ACR Meeting Abstracts

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Abstracts tagged "Mitochondrial Dysfunction"

  • Abstract Number: 1141 • ACR Convergence 2024

    Defining a Novel Type of Myositis: Immune Mediated Megaconial Myopathy (IMMM)

    Teerin Liewluck1, Ashley Santilli2, Oliver Ni3, Margherita Milone2, Duygu Selcen2, Anahit Mehrabyan4, Arjun Seth5, Christine Hsieh5, Wasim Raslan6, Moayd Alkhalifah6, Raed Alenezi6, Stefan Nicolau7 and Pannathat Soontrapa8, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic-Rochester, Rochester, MN, 3Hennepin Healthcare, Minneapolis, MN, 4University of North Carolina, Chapel Hill, NC, 5Northwestern University, Chicago, IL, 6Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia, 7Nationwide Children’s Hospital, Columbus, OH, 8Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Background/Purpose: To describe a novel type of myositis, immune mediated megaconial myopathy (IMMM),  pathologically characterized by giant mitochondria (megaconia).Methods: We reviewed the Mayo Clinic Muscle…
  • Abstract Number: 1266 • ACR Convergence 2024

    Anti-Mitochondrial Antibodies Associate with Disease Activity and IFNα Expression in Childhood-onset Systemic Lupus Erythematosus

    Marina Barguil Macedo1, Javad Wahadat2, Albin Bjoerk3, Sylvia Kamphuis2, Marjan Versnel2 and Christian Lood1, 1University of Washington, Seattle, WA, 2Erasmus University Medical Center, Rotterdam, Netherlands, 3Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Extracellular mitochondria may represent a source of antigenic burden in autoimmune disorders, such as in systemic lupus erythematosus (SLE), in which those organelles, released…
  • Abstract Number: 1684 • ACR Convergence 2024

    Autoantibodies to Transcription Factor a Mitochondria Are Associated with Damage Accrual, Malignancy Risk and Mortality in SLE

    Eduardo Gomez1, Daniel Goldman2, Merlin Paz3, Michelle Petri2 and Felipe Andrade4, 1The Johns Hopkins University, Baltimore, MD, 2Johns Hopkins University School of Medicine, Timonium, MD, 3Johns Hopkins Medicine, Baltimore, MD, 4The Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: We recently identified autoantibodies in SLE that target transcription factor A mitochondrial (TFAM), a critical protein in mitochondrial DNA transcription and packaging1. These autoantibodies…
  • Abstract Number: 1735 • ACR Convergence 2024

    High-Intensity Interval Training Outperforms Moderate Exercise in Aerobic Capacity for Recent-Onset Idiopathic Inflammatory Myopathies: A Randomized Controlled Trial

    Kristofer Andreasson1, Cecilia Leijding1, Maryam Dastmalchi2, Antonella Notarnicola3, Stefano Gastaldello1, Heléne Sandlund2, Daniel Andersson4, Ingrid Lundberg5 and Helene Alexanderson2, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska University hospital, Stockholm, Sweden, 3Karolinska University Hospital and Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 4Karolinska Institutet, Solna, Sweden, 5Karolinska Universitetssjukhuset, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Exercise is a recognized adjunctive therapy for patients with idiopathic inflammatory myopathies (IIM), enhancing physical capacity and reducing inflammation. Hitherto, moderate-to-intensive exercise has been…
  • Abstract Number: 1783 • ACR Convergence 2024

    Deciphering the Roles of Mitochondrial-Related Genes and Ferroptosis in Systemic Lupus Erythematosus: Integrated Analysis for Diagnostic Biomarker Identification and Therapeutic Insights

    Yunfeng Dai and Zhihan Chen, Fujian Medical University, Fuzhou City, Fujian, China (People's Republic)

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous clinical manifestations. Understanding the molecular mechanisms of SLE is crucial for developing effective…
  • Abstract Number: 2036 • ACR Convergence 2024

    CCN6 Gene Mutation Induces Mitochondrial Dysfunction: The Cause of Progressive Pseudo-rheumatoid Dysplasia

    Yanhong Li1, Xiufeng Bai2 and Yi Liu3, 1West China School of Medicine and West China Hospital, Sichuan University, Cheng Du, Sichuan, China, 2West China Hospital, Sichuan University, Chengdu, Sichuan, China (People's Republic), 3West China Hospital of Sichuan University, Chengdu, Sichuan, China

    Background/Purpose: Progressive pseudo-rheumatoid dysplasia (PPRD) is a rare autosomal recessive disorder characterized by non-inflammatory joint issues that primarily affect the articular cartilage. This leads to…
  • Abstract Number: 2298 • ACR Convergence 2024

    Fibroblast-driven Ttek Activation May Drive Acinar Cell Dysfunction in Sjögren’s Disease, Prior to Lymphocytic Infiltration

    Ting Yang1, Rick Wilbrink1, Janneke Terpstra1, Silvia Liefers2, Arjan Vissink1, Fred Spijkervet1, Hendrika Bootsma3, Frans Kroese4 and Sarah Pringle4, 1UMCG, Groningen, Netherlands, 2University Medical Center Groningen, University of Groningen, Groningen, Groningen, Netherlands, 3Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, 4University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Lymphocytic infiltration of the salivary glands (SGs) represents one hallmark of the autoimmune conditions Sjögren’s Disease (SjD). It is becoming apparent however that loss…
  • Abstract Number: 2670 • ACR Convergence 2024

    Sera from Patients with Idiopathic Inflammatory Myopathy Induces Muscle Weakness, Mitochondrial Dysfunction and Induction of Cytokines in Isolated Skeletal Muscle

    Cecilia Leijding1, Suchada Kaewin2, Kristofer Andreasson1, Tomas Schiffer1, Angeles Galindo-Feria3, Begum Horuluoglu1, Mattias Carlstrom1, Stefano Gastaldello1, Helene Alexanderson4, Ingrid Lundberg5 and Daniel Andersson6, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, 3Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 4Karolinska University Hospital, Stockholm, Sweden, 5Karolinska Universitetssjukhuset, Karolinska Institutet, Stockholm, Sweden, 6Karolinska Institutet, Solna, Sweden

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune inflammatory muscle disorders characterized by symmetrical skeletal muscle weakness and accelerated fatigue. Although signs…
  • Abstract Number: 1592 • ACR Convergence 2023

    Memantine Attenuates the Development of Osteoarthritis by Blocking NMDA Receptor Mediated Calcium Overload and Chondrocyte Senescence

    Ning Wang1, Qingmei Cheng1, Xiaoxiao Li2, ke he1, Junyu Zhu1, Hui Li3 and Jie Wei4, 1中南大学湘雅医院, Changsha, China, 2Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, 3Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, 4Health Management Center, Xiangya Hospital Central South University, Changsha, China

    Background/Purpose: Memantine is an FDA proved drug utilized for the treatment of dementia and exerts its function by blocking the NMDA (N-methyl-D-aspartate) receptor, a calcium…
  • Abstract Number: 1611 • ACR Convergence 2023

    Mitochondrial Structural Alterations in Fibromyalgia – A Pilot Electron Microscopy Study

    Linoy Israel1, Victoria Furer2, Atan Gross1 and Jacob Ablin2, 1Weizmann Institute of Science, Rehovot, Israel, 2Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Background/Purpose: Fibromyalgia (FM) is among the most common chronic pain conditions, clinically characterized by widespread pain and fatigue. FM pathogenesis remains unknown, leading to challenges…
  • Abstract Number: 2182 • ACR Convergence 2023

    Mitochondrial Alterations in Primary Sjögren´s Syndrome

    Pavlina Javorova1, Johannes Fessler1, Melanie Zeiler1, Angelika Lackner1, Josef Hermann2, Sabine Zenz3, Jens Thiel4 and Martin Stradner1, 1Medical University of Graz, Graz, Austria, 2Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University Graz, Graz, Austria, 3Medical University Graz, Graz, Austria, 4University Hospital Freiburg, Freiburg, Germany

    Background/Purpose: Primary Sjögren's Syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocytic infiltrations in exocrine glands. T-cells are considered major players in the pathogenesis…
  • Abstract Number: 2405 • ACR Convergence 2023

    Role of Mitochondria in Activation of Platelets in Giant Cell Arteritis

    Despoina Michailidou1, Peter Grayson2, Payton Hermanson1, Jorge Armando Gonzalez-Chapa1, David Cuthbertson3, Nader A. Khalidi4, Curry Koening5, Carol Langford6, Carol McAlear7, Larry Moreland8, Christian Pagnoux9, Philip Seo10, Antoine G Sreih11, Kenneth Warrington12, Paul Monach13, Peter Merkel7 and Christian Lood1, 1University of Washington, Seattle, WA, 2National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD, 3University of South Florida, Tampa, FL, 4McMaster University, Hamilton, ON, Canada, 5University of Texas Dell Medical School, Austin, TX, 6Cleveland Clinic, Cleveland, OH, 7University of Pennsylvania, Philadelphia, PA, 8University of Colorado, Denver, CO, 9Mount Sinai Hospital, Toronto, ON, Canada, 10Johns Hopkins University, Baltimore, MD, 11Bristol Myers Squibb, Princeton Pike, NJ, 12Mayo Clinic, Rochester, MN, 13VA Boston Healthcare System, Boston, MA

    Background/Purpose: We recently found extracellular mitochondrial-derived N-formyl methionine in patients with giant cell arteritis (GCA. Extracellular mitochondria can be extruded by several mechanisms, including platelet…
  • Abstract Number: 2462 • ACR Convergence 2023

    Mitochondrial-Mediated Neutrophil Activation in Dermatomyositis (DM) and Inclusion Body Myositis (IBM): Insights into Pathogenesis and Therapeutic Implications

    Jorge Armando Gonzalez-Chapa1, Jemima Albayda2, Begum Horuluoglu3, Despina Michailidou1, Marina Barguil Macedo1, Lisa Christopher-Stine2, Ingrid Lundberg4 and Christian Lood1, 1University of Washington, Seattle, WA, 2Johns Hopkins University, Baltimore, MD, 3Karolinska Institutet, Stockholm, Sweden, 4Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Gastroenterology, Dermatotology, Rhematology, Karolinska Universitetssjukhuset, Stockholm, Sweden

    Background/Purpose: Dermatomyositis (DM) and inclusion body myositis (IBM) are characterized by muscle weakness and inflammation, with emerging evidence of mitochondrial and neutrophil involvement. Prior work…
  • Abstract Number: 2467 • ACR Convergence 2023

    Quadriceps Muscle Fat Composition but Not Muscle Energetics Is Associated with Knee Osteoarthritis: Initial Results from the Study of Muscle, Mobility, and Aging

    Giovanna Distefano1, Daniel Evans2, Peggy Cawthon2, John Lynch2, Thomas Link2, Philip Kramer3, Stephanie Harrison2, Bret Goodpaster4, Jane Cauley5, Theresa Mau2, Paul Coen4, Lauren Sparks4 and Nancy Lane6, 1AventisHealth, Orlando, FL, 2University of California San Francisco, San Francisco, CA, 3Wake Forest, Winston-Salem, NC, 4Aventis Health, Orlando, FL, 5University of Pittsburgh, Pittsburgh, PA, 6University of California, Hillsborough, CA

    Background/Purpose: Osteoarthritis (OA) remains the most common cause of joint pain and disability with age, and to date, effective treatments to reduce pain and slow…
  • Abstract Number: 2604 • ACR Convergence 2023

    Premature Vascular Smooth Muscle Cells Senescence Driven by Interleukin-6-Mitochondrial STAT3-Mitofusin 2 Signaling in Takayasu’s Arteritis

    Chenglong Fang1, Lihong Du1, Lili Li2, Yuexin Chen3, Zuoguan Chen4, Yongjun Li4, Jing Li1, Mengtao Li5, xiaofeng Zeng6 and Xinping Tian5, 1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, 2The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China, 3Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, 4Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 6Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Background/Purpose: Takayasu’s arteritis (TAK) is characterized by persistent vascular inflammation involving aorta and its main branches, which is an important prosenescent factor that in turn…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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