Abstracts tagged "Mixed connective tissue disease (MCTD)"

Abstract Number: 035 • 2020 Pediatric Rheumatology Symposium
The Childhood and Rheumatology Research Alliance Systemic Lupus Erythematosus and Related Disorders Cohort
Stacy Ardoin¹, Stephen Balevic ², Aimee Hersh ³, Yukiko Kimura ⁴, Andrea Knight ⁵, Laura Schanberg ⁶, Mary Beth Son ⁷ and Timothy Beukelman ⁸ for the CARRA investigators, ¹Nationwide Children's Hospital, Columbus, ²Duke University, Hillsborough, ³University of Utah Primary Children's Hospital, Salt Lake City, ⁴Hackensack Meridian School of Medicine, Hackensack, ⁵SickKids Research Institute, Toronto, Canada, ⁶Duke Children's Hospital & Health Center, Durham, North Carolina, ⁷Boston Children's Hospital, Boston, Massachusetts, ⁸University of Alabama at Birmingham, Birmingham
Background/Purpose: Optimal therapy in childhood onset systemic lupus erythematosus (SLE) lack sufficient data to support clinical decision making. To address this knowledge gap, the Childhood…
Abstract Number: 056 • 2020 Pediatric Rheumatology Symposium
Non-criteria Antiphospholipid Antibodies Associated with Pediatric Rheumatic Disease: A Single-Center Case Series
Shawn Mahmud¹, Danielle Bullock ¹, Colleen Correll ¹, Patricia Hobday ², Mona Riskalla ³, Richard Vehe ⁴ and Bryce Binstadt ¹, ¹University of Minnesota, Minneapolis, ²Minneapolis, ³University of Minnesota, Minneapolis, Minnesota, ⁴University of Minnesota, Roseville
Background/Purpose: Non-criteria antiphospholipid antibodies (NC-aPL) bind molecules such as phosphatidylethanolamine (PE), phosphatidylserine (PS), and prothrombin (Pt), but not the targets of routine antiphospholipid (aPL) testing…
Abstract Number: 2413 • 2018 ACR/ARHP Annual Meeting
Pregnancy Outcomes in Mixed Connective Tissue Disease: Results from a Multicentre Cohort Study
Massimo Radin¹, Karen Schreiber², Maria Jose Cuadrado³, Irene Cecchi⁴, Laura Andreoli⁵, Franco Franceschini⁶, Maria Teresa Caleiro⁷, Danieli Andrade⁸, Elena Gibbone⁹, Munther A Khamashta¹⁰, Jill P. Buyon¹¹, Peter M. Izmirly¹², Maria Aguirre¹³, Chiara Benedetto⁹, Dario Roccatello¹⁴, Luca Marozio¹⁵ and Savino Sciascia¹⁶, ¹Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ²Department of Thrombosis and Haemophilia, Guy's and St Thomas' Hospital, London, United Kingdom., London, United Kingdom, ³Clinica Universidad de Navarra, Madrid, Spain, ⁴Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁵Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ⁶Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Brescia, Italy, ⁷Rheumatology, University of São Paulo, Tucson, AZ, ⁸Rheumatology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁹University of Turin, Turin, Italy, ¹⁰Graham Hughes Lupus Research Laboratory, The Rayne Institute, London, United Kingdom, ¹¹Medicine, New York University School of Medicine, New York, NY, ¹²NYU Langone Health, New York, NY, ¹³IMIBIC, Cordoba, Cordoba, Spain, ¹⁴Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, ¹⁵University of Turin, Torino, Italy, ¹⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: Mixed connective tissue disease (MCTD) is characterized by signs and symptoms of a combination of disorders, primarily systemic lupus erythematosus (SLE), scleroderma and polymyositis…
Abstract Number: 2698 • 2018 ACR/ARHP Annual Meeting
Renal Involvement in Mixed Connective Tissue Disease: A Single Center Experience
Eduardo Martín Nares¹, Silvia Eunice Ramírez Andrade², Luis Eduardo Morales Buenrostro², Norma Ofelia Uribe Uribe³, Laura R Cárdenas M³, Montserrat Reyes Macedo³ and Tatiana S. Rodriguez-Reyna¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Kidney injury in mixed connective tissue disease (MCTD) is an uncommon manifestation. Prevalence has been reported to be <4% in some cohorts. The frequency…
Abstract Number: 339 • 2017 ACR/ARHP Annual Meeting
Patients’ Attitudes and Experiences of Transitional Care in Paediatric Rheumatology: A Systematic Review of Qualitative Studies
Ayano Kelly^1,2,3,4, Fiona Niddrie⁵, David Tunnicliffe^4,6, Camilla Hanson^4,7, Gabor Major^8,9, Davinder Singh-Grewal^10,11,12 and Allison Tong⁴, ¹Rheumatology, The Canberra Hospital, Canberra, Australia, ²School of Medicine, Australian National University, Canberra, Australia, ³Canberra Rheumatology, Canberra, Australia, ⁴Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia, ⁵Rheumatology, Bone and Joint Institute,John Hunter Hospital, Newcatle, Australia, ⁶Sydney School of Public Health, University of Sydney, Sydney, Australia, ⁷Sydney School of Pubic Health, University of Sydney, Sydney, Australia, ⁸Medicine, University of Newcastle, Newcastle, Australia, ⁹Rheumatology, Bone and Joint Institute, John Hunter Hospital NSW Australia, Newcastle, Australia, ¹⁰Faculty of Medicine, University of New South Wales, Sydney, Australia, ¹¹Department of Rheumatology, The Sydney Children's Hospital Network, Sydney, Australia, ¹²Sydney Medical School, University of Sydney, Sydney, Australia
Background/Purpose: Despite the increasing number of transition programs available for rheumatology patients moving from paediatric to adult care, transition continues to pose challenges for patients…
Abstract Number: 1639 • 2017 ACR/ARHP Annual Meeting
Longitudinal Evolution in a Nationwide Cohort Originally Classified As Mixed Connective Tissue Disease
Silje Reiseter¹, Ragnar Gunnarsson², Jukka Corander³, Johanna Haydon⁴, May Brit Lund⁵ and Øyvind Molberg¹, ¹Oslo University Hospital, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital, Oslo, Norway, OSLO, Norway, ³Departement of Biostatistics, University of Oslo, Oslo, Norway, ⁴Rheumatology, Vestre Viken Hospital, Drammen, Norway, ⁵Respiratory Medicine, Oslo University Hospital, Oslo, Norway
Background/Purpose: Ever since Mixed Connective Tissue Disease was presented as a distinct entity in 1972, it has been discussed whether MCTD represents an undifferentiated, transient…
Abstract Number: 2094 • 2017 ACR/ARHP Annual Meeting
Prevalence of Organ Involvement in Mixed Connective Tissue Disease
Javier Narváez¹, Maria Pascual², Gloria Albert Espi³, Milena Millan⁴, Mercè López de Recalde⁵, Juan José Alegre⁶, Ivan Castellví⁷, Carmen Gomez Vaquero⁵ and Joan Miquel Nolla⁸, ¹Rheumatology Department, Hospital de Bellvitge. Barcelona. Spain, L’Hospitalet de Llobregat, Spain, ²Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ³Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ⁴Rheumatology, Hospital de Sant Pau, Barcelona, Spain, ⁵Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁶Sección de Reumatología Hospital Universitario Dr Peset Valencia, Valencia, Spain, ⁷Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ⁸Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: : Mixed connective tissue disease (MCTD) is characterized by overlapping features of SLE, SSc, PM/DM and rheumatoid arthritis together with the presence of high-titre…
Abstract Number: 1263 • 2015 ACR/ARHP Annual Meeting
Applications of Protein Microarray for Saliva Diagnostics in Autoimmune Diseases
Yeon-Ah Lee¹, Yong-Gil Kim², Seung-Jae Hong¹ and Paul J. Utz³, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: There have been many reports showing that saliva could be a source of biomarkers capable of detecting certain diseases. However, very few studies have…
Abstract Number: 409 • 2015 ACR/ARHP Annual Meeting
Disease Activity, Disease Damage and Predictive Factors in Juvenile Onset Mixed Connective Tissue Disease – a Norwegian Nationwide Study
Siri Opsahl Hetlevik¹, Berit Flatø^1,2, Marite Rygg^3,4, Ellen Berit Nordal⁵ and Vibke Lilleby⁶, ¹Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, ³Department of Pediatrics, St Olav University Hospital, Trondheim, Norway, ⁴Department of Laboratory Medicine, Children's and Women's health, Norwegian University of Science and Technology, Trondheim, Norway, ⁵Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway, ⁶Rheumatology, Oslo University Hospital, Oslo, Norway
Background/Purpose: Mixed Connective Tissue Disease (MCTD) is a rare rheumatic disease with overlapping features from Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc) and Polymyositis. Juvenile…
Abstract Number: 2703 • 2014 ACR/ARHP Annual Meeting
Elevated Serum Levels of Endostatin in Mixed Connective Tissue Disease – Association with Pulmonary Fibrosis and Digital Ulcers
Silje Reiseter¹, Ragnar Gunnarsson², Torhild Garen², May Brit Lund³, T. Mogens Aalokken⁴, Anna-Maria Hoffmann-Vold⁵, Øyvind Molberg^2,6 and Thor Ueland⁷, ¹Department of Rheumatology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ³Department of Respiratory Medicine, Oslo University Hospital Rikshopitalet, Oslo, Norway, ⁴Department of Radiology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ⁵Department of Rheumatology, Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ⁶Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ⁷Research Institute for Internal Medicine, University of Oslo, Oslo, Norway
Background/Purpose Mixed Connective Tissue Disease (MCTD) is a chronic, immune-mediated disorder defined by the combined presence of serum anti-RNP antibodies and selected clinical features of…
Abstract Number: 1299 • 2014 ACR/ARHP Annual Meeting
A Cross-Sectional Study of Mental Health Symptoms and Mental Health Care in Pediatric SLE/MCTD Patients and Their Peers
Andrea Knight^1,2, Michelle Vickery¹, Pamela Weiss^1,2,3, Knashawn Morales³ and Ron Keren^3,4, ¹Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ²Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, ⁴Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Mental health problems are prevalent in pediatric systemic lupus erythematosus (SLE). We aimed to compare the rates of mental health problems and mental health…
Abstract Number: 2588 • 2013 ACR/ARHP Annual Meeting
Pulmonary Hypertension In Patients With Anti-U1-RNP Antibodies
Vincent Sobanski¹, Bernadette Lynch², Benjamin E. Schreiber³, Svetlana I. Nihtyanova⁴, Jennifer Harvey⁵, Clive Handler⁶, Christopher P. Denton⁷ and John G. Coghlan⁸, ¹Department of Rheumatology, Royal Free Hospital, London, United Kingdom, ²Department of Rheumatology, The Royal Free Hospital, London, United Kingdom, ³Royal Free Hospital NHS Foundation Trust, National Pulmonary Hypertension Service, London, United Kingdom, ⁴Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁵Clinical Immunology, Royal Free Hospital, London, United Kingdom, ⁶Department of Pulmonary Hypertension, The Royal Free Hospital, London, United Kingdom, ⁷Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁸National Pulmonary Hypertension Service, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom
Background/Purpose: Pulmonary hypertension (PH) is a leading cause of morbidity and mortality in patients with connective tissue diseases (CTD). Patients with anti-U1-RNP antibodies belong to…
Abstract Number: 2034 • 2013 ACR/ARHP Annual Meeting
Does Mixed Connective Tissue Disease Or Sharp’s Syndrome Really Exist?
Anne Barbarini¹, Christelle Sordet¹, Emmanuel Chatelus¹, Rose-Marie Javier¹, Joelle Goetz², Francois Lefebvre³, Jacques-Eric Gottenberg⁴, Thierry Martin⁵ and Jean Sibilia⁴, ¹Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²rheumatology, Strasbourg University Hospital, Strasbourg, France, ³Strasbourg University Hospital, strasbourg, France, ⁴Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ⁵Strasbourg University Hospital, Strasbourg, France
Background/Purpose: The existence of Mixed Connective Tissue Disease (MCTD) has often been discussed in literature and its diagnostic criteria are very heterogeneous. Anti-U1-RNP antibodies are…
Abstract Number: 1928 • 2012 ACR/ARHP Annual Meeting
Evaluating the Therapeutic Effects of B Cell Depletion Therapy with Rituximab in a Longitudinal Cohort of Mixed Connective Tissue Disease Patients
Ragnar Gunnarsson¹, Inge-Margrethe Gilboe¹, Torhild Garen² and Øyvind Molberg³, ¹Rheumatology unit, Oslo University Hospital Rikshospitalet, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ³Oslo University Hospital, Oslo, Norway
Background/Purpose: Even though 40 years have passed since MCTD was defined as a distinct disorder, there is still no evidence based therapy available. The choice…