ACR Meeting Abstracts

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Abstracts tagged "Miscellaneous Rheumatic and Inflammatory Diseases"

  • Abstract Number: 0856 • ACR Convergence 2024

    Comparative Effectiveness of Disease Modifying Antirheumatic Drugs for Cardiac Sarcoidosis

    Michael Putman1, Lisbeth Brooks2, William Kivlin2, Divyanshu Mohananey2 and Viktoriya Sabchyshyn2, 1The Medical College of Wisconsin, Milwaukee, WI, 2Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: No studies to date have evaluated the comparative efficacy of disease modifying antirheumatic drugs (DMARDs) for cardiac sarcoidosis. Methods: We performed a retrospective cohort…
  • Abstract Number: 2049 • ACR Convergence 2024

    Genetically Proxied Glucose‑lowering Drug Target and Risk of Immune Mediated Inflammatory Disease: A Mendelian Randomization Study

    Dongze Wu1 and Yingzhao jin2, 1Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China (People's Republic), 2Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: There are conflicting findings on the relationship between glucose-lowering drugs and risk of development of immune mediated inflammatory diseases (IMIDs). The study aimed to…
  • Abstract Number: 0857 • ACR Convergence 2024

    Exploring Clinical Outcomes of Patients with Cardiac Sarcoidosis on TNF Inhibitors: A Nationwide Retrospective Cohort Study

    Yurilu Gonzalez Moret1, Diego Lema2 and Fabian Rodriguez Quinonez3, 1Jefferson Einstein Hospital, Philadelphia, PA, 2Universidad Central de Venezuela, University of Wisconsin, Philadelphia, PA, 3Einstein Medical Center Philadelphia, Philadelphia, PA

    Background/Purpose: Immunosuppressive therapy, including Tumor necrosis factor inhibitors (TNFi), is commonly used in the treatment of various inflammatory conditions, including extracardiac sarcoidosis. However, the use…
  • Abstract Number: 2054 • ACR Convergence 2024

    Phenotypical Differences in VEXAS Syndrome, Where Are We a Year Later? Results from a National Cohort Focused on Rheumatological Patients

    Paula García Escudero1, Marta López I Gómez2, Berta Magallanes López3, Diego Dios Santos4, Francisco Javier Toyos Sáenz de Miera5, Alicia García Dorta6, José Ángel Hernández Beriain7, Íñigo Rúa-Figueroa8, cristiana sieiro santos9, Elvira Díez Álvarez10, Marta Ibáñez Martínez11, Beatriz Frade-Sosa12, Judit Font Urgelles13, Meritxell Sallés Lizarzaburu14, Elena Riera Alonso15, Ernesto Trallero Araguás16, Eugenia Enríquez Merayo17, Maria Rodriguez-Laguna18, irene monjo19, Carolina Merino20, Paloma Vela-Casasempere21, Ignacio Vázquez Gómez22, Jose Alberto Miranda Filloy23, Rafael Benito Melero-Gonzalez24, Clara Garcia Belando25, Giuliano Boselli26, Alina Lucica Boteanu27, Dolly Viviana Fiallo Suárez28, Cristina Corrales Selaya29, ALBERTO MARIANO RUIZ ROMAN30 and Jaime Calvo-Alén31, 1Hospital Universitario Araba, Vitoria, 2Hospital Universitario Alava, Vitoria, Pais Vasco, Spain, 3Hospital de la Santa Creu i Sant Pau, Barcelona, 4C. H. U. A Coruña, C. H. U. A Coruña, 5H. U. Virgen Macarena, H. U. Virgen Macarena, 6Rheumatologist, La Laguna, Spain, 7Rheumatology Department. Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran C, Spain, 8Department of Rheumatology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas GC, Spain, 9Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 10Complejo Asistencial Universitario de León, León, Spain, 11Hospital Clínico Universitario de Salamanca, Salamanca, Spain, 12Hospital Clinic de Barcelona, Barcelona, Spain, 13Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 14Althaia Xarxa Assistencial Universitària Manresa, Manresa, Catalonia, Spain, 15Mutua de Terrasa, Barcelona, 16Hospital Vall D'Hebron, Barcelona, Spain, 17Hospital 12 de Octubre, Madrid, 18Resident in Rheumatology, Madrid, Spain, 19University Hospital La Paz, Madrid, Spain, 20Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda (Madrid), Spain, 21Hospital General Universitario Alicante, Alicante, Spain, 22H. U. Dr. Peset, Valencia, 23C. H. U. Lucus Augusti, Lugo, Spain, 24CHU Ourense, O Carballino, Spain, 25H. C. U. Virgen de la Arrixaca, Murcia, 26hospital miguel servet, zaragoza, Aragon, Spain, 27H.U. Ramón y Cajal, Madrid, Spain, 28H. U. de Gran Canaria. Dr. Negrin, H. U. de Gran Canaria, 29Rheumatology, Marques de Valdecilla University Hospital. IDIVAL, Santander, Cantabria, Spain, 30Hospital Universitario Juan Ramón Jiménez, Huelva, Spain, 31Department of Rheumatology, Hospital Araba, Vitoria, Pais Vasco, Spain

    Background/Purpose: VEXAS syndrome is an autoinflammatory disorder caused by a mutation in the UBA1 gene, which leads to a heterogeneous clinical presentation and progressive bone…
  • Abstract Number: 0877 • ACR Convergence 2024

    Zasocitinib (TAK-279) Displays High Levels of TYK2 Inhibition and No Inhibition of JAK 1/3 Compared with Licensed TYK2 and JAK Inhibitors

    Shailly Mehrotra1, Yasuyo Sano1, Elizabeth Wilson1, Chandrasekar Durairaj2, Kok-Fai Kong1, Guliang Xia3, Faith Dunbar3, Taylor Spector1, Christopher Bunick4 and Iain McInnes5, 1Takeda Development Center Americas, Inc., Cambridge, 2Takeda Development Center Americas, Inc., Cambridge, MA, 3Takeda Development Center Americas, Inc, Cambridge, 4Yale University School of Medicine, New Haven, 5University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom

    Background/Purpose: Zasocitinib (TAK-279), an oral, allosteric, selective, tyrosine kinase 2 (TYK2) inhibitor in late-stage clinical development for the treatment of immune-mediated inflammatory diseases including psoriatic…
  • Abstract Number: 2660 • ACR Convergence 2024

    Developing Predictive Models for the Diagnosis of VEXAS Syndrome

    Daniel Montes1, Andrew C. Hanson2, Hannah Langenfeld1, Cynthia Crowson1, Mrinal Patnaik1, Ronald Go1, Alexander Hines1, Kambiz Kalantari1, Yael Kusne3, Terra Lasho2, Abhishek Mangaonkar1, Horatiu Olteanu1, Kaaren Reichard1, Megan Sullivan4, David Viswanatha1, Kenneth Warrington1 and Matthew Koster1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, 3Mayo Clinic, Phoenix, AZ, 4Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a recently identified autoinflammatory disorder with a heterogenous presentation. Patients may experience delays in diagnosis…
  • Abstract Number: 0131 • ACR Convergence 2024

    Methotrexate and Tumor Necrosis Factor Inhibitors Independently Decrease Neutralizing Antibodies After SARS-CoV-2 Vaccination: Updated Results from the SUCCEED Study

    Carol Hitchon1, Dawn Bowdish2, Gilles Boire3, Paul Fortin4, Louis Flamand5, Vinod Chandran6, Roya M Dayam7, Anne-Claude Gingras8, Catherine Card9, Ines Colmegna10, Maggie Larche2, Gil Kaplan11, Luck Lukusa12, Jennifer Lee12 and Sasha Bernatsky13, and SUCCEED investigative team, 1University of Manitoba, Winnipeg, MB, Canada, 2McMaster University, Hamilton, ON, Canada, 3Retired, Sherbrooke, QC, Canada, 4Centre ARThrite - CHU de Québec - Université Laval, Quebec, QC, Canada, 5Centre Hospitalier Universitaire (CHU) de Québec-Université Laval Research Center, Quebec City, 6University of Toronto, Toronto, ON, Canada, 7Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health, Toronto, ON, Canada, 8Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada, 9National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada, 10The Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 11University of Calgary, Calgary, AB, Canada, 12The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 13Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: Given ongoing SARS-CoV-2 circulation, COVID-19 vaccination response in immune-mediated inflammatory disease (IMID) remains a key issue, particularly regarding effects of common immunosuppressives like methotrexate…
  • Abstract Number: 1112 • ACR Convergence 2024

    Pleuroparenchymal Fibroelastosis Associated with Connective Tissue Diseases (PPFE-CTD)

    Maximiliano Diaz Menindez1, Alejandro Diaz Arumir Vergara2, Vivian Shing2, carolyn mead harvey3, Ana Zamora Martinez2 and Vivek Nagaraja4, 1Mayo Clinic School of Graduate Medical Education, Phoenix, AZ, 2Mayo Clinic, Phoenix, 3Mayo Clinic Florida, Jacksonville, FL, 4Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: Pleuroparenchymal Fibroelastosis (PPFE) is a rare idiopathic interstitial pneumonia characterized by fibrosis of the visceral pleura and subpleural parenchyma, predominantly affecting the upper lobes.…
  • Abstract Number: PP11 • ACR Convergence 2024

    Living Well with Chronic Illness: Decades with MCTD

    Carol KAMINSKI, HP (Hewlett Packard) Retired, Wilmington, NC

    Background/Purpose: In the fall of 1985, I was not feeling well. I attributed my tiredness, weakness and malaise to stress and carried on. Walking upstairs I…
  • Abstract Number: 0246 • ACR Convergence 2024

    Selectively Targeting TRBV11-2+ T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Using Bispecific T Cell-Engaging Antibodies

    Elana Shaw, Stephanie Glavaris, Brian Mog, Alexander Pearlman, Sarah DiNapoli, Jin Liu, Kyle J. Kaeo, Kenneth W. Kinzler, Chetan Bettegowda, Shibin Zhou, Bert Vogelstein, Suman Paul and Maximilian F. Konig, The Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but potentially deadly immune complication after infection with SARS-CoV-2. In patients with MIS-C, a striking…
  • Abstract Number: 1131 • ACR Convergence 2024

    Zasocitinib (TAK-279), a Selective Oral Tyrosine Kinase 2 Inhibitor, Reduces Body Surface Area Involvement in a Phase 2b Trial in Moderate-to-Severe Plaque Psoriasis

    Vivian Laquer1, Leon Kircik2, Neil Sadick3, Jamie Weisman4, Yiwei Zhao5, Jessamyn Blau5, Wenwen Zhang6, Jonathan Uy5, Warren Winkelman6 and Melinda Gooderham7, 1First OC Dermatology Research, Fountain Valley, CA, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Weill Cornell Medical College, New York, NY, 4Piedmont Atlanta, Atlanta, GA, 5Takeda Development Center Americas, Inc., Cambridge, MA, 6Takeda Development Center Americas, Inc., Cambridge, 7SKiN Centre for Dermatology and Probity Medical Research, Peterborough, ON, Canada

    Background/Purpose: Zasocitinib (TAK-279) is a highly selective, allosteric, oral inhibitor of tyrosine kinase 2 (TYK2). TYK2 mediates signaling from cytokines involved in the pathogenesis of…
  • Abstract Number: 0287 • ACR Convergence 2024

    Joint Involvement in Cystic Fibrosis: Description of Clinical Phenotypes

    Omar Al Tabaa1, manon Lesturgie1, Pierre Régis Burgel2, Nicolas Carlier2 and Jérôme Avouac3, 1Rheumatology Department, Cochin Hospital, Paris, France, 2Pulmonology department, Cochin Hospital, Paris, France, 3Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France

    Background/Purpose: Cystic fibrosis (CF) is the most common lethal autosomal recessive genetic disorder. The improvement in life expectancy due to the advent of new treatments…
  • Abstract Number: 1224 • ACR Convergence 2024

    Occupational Stress and Fibromyalgia Among Healthcare Professionals in Abu Dhabi Region, United Arab Emirates: A Cross-sectional Study

    Shamma Al Nokhatha1, Asma Alneyadi2, Noor Alnuaimi3, Hajar Almansoori3, Sara Alhosani3, Shammah Almemari4 and Muhammad Hashim3, 1Tawam hospital/ College of Medicine and Health Sciences, Al Ain, Abu Dhabi, United Arab Emirates, 2Tawam hospital, Al Ain, Abu Dhabi, United Arab Emirates, 3College of Medicine and Health Sciences, Al Ain, Abu Dhabi, United Arab Emirates, 4Ambulatory Health Services, Al Ain, Abu Dhabi, United Arab Emirates

    Background/Purpose: The stress level of healthcare workers may impact the quality of care provided to patients. The prevalence of occupational stress among healthcare workers can…
  • Abstract Number: 0295 • ACR Convergence 2024

    Mycophenolate Mofetil in the Treatment of Patients with Isolated Cardiac Sarcoidosis

    Namitha Nair1, Leen Al Saleh2, Haya Haddad3, Maria Jaimes Reyes4, Vishakha Chetram5, Farooq Sheikh6, FLORINA CONSTANTINESCU7 and Anjani Pillarisetty8, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2Watson Clinic, Lakeland, FL, 3Medstar Washington Hospital Center, Silver Spring, MD, 4Medstar Washington Hospital Center/Georgetown University, Washington, DC, 5Inova Schar Heart and Vascular, Falls Chirch, VA, 6MedStar Heart and Vascular Institute, Georgetown University School of Medicine, Washington, DC, 7MedStar Washington Hospital Center, Washington, DC, 8Carson Tahoe Medical Group, Reno, NV

    Background/Purpose: Cardiac involvement is seen in approximately a fourth of patients with sarcoidosis, a non-necrotizing granulomatous systemic disease. Among these patients, 25% may have isolated cardiac…
  • Abstract Number: 1299 • ACR Convergence 2024

    Board-Style Rheumatology Teaching for Medicine Residents: Novel Approach to Curriculum Development

    Merve Aksoy*, Shadi Jafari-Esfahani*, Yasaman Ahmadzadeh and Katarzyna Gilek-Seibert, Roger Williams Medical Center, Providence, RI

    Background/Purpose: During their training, internal medicine (IM) residents often have limited exposure to rheumatology, resulting in decreased confidence levels and inadequate scores on the In-training…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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