Abstracts tagged "MicroRNA"

Abstract Number: 23 • 2015 ACR/ARHP Annual Meeting
Microvesicle-Associated Hsa-Mir-223-3p Is Elevated in Rheumatoid Synovial Fluid Compared with Osteoarthritis Synovial Fluid
Nancy D. Kim¹, Robert B. Lochhead¹, Pauline Schmit², Minna J. Kohler³ and Andrew D. Luster⁴, ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Charlestown, MA, ³Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Microvesicles (MVs) (100-1000 nm diameter) are subcellular particles that are enriched in nucleic acid, including microRNA (miR), which may be transferred from cell to…
Abstract Number: 2135 • 2015 ACR/ARHP Annual Meeting
miRNA-223 Delivery to Synovial Fibroblasts Via Monocyte-Derived Extracellular Vesicles Promotes Their Proliferation
Florian M.P. Meier¹, Derek S. Gilchrist¹, Derek Baxter², Diane Vaughan¹, Margaret Mullin³, David W. McCarey⁴, Pawel Herzyk⁵, Julie Galbraith⁵, Donna McIntyre¹, Russka Shumnalieva⁶, Ulf Müller-Ladner⁷, Iain B. McInnes⁸ and Mariola Kurowska-Stolarska¹, ¹Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Department of Rheumatology, University Hospital Ayr, Ayr, United Kingdom, ³School of Life Sciences, University of Glasgow, Glasgow, United Kingdom, ⁴Glasgow Royal Infirmary, Glasgow, United Kingdom, ⁵Polyomics Facility, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom, ⁶Department of Internal Medicine, Clinic of Rheumatology, Sofia, Bulgaria, ⁷Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁸Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Recently, it was shown that extracellular vesicles (EV) convey microRNAs (miR) from platelets to endothelial cells1and regulate recipient cell gene expression. Interaction of synovial…
Abstract Number: 306 • 2015 ACR/ARHP Annual Meeting
Investigating the Pathogenic Role of ER Stress Pathways in the Idiopathic Inflammatory Myopathies (IIM): Interrogating the Role of Micro-RNA 133a As an Important Regulator of ER Stress Activation
Adam P. Lightfoot¹, Katarzyna Goljanek-Whysall², Anne McArdle¹ and Robert G. Cooper^3,4, ¹Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Rheumatic Diseaes Center, Salford Royal Foundation Trust, University of Manchester, Salford, United Kingdom, ⁴MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom
Background/Purpose: The Idiopathic Inflammatory Myopathies (IIM) is a heterogeneous group of acquired autoimmune disorders, characterised by symmetrical muscle weakness. Whilst immune cells clearly play a…
Abstract Number: 2211 • 2015 ACR/ARHP Annual Meeting
Extracellular Vesicles from Cow Milk Accelerate Osteoblast Differentiation into Osteocytes, However, Type I Collagen Synthesis Is Reduced and Bone Matrix Organization Is Impaired
Marina C. Oliveira¹, Onno J. Arntz¹, Esmeralda Blaney Davidson¹, Wim van den Berg¹, Adaliene V.M. Ferreira² and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Nutrition, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Milk consumption during childhood stimulates bone growth but the claimed beneficial effect of milk on bone at adulthood is a matter of debate. Recently…
Abstract Number: 806 • 2015 ACR/ARHP Annual Meeting
STAT1 Activation Promotes TLR8 Overexpression and Facilitates Mirokine Signaling Via Exosomes Containing a Mir-21 Endogenous Ligand: A Novel Innate Inflammatory Pathway in Systemic Lupus Erythematosus
Giancarlo R. Valiente^1,2, Nicholas A. Young², Lai-Chu Wu^3,4, Jeffrey Hampton⁵, Mary Severin⁶, Amy Lovett-Racke⁶ and Wael N. Jarjour⁷, ¹Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, ²Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Biological Chemistry and Pharmacology, The Ohio State University College of Medicine, Columbus, OH, ⁵Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH, ⁷Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The adaptive arm of the immune system plays a significant role in the pathophysiology of Systemic Lupus Erythematosus (SLE). However, recent studies suggest that…
Abstract Number: 2398 • 2015 ACR/ARHP Annual Meeting
Microrna Biomarker Signature in Osteoarthritis
L. A. Bennett¹, T. Coleman¹, W. Ferrell¹, J. Lockhart², C. Huesa¹, L. Dunning¹, B. Jones³, M. Blyth³, I. B. McInnes¹, M. Kurowska-Stolarska¹ and C. S. Goodyear¹, ¹Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²The Centre for Musculoskeletal Science, University of the West of Scotland, Paisley, United Kingdom, ³Orthopedic Research Group, Orthopedic Department, Glasgow Royal Infirmary, Glasgow, United Kingdom
Background/Purpose: Our current understanding of osteoarthritis (OA) comes mainly from late stage disease and this is partly due to when patients present with symptoms. It…
Abstract Number: 935 • 2015 ACR/ARHP Annual Meeting
Microrna-146a Provides Feedback Regulation of Monosodium Urate-Induced Gouty Arthritis in Mice By Targeting Tumor Necrosis Factor Receptor Associated Factor 6 and Interleukin-1 Receptor-Associated Kinase 1
Quan-Bo Zhang^1,2, Jing-Guo Zhou³, Cong-Cong Yin¹, Yu-Feng Qing⁴, Chang-Gui Li⁵, Li Zhou¹ and Qing-Sheng Mi⁶, ¹Immunology Program, Department of Dermatology, Henry Ford Health System, Detroit, MI, ²Geriatrics, Affliated hospital of North Sichuan Medical College, Nanchong, China, ³Department of Rheumatology and Immunology, Affliated hospital of North Sichuan Medical College, Nanchong, China, ⁴Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China, Nanchong, China, ⁵Affiliated Hospital of Qingdao University, Qingdao, China, ⁶Immunology, Dermatology, Henry Ford Health System, Detroit, MI
Background/Purpose: MicroRNAs (miRNAs) have been shown to serve as important regulators for inflammatory and immune responses and are implicated in several immune disorders including gouty…
Abstract Number: 2546 • 2015 ACR/ARHP Annual Meeting
Targeting Synovial Fibroblasts By the Intra-Articular Delivery of microRNA-140-3p and -5p Ameliorates Experimental Autoimmune Arthritis
Chrong-Reen Wang¹, Jia-Shiou Peng², Shih-Yao Chen³, Chao-Liang Wu⁴ and Ai-Li Shiau⁵, ¹Rheum/Immun Sec/Int Med Dept, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, ²Institute of Basic Medical Sciences, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, ³Internal Medicine, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, ⁵Microbiology and Immunology, College of Medicine, National Cheng Kung University, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan
Background/Purpose: Synovial fibroblasts (SF) with aberrant expression of microRNAs (miRNA) are critical pathogenic regulators of rheumatoid joint, and studies examining the effect of overexpressing or…
Abstract Number: 1026 • 2015 ACR/ARHP Annual Meeting
Microrna-125a-5p Has Increased Expression in Active Systemic Juvenile Idiopathic Arthritis and Is an Essential Modulator of Regulatory Macrophage Phenotypes in Vitro
Grant Schulert¹, Ndate Fall², Nan Shen³, Sherry Thornton² and Alexei A. Grom⁴, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease of childhood, characterized by a predominance of mononuclear phagocytic effector cells, compared to the lymphocyte…
Abstract Number: 2804 • 2015 ACR/ARHP Annual Meeting
The Global miRNA Whole Blood Profile of Ankylosing Spondylitis
Carolina Mejia Otero¹, Shervin Assassi¹, Michael H. Weisman², Michael M. Ward³, Lianne S. Gensler⁴, Matthew A. Brown⁵, Minghua Wu¹, John Hagan⁶, John D. Reveille⁷ and Gloria Salazar¹, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³NIH/NIAMS, Bethesda, MD, ⁴Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵The University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Neurosurgery, University of Texas at Houston, Houston, TX, ⁷Internal Medicine/Rheumatology, University of Texas Medical School at Houston, Houston, TX
Background/Purpose: MicroRNA (miRNA) are small non-coding RNAs that play an important role in posttranscriptional gene regulation and their involvement in the pathophysiology of several autoimmune…
Abstract Number: 1035 • 2015 ACR/ARHP Annual Meeting
Synovium-Derived microRNAs Inhibit Bone Formation in Rheumatoid Arthritis
Ellen M. Gravallese¹, Yukiko Maeda², Nicholas H Farina³, Paul Fanning⁴ and Jane Lian³, ¹Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Department of Biochemistry, University of Vermont, Burlington, VT, ⁴Department of Orthopedics, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Articular bone erosion in rheumatoid arthritis (RA) is a consequence of synovial inflammation that leads to disability for patients. Cells within the synovium secrete…
Abstract Number: 2994 • 2015 ACR/ARHP Annual Meeting
The Global Microrna Profile of Systemic Sclerosis Whole Skin/Dermal Fibroblasts and the Role of the Xq26.3 miRNA Cluster As a TGF-b Pathway Positive Feedback Mechanism
Gloria Salazar¹, John Hagan², Minghua Wu³, Xinjian Guo⁴, Xiaodong Zhou⁴, Julio Charles¹, Maureen D Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²Neurosurgery, University of Texas at Houston, Houston, TX, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Internal Medicine, University of Texas Medical School at Houston, Houston, TX
Background/Purpose: MicroRNA (miRNA) are critical gene regulators that frequently play central roles in disease. Here, we report the miRNA expression signatures of systemic sclerosis (SSc)…
Abstract Number: 1131 • 2015 ACR/ARHP Annual Meeting
A Histone Deacetylase Inhibitor SAHA Induce MCPIP1 Expression and Suppress IL-6 Expression By Upregulating Cebpα Expression and Downregulating the Expression of Mir-9 in Human OA Chondrocytes
Mohammad Shahidul Makki¹ and Tariq Haqqi², ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Histone deacetylase inhibitors (HDACi) are a class of compounds that inhibits the histone deacetylase activity. MCPIP1 is a negative regulator of IL-6 expression…
Abstract Number: 3124 • 2015 ACR/ARHP Annual Meeting
Associations of Circulating Cell-Free Micro-RNA with Vasculopathy and Vascular Events in SLE Patients
Susan Due Kay¹, Anting L. Carlsen², Anne Voss¹, Mikael Kjær Poulsen³, Axel Cosmus Pyndt Diederichsen⁴ and Niels H. H. Heegaard⁵, ¹Department of Rheumatology, Odense University Hospital, Odense C, Denmark, ²Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark, ³Department of Cardiology, Odense University Hospital, Odense C, Denmark, ⁴Department of Cardiology,, Odense University Hospital, Odense C, Denmark, ⁵Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark
Background/Purpose: MicroRNAs (miRNAs) are small noncoding RNAs that modulate protein translation and regulate numerous immunologic and inflammatory pathways. Certain miRNA profiles have been associated with…
Abstract Number: 1133 • 2015 ACR/ARHP Annual Meeting
Microrna-128 Interference Mitigates the Progression of Keen Osteoarthritis By Regulating Sirtuin-1
Feng-Sheng Wang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: MicroRNAs, non-coding small RNAs, reportedly regulate development, remodeling and pathogenesis activities in various tissues through silencing mRNA targets and protein translation. This study is…

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