ACR Meeting Abstracts

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Abstracts tagged "MicroRNA"

  • Abstract Number: 1613 • 2014 ACR/ARHP Annual Meeting

    Circulating microRNAs As Candidate Biomarkers of Diagnosis in Systemic Lupus Erythematosus

    Juyang Jung1, Ja-Young Jeon2, Bong-Sik Kim3, Hyoun-Ah Kim2 and Chang-Hee Suh4, 1Ajou university of medical school, Suwon, South Korea, 2Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, 3Rheumatology, Ajou University School of Medicine, Suwon, South Korea, 4Rheumatology, Ajou University School of Med, Suwon, South Korea

    Background/Purpose : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by polyclonal B-cell activation and elevated production of pathogenic autoantibodies. MicroRNAs (miRNAs) are short,…
  • Abstract Number: 1202 • 2014 ACR/ARHP Annual Meeting

    Type I Interferon Promotes Inflammatory Cytokine Production By Inhibiting Mir-146a Maturation in SLE

    Bo Qu1, Jianchang Cao2, Feifei Zhang2 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 2Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, 3The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH

    Background/Purpose Systemic lupus erythematosus (SLE) is characterized by the uncontrolled inflammation along with over produced inflammatory cytokines, among which type I interferon (IFN) is recognized…
  • Abstract Number: 1049 • 2014 ACR/ARHP Annual Meeting

    Bioactive TGF-β Is Present on Bovine Milk-Derived Exosomes: Consequences for Patients?

    Bartijn C.H. Pieters, Onno J. Arntz, Mathijs G.A. Broeren, Arjan van Caam, Peter M. van der Kraan, Marieke de Vries and Fons A.J. van de Loo, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Development of rheumatoid arthritis (RA) is associated with different genetic and environmental factors. We postulate that cow milk could be such an environmental trigger…
  • Abstract Number: 2907 • 2014 ACR/ARHP Annual Meeting

    Loss of microRNA-146a Exacerbates Inflammatory Arthritis

    Victoria Saferding1, Antonia Puchner2, Eliana Goncalvesalves3, Birgit Niederreiter4, Silvia Hayer4, Gernot Schabbauer5, Marije Koenders6, Josef Smolen1, Kurt Redlich3 and Stephan Blueml3, 1Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 5Vascular Biology and Thrombosis research, Medical University Vienna, Vienna, Austria, 6Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

    Background/Purpose: MicroRNA (MiR-) 146a is a key regulator of the innate immune response and has also been shown to suppress cancer development in myeloid cells.…
  • Abstract Number: 1015 • 2014 ACR/ARHP Annual Meeting

    Mir-9/MCPIP1 Axis Mediated Regulation of IL-6 Expression in Osteoarthritis Chondrocytes

    Tariq Haqqi1, Abdul Haseeb2 and Mohammad Shahidul Makki2, 1Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH

    Background/Purpose Post-transcriptional regulation of cytokine expression is important for maintaining tissue integrity. MCPIP1 was identified as a novel protein, which destabilizes inflammatory cytokines mRNAs via…
  • Abstract Number: 2850 • 2014 ACR/ARHP Annual Meeting

    MiR-125a Is Critical Regulator for Controlling Autoimmunity in Multiple Autoimmune Diseases through Stabilizing Treg Mediated Immune Homeostasis

    Wan Pan1,2, Shu Zhu2, Dai Dai2, John Harley3 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 2Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, 3The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH

    Background/Purpose Although different autoimmune diseases show distinct clinical phenotypes, common cellular and molecular immune pathways have been shown to be intimately involved in the autoimmune…
  • Abstract Number: 967 • 2014 ACR/ARHP Annual Meeting

    Mir-145 Protects Against Skin Fibrosis in Vivo by targeting TGF-β Signaling

    Serena Vettori1,2, Christian Beyer3, Matthias Brock1, Naoki Iwamoto1, Britta Maurer1, Michelle Trenkmann1, Astrid Jüngel1, Renate E. Gay1, Maurizio Calcagni4, Gabriele Valentini5, Steffen Gay1, Joerg H. W. Distler3 and Oliver Distler1, 1Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 2Internal and Experimental Medicine, Second University of Naples, Naples, Italy, 3Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland, 5Internal and Experimental Medicine, Second University of Naples, Napoli, Italy

    Background/Purpose In vitro, miR-145 exerts anti-fibrotic effects in systemic sclerosis (SSc) by downregulating TGF-β signaling. In turn, ectopic TGF-β downregulates miR-145 thereby optimizing TGF-β signaling…
  • Abstract Number: 2785 • 2014 ACR/ARHP Annual Meeting

    Joint Specific Positional Differences in Coding and Noncoding Transcriptome of Synovial Fibroblasts As a Determinant of the Susceptibility of Synovial Joints to Rheumatoid Arthritis

    Caroline Ospelt1, Maria Armaka2, Giancarlo Russo3, Anna Bratus3, Michelle Trenkmann4, Emmanuel Karouzakis1, Christoph Kolling5, Renate E. Gay4, George Kollias6, Steffen Gay1 and Mojca Frank Bertoncelj1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Institute of Immunology,, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, 3Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland, 4Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 5Schulthess Clinic, Zurich, Switzerland, 6Institute of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece

    Background/Purpose The molecular mechanisms underlying the topographic differences in the susceptibility of synovial joints to develop rheumatoid arthritis (RA) are unknown. Positional embryonic expression of…
  • Abstract Number: 882 • 2014 ACR/ARHP Annual Meeting

    A Signature of microRNAs Overexpressed in Inflamed Temporal Arteries of Patients with Giant Cell Arteritis

    Stefania Croci1, Alessandro Zerbini1, Luigi Boiardi2, Francesco Muratore2, Alessandra Bisagni3, Giulia Pazzola2, Luca Cimino4, Antonio Moramarco4, Davide Nicoli5, Enrico Farnetti6, Bruno Casali6, Alberto Cavazza3, Maria Parmeggiani7 and Carlo Salvarani2, 1Clinical Immunology, Allergology and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 5Laboratory of Molecular Biology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 6Laboratory of Molecular Biology,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 7Clinical Immunology, Allergology and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy

    Background/Purpose: MicroRNAs (miRNAs) are small, non-coding RNAs that suppress gene expression at post-transcriptional level. MiRNAs can regulate innate and adaptive immunity. Moreover, they have been…
  • Abstract Number: 2737 • 2014 ACR/ARHP Annual Meeting

    Microrna-155 Suppresses IL-21 Signaling and Production in Systemic Lupus Erythematosus

    Tue K. Rasmussen1, Thomas Andersen1, Rasmus Bak1, Gloria Yiu2, Kristian Steengaard-Petersen3, Jacob G. Mikkelsen1, Paul J. Utz4, Christian Holm1 and Bent Deleuran3,5, 1Department of Biomedicine, Aarhus University, Aarhus C, Denmark, 2Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 4Medicine, Stanford University School of Medicine, Stanford, CA, 5Department of Biomedicine, Aarhus University, Aarhus, Denmark

    Background/Purpose IL-21 is a key regulator of B cells functions and autoantibody production and is mainly produced by follicular T helper cells. The purpose of…
  • Abstract Number: 772 • 2014 ACR/ARHP Annual Meeting

    RNA-Seq and Mir-Seq Analysis of SSc Skin Across Intrinsic Gene Expression Subsets Shows Differential Expression of Non-Coding RNAs Regulating SSc Gene Expression

    Zhenghui Li1, Eleni Marmarelis2, Kun Qu3, Lionel Brooks4, Patricia Pioli4, Howard Chang3, Robert Lafyatis5 and Michael Whitfield4, 1Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, 3Stanford University School of Medicine, Stanford, CA, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Arthritis Center, Boston University, Boston, MA

    Background/Purpose:   Systemic sclerosis (SSc) is an autoimmune disease with a heterogenous and complex phenotype. Previously, our lab has identified four gene expression subsets (fibroproliferative,…
  • Abstract Number: 2744 • 2014 ACR/ARHP Annual Meeting

    Mi-RNA Profile of Active Vascular BEHÇET’S Patients

    Ahmet Mesut Onat1, Ozan Gerenli2, Bunyamin Kisacik1, Mustafa Ulasli3, Gezmis Kimyon4, Yavuz Pehlivan5 and Serdar Oztuzcu6, 1Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, 2Rheumatology, Gaziantep UniversitySchool of Medicine, Gaziantep, Turkey, 3Genetics, Gaziantep UniversitySchool of Medicine, Gaziantep, Turkey, 4Department of Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, 5Rheumatology, Uludag University, School of Medicine, Bursa, Turkey, 6Genetcs, Gaziantep UniversitySchool of Medicine, Gaziantep, Turkey

    Background/Purpose Behçet’s Disease (BD) is a systemic vasculitis that predominantly presented with oral aphtous ulcers and additionally at least two of the following findings like…
  • Abstract Number: 761 • 2014 ACR/ARHP Annual Meeting

    Specific Autoantibody Profiles and Disease Subgroups Correlate with Circulating Micro-RNA in Systemic Sclerosis

    Dirk Wuttge1, Anting L. Carlsen2, Gabriel Teku3, Samantha Steen4, Marie Wildt1, Mauno Vihinen3, Roger Hesselstrand1 and Niels H. H. Heegaard4,5, 1Rheumatology, Lund University, Lund, Sweden, 2Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, 3Experimental Medical Science, Lund University, Lund, Sweden, 4Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, 5Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark

    Background/Purpose: Systemic sclerosis (SSc) is a serious autoimmune disease with clinical phenotypes of different prognosis, progression rate, and different extent of involvement of internal organs.…
  • Abstract Number: 2449 • 2014 ACR/ARHP Annual Meeting

    Microrna-346 Regulation of Follicular Helper T Cells Is Involved in the Pathogenesis of rheumatoid Arthritis Disease

    Xinyi Tang1, Jie Ma2 and Shengjun Wang3, 1Department of Laboratory Medicine, Jiangsu University Affi�liated People’s Hospital, Zhenjiang, China, 2Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China, 3Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China

    Background/Purpose Follicular helper T (Tfh) cells have been identified as a new subset of effector helper T cells that are essential in regulating the development…
  • Abstract Number: 754 • 2014 ACR/ARHP Annual Meeting

    The Global miRNA Whole Blood Profile in Systemic Sclerosis and Its Correlation with Serum Cytokine Levels

    Gloria Salazar1, Maureen Mayes2, John Hagan3, Minghua Wu1, John D. Reveille4,5 and Shervin Assassi1, 1Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 2Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX, 3Neurosurgery, University of Texas at Houston, Houston, TX, 4Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 5Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX

    The Global miRNA Whole Blood Profile in Systemic Sclerosis and its Correlation with Serum Cytokine LevelsBackground/Purpose: Several studies have implicated miRNAs in the pathogenesis of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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