Abstracts tagged "MicroRNA"

Abstract Number: 1613 • 2014 ACR/ARHP Annual Meeting
Circulating microRNAs As Candidate Biomarkers of Diagnosis in Systemic Lupus Erythematosus
Juyang Jung¹, Ja-Young Jeon², Bong-Sik Kim³, Hyoun-Ah Kim² and Chang-Hee Suh⁴, ¹Ajou university of medical school, Suwon, South Korea, ²Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ³Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ⁴Rheumatology, Ajou University School of Med, Suwon, South Korea
Background/Purpose : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by polyclonal B-cell activation and elevated production of pathogenic autoantibodies. MicroRNAs (miRNAs) are short,…
Abstract Number: 1202 • 2014 ACR/ARHP Annual Meeting
Type I Interferon Promotes Inflammatory Cytokine Production By Inhibiting Mir-146a Maturation in SLE
Bo Qu¹, Jianchang Cao², Feifei Zhang² and Nan Shen^1,2,3, ¹Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, ³The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose Systemic lupus erythematosus (SLE) is characterized by the uncontrolled inflammation along with over produced inflammatory cytokines, among which type I interferon (IFN) is recognized…
Abstract Number: 1049 • 2014 ACR/ARHP Annual Meeting
Bioactive TGF-β Is Present on Bovine Milk-Derived Exosomes: Consequences for Patients?
Bartijn C.H. Pieters, Onno J. Arntz, Mathijs G.A. Broeren, Arjan van Caam, Peter M. van der Kraan, Marieke de Vries and Fons A.J. van de Loo, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Development of rheumatoid arthritis (RA) is associated with different genetic and environmental factors. We postulate that cow milk could be such an environmental trigger…
Abstract Number: 2907 • 2014 ACR/ARHP Annual Meeting
Loss of microRNA-146a Exacerbates Inflammatory Arthritis
Victoria Saferding¹, Antonia Puchner², Eliana Goncalvesalves³, Birgit Niederreiter⁴, Silvia Hayer⁴, Gernot Schabbauer⁵, Marije Koenders⁶, Josef Smolen¹, Kurt Redlich³ and Stephan Blueml³, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁵Vascular Biology and Thrombosis research, Medical University Vienna, Vienna, Austria, ⁶Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Background/Purpose: MicroRNA (MiR-) 146a is a key regulator of the innate immune response and has also been shown to suppress cancer development in myeloid cells.…
Abstract Number: 1015 • 2014 ACR/ARHP Annual Meeting
Mir-9/MCPIP1 Axis Mediated Regulation of IL-6 Expression in Osteoarthritis Chondrocytes
Tariq Haqqi¹, Abdul Haseeb² and Mohammad Shahidul Makki², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH
Background/Purpose Post-transcriptional regulation of cytokine expression is important for maintaining tissue integrity. MCPIP1 was identified as a novel protein, which destabilizes inflammatory cytokines mRNAs via…
Abstract Number: 2850 • 2014 ACR/ARHP Annual Meeting
MiR-125a Is Critical Regulator for Controlling Autoimmunity in Multiple Autoimmune Diseases through Stabilizing Treg Mediated Immune Homeostasis
Wan Pan^1,2, Shu Zhu², Dai Dai², John Harley³ and Nan Shen^1,2,3, ¹Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, ³The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose Although different autoimmune diseases show distinct clinical phenotypes, common cellular and molecular immune pathways have been shown to be intimately involved in the autoimmune…
Abstract Number: 967 • 2014 ACR/ARHP Annual Meeting
Mir-145 Protects Against Skin Fibrosis in Vivo by targeting TGF-β Signaling
Serena Vettori^1,2, Christian Beyer³, Matthias Brock¹, Naoki Iwamoto¹, Britta Maurer¹, Michelle Trenkmann¹, Astrid Jüngel¹, Renate E. Gay¹, Maurizio Calcagni⁴, Gabriele Valentini⁵, Steffen Gay¹, Joerg H. W. Distler³ and Oliver Distler¹, ¹Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ²Internal and Experimental Medicine, Second University of Naples, Naples, Italy, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland, ⁵Internal and Experimental Medicine, Second University of Naples, Napoli, Italy
Background/Purpose In vitro, miR-145 exerts anti-fibrotic effects in systemic sclerosis (SSc) by downregulating TGF-β signaling. In turn, ectopic TGF-β downregulates miR-145 thereby optimizing TGF-β signaling…
Abstract Number: 2785 • 2014 ACR/ARHP Annual Meeting
Joint Specific Positional Differences in Coding and Noncoding Transcriptome of Synovial Fibroblasts As a Determinant of the Susceptibility of Synovial Joints to Rheumatoid Arthritis
Caroline Ospelt¹, Maria Armaka², Giancarlo Russo³, Anna Bratus³, Michelle Trenkmann⁴, Emmanuel Karouzakis¹, Christoph Kolling⁵, Renate E. Gay⁴, George Kollias⁶, Steffen Gay¹ and Mojca Frank Bertoncelj¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Institute of Immunology,, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, ³Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Schulthess Clinic, Zurich, Switzerland, ⁶Institute of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece
Background/Purpose The molecular mechanisms underlying the topographic differences in the susceptibility of synovial joints to develop rheumatoid arthritis (RA) are unknown. Positional embryonic expression of…
Abstract Number: 882 • 2014 ACR/ARHP Annual Meeting
A Signature of microRNAs Overexpressed in Inflamed Temporal Arteries of Patients with Giant Cell Arteritis
Stefania Croci¹, Alessandro Zerbini¹, Luigi Boiardi², Francesco Muratore², Alessandra Bisagni³, Giulia Pazzola², Luca Cimino⁴, Antonio Moramarco⁴, Davide Nicoli⁵, Enrico Farnetti⁶, Bruno Casali⁶, Alberto Cavazza³, Maria Parmeggiani⁷ and Carlo Salvarani², ¹Clinical Immunology, Allergology and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁴Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Laboratory of Molecular Biology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁶Laboratory of Molecular Biology,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁷Clinical Immunology, Allergology and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy
Background/Purpose: MicroRNAs (miRNAs) are small, non-coding RNAs that suppress gene expression at post-transcriptional level. MiRNAs can regulate innate and adaptive immunity. Moreover, they have been…
Abstract Number: 2737 • 2014 ACR/ARHP Annual Meeting
Microrna-155 Suppresses IL-21 Signaling and Production in Systemic Lupus Erythematosus
Tue K. Rasmussen¹, Thomas Andersen¹, Rasmus Bak¹, Gloria Yiu², Kristian Steengaard-Petersen³, Jacob G. Mikkelsen¹, Paul J. Utz⁴, Christian Holm¹ and Bent Deleuran^3,5, ¹Department of Biomedicine, Aarhus University, Aarhus C, Denmark, ²Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Department of Biomedicine, Aarhus University, Aarhus, Denmark
Background/Purpose IL-21 is a key regulator of B cells functions and autoantibody production and is mainly produced by follicular T helper cells. The purpose of…
Abstract Number: 772 • 2014 ACR/ARHP Annual Meeting
RNA-Seq and Mir-Seq Analysis of SSc Skin Across Intrinsic Gene Expression Subsets Shows Differential Expression of Non-Coding RNAs Regulating SSc Gene Expression
Zhenghui Li¹, Eleni Marmarelis², Kun Qu³, Lionel Brooks⁴, Patricia Pioli⁴, Howard Chang³, Robert Lafyatis⁵ and Michael Whitfield⁴, ¹Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Stanford University School of Medicine, Stanford, CA, ⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ⁵Arthritis Center, Boston University, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease with a heterogenous and complex phenotype. Previously, our lab has identified four gene expression subsets (fibroproliferative,…
Abstract Number: 2744 • 2014 ACR/ARHP Annual Meeting
Mi-RNA Profile of Active Vascular BEHÇET’S Patients
Ahmet Mesut Onat¹, Ozan Gerenli², Bunyamin Kisacik¹, Mustafa Ulasli³, Gezmis Kimyon⁴, Yavuz Pehlivan⁵ and Serdar Oztuzcu⁶, ¹Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ²Rheumatology, Gaziantep UniversitySchool of Medicine, Gaziantep, Turkey, ³Genetics, Gaziantep UniversitySchool of Medicine, Gaziantep, Turkey, ⁴Department of Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁵Rheumatology, Uludag University, School of Medicine, Bursa, Turkey, ⁶Genetcs, Gaziantep UniversitySchool of Medicine, Gaziantep, Turkey
Background/Purpose Behçet’s Disease (BD) is a systemic vasculitis that predominantly presented with oral aphtous ulcers and additionally at least two of the following findings like…
Abstract Number: 761 • 2014 ACR/ARHP Annual Meeting
Specific Autoantibody Profiles and Disease Subgroups Correlate with Circulating Micro-RNA in Systemic Sclerosis
Dirk Wuttge¹, Anting L. Carlsen², Gabriel Teku³, Samantha Steen⁴, Marie Wildt¹, Mauno Vihinen³, Roger Hesselstrand¹ and Niels H. H. Heegaard^4,5, ¹Rheumatology, Lund University, Lund, Sweden, ²Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ³Experimental Medical Science, Lund University, Lund, Sweden, ⁴Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁵Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark
Background/Purpose: Systemic sclerosis (SSc) is a serious autoimmune disease with clinical phenotypes of different prognosis, progression rate, and different extent of involvement of internal organs.…
Abstract Number: 2449 • 2014 ACR/ARHP Annual Meeting
Microrna-346 Regulation of Follicular Helper T Cells Is Involved in the Pathogenesis of rheumatoid Arthritis Disease
Xinyi Tang¹, Jie Ma² and Shengjun Wang³, ¹Department of Laboratory Medicine, Jiangsu University Affi�liated People’s Hospital, Zhenjiang, China, ²Department of Laboratory Medicine, Jiangsu University Afﬁliated People’s Hospital, Zhenjiang, China, ³Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China
Background/Purpose Follicular helper T (Tfh) cells have been identified as a new subset of effector helper T cells that are essential in regulating the development…
Abstract Number: 754 • 2014 ACR/ARHP Annual Meeting
The Global miRNA Whole Blood Profile in Systemic Sclerosis and Its Correlation with Serum Cytokine Levels
Gloria Salazar¹, Maureen Mayes², John Hagan³, Minghua Wu¹, John D. Reveille^4,5 and Shervin Assassi¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX, ³Neurosurgery, University of Texas at Houston, Houston, TX, ⁴Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
The Global miRNA Whole Blood Profile in Systemic Sclerosis and its Correlation with Serum Cytokine LevelsBackground/Purpose: Several studies have implicated miRNAs in the pathogenesis of…

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