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Abstracts tagged "Mixed connective tissue disease (MCTD)"

  • Abstract Number: 2413 • 2018 ACR/ARHP Annual Meeting

    Pregnancy Outcomes in Mixed Connective Tissue Disease: Results from a Multicentre Cohort Study

    Massimo Radin1, Karen Schreiber2, Maria Jose Cuadrado3, Irene Cecchi4, Laura Andreoli5, Franco Franceschini6, Maria Teresa Caleiro7, Danieli Andrade8, Elena Gibbone9, Munther A Khamashta10, Jill P. Buyon11, Peter M. Izmirly12, Maria Aguirre13, Chiara Benedetto9, Dario Roccatello14, Luca Marozio15 and Savino Sciascia16, 1Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 2Department of Thrombosis and Haemophilia, Guy's and St Thomas' Hospital, London, United Kingdom., London, United Kingdom, 3Clinica Universidad de Navarra, Madrid, Spain, 4Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 5Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, 6Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Brescia, Italy, 7Rheumatology, University of São Paulo, Tucson, AZ, 8Rheumatology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 9University of Turin, Turin, Italy, 10Graham Hughes Lupus Research Laboratory, The Rayne Institute, London, United Kingdom, 11Medicine, New York University School of Medicine, New York, NY, 12NYU Langone Health, New York, NY, 13IMIBIC, Cordoba, Cordoba, Spain, 14Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 15University of Turin, Torino, Italy, 16Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: Mixed connective tissue disease (MCTD) is characterized by signs and symptoms of a combination of disorders, primarily systemic lupus erythematosus (SLE), scleroderma and polymyositis…
  • Abstract Number: 2698 • 2018 ACR/ARHP Annual Meeting

    Renal Involvement in Mixed Connective Tissue Disease: A Single Center Experience

    Eduardo Martín Nares1, Silvia Eunice Ramírez Andrade2, Luis Eduardo Morales Buenrostro2, Norma Ofelia Uribe Uribe3, Laura R Cárdenas M3, Montserrat Reyes Macedo3 and Tatiana S. Rodriguez-Reyna1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Kidney injury in mixed connective tissue disease (MCTD) is an uncommon manifestation. Prevalence has been reported to be <4% in some cohorts. The frequency…
  • Abstract Number: 339 • 2017 ACR/ARHP Annual Meeting

    Patients’ Attitudes and Experiences of Transitional Care in Paediatric Rheumatology: A Systematic Review of Qualitative Studies

    Ayano Kelly1,2,3,4, Fiona Niddrie5, David Tunnicliffe4,6, Camilla Hanson4,7, Gabor Major8,9, Davinder Singh-Grewal10,11,12 and Allison Tong4, 1Rheumatology, The Canberra Hospital, Canberra, Australia, 2School of Medicine, Australian National University, Canberra, Australia, 3Canberra Rheumatology, Canberra, Australia, 4Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia, 5Rheumatology, Bone and Joint Institute,John Hunter Hospital, Newcatle, Australia, 6Sydney School of Public Health, University of Sydney, Sydney, Australia, 7Sydney School of Pubic Health, University of Sydney, Sydney, Australia, 8Medicine, University of Newcastle, Newcastle, Australia, 9Rheumatology, Bone and Joint Institute, John Hunter Hospital NSW Australia, Newcastle, Australia, 10Faculty of Medicine, University of New South Wales, Sydney, Australia, 11Department of Rheumatology, The Sydney Children's Hospital Network, Sydney, Australia, 12Sydney Medical School, University of Sydney, Sydney, Australia

    Background/Purpose: Despite the increasing number of transition programs available for rheumatology patients moving from paediatric to adult care, transition continues to pose challenges for patients…
  • Abstract Number: 1639 • 2017 ACR/ARHP Annual Meeting

    Longitudinal Evolution in a Nationwide Cohort Originally Classified As Mixed Connective Tissue Disease

    Silje Reiseter1, Ragnar Gunnarsson2, Jukka Corander3, Johanna Haydon4, May Brit Lund5 and Øyvind Molberg1, 1Oslo University Hospital, Oslo, Norway, 2Department of Rheumatology, Oslo University Hospital, Oslo, Norway, OSLO, Norway, 3Departement of Biostatistics, University of Oslo, Oslo, Norway, 4Rheumatology, Vestre Viken Hospital, Drammen, Norway, 5Respiratory Medicine, Oslo University Hospital, Oslo, Norway

    Background/Purpose: Ever since Mixed Connective Tissue Disease was presented as a distinct entity in 1972, it has been discussed whether MCTD represents an undifferentiated, transient…
  • Abstract Number: 2094 • 2017 ACR/ARHP Annual Meeting

    Prevalence of Organ Involvement in Mixed Connective Tissue Disease

    Javier Narváez1, Maria Pascual2, Gloria Albert Espi3, Milena Millan4, Mercè López de Recalde5, Juan José Alegre6, Ivan Castellví7, Carmen Gomez Vaquero5 and Joan Miquel Nolla8, 1Rheumatology Department, Hospital de Bellvitge. Barcelona. Spain, L’Hospitalet de Llobregat, Spain, 2Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, 3Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, 4Rheumatology, Hospital de Sant Pau, Barcelona, Spain, 5Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 6Sección de Reumatología Hospital Universitario Dr Peset Valencia, Valencia, Spain, 7Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, 8Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain

    Background/Purpose:  : Mixed connective tissue disease (MCTD) is characterized by overlapping features of SLE, SSc, PM/DM and rheumatoid arthritis together with the presence of high-titre…
  • Abstract Number: 1263 • 2015 ACR/ARHP Annual Meeting

    Applications of Protein Microarray for Saliva Diagnostics in Autoimmune Diseases

    Yeon-Ah Lee1, Yong-Gil Kim2, Seung-Jae Hong1 and Paul J. Utz3, 1Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 3Medicine, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: There have been many reports showing that saliva could be a source of biomarkers capable of detecting certain diseases. However, very few studies have…
  • Abstract Number: 409 • 2015 ACR/ARHP Annual Meeting

    Disease Activity, Disease Damage and Predictive Factors in Juvenile Onset Mixed Connective Tissue Disease – a Norwegian Nationwide Study

    Siri Opsahl Hetlevik1, Berit Flatø1,2, Marite Rygg3,4, Ellen Berit Nordal5 and Vibke Lilleby6, 1Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 2Department of Rheumatology, Oslo University Hospital, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, 3Department of Pediatrics, St Olav University Hospital, Trondheim, Norway, 4Department of Laboratory Medicine, Children's and Women's health, Norwegian University of Science and Technology, Trondheim, Norway, 5Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway, 6Rheumatology, Oslo University Hospital, Oslo, Norway

    Background/Purpose: Mixed Connective Tissue Disease (MCTD) is a rare rheumatic disease with overlapping features from Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc) and Polymyositis. Juvenile…
  • Abstract Number: 2703 • 2014 ACR/ARHP Annual Meeting

    Elevated Serum Levels of Endostatin in Mixed Connective Tissue Disease – Association with Pulmonary Fibrosis and Digital Ulcers

    Silje Reiseter1, Ragnar Gunnarsson2, Torhild Garen2, May Brit Lund3, T. Mogens Aalokken4, Anna-Maria Hoffmann-Vold5, Øyvind Molberg2,6 and Thor Ueland7, 1Department of Rheumatology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 2Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, 3Department of Respiratory Medicine, Oslo University Hospital Rikshopitalet, Oslo, Norway, 4Department of Radiology, Oslo University Hospital Rikshospitalet, Oslo, Norway, 5Department of Rheumatology, Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, 6Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 7Research Institute for Internal Medicine, University of Oslo, Oslo, Norway

    Background/Purpose Mixed Connective Tissue Disease (MCTD) is a chronic, immune-mediated disorder defined by the combined presence of serum anti-RNP antibodies and selected clinical features of…
  • Abstract Number: 1299 • 2014 ACR/ARHP Annual Meeting

    A Cross-Sectional Study of Mental Health Symptoms and Mental Health Care in Pediatric SLE/MCTD Patients and Their Peers

    Andrea Knight1,2, Michelle Vickery1, Pamela Weiss1,2,3, Knashawn Morales3 and Ron Keren3,4, 1Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, 2Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 3Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, 4Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Mental health problems are prevalent in pediatric systemic lupus erythematosus (SLE). We aimed to compare the rates of mental health problems and mental health…
  • Abstract Number: 2588 • 2013 ACR/ARHP Annual Meeting

    Pulmonary Hypertension In Patients With Anti-U1-RNP Antibodies

    Vincent Sobanski1, Bernadette Lynch2, Benjamin E. Schreiber3, Svetlana I. Nihtyanova4, Jennifer Harvey5, Clive Handler6, Christopher P. Denton7 and John G. Coghlan8, 1Department of Rheumatology, Royal Free Hospital, London, United Kingdom, 2Department of Rheumatology, The Royal Free Hospital, London, United Kingdom, 3Royal Free Hospital NHS Foundation Trust, National Pulmonary Hypertension Service, London, United Kingdom, 4Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, 5Clinical Immunology, Royal Free Hospital, London, United Kingdom, 6Department of Pulmonary Hypertension, The Royal Free Hospital, London, United Kingdom, 7Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, 8National Pulmonary Hypertension Service, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom

    Background/Purpose: Pulmonary hypertension (PH) is a leading cause of morbidity and mortality in patients with connective tissue diseases (CTD). Patients with anti-U1-RNP antibodies belong to…
  • Abstract Number: 2034 • 2013 ACR/ARHP Annual Meeting

    Does Mixed Connective Tissue Disease Or Sharp’s Syndrome Really Exist?

    Anne Barbarini1, Christelle Sordet1, Emmanuel Chatelus1, Rose-Marie Javier1, Joelle Goetz2, Francois Lefebvre3, Jacques-Eric Gottenberg4, Thierry Martin5 and Jean Sibilia4, 1Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2rheumatology, Strasbourg University Hospital, Strasbourg, France, 3Strasbourg University Hospital, strasbourg, France, 4Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, 5Strasbourg University Hospital, Strasbourg, France

    Background/Purpose: The existence of Mixed Connective Tissue Disease (MCTD) has often been discussed in literature and its diagnostic criteria are very heterogeneous. Anti-U1-RNP antibodies are…
  • Abstract Number: 1928 • 2012 ACR/ARHP Annual Meeting

    Evaluating the Therapeutic Effects of B Cell Depletion Therapy with Rituximab in a Longitudinal Cohort of Mixed Connective Tissue Disease Patients

    Ragnar Gunnarsson1, Inge-Margrethe Gilboe1, Torhild Garen2 and Øyvind Molberg3, 1Rheumatology unit, Oslo University Hospital Rikshospitalet, Oslo, Norway, 2Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, 3Oslo University Hospital, Oslo, Norway

    Background/Purpose: Even though 40 years have passed since MCTD was defined as a distinct disorder, there is still no evidence based therapy available. The choice…
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