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Abstracts tagged "Mitochondrial Dysfunction"

  • Abstract Number: 0871 • ACR Convergence 2023

    Mitochondrial Transfer Functionally Restores the Human Osteoarthritis (OA) Chondrocyte, Is Protective Against Oxidative Stress and Improves OA in a Clinical Model of Disease

    Fernando Figueroa1, Angela Court2, Patricia Luz Crawford2, Ana Maria Vega Letter2, Francesca Velarde2, Cynthia Garcia2 and Maroun Khoury2, 1IMPACT, Santiago de Chile, Chile, 2IMPACT, Santiago, Chile

    Background/Purpose: Osteoarthrosis (OA) is a leading cause of pain, disability and early mortality, with no disease modifying treatments. Mitochondrial dysfunction is a known driver of…
  • Abstract Number: 0900 • ACR Convergence 2023

    Complement Deposition on Extracellular Mitochondria Induces Platelet Activation in Vitro

    Marina Barguil Macedo and Christian Lood, University of Washington, Seattle, WA

    Background/Purpose: Mitochondria are extruded upon cell death and platelet activation, being elevated in several inflammatory conditions, including systemic lupus erythematosus (SLE). Mitochondria are immunogenic, with…
  • Abstract Number: 0931 • ACR Convergence 2023

    Down-Regulation of Human NADH-Ubiquinone Oxidoreductase Chain 6 by N6-Methyladenosine Methylation Is Associated with Lupus CD4+ T Cell Activation

    Miheraiy Abdukiyum1, Nan Zhao2, Yuanyuan Zheng1, Tohtihan Alim3, Xiaojun Tang1 and Xuebing Feng2, 1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College, Nanjing University of Chinese Medicine, Nan Jing, China, 2Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College, Nanjing University of Chinese Medicine, Nanjing, China, 3Nanjing University, Nanjing, China

    Background/Purpose: Recently mitochondria have been recognized as a key player in the pathogenesis of systemic lupus erythematosus (SLE). Given that N6-methyladenosine (m6A) modifications can regulate…
  • Abstract Number: 1188 • ACR Convergence 2023

    Development of a Method to Isolate Functional Mitochondria and Assess Their Functionality and Integration in Joint Tissues: In Vitro and in Vivo Models

    Mercedes Fernandez-Moreno1, Tamara Hermida-Gomez2, Sara Paniagua-Barro1, Arianna Rodriguez-Coello1, Carlos Vaamonde-garcia1 and Francisco J. Blanco3, 1Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Spain; Universidade de A Coruña (UDC), A Coruña, Spain; Grupo de Investigación en Reumatología y Salud (GIR-S), Departamento de Biologia, Facultad de Ciencias. Centro Interdisciplinar de Química y Biología (CICA), INIBIC-Sergas, Universidade de A Coruña (UDC), A Coruña, Spain, 22) Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). Centro interdisciplinar de química e bioloxia (CICA). As Xubias, 15006. A Coruña, España. 3) Centro de investigación biomédica en Red, Bioingenieria, Biomatereial y Nanomedicina (CIBER-BBN), A Coruña, Spain, 3Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain

    Background/Purpose: There is not cure or an efficient treatment for the osteoarthritis (OA). Mitochondrial damage and dysfunction are described during OA process modulating chondrocyte function…
  • Abstract Number: 0150 • ACR Convergence 2022

    Growth and Differentiation Factor 15, an Emerging Biomarker of Mitochondrial Dysfunction- Associated Myopathies: Implications for Juvenile Dermatomyositis

    Bhargavi Duvvuri1, Lauren Pachman2, Gabrielle Morgan3, Payton Hermanson4, TING WANG4 and Christian Lood4, 1University of Washington, Seattle, WA, 2Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL, 3Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 4Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Our prior work has demonstrated mitochondrial involvement in JDM including the accumulation of calcified mitochondria in affected muscle tissue, and elevated levels of circulating…
  • Abstract Number: 0158 • ACR Convergence 2022

    Effect of Type I IFN on Mitochondria and Muscle Weakness in Myositis

    Melissa Morales, Joanna Parkes, Sabrina Narvesen and Rita Spathis, Department of Pharmaceutical Sciences, Binghamton University, Binghamton, NY

    Background/Purpose: Muscle weakness is a hallmark of autoimmune myositis. The mechanisms that contribute to muscle weakness are currently unknown. The observed ineffectiveness after immunomodulatory treatment…
  • Abstract Number: 0629 • ACR Convergence 2022

    The Cellular Metabolism of SLE NK Cells Is Primarily Altered at the Level of Mitochondrial Respiration

    Natalia Fluder, Morgane Humbel, camillo Ribi and Denis Comte, Service of Immunology and Allergy / CHUV, Lausanne, Switzerland

    Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic inflammatory disorder, which involves a loss of tolerance and development of autoantibodies. The role of Natural Killer…
  • Abstract Number: 0635 • ACR Convergence 2022

    Blood RNA-sequencing Reveals Complex Immune Dysregulation in ANA-positive Individuals with Distinct Profiles Preceding Progression to SLE versus Stable Autoimmunity

    Lucy Marie Carter1, Md Yuzaiful Md Yusof2, Darren Plant3, Julien Bauer4, Stephanie Wenlock4, Adewonuola Alase1, Antonios Psarras1, Zoe Wigston1 and Edward M Vital2, 1University of Leeds, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3The University of Manchester, Manchester, United Kingdom, 4University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: Anti-nuclear antibody (ANA) positivity represents a complex ‘At-Risk’ state for development of connective tissue disease (CTD). ANA may become positive years in advance of…
  • Abstract Number: 1537 • ACR Convergence 2022

    Proteomic Profiling of Plasma Microvesicles Isolated from Patients with Systemic Sclerosis

    Line Iversen1, Ole Østergaard2, Tina Friis3, susanne Ullman4, Søren Jacobsen5 and Jesper Olsen2, 1Department of Dermatology, Odense University Hospital., Odense, Denmark, 2Novo Nordisk Foundation Center for Protein Research, Copenhagen University, Copenhagen, Denmark, 3Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark, 4Department of Dermatology, Bispebjerg, Copenhagen University Hospitals, Copenhagen, Denmark, 5Department of Rheumatology, Rigshospitalet, Copenhagen University Hospitals, Copenhagen, Denmark

    Background/Purpose: In the current work, we used a mass spectrometry based proteomics workflow to analyze isolated plasma microvesicles from systemic sclerosis (SSc) patients and from…
  • Abstract Number: 2042 • ACR Convergence 2022

    Sjögren’s Disease and Mitochondrial Function

    Biji T Kurien1, Pharaoh Gavin2, Joshua Cavett1, Valerie Lewis3, Ambre Chambers1, Bhaskaran Shylesh4, Anjum Juvaria1, Brittany Karfonta1, Lida Radfar1, Astrid Rasmussen4, Christopher Lessard4, Darise Farris4, Kathy Sivils5, Kristi A Koelsch4, Holly Van Remmen4 and R. Hal Scofield1, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2University of Washington, Seattle, WA, 3Veterans Affairs Medical Center, Oklahoma City, OK, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Janssen Research and Development, LLC, Spring House, PA

    Background/Purpose: Sjögren's disease (SjD) is a chronic inflammatory, autoimmune disorder with reduced lacrimal/salivary gland secretion resulting in keratoconjunctivitis sicca and xerostomia, respectively. Also, SjD patients…
  • Abstract Number: 2270 • ACR Convergence 2022

    Evidence for Mitochondrial Dysfunction in Blood-derived Endothelial Colony Forming Cells Isolated from Patients with Antiphospholipid Syndrome

    Lida Kabir, Robert Maughan, Koralia Paschalaki, Anna Randi, David Carling, Deepa Arachchillage, Justin Mason and Charis Pericleous, Imperial College London, London, United Kingdom

    Background/Purpose: The endothelium is a major target of pathogenic antiphospholipid antibodies (aPL) found in patients with antiphospholipid syndrome (APS). It is well established that aPL…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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