ACR Meeting Abstracts

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Abstracts tagged "Mortality"

  • Abstract Number: 1622 • ACR Convergence 2023

    Myositis-associated Autoantibodies in Juvenile Myositis Are Associated with Severe Disease Features and Mortality

    Matthew Sherman1, Payam Noroozi Farhad2, Katherine Pak3, Iago Pinal-Fernandez3, Kakali Sarkar2, Megan Neely4, Ira Targoff5, Frederick Miller6, Andrew Mammen7 and Lisa Rider8, 1NIAMS/NIH, Washington, DC, 2Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, 3National Institutes of Health, Bethesda, MD, 4Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, 5Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK, 6NIH, NIEHS, Chapel Hill, NC, 7NIH, Bethesda, MD, 8NIEHS, NIH, Bethesda, MD

    Background/Purpose: Myositis-associated autoantibodies (MAAs), such as anti-Ro52 autoantibodies (Abs), have been found to be associated with interstitial lung disease (ILD) and worse prognosis in the…
  • Abstract Number: 2128 • ACR Convergence 2023

    Higher Vitamin D Levels Before Methotrexate Start Are Associated with Lower Subsequent Mortality in Rheumatoid Arthritis

    Shahdi Malakooti1, Hinnah Siddiqui2, Brigid Wilson2, Taissa Bej2, Megan O'Mara2, Nora Singer3, Grace McComsey4, Lenche Kostadinova5, Maya Mattar6, David Zidar5 and Donald Anthony7, 1Case Western Reserve University, Cleveland, OH, 2Louis Stokes Cleveland VA Medical Center, Cleveland, OH, 3The MetroHealth System at Case Western Reserve University School of Medicine, Cleveland, OH, 4University Hospitals Health System at Case Western Reserve University, Cleveland, OH, 5Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, OH, 6Louis Stokes VA Medical Center, Cleveland, OH, 7Case Western Reserve University, Cleveland VA Medical Center, The MetroHealth System, Cleveland, OH

    Background/Purpose: Vitamin D is an immune-modulating hormone. Low Vitamin D levels have been associated with development of autoimmune disease and higher disease activity in early…
  • Abstract Number: 0645 • ACR Convergence 2023

    Continuous Progressive ILD in Systemic Sclerosis Is Associated with Mortality

    Anna-Maria Hoffmann-Vold1, Liubov Petelytska2, Havard Fretheim1, Trond Mogens Aaløkken3, Mike Becker4, Cathrine Brunborg5, Cosimo Bruni6, Christian Clarenbach7, Phuong Phuong Diep8, Rucsandra Dobrota6, Michael Durheim9, Muriel Elhai10, Thomas Frauenfelder11, Suzana Jordan6, Emily Langballe12, Oyvind Midtvedt1, Carina Mihai6, Oyvind Molberg13 and Oliver Distler6, 1Oslo University Hospital, Oslo, Norway, 2Bogomolets National Medical University, Kyiv, Ukraine, 3Dept of Radiology, Oslo University Hospital, Oslo, Norway, 4Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 5Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital - Rikshospitalet, Oslo, Norway, 6Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 7Dept of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 8Dept of Respiratory diseases, University Hospital Oslo, Oslo, Norway, 9Dept of Respiratory diseases, Oslo University Hospital, Oslo, Norway, 10University Hospital zurich, University of Zurich, Zurich, Switzerland, 11Dept of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 12Universitetet i Oslo, Oslo, Norway, 13Dept of Rheumatology, University Hospital Oslo, Oslo, Norway

    Background/Purpose: We have previously shown that short term progression of interstitial lung disease (ILD) in systemic sclerosis (SSc) is associated with mortality. However, it is…
  • Abstract Number: 1169 • ACR Convergence 2023

    All-cause Mortality and Risk Factors for Death in a Large Multi-center Prospective Registry Cohort of Idiopathic Inflammatory Myositis in China

    Liying Peng1, Peng Yin2, Mucong Li3, Qian Wang4, Yanhong wang1, Shuang Zhou4, chanyuan wu4, Jiuliang zhao1, Dong xu5, Mengtao Li3 and xiaofeng Zeng4, 1Peking Union Medical College, Beijing, China, 2Chinese Center for Disease Control and Prevention, Beijing, China, 3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 4Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 5Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: Our study depicted the mortality and independent risk factors of IIM patients in a large multi-center prospective registry cohort in China. Methods: Patients registered…
  • Abstract Number: 1699 • ACR Convergence 2023

    Immunosuppression with Targeted Therapies Reduces Morbidity and Mortality in Pre-Capillary Pulmonary Hypertension Associated with Systemic Sclerosis: A EUSTAR Analysis

    Cosimo Bruni1, Havard Fretheim2, Lorenzo Tofani3, Yannick Weber1, Eric Hachulla4, Patricia Carreira5, Dilia Giuggioli6, Paolo Airò7, Elise Siegert8, Ulf Müller-Ladner9, marco Matucci Cerinic10, Gabriela Riemekasten11, Carmen Pilar Simeon-Aznar12, Jeska de Vries-Bouwstra13, Lesley Ann Saketkoo14, Joerg Distler15, Alexandra Balbir-Gurman16, Ivan Castellvi17, Elisabetta Zanatta18, Vanessa Smith19, Christopher Denton20, Britta Maurer21, Alessandro Giollo18, Florenzo Iannone22, Lorenzo Dagna23, Marie-Elise Truchetet24, Masataka Kuwana25, Yannick ALLANORE26, Yoshiya Tanaka27, Mickael Martin28, Edoardo Rosato29, Ana Maria Gheorghiu30, Francesco Del Galdo31, Kamal Solanki32, Alessandra Vacca33, CATARINA RESENDE34, SUSANA VIEIRA35, Laszlo Czirjak36, Marko Barisic37, Francesco Paolo Cantatore38, valeria Riccieri39, Kristofer Andréasson40, Lorinda Chung41, Carolina Muller42, Daniela OPRIS-BELINSKI43, Simona Rednic44, Petros Sfikakis45, Yair Levy46, Anna Maria Hoffmann-Vold47, Oliver Distler1, Vivien Hsu48, Stefan Heitmann49, Gianluca Moroncini50, Michele Iudici51, Joerg Henes52, Ellen De Langhe53, Ariane Herrick54 and Carlomaurizio Montecucco55, 1Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2Oslo University Hospital, Oslo, Norway, 3Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy, 4University of Lille, Lille, France, 5Hospital Universitario 12 de Octubre, Madrid, Spain, 6Scleroderma Unit, Rheumatology Unit, University Hospital of Modena and Reggio Emilia, Modena, Italy, 7Spedali Civili di Brescia, Scleroderma UNIT, UOC Reumatologia ed Immunologia Clinica, Piazzale Spedali Civili 1, 25123, Brescia, Italy, 8Department of Rheumatology, Charité University Hospital, Charité Platz 1, D-10117, Berlin, Germany, 9Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 10Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Hospital, Milan, Milan, Italy, 11University Clinic Schleswit-Holstein (UKSH), Lübeck, Germany, 12Department of Internal Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitario Vall d'Hebronh, Barcelona, Spain, 13Leiden University Medical Center, Leiden, Netherlands, 14University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 15Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, 16Rheumatology Institute, Rambam Health Care Campus and Rappaport Faculty of |Medicine, Technion, Haifa, Israel, 17Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Sant Just Desvern, Spain, 18Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Padua, Italy, 19Ghent University Hospital, Gent, Belgium, 20University College London, London, United Kingdom, 21University Hospital Bern, University Bern, Bern, Switzerland, 22Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy, 23Ospedale San Raffaele, Milano, Italy, 24Bordeaux University Hospital, Bordeaux, France, 25Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 26Université Paris Cité, Paris, France, 27University of Occupational and Environmental Health, Kitakyushu, Japan, 28Department of Internal Medicine, INSERM U1313, Poitiers University, Poitiers University Hospital, Poitiers, France, 29Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy, 30Department of Internal Medicine and Rheumatology, Ion Cantacuzino Clinical Hospital, Bucharest, Romania, 31University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom, 32Department of Rheumatology, Te Whatu Ora Health New Zealand Waikato, Hamilton, New Zealand, 33II Chair of Rheumatology, University of Cagliari-Policlinico Universitario, Monserrato, Italy, 34Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Lisboa, Portugal, 35Hospital Fernando Fonseca, Lisbon, Portugal, 36Dept. Rheumatol Immunol, Medical School, university of Pecs, Pecs, Hungary, 37Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia, 38Rheumatology Clinic – Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy, 39Department of Clinical, Internal and Cardiovascular Specialities, Sapienza University of Rome, Roma, Italy, 40Lund University, Lund, Sweden, 41Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA, 42Federal University of Parana, CURITIBA / PR, Brazil, 43Saint Mary Hospital, Bucharest, Romania, 44Prof Dr Simona Rednic, Cluj, Romania, 45National Kapodistrian University of Athens Medical School, Athens, Greece, 46Meir Medical Center, Autoimmune Research Laboratory, Kfar-Saba, Israel, 47Oslo University Hospital, Department of Rheumatology, Oslo, Norway, 48Rutgers-RWJ Medical School, South Plainfield, NJ, 49Department of Rheumatology, Marienhospital Stuttgart, Böheimstrasse 37, D-70199, Stuttgart, Germany, 50Marche Polytechnic University, Ancona, Italy, 51Division of Rheumatology, Department of Internal Medicine Specialties, Geneva University Hospitals, Geneva, Switzerland, 52University Hospital Tuebingen, Tuebingen, Germany, 53Division of Rheumatology, University Hospitals Leuven, Leuven, Belgium, 54University of Manchester, Salford, United Kingdom, 55Unità Operativa e Cattedra di Reumatologia, IRCCS Policlinico S Matteo, Pavia, Italy

    Background/Purpose: Systemic sclerosis (SSc) associated pre-capillary pulmonary hypertension (precapPH) is a severe condition that requires prompt treatment. Although immunosuppressants (IMS) are standard of care for…
  • Abstract Number: 2152 • ACR Convergence 2023

    Survival Benefits of Knee and Hip Arthroplasty in Patients with Rheumatoid Arthritis: A General Population-based Cohort Study

    Xinjia Deng1, Yuqing Zhang2, Yilun Wang1, Na Lu3, Dongxing Xie4, Houchen Lyu5, Jie Wei6, Chao Zeng1, Guanghua Lei1 and Hui Li1, 1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, 2Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Xiangya Hospital, Central South University, Changsha, China, 5Chinese PLA General Hospital, Department of Orthopedics, Beijing, China, 6Health Management Center, Xiangya Hospital Central South University, Changsha, China

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease (CVD), venous thromboembolism (VTE), and mortality. Many patients with RA underwent knee and…
  • Abstract Number: 0098 • ACR Convergence 2023

    Predictors of Mortality in Antiphospholipid Antibody Positive Patients: Prospective Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Clinical Database and Repository “Registry”

    Yasaman Ahmadzadeh1, Larry Magder2, Zeynep Ozge Ozdemir3, Danieli Andrade4, Megan R.W. Barber5, Maria Tektonidou6, Savino Sciascia7, Vittorio Pengo8, Ariadna Anunciación-Llunell9, Guillermo Ruiz-Irastorza10, Mª Angeles Aguirre11, Michael Belmont12, Kello Nina13, Paul R. Fortin14, Denis WAHL15, Maria Gerosa16, Guilherme De Jesús17, Zhuoli Zhang18, Tatsuya Atsuma19, Maria Efthymiou20, D. Ware Branch21, Angela Tincani22, Esther Rodriguez almaraz23, Giulia Pazzola24, Ricard Cervera25, Bahar Artim Esen26, Hui Shi27, Jason Knight28, Guillermo Pons-Estel29, Rohan Willis30, Ali Duarte-Garcia31, Maria Laura Bertolaccini32, Hannah Cohen33, Michelle Petri34, Doruk Erkan35 and On Behalf Of APS ACTION36, 1Roger Williams Medical Center, Providence, RI, 2University of Maryland, Baltimore, MD, 3Hacettepe University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, 4University of São Paulo, São Paulo, Brazil, 5University of Calgary, Calgary, AB, Canada, 6Joint Academic Rheumatology Program, First Department of Propedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, 7University of Turin, Torino, Italy, 8Department of Cardiac-Thoracic-Vascular Sciences and Public Health University of Padova, Padova, Italy, 9VHIR Vall d'Hebron Institut de Investigación, Barcelona, Spain, 10Hospital Universitario Cruces, Barakaldo, Spain, 11Reina Sofía University Hospital/ Rheumatology Department, Córdoba, Spain, 12New York University Langone Medical Center, New York, NY, 13Northwell Health, Brooklyn, NY, 14Centre ARThrite - CHU de Québec - Université Laval, Quebec City, QC, Canada, 15University of Lorraine, Nancy, France, 16University of Milan, Milano, Italy, 17Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Brazil, 18Peking University First Hospital, Rheumatology and Immunology Department, Beijing, China, 19Hokkaido University, Department of Rheumatology, Endocrinology and Nephrology, Sapporo, Japan, 20University College London, London, United Kingdom, 21University of Utah, Salt Lake City, UT, 22Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, University of Brescia, Gussago, Italy, 23Hospital Universitario 12 de Octubre, Madrid, Spain, 24Azienda Ospedaliera Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Italy, 25Hospital Clínic de Barcelona, Barcelona, Spain, 26Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 27Rijin Hospital, Shanghai, China, 28University of Michigan, Ann Arbor, MI, 29CREAR, Rosario, Argentina, 30University of Texas Medical Branch, Galveston, TX, 31Mayo Clinic, Rochester, MN, 32King's College London, London, United Kingdom, 33Haemostasis Research Unit, Department of Hematology, University College London, London, United Kingdom, 34Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 35Hospital for Special Surgery, New York, NY, 36on behalf of APS ACTION, New York, NY

    Background/Purpose: APS ACTION "Registry" was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive patients with/without other systemic…
  • Abstract Number: 0648 • ACR Convergence 2023

    Incidence and Prevalence of Malnutrition and Its Impact on Mortality in the Multicentre Singapore Systemic Sclerosis Cohort

    Bochao Jiang1, Ennaliza Salazar2, Seyed Ehsan Saffari3, Gim Gee Teng4, Xin Rong Lim5, Sue-Ann Ng2, Amelia Santosa6, Cassandra Hong2 and Andrea Hsiu Ling Low7, 1Ministry of Health Holdings, Singapura, Singapore, 2Singapore General Hospital, Singapore, Singapore, 3Center for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore, 4Alexandra Hospital, Department of Medicine, Division of Rheumatology, National University Health System, Singapore, Singapore, 5Tan Tock Seng Hospital, Singapore, Singapore, 6Division of Rheumatology, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore, 7Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore

    Background/Purpose: Gastrointestinal (GI) involvement is common in patients with systemic sclerosis (SSc), and may lead to malnutrition that adversely affects quality of life, morbidity and…
  • Abstract Number: 1180 • ACR Convergence 2023

    Machine Learning Approach for the Prediction of anti-MDA5 Positive Dermatomyositis Mortality

    Xinlei Liu1, Fumin Qi2, Wei Wei1 and Yin Zhao1, 1Tianjin Medical University General Hospital, Tianjin, China, 2Tianjin Medical University, Tianjin, China

    Background/Purpose: We describe a single-center clinical cohort of MDA5 positive dermatomyositis(DM) in China and apply a machine learning approach to predict the risk of mortality…
  • Abstract Number: 1702 • ACR Convergence 2023

    Outcomes in Systemic Sclerosis Patients Treated with Rituximab and Mycophenolate Mofetil Combination Therapy Compared to Autologous Hematological Stem Cell Transplantation

    shiri keret1, Lisa Kaly2, Aniela Shouval2, Tsila Zuckerman3, Israel Henig4, Abid Awisat5, Itzhak Rosner6, Michel Rozenbaum2, Nina Boulman2, Yair Molad7, ariela Dortort Lazar8, Gleb Slobodin2 and Doron Rimar2, 1Bnai Zion, Atlit, Israel, 2Bnai Zion Medical Center, Haifa, Israel, 3Hematology department, Rambam Medical Center, Haifa, Israel, 4Stem cell transplantation unit, Hematology department, Rambam Medical Center, Haifa, Israel, 5Bney-Zion Medical Center, Baqa Elgharbiya, Israel, 6Bnai Zion Medical Center/Technion, Haifa, Israel, 7Rabin Medical Center, Beilinson Hospital, and Tel Aviv University, Petah-Tikva, Israel, 8Rabin Medical Center and Tel Aviv university, Tel Aviv, Israel

    Background/Purpose: Autologous hematological stem cell transplantation (AHSCT) is a grade A therapy for early diffuse progressive systemic sclerosis (SSc), that has been validated in three…
  • Abstract Number: 2185 • ACR Convergence 2023

    35 Years Follow-up of Primary Sjögren’s Disease: A Single Center Study

    Lorena Montano-Tapia1, Resit Yildrim2, Ana Mafalda Abrantes3 and David Isenberg4, 1Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain, 2Eskişehir Osmangazi University I, Eskişehir, Turkey, 3Centro Hospitalar Universitario Lisboa Norte, Lisbon, Portugal, 4University College London, London, United Kingdom

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is an autoimmune rheumatic disease characterized by lymphocytic infiltration of exocrine glands. Its clinical manifestations are heterogeneous. Currently, the evidence…
  • Abstract Number: 0107 • ACR Convergence 2023

    Impact of Antiphospholipid Syndrome on Mortality of Hospitalized Ischemic Stroke Patients: A Retrospective Analysis of the National Inpatient Sample Database 2020

    Sami Rabah, Lincoln Medical Center, New York, NY

    Background/Purpose: Antiphospholipid syndrome (APS) is recognized for its association with an elevated risk of ischemic strokes and other thromboembolic events. This study aims to compare…
  • Abstract Number: 0652 • ACR Convergence 2023

    Ethnic Variations in Systemic Sclerosis Associated Interstitial Lung Disease

    Patrick Donio1, Wesley Fidler2, Juan Pablo Diaz-Martinez3, Elvira Bangert4, Zareen Ahmad5, Medha Soowamber6 and Sindhu Johnson7, 1Thunder Bay Regional Health Sciences Centre, Northern Ontario School of Medicine University, Queen's University, Thunder Bay, ON, Canada, 2Northern Ontario School of Medicine, Thunder Bay, ON, Canada, 3Toronto Western Hospital, Toronto, ON, Canada, 4Toronto Scleroderma Program, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Toronto Scleroderma Program, Mount Sinai Hospital, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 6Toronto Scleroderma Program, Mount Sinai Hospital, Toronto Western Hospital, University of Toronto, Woodbridge, ON, Canada, 7Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem fibrosing autoimmune disease with a high mortality rate. Ethnicity can influence prevalence and disease characteristics in SSc. Less…
  • Abstract Number: 1207 • ACR Convergence 2023

    Cardiovascular Mortality of Acute Myocardial Infraction and Acute Heart Failure Hospitalization in Rheumatic Diseases Patients Evaluation from the 2016-2020 National Inpatient Sample (NIS) Database

    Zi Ying Li1, Siyi Huang2, senay Gokcebel3 and Anthony Reginato4, 1Roger Williams Medical Center, Providence, RI, 2UCSF Fresno, Fresno, CA, 3School of Public Health | Brown University, Providence, RI, 4The Warren Alpert Medical School of Brown University, Providence, RI

    Background/Purpose: Rheumatic diseases such as rheumatoid arthritis (RA) and Systemic lupus erythematosus (SLE) were known for increased prevalence and risk of death from cardiovascular disease…
  • Abstract Number: 1703 • ACR Convergence 2023

    Increased Mortality and Cardiovascular Events in Male Patients with Systemic Sclerosis: Left Ventricular Global Longitudinal Strain as Possible Screening Tool

    Jeska de Vries-Bouwstra1, Tea Gegenava2, Federico Fortuni3, Nina Van Leeuwen4, Anders Tennoe5, Anna Maria Hoffmann-Vold6, Ruxandra Jurcut7, Adrian Giuca7, Laura Groseanu8, Felix Tanner9, Oliver Distler10, Jeroen Bax11 and Nina Ajmone Marsan11, 1Leiden University Medical Center, Leiden, Netherlands, 2Department of Cardiology, Heart Lung Centre, Leiden University Medical Centre; Department of Internal Medicine,Tbilisi State Medical University, Tbilisi, Georgia, 3Department of Cardiology, San Giovanni Battista Hospital, Foligno, Italy, 4Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, 5Department of Rheumatology, Oslo University Hospital, Oslo, Norway, 6Oslo University Hospital, Department of Rheumatology, Oslo, Norway, 7Department of Cardiology, Emergency Institute for Cardiovascular Diseases “Prof .Dr. C. C. Iliescu”, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania, 8University of Medicine and Pharmacy "Carol Davila", Department of Internal Medicine -Rheumatology; Santa Maria Clinical Hospital, Internal Medicine and Rheumatology, Bucharest, Romania, 9Department of Cardiology, University Heart Centre, University Hospital Zurich, Zurich, Switzerland, 10Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 11Department of Cardiology, Heart Lung Centre, Leiden University Medical Centre, Leiden, Netherlands

    Background/Purpose: Systemic sclerosis (SSc) is less frequent in males, but the risk of severe outcomes is higher in males than in females(1). Seven to 30%…
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