Abstracts tagged "Mitochondria"

Abstract Number: 3189 • 2015 ACR/ARHP Annual Meeting
Enhancement of Mitochondrial Biogenesis Inhibits Cell Proliferation and MMP-3/RANKL Secretion in Rheumatoid Arthritis Fibroblast-like Synovial Cells and Joint Destruction in Arthritis Model Mice
Takeshi Ueha¹, Yoshitada Sakai¹, Masayuki Morishita², Toshihisa Maeda², Koji Fukuda², Miho Inoue², Risa Harada², Masaya Minoda², Yasushi Miura^3,4,5, Akira Hashiramoto⁶ and Masahiro Kurosaka^1,4, ¹Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ³Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, ⁶Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan
Background/Purpose: Joint destruction in rheumatoid arthritis (RA) progresses via the hyperproliferation of the synovium and secretion of MMP-3/RANKL from fibroblast-like synoviocytes (FLS). In tumors, we previously…
Abstract Number: 152 • 2013 ACR/ARHP Annual Meeting
The Uncoupling mtDNA Haplogroup T Associates With Better Radiographic Progression Of Osteoarthritis. Data From The Osteoarthritis Initiative (OAI)
Angel Soto-Hermida¹, Ignacio Rego-Pérez², Mercedes Fernández-Moreno¹, Sonia Pértega-Díaz³, Juan Fernández-Tajes¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Sara Relaño-Fernández¹, Natividad Oreiro-Villar¹, Carlos Fernández-López¹ and Francisco J. Blanco^1,4,5, ¹INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴CIBER-BBN-ISCIII, Madrid, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain
Background/Purpose: The Osteoarthritis Initiative (OAI) is a multicentre study focused on identifying and evaluating risk factors of knee osteoarthritis (OA). Previous studies carried out by…

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