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Abstracts tagged "Mitochondria"

  • Abstract Number: 1489 • ACR Convergence 2021

    Identification of Mitochondrial Antigens Targeted by Autoantibodies in Systemic Lupus Erythematosus (SLE)

    Yann BECKER1, Jean-Philippe Gagné2, Anne-Sophie Julien3, Tania Lévesque1, Nadine Gougeard4, Vicente Rubio4, François-Michel Boisvert5, Dominique Jean6, Guy Poirier2, Paul R Fortin7 and Éric Boilard1, 1Centre de Recherche ARThrite, Université Laval, Québec City, QC, Canada, 2Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval, Québec City, QC, Canada, 3Département de mathématiques et statistique, Université Laval, Québec, QC, Canada, 4Structural Enzymopathology Unit, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain, 5Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, QC, Canada, 6Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, Canada, 7CHU de Quebec - Universite Laval, Québec City, QC, Canada

    Background/Purpose: Mitochondria are organelles that possess several bacterial features such as a double-stranded genome with hypomethylated CpG islets, formylated proteins, and a double membrane composed…
  • Abstract Number: 69 • 2019 ACR/ARP Annual Meeting

    Treatment of Lupus-prone MRL-lpr Mice with the Mitochondrial Antioxidant MitoQ

    Ralph Budd1, Karen Fortner 1, Luz Blanco 2, Mariana Kaplan 3, Andras Perl 4, Iwona Busliewicz 5, Greg MacPherson 6 and Mike Murphy 7, 1The University of Vermont Larner College of Medicine, Burlington, VT, 2NIH NIAMS, Bethesda, MD, 3National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, 4SUNY Upstate Medical University, Syracuse, NY, 5Upstate Medical Center, Syracuse, NY, 6MitoQ, Aukland, New Zealand, 7Wellcome MRC Mitochondrial Biology Unit, Cambridge, United Kingdom

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by a type I Interferon (IFN-I) gene signature in peripheral blood lymphocytes (PBL), which contain enlarged mitochondria and…
  • Abstract Number: 82 • 2019 ACR/ARP Annual Meeting

    Rab4A Increases Mitochondrial Oxidative Stress and Glutathione Disulfide Accumulation That Underlie Neurobehavioral Changes in Lupus-Prone Mice

    Thomas Winans1, Tamas Faludi 2, Brandon Wyman 1, Nick Huang 2, Joshua Lewis 1, Manuel Duarte 1, Laurence Morel 3, Frank Middleton 2 and Andras Perl 4, 1Upstate Medical University, Syracuse, 2Upstate Medical University, Syracuse, NY, 3University of Florida, Gainesville, FL, 4SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: Background/Purpose            The human GTPase HRES-1/Rab4 has been identified as a susceptibility locus for systemic lupus erythematosus (SLE) and is overexpressed in T cells of…
  • Abstract Number: 888 • 2019 ACR/ARP Annual Meeting

    Mitochondrial DNA Impact on Joint Degeneration Process Using DMM OA and Spontaneous Aging Conplastic Mice Models

    Morena Scotece1, Ignacio Rego-Pérez 2, Ana Victoria Lechuga-Vieco 3, María Concepción Jiménez Gómez 3, Purificación Filgueira-Fernández 4, José Antonio Enriquez 3 and Francisco J. Blanco 2, 1Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, 2Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 3Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Madrid, Spain, 4Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Galicia, Spain

    Background/Purpose: Accumulated data indicated that osteoarthritis has a strong genetic component with a prevalent role of mitochondria and mtDNA variations. In the present work, we…
  • Abstract Number: 1946 • 2019 ACR/ARP Annual Meeting

    Metabolic Regulation in Cybrids Obtained from Healthy and Osteoarthritic (OA) Patients: Impaired Metabolic Flexibility in OA Process

    Andrea Dalmao-Fernández1, Jenny Lund 2, Tamara Hermida-Gómez 3, María E. Vázquez-Mosquera 1, Ignacio Rego-Pérez 4, Francisco J. Blanco 4 and Mercedes Fernandez-Moreno 5, 1Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain, 2Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway, 3Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, 4Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 5Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain

    Background/Purpose: Background: Osteoarthritis (OA) is the most frequent joint disease.The OA is a heterogeneous disorder. With acceptance of the joint as an organ, the pathogenesis…
  • Abstract Number: 1992 • 2019 ACR/ARP Annual Meeting

    Adenosine A2A Receptor (A2AR) Stimulation Mitigates Mitochondrial Inflammaging, Enhances Mitochondrial Metabolism and Reduces Reactive Oxygen Species-Mediated Mitochondrial Injury In Vitro and In Vivo in Osteoarthritis

    Cristina Castro1, Carmen Corciulo 2, Maria Solecio 3, Benjamin Friedman 4, Fengxia Liang 5, Zhi Li 6, Samson Jacob 7, David Fenyo 8, Evgeny Pavlov 9 and Bruce Cronstein 4, 1Immunology and Inflammation Training Program at Skirball Institute of Graduate Biomolecular Sciences, New York University School of Medicine (NYUSoM), NYC, 2Division of Translational Medicine NYUSoM, NYC, 3NYU College of Dentistry, NYC, 4Department of Medicine, Division of Rheumatology NYUSoM, NYC, 5Department of Cell Biology, NYU Langone Health, NYC, 6Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYU Langone Helalth, NYC, 7Institute for Systems Genetics, NYU Langone Health, NYC, 8Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYC, 9Basic Science and Craniofacial Biology, NYU College of Dentistry, NYC

    Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population and one of the contributing factors in OA…
  • Abstract Number: 2005 • 2019 ACR/ARP Annual Meeting

    Circulating Mitochondrial Danger-Associated Molecular Patterns as Novel Biomarkers of Disease Activity and Inflammation in Rheumatoid Arthritis

    Bhargavi Duvvuri1 and Christian Lood 1, 1University of Washington, Seattle

    Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease causing erosive and disabling joint damage. We recently found that mitochondria are extruded upon formation of…
  • Abstract Number: 2036 • 2019 ACR/ARP Annual Meeting

    Mitochondrial DNA: A Potential Trigger of Cyclic GMP-AMP Synthase Activation in Systemic Lupus Erythematosus

    Jie An1, Bhargavi Duvvuri 1, Xizhang Sun 1, Lena Tanaka 1, Christian Lood 1 and Keith Elkon 1, 1University of Washington, Seattle

    Background/Purpose: Approximately 70% of patients with Systemic Lupus Erythematosus (SLE) show a striking Type I Interferon (IFN-I) signature in peripheral blood. Although we have some…
  • Abstract Number: 2727 • 2019 ACR/ARP Annual Meeting

    Mitochondrial Contribution to Juvenile Dermatomyositis Pathogenesis

    Bhargavi Duvvuri1, Lauren Pachman 2, Richard Moore 1, Gabrielle Morgan 2, Marisa Klein-Gitelman 2, Megan L. Curran 3, Stephen Doty 4 and Christian Lood 1, 1University of Washington, Seattle, 2Northwestern University, Chicago, 3University of Colorado, Aurora, CO, 4Hospital for Special Surgery, New York

    Background/Purpose: Though mainly found intracellularly, we recently observed mitochondrial extrusion upon cell death, contributing to inflammation and organ damage in lupus-prone mice. Of note, mitochondria…
  • Abstract Number: 106 • 2018 ACR/ARHP Annual Meeting

    Highly Elevated Levels of Anti-Mitochondrial Antibodies in Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Richard Moore1 and Christian Lood2, 1Division of Rheumatology, University of Washington, Seattle, WA, 2Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: We recently described the phenomenon in systemic lupus erythematosus (SLE) in which mitochondria are extruded into the extracellular space during formation of neutrophil extracellular…
  • Abstract Number: 1008 • 2017 ACR/ARHP Annual Meeting

    mtDNA Cybrids from OA Patients Are Less Efficient Using Glycolysis and Are More Susceptible to Apoptosis Under Stress Conditions

    Mercedes Fernandez Moreno1,2, Tamara Hermida-Gómez3, Andrea Dalamao-Fernandez4, M. Eugenia Vazquez Mosquera4, Estefanía Cortés-Pereira1, Morena Scotece4, Sara Relaño-Fernandez5, Ignacio Rego-Pérez1 and Francisco J Blanco6, 1Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 2CIBER-BBM, Madrid, Spain, 3Rheumatology, INIBIC. Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. CIBER-BBN., A Coruña, Spain, 4Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A CORUÑA, Spain, 5Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 6Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain

    Background/Purpose:  Previous studies have showed that chondrocytes from OA patients had mitochondrial alteration in comparison with healthy. However the role of mitochondria in the biological…
  • Abstract Number: 2342 • 2017 ACR/ARHP Annual Meeting

    Transcriptomic Analysis Reveals Mitochondrial and Monocyte Dysfunctions Are Linked to the Interferonopathy of Juvenile Dermatomyositis

    Claire Deakin1, Elizabeth Rosser1, Lucy Marshall1, Meredyth Wilkinson2, Aziza Khabbush3, Stefania Simou1, Georg Otto3, Stefanie Dowle3, Daniel Kelberman3, Simon Yona2, Simon Eaton3 and Lucy R Wedderburn1, 1Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom, 2Division of Medicine, University College London, London, United Kingdom, 3Genetics and Genomic Medicine Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom

    Background/Purpose: Although type I interferon (IFN1) and endoplasmic reticulum (ER) stress have been implicated in pathogenesis of juvenile dermatomyositis (JDM), little else is known about…
  • Abstract Number: 1571 • 2016 ACR/ARHP Annual Meeting

    Altered Bioenergetics, Mitochondrial Function and Pro-Inflammatory Pathways in RA Synovium in Response to Tofacitinib

    Carl Orr1, Trudy McGarry2, Monika Biniecka3, Jennifer McCormick4, Ursula Fearon5 and Douglas J. Veale1, 1Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, 2St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, 3St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 4Department of Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 5Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland

    Background/Purpose:  Rheumatoid arthritis (RA) is a chronic joint disease, characterised by synovial inflammation and destruction of articular cartilage/bone. The Janus-Kinase and Signal Transducer and Activator…
  • Abstract Number: 3189 • 2015 ACR/ARHP Annual Meeting

    Enhancement of Mitochondrial Biogenesis Inhibits Cell Proliferation and MMP-3/RANKL Secretion in Rheumatoid Arthritis Fibroblast-like Synovial Cells and Joint Destruction in Arthritis Model Mice

    Takeshi Ueha1, Yoshitada Sakai1, Masayuki Morishita2, Toshihisa Maeda2, Koji Fukuda2, Miho Inoue2, Risa Harada2, Masaya Minoda2, Yasushi Miura3,4,5, Akira Hashiramoto6 and Masahiro Kurosaka1,4, 1Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 3Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 4Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 5Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, 6Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

    Background/Purpose: Joint destruction in rheumatoid arthritis (RA) progresses via the hyperproliferation of the synovium and secretion of MMP-3/RANKL from fibroblast-like synoviocytes (FLS). In tumors, we previously…
  • Abstract Number: 2073 • 2015 ACR/ARHP Annual Meeting

    Mitochondrial ROS Is a Novel Regulator of Sting-Mediated Type I IFN Production By Governing Extrusion of Oxidized Mitochondrial DNA upon Neutrophil Extracellular Trap Formation.

    Christian Lood1, Luz P. Blanco2, Monica Purmalek3, Carolyne K. Smith3, Carmelo Carmona-Rivera3, Jeffrey Ledbetter4, Mariana J. Kaplan2 and Keith B. Elkon5, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Washington, Seattle, WA, 5Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Neutrophil extracellular trap generation (NETosis) is a reactive oxygen species (ROS)-dependent cell death pathway implicated in autoimmune disorders such as systemic lupus erythematosus (SLE).…
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