ACR Meeting Abstracts

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Abstracts tagged "MicroRNA"

  • Abstract Number: 809 • 2016 ACR/ARHP Annual Meeting

    Micrornas Targeting the Wnt Signalling Pathway in Black African Patients with Diffuse Cutaneous Systemic Sclerosis

    Mohammed Tikly1, Jacqueline Frost2, Michèle Ramsay3, Eulalia Marti Puig4, Raquel Rabionet4, Xavier Estivill4 and Marc Friedländer5, 1Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 2University of the Witwatersrand, Johannesburg, South Africa, 3Division of Human Genetics, Sydney Brenner Institute for Molecular Biosciences, University of the Witwatersrand, Johannesburg, South Africa, 4Center for Genomic Regulation, Barcelona, Spain, 5Department of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm, Sweden

    Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease involving the immune system, vasculature and extracellular matrix [1]. Dysregulation of the Wnt pathway has been implicated in…
  • Abstract Number: 2122 • 2016 ACR/ARHP Annual Meeting

    KiSS1 Is a Regulator of ADAMTS4 and ADAMTS5 Expression and Is Post-Transcriptionally Regulated By Micro-RNA N105 in Human OA Chondrocytes

    Mohammad Shahidul Makki1,2 and Tariq Haqqi3, 14209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, 3Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH

    Background/Purpose:  Osteoarthritis (OA) is a chronic and debilitating disease of the articulating joints in every population. Micro-RNAs are ~22 nucleotides long non-coding single stranded RNAs…
  • Abstract Number: 810 • 2016 ACR/ARHP Annual Meeting

    Microrna-125b As a Potential Anti-Fibrotic and Anti-Apoptotic Regulator in Systemic Sclerosis

    Anastasiia Kozlova1, Elena Pachera1, Florian Renoux2, Michal Rudnik1, Britta Maurer1, Astrid Jüngel3, Joerg H.W Distler4, Gabriela Kania1 and Oliver Distler1, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, 3Ctr Exp Rheum, Univ Hosp Zurich / Zurich Ctr Integr Hum Physiol (ZIHP), Zurich, Switzerland, 4Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: MicroRNAs (miRs) are a class of small, noncoding RNAs that regulate many biological processes. Some microRNAs are involved in skin fibrosis. Here, we aimed…
  • Abstract Number: 2141 • 2016 ACR/ARHP Annual Meeting

    Terminal Uridylyl Transferase ZCCHC6-Dependent Generation of miRNA Diversity in Primary Human Chondrocytes

    Abdul Haseeb1, Mohammad Shahidul Makki2, Mohammad Ansari3, Helen Piontkivska4 and Tariq M. Haqqi1, 1Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 24209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, 3Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, 4Kent State University, Kent, OH

    Terminal Uridylyl Transferase ZCCHC6-dependent Generation Of miRNA Diversity In Primary Human Chondrocytes Background/Purpose: MicroRNAs (miRNAs) are a group of small, noncoding RNAs that post-transcriptionally regulate…
  • Abstract Number: 817 • 2016 ACR/ARHP Annual Meeting

    RNA and Protein Cargo of  Exosomes Isolated from Serum of Systemic Sclerosis Patients Induce a Profibrotic Phenotype in Cultured Normal Human Dermal Fibroblasts: A Potential Mechanism for the Initiation and Progression of a Profibrotic Phenotype in SSc

    Peter J. Wermuth, Kellan R. Carney, Sonsoles Piera-Velazquez and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose:  Exosomes are lipid bilayer-bound microvesicles that contain various macromolecules including numerous microRNA (miRNA) and proteins. Exosomes mediate intercellular communication by fusing and releasing their…
  • Abstract Number: 2413 • 2016 ACR/ARHP Annual Meeting

    Inflammation Regulating microRNAs, Mir-146b, Mir-155 and Mir-192-5p Are Altered in Plasma and Synovial Fluid of Oligoarticular Juvenile Idiopathic Arthritis

    Beata Derfalvi1,2,3, Sarah Roberts4, Breanna Hargreaves4 and Sarah McAlpine4, 1Pediatrics, Dalhousie University, Halifax, NS, Canada, 2IWK Health Centre, Halifax, NS, Canada, 32nd. Dept. of Pediatrics, Semmelweis University, Budapest, Hungary, 4Dalhousie University, Halifax, NS, Canada

    Background/Purpose: MicroRNAs (miRNAs) modulate gene expression by inhibiting the translation of targeted mRNAs and causing mRNA degradation in a transcript-specific manner. Several miRNAs have been reported…
  • Abstract Number: 1034 • 2016 ACR/ARHP Annual Meeting

    Microrna-146a Controls Local Bone Destruction By Regulating Fibroblast Induced Osteoclastogenesis in Inflammatory Arthritis

    Victoria Saferding1, Antonia Puchner2, Eliana Goncalves-Alves3, Melanie Hofmann3, Julia Brunner4, Emine Sahin4, Silvia Hayer5, Philippe Georgel6, Marije M. Koenders7, Gernot Schabbauer4, Josef S. Smolen8, Günter Steiner9, Kurt Redlich3 and Stephan Blüml10, 1Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Vascular Biology and Thrombosis research, Medical University of Vienna, Vienna, Austria, 5Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Vienna, Austria, 6Centre de Recherche en Immunologie et Hématologie, Université de Strasbourg, Strasbourg, France, 7Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, 8Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 9Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 10Internal Medicine 3; Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: MicroRNA (MiR-) 146a plays an important role in the regulation of the innate immune response and has also been shown to suppress cancer development…
  • Abstract Number: 2414 • 2016 ACR/ARHP Annual Meeting

    Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms

    Thuy Do1, Rachel Tan2, Mark Bennett2, Mario Medvedovic2, Nan Shen3, Sherry Thornton1, Alexei Grom1 and Grant Schulert4, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH, 3Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose:  CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…
  • Abstract Number: 1197 • 2016 ACR/ARHP Annual Meeting

    Certain Serum Micro-RNAs Are Associated with Osteoarthritis

    Jean-Charles Rousseau1, Elisabeth Sornay-Rendu1, Olivier Borel1 and Roland Chapurlat2, 1INSERM UMR 1033, Lyon, France, 2Service de Rhumatologie et Pathologie Osseuse, Hôpital Edouard Herriot, INSERM UMR 1033 and Université de Lyon and Hospices Civils de Lyon, Lyon, France

    Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
  • Abstract Number: 2713 • 2016 ACR/ARHP Annual Meeting

    Differentially Expressed Microrna As Candidate Biomarker for Disease Activity in Ankylosing Spondylitis

    Marina N. Magrey1, Abdul Haseeb2 and Tariq M Haqqi2, 1Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, 2Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH

    Differentially Expressed MicroRNA as candidate Biomarker for Disease Activity in Ankylosing Spondylitis Background/Purpose: MicroRNAs (miRNAs) have evolved as a novel class of biomarkers We proposed…
  • Abstract Number: 1568 • 2016 ACR/ARHP Annual Meeting

    Microrna-17 Suppresses TNF-α Signaling By Reducing TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts

    Nahid Akhtar1, Anil Singh2 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Washington State University, College of Pharmacy, Spokane, WA

    Background/Purpose:   TNF-α is a major cytokine implicated in rheumatoid arthritis (RA) and its expression has shown to be regulated at transcriptional and posttranscriptional levels.…
  • Abstract Number: 2997 • 2016 ACR/ARHP Annual Meeting

    Microrna-29a Curtails Synovitis in the Development of Knee Osteoarthritis By Disrupting VEGF

    Feng-Sheng Wang1, Yi-Chih Sun1, Yu-Shan Chen1 and Jih-Yang Ko2, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose:  Intensive synovitis is a prominent feature that progressively aggravated excessive fibrosis reactions relative to joint stiffness in the pathogenesis of osteoarthritis (OA). MicroRNA-29a (miR-29a)…
  • Abstract Number: 306 • 2015 ACR/ARHP Annual Meeting

    Investigating the Pathogenic Role of ER Stress Pathways in the Idiopathic Inflammatory Myopathies (IIM): Interrogating the Role of Micro-RNA 133a As an Important Regulator of ER Stress Activation

    Adam P. Lightfoot1, Katarzyna Goljanek-Whysall2, Anne McArdle1 and Robert G. Cooper3,4, 1Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, 2University of Liverpool, Liverpool, United Kingdom, 3Rheumatic Diseaes Center, Salford Royal Foundation Trust, University of Manchester, Salford, United Kingdom, 4MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: The Idiopathic Inflammatory Myopathies (IIM) is a heterogeneous group of acquired autoimmune disorders, characterised by symmetrical muscle weakness. Whilst immune cells clearly play a…
  • Abstract Number: 2211 • 2015 ACR/ARHP Annual Meeting

    Extracellular Vesicles from Cow Milk Accelerate Osteoblast Differentiation into Osteocytes, However, Type I Collagen Synthesis Is Reduced and Bone Matrix Organization Is Impaired

    Marina C. Oliveira1, Onno J. Arntz1, Esmeralda Blaney Davidson1, Wim van den Berg1, Adaliene V.M. Ferreira2 and Fons A.J. van de Loo1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Department of Nutrition, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Background/Purpose: Milk consumption during childhood stimulates bone growth but the claimed beneficial effect of milk on bone at adulthood is a matter of debate. Recently…
  • Abstract Number: 806 • 2015 ACR/ARHP Annual Meeting

    STAT1 Activation Promotes TLR8 Overexpression and Facilitates Mirokine Signaling Via Exosomes Containing a Mir-21 Endogenous Ligand: A Novel Innate Inflammatory Pathway in Systemic Lupus Erythematosus

    Giancarlo R. Valiente1,2, Nicholas A. Young2, Lai-Chu Wu3,4, Jeffrey Hampton5, Mary Severin6, Amy Lovett-Racke6 and Wael N. Jarjour7, 1Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, 2Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Biological Chemistry and Pharmacology, The Ohio State University College of Medicine, Columbus, OH, 5Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, 6Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH, 7Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: The adaptive arm of the immune system plays a significant role in the pathophysiology of Systemic Lupus Erythematosus (SLE). However, recent studies suggest that…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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