA
Background/Purpose: Disease progression and therapy response in patients with rheumatoid arthritis (RA) is currently evaluated using clinical and functional assessments that include subjective measurements such…
Abstract Number: 591 • 2017 ACR/ARHP Annual Meeting
Inflammation on MRI of Spine and Sacroiliac Joints Is Highly Predictive of Structural Damage in Axial Spondyloarthritis: The 5 Years Data of the DESIR Cohort
Alexandre Sepriano¹, Sofia Ramiro², Robert B.M. Landewé³, Maxime Dougados⁴ and Désirée van der Heijde¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ³University of Amsterdam and Atrium Medical Center, Amsterdam, Netherlands, ⁴Paris-Descartes University,, Paris, France
Background/Purpose: The effect of local inflammation on structural damage in patients (pts) with axial spondyloarthritis is not well known. We aimed to test the possible…
Abstract Number: 2208 • 2017 ACR/ARHP Annual Meeting
A Novel Omeract MRI Scoring System Providing Insights in the Association of MRI Synovitis and Bone Marrow Lesions with Pain in Thumb Base Osteoarthritis
F.P.B. Kroon¹, S. van Beest¹, W. Damman¹, R. Liu¹, J.L. Bloem², M. Reijnierse² and M. Kloppenburg^1,3, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Osteoarthritis (OA) in the thumb base joints (first carpometacarpal [CMC1] and scaphotrapeziotrapezoid [STT]) is highly prevalent and disabling, however much is still unknown about…
Abstract Number: 592 • 2017 ACR/ARHP Annual Meeting
Which Imaging Outcomes for AxSpA Are Most Sensitive to Change? a 5-Year Analysis of the DESIR Cohort
Alexandre Sepriano¹, Sofia Ramiro², Désirée van der Heijde¹, Maxime Dougados³, Pascal Claudepierre⁴, Antoine Feydy⁵, M. Reijnierse⁶, Damien Loeuille⁷ and Robert B.M. Landewé⁸, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ³Paris-Descartes University,, Paris, France, ⁴Hôpital Henri Mondor, Créteil, France, ⁵Univ. Paris Descartes, PRES Sorbonne Paris Cité, Service de radiologie B, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, Paris, France, ⁶Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁷Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ⁸University of Amsterdam and Atrium Medical Center, Amsterdam, Netherlands
Background/Purpose: Several imaging outcomes have become available to assess inflammation and structural damage over time in patients with axial spondyloarthris (axSpA). However, no formal comparison…
Abstract Number: 2368 • 2017 ACR/ARHP Annual Meeting
Global Circumferential Strain By Assessed a Feature Tracking Cardiac Magnetic Resonance (CMR) Imaging Was Associated with Myocardial Fibrosis in RA Patients
Yasuyuki Kobayashi¹, Hitomi Kobayashi², Isamu Yokoe³, Atsuma Nishiwaki⁴, Akiyuki Kotoku⁵ and Masami Takei⁴, ¹Advanced Biomedical Imaging Informatics, St.Marianna University School of Medicine, Kawasaki, Japan, ²Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ³Rheumatology, Kyoundo Hospital, Sasaki Institute, Tokyo, Japan, ⁴Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ⁵Advanced Biomedical Imaging Informatics, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Individuals with RA have a 1.5-2.0 fold higher risk of developing congestive heart failure (CHF) than the general population. It is important to understand…

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