ACR Meeting Abstracts

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Abstracts tagged "MicroRNA"

  • Abstract Number: 2398 • 2015 ACR/ARHP Annual Meeting

    Microrna Biomarker Signature in Osteoarthritis

    L. A. Bennett1, T. Coleman1, W. Ferrell1, J. Lockhart2, C. Huesa1, L. Dunning1, B. Jones3, M. Blyth3, I. B. McInnes1, M. Kurowska-Stolarska1 and C. S. Goodyear1, 1Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 2The Centre for Musculoskeletal Science, University of the West of Scotland, Paisley, United Kingdom, 3Orthopedic Research Group, Orthopedic Department, Glasgow Royal Infirmary, Glasgow, United Kingdom

    Background/Purpose: Our current understanding of osteoarthritis (OA) comes mainly from late stage disease and this is partly due to when patients present with symptoms. It…
  • Abstract Number: 935 • 2015 ACR/ARHP Annual Meeting

    Microrna-146a Provides Feedback Regulation of Monosodium Urate-Induced Gouty Arthritis in Mice By Targeting Tumor Necrosis Factor Receptor Associated Factor 6 and Interleukin-1 Receptor-Associated Kinase 1

    Quan-Bo Zhang1,2, Jing-Guo Zhou3, Cong-Cong Yin1, Yu-Feng Qing4, Chang-Gui Li5, Li Zhou1 and Qing-Sheng Mi6, 1Immunology Program, Department of Dermatology, Henry Ford Health System, Detroit, MI, 2Geriatrics, Affliated hospital of North Sichuan Medical College, Nanchong, China, 3Department of Rheumatology and Immunology, Affliated hospital of North Sichuan Medical College, Nanchong, China, 4Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China, Nanchong, China, 5Affiliated Hospital of Qingdao University, Qingdao, China, 6Immunology, Dermatology, Henry Ford Health System, Detroit, MI

    Background/Purpose: MicroRNAs (miRNAs) have been shown to serve as important regulators for inflammatory and immune responses and are implicated in several immune disorders including gouty…
  • Abstract Number: 2546 • 2015 ACR/ARHP Annual Meeting

    Targeting Synovial Fibroblasts By the Intra-Articular Delivery of microRNA-140-3p and -5p Ameliorates Experimental Autoimmune Arthritis

    Chrong-Reen Wang1, Jia-Shiou Peng2, Shih-Yao Chen3, Chao-Liang Wu4 and Ai-Li Shiau5, 1Rheum/Immun Sec/Int Med Dept, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, 2Institute of Basic Medical Sciences, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, 3Internal Medicine, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, 4Biochemistry and Molecular Biology, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, 5Microbiology and Immunology, College of Medicine, National Cheng Kung University, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan

    Background/Purpose: Synovial fibroblasts (SF) with aberrant expression of microRNAs (miRNA) are critical pathogenic regulators of rheumatoid joint, and studies examining the effect of overexpressing or…
  • Abstract Number: 1026 • 2015 ACR/ARHP Annual Meeting

    Microrna-125a-5p Has Increased Expression in Active Systemic Juvenile Idiopathic Arthritis and Is an Essential Modulator of Regulatory Macrophage Phenotypes in Vitro

    Grant Schulert1, Ndate Fall2, Nan Shen3, Sherry Thornton2 and Alexei A. Grom4, 1Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, 3Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease of childhood, characterized by a predominance of mononuclear phagocytic effector cells, compared to the lymphocyte…
  • Abstract Number: 2804 • 2015 ACR/ARHP Annual Meeting

    The Global miRNA Whole Blood Profile of Ankylosing Spondylitis

    Carolina Mejia Otero1, Shervin Assassi1, Michael H. Weisman2, Michael M. Ward3, Lianne S. Gensler4, Matthew A. Brown5, Minghua Wu1, John Hagan6, John D. Reveille7 and Gloria Salazar1, 1Rheumatology, University of Texas Medical School at Houston, Houston, TX, 2Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 3NIH/NIAMS, Bethesda, MD, 4Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 5The University of Queensland Diamantina Institute, Brisbane, Australia, 6Neurosurgery, University of Texas at Houston, Houston, TX, 7Internal Medicine/Rheumatology, University of Texas Medical School at Houston, Houston, TX

    Background/Purpose: MicroRNA (miRNA) are small non-coding RNAs that play an important role in posttranscriptional gene regulation and their involvement in the pathophysiology of several autoimmune…
  • Abstract Number: 1035 • 2015 ACR/ARHP Annual Meeting

    Synovium-Derived microRNAs Inhibit Bone Formation in Rheumatoid Arthritis

    Ellen M. Gravallese1, Yukiko Maeda2, Nicholas H Farina3, Paul Fanning4 and Jane Lian3, 1Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, 2Medicine, University of Massachusetts Medical School, Worcester, MA, 3Department of Biochemistry, University of Vermont, Burlington, VT, 4Department of Orthopedics, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Articular bone erosion in rheumatoid arthritis (RA) is a consequence of synovial inflammation that leads to disability for patients. Cells within the synovium secrete…
  • Abstract Number: 2994 • 2015 ACR/ARHP Annual Meeting

    The Global Microrna Profile of Systemic Sclerosis Whole Skin/Dermal Fibroblasts and the Role of the Xq26.3 miRNA Cluster As a TGF-b Pathway Positive Feedback Mechanism

    Gloria Salazar1, John Hagan2, Minghua Wu3, Xinjian Guo4, Xiaodong Zhou4, Julio Charles1, Maureen D Mayes1 and Shervin Assassi1, 1Rheumatology, University of Texas Medical School at Houston, Houston, TX, 2Neurosurgery, University of Texas at Houston, Houston, TX, 3Feinberg School of Medicine, Northwestern University, Chicago, IL, 4Internal Medicine, University of Texas Medical School at Houston, Houston, TX

    Background/Purpose: MicroRNA (miRNA) are critical gene regulators that frequently play central roles in disease. Here, we report the miRNA expression signatures of systemic sclerosis (SSc)…
  • Abstract Number: 1131 • 2015 ACR/ARHP Annual Meeting

    A Histone Deacetylase Inhibitor SAHA Induce MCPIP1 Expression and Suppress IL-6 Expression By Upregulating Cebpα Expression and Downregulating the Expression of Mir-9 in Human OA Chondrocytes

    Mohammad Shahidul Makki1 and Tariq Haqqi2, 14209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH

    Background/Purpose:   Histone deacetylase inhibitors (HDACi) are a class of compounds that inhibits the histone deacetylase activity. MCPIP1 is a negative regulator of IL-6 expression…
  • Abstract Number: 3124 • 2015 ACR/ARHP Annual Meeting

    Associations of Circulating Cell-Free Micro-RNA with Vasculopathy and Vascular Events in SLE Patients

    Susan Due Kay1, Anting L. Carlsen2, Anne Voss1, Mikael Kjær Poulsen3, Axel Cosmus Pyndt Diederichsen4 and Niels H. H. Heegaard5, 1Department of Rheumatology, Odense University Hospital, Odense C, Denmark, 2Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark, 3Department of Cardiology, Odense University Hospital, Odense C, Denmark, 4Department of Cardiology,, Odense University Hospital, Odense C, Denmark, 5Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark

    Background/Purpose: MicroRNAs (miRNAs) are small noncoding RNAs that modulate protein translation and regulate numerous immunologic and inflammatory pathways. Certain miRNA profiles have been associated with…
  • Abstract Number: 1133 • 2015 ACR/ARHP Annual Meeting

    Microrna-128 Interference Mitigates the Progression of Keen Osteoarthritis By Regulating Sirtuin-1

    Feng-Sheng Wang1, Yi-Chih Sun1, Yu-Shan Chen1 and Jih-Yang Ko2, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose:  MicroRNAs, non-coding small RNAs, reportedly regulate development, remodeling and pathogenesis activities in various tissues through silencing mRNA targets and protein translation. This study is…
  • Abstract Number: 3195 • 2015 ACR/ARHP Annual Meeting

    Circulating Micro-RNA Profiles in Responders to Adalimumab Plus Methotrexate Versus Methotrexate Alone: A Placebo-Controlled Clinical Trial

    Jacob Sode1,2,3, Sophine B. Krintel4, Anting L. Carlsen5, Merete Lund Hetland6, Julia Johansen7,8, Kim Hørslev-Petersen9, Kristian Stengaard-Pedersen10, Peter Junker11, Mikkel Østergaard12,13, Niels H. H. Heegaard14,15 and OPERA study group, 1Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark, 2Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, 3Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark, 4Department of Rheumatology, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, 5Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark, 6The DANBIO Registry, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 7Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, 8Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark, 9Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Graasten, Denmark, 10Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 11Department of Rheumatology, Odense University Hospital, Odense, Denmark, 12Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Glostrup, Denmark, 13Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 14Department of Autoimmunology & Biomarkers, Statens Serum Institut, Copenhagen, Denmark, 15Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark

    Background/Purpose: The variable response to anti-TNF therapy in patients with rheumatoid arthritis (RA) remains largely unexplained, and biomarkers for treatment response are scarce. We previously…
  • Abstract Number: 1134 • 2015 ACR/ARHP Annual Meeting

    Identification of Novel Micro-RNAs in IL-1β-Stimulated OA Chondrocytes By Next-Generation Sequencing

    Mohammad Shahidul Makki1 and Tariq Haqqi2, 14209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH

    Background/Purpose:  Osteoarthritis (OA) is a chronic and debilitating disease of articulating joints. Mechanical stress, genetic and environmental factors play critical role in the pathogenesis of…
  • Abstract Number: 1168 • 2015 ACR/ARHP Annual Meeting

    MiR125a-5p Mediates Angiogenic Mechanisms in Inflammatory Arthritis

    Mary Connolly1, Sarah Wade1, Douglas J. Veale2 and Ursula Fearon1, 1St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, 2St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland

    Background/Purpose: MicroRNAs (miRNA) belong to a class of small, evolutionarily conserved, noncoding RNAs that function as post-transcriptional repressors of gene expression. An accumulating body of…
  • Abstract Number: 1239 • 2015 ACR/ARHP Annual Meeting

    Significant Impact of Microrna-Target Gene Networks on the Genetics of Rheumatoid Arthritis

    Yukinori Okada1,2 and Toshihiro Tanaka3,4, 1Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 2Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 3Bioresource Research Center, Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo, Japan, 4Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

    Background/Purpose: MicroRNA (miRNA), a short endogenous noncoding RNA, has a major role in the degradation and translational repression of a specific gene through its binding…
  • Abstract Number: 1244 • 2015 ACR/ARHP Annual Meeting

    Extracellular MicroRNAs in Synovial Fluid Reveal a Marked Proliferative Signature in Patients with Antibiotic-Refractory Lyme Arthritis

    Robert B. Lochhead, Nancy D. Kim, Sheila Arvikar, Klemen Strle and Allen C. Steere, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Lyme arthritis (LA), caused by a tick-borne spirochete Borrelia burgdorferi, usually resolves appropriately with antibiotic treatment, called antibiotic-responsive LA. However, in some patients, arthritis…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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