Abstracts tagged "MicroRNA"

Abstract Number: 2997 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Curtails Synovitis in the Development of Knee Osteoarthritis By Disrupting VEGF
Feng-Sheng Wang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Intensive synovitis is a prominent feature that progressively aggravated excessive fibrosis reactions relative to joint stiffness in the pathogenesis of osteoarthritis (OA). MicroRNA-29a (miR-29a)…
Abstract Number: 1578 • 2016 ACR/ARHP Annual Meeting
Functional Screening of Micrornas Using the Inhibitor Library Identified Micrornas to Regulate Expression of MMP-3 and IL-6 in Rheumatoid Arthritis Synovial Fibroblasts
Fumitaka Mizoguchi, Hisanori Hasegawa and Hitoshi Kohsaka, Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Background/Purpose: Synovial fibroblasts play crucial roles in the pathogenesis of rheumatoid arthritis (RA). They secrete proteinases and proinflammatory cytokines to damage the synovial tissues in…
Abstract Number: 3219 • 2016 ACR/ARHP Annual Meeting
Altered microRNA Expression Pattern in Synovial and Blood Neutrophils in Rheumatoid Arthritis Reveals the Pathogenic Profile of These Cells. Effect of Biological Therapies
Nuria Barbarroja¹, Ivan Arias de la Rosa¹, Carlos Perez-Sanchez¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera², Miguel Angel Caracuel-Ruiz³, Jerusalem Calvo-Gutierrez¹, Rafaela Ortega-Castro¹, Eduardo Collantes-Estévez¹, Alejandro Escudero-Contreras¹, Chary Lopez-Pedrera¹ and Patricia Ruiz-Limon², ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain
Background/Purpose: MicroRNAs (miRNA) have recently emerged as a new class of modulators of gene expression, regulating inflammation, degradation of extracellular matrix and invasive behavior of the…
Abstract Number: 1579 • 2016 ACR/ARHP Annual Meeting
Small Rnaseq Reveals Different Plasma miRNA Signature in Patients with RA and SLE: A Pilot Study
Michelle J. Ormseth¹, Joseph F. Solus², Yan Guo³, Quanhu Sheng³, Ryan Allen³, Kasey C. Vickers³ and C Michael Stein³, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, ³Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: MicroRNAs (miRNAs) are ~22-nt RNAs that post-transcriptionally regulate gene expression and serve as biomarkers of many disease states. Most previous plasma miRNA studies in…
Abstract Number: 3232 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Micro-RNA 130a and Micro-RNA 708 in Type-1 Classical Dendritic Cells of Patients with Primary SS Indicates Their Dysregulation
Maarten R. Hillen^1,2, Sofie L.M. Blokland^1,2, Elena Chouri^1,2, Ana Lopes^1,2, Aike A. Kruize², Marzia Rossato^1,2, Timothy R.D.J. Radstake^1,2 and Joel A.G. van Roon^1,2, ¹Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: cDespite the fact that especially cDC1s are candidate key players in the activation of local T and B-cells in pSS, they have rarely been…
Abstract Number: 1655 • 2016 ACR/ARHP Annual Meeting
Plasma microRNA Expression Profiles in Ankylosing Spondylitis Patients
Pilar Font-Ugalde¹, Carlos Perez-Sanchez¹, Chary Lopez-Pedrera¹, M. Carmen Castro-Villegas², Maria Carmen Abalos-Aguilera³, Patricia Ruiz-Limon³, Nuria Barbarroja¹, Ivan Arias de la Rosa³, Rafaela Ortega-Castro¹, Alejandro Escudero-Contreras³, Eduardo Collantes-Estévez¹ and Yolanda Jiménez-Gómez¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: MicroRNAs (miRNAs) are a group of single-stranded non-coding RNAs of 20-25 nucleotides in length that can potentially regulate every aspect of cellular function. Recent…
Abstract Number: 1666 • 2016 ACR/ARHP Annual Meeting
Micrornas Mir-30b-5p, Mir-34a-5p, and Mir-431-3p Are Highly Expressed in the Plasma of Patients with Ankylosing Spondylitis
Abdul Haseeb¹, Tariq M. Haqqi¹ and Marina N. Magrey², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH
Background/Purpose: The role of miRNAs in immune and inflammatory diseases is increasing exponentially. miRNAs are present in the human plasma in stable form. We proposed…
Abstract Number: 1672 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Activation of Canonical Wnt Signaling By Targeting LRP6 in Ankylosing Spondylitis
Jinxian Huang¹, Zhihua Yin², Zhongchao Fu³, Zhizhong Ye³ and Lijun Zhang⁴, ¹Rheumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China, ²Rheumatology, The Fourth People’s Hospital of Shenzhen, Shenzhen, China, ³The Fourth People’s Hospital of Shenzhen, Shenzhen, China, ⁴The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
Background/Purpose: Aberrant regulation of the Wnt pathway is a key element in the pathogenesis of Ankylosing spondylitis (AS). We previously found that miR-29a was significantly…
Abstract Number: 1750 • 2016 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-200a-3p, Targeting C-Terminal Binding Protein-2 (CtBP2), Is Involved in Hypoproduction of IL-2 in SLE-Derived T Cells
Eri Katsuyama¹, Yan Minglu¹, Katsue Sunahori-Watanabe¹, Sonia Zeggar¹, Sumie Hiramatsu¹, Keiji Ohashi¹, Haruki Watanabe¹, Takayuki Katsuyama¹, Noriko Toyota-Tatebe², Ken-ei Sada¹ and Jun Wada¹, ¹Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ²Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease caused by genetic and epigenetic mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs, post-transcriptionally regulate the…
Abstract Number: 1917 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Cells Produce Extracellular Vesicles That Incorporate PD-1 and microRNAs Targeting the PD-1 Pathway in Surrounding Cells
Stinne Greisen^1,2, Yan Yan³, Aida Hansen¹, Morten Venø³, Jens Randel Nyengaard⁴, Malene Hvid⁵, Arlene Sharpe⁶, Jørgen Kjems³ and Bent Deleuran^7,8, ¹Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Interdisciplinari Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark, ⁴Clinical Medicine, Electro Microscopy Laboratory, Aarhus University Hospital, Aarhus, Denmark, ⁵Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁶Microbiology and Immunobiology, Harvard Medical School, Boston, MA, ⁷Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁸Department of Biomedicine, Aarhus University, Aarhus, Denmark
Background/Purpose: Programmed death-1 (PD-1) is a central marker of T cell exhaustion. Exhausted T cells are present in inflammatory conditions, where they fail to eliminate…
Abstract Number: 77 • 2016 ACR/ARHP Annual Meeting
Integrated Analysis of Microrna and mRNA Expression Profiles Related to Cardiovascular Disease in Monocytes from Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome Patients
Carlos Perez-Sanchez¹, Maria Ángeles Aguirre Zamorano¹, Patricia Ruiz-Limon², Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera², Ivan Arias de la Rosa², María Galindo³, Eduardo Collantes-Estévez¹, Maria Jose Cuadrado⁴ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ⁴St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: The interplay between miRNAs and their mRNA targets might constitute an important mechanism in the regulation of the proatherothrombotic status of SLE and APS…
Abstract Number: 2063 • 2016 ACR/ARHP Annual Meeting
Identification of Microrna Predictive of Outcome in Lupus Nephritis
Mohammad Hadavand¹, Nada Binmadi², Hua Zhou³, Mayank Tandon⁴, Sarfaraz Hasni⁵ and Illias Alevizos⁶, ¹National Institute of Dental and Craniofacial Research, Bethesda, MD, ²Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, ³Molecular Physiology and Therapeutics Branch,, National Institute of Dental and Craniofacial Research, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/NIH, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
Background/Purpose: High dose corticosteroids such as cyclophosphamide are commonly used to treat lupus nephritis (LN). Although effective in preventing end stage renal disease (ESRD)…
Abstract Number: 1168 • 2015 ACR/ARHP Annual Meeting
MiR125a-5p Mediates Angiogenic Mechanisms in Inflammatory Arthritis
Mary Connolly¹, Sarah Wade¹, Douglas J. Veale² and Ursula Fearon¹, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ²St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: MicroRNAs (miRNA) belong to a class of small, evolutionarily conserved, noncoding RNAs that function as post-transcriptional repressors of gene expression. An accumulating body of…
Abstract Number: 1239 • 2015 ACR/ARHP Annual Meeting
Significant Impact of Microrna-Target Gene Networks on the Genetics of Rheumatoid Arthritis
Yukinori Okada^1,2 and Toshihiro Tanaka^3,4, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ³Bioresource Research Center, Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Background/Purpose: MicroRNA (miRNA), a short endogenous noncoding RNA, has a major role in the degradation and translational repression of a specific gene through its binding…
Abstract Number: 1244 • 2015 ACR/ARHP Annual Meeting
Extracellular MicroRNAs in Synovial Fluid Reveal a Marked Proliferative Signature in Patients with Antibiotic-Refractory Lyme Arthritis
Robert B. Lochhead, Nancy D. Kim, Sheila Arvikar, Klemen Strle and Allen C. Steere, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Lyme arthritis (LA), caused by a tick-borne spirochete Borrelia burgdorferi, usually resolves appropriately with antibiotic treatment, called antibiotic-responsive LA. However, in some patients, arthritis…

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