Abstract Number: 2997 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Curtails Synovitis in the Development of Knee Osteoarthritis By Disrupting VEGF
Background/Purpose: Intensive synovitis is a prominent feature that progressively aggravated excessive fibrosis reactions relative to joint stiffness in the pathogenesis of osteoarthritis (OA). MicroRNA-29a (miR-29a)…Abstract Number: 1578 • 2016 ACR/ARHP Annual Meeting
Functional Screening of Micrornas Using the Inhibitor Library Identified Micrornas to Regulate Expression of MMP-3 and IL-6 in Rheumatoid Arthritis Synovial Fibroblasts
Background/Purpose: Synovial fibroblasts play crucial roles in the pathogenesis of rheumatoid arthritis (RA). They secrete proteinases and proinflammatory cytokines to damage the synovial tissues in…Abstract Number: 3219 • 2016 ACR/ARHP Annual Meeting
Altered microRNA Expression Pattern in Synovial and Blood Neutrophils in Rheumatoid Arthritis Reveals the Pathogenic Profile of These Cells. Effect of Biological Therapies
Background/Purpose: MicroRNAs (miRNA) have recently emerged as a new class of modulators of gene expression, regulating inflammation, degradation of extracellular matrix and invasive behavior of the…Abstract Number: 1579 • 2016 ACR/ARHP Annual Meeting
Small Rnaseq Reveals Different Plasma miRNA Signature in Patients with RA and SLE: A Pilot Study
Background/Purpose: MicroRNAs (miRNAs) are ~22-nt RNAs that post-transcriptionally regulate gene expression and serve as biomarkers of many disease states. Most previous plasma miRNA studies in…Abstract Number: 3232 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Micro-RNA 130a and Micro-RNA 708 in Type-1 Classical Dendritic Cells of Patients with Primary SS Indicates Their Dysregulation
Background/Purpose: cDespite the fact that especially cDC1s are candidate key players in the activation of local T and B-cells in pSS, they have rarely been…Abstract Number: 1655 • 2016 ACR/ARHP Annual Meeting
Plasma microRNA Expression Profiles in Ankylosing Spondylitis Patients
Background/Purpose: MicroRNAs (miRNAs) are a group of single-stranded non-coding RNAs of 20-25 nucleotides in length that can potentially regulate every aspect of cellular function. Recent…Abstract Number: 1666 • 2016 ACR/ARHP Annual Meeting
Micrornas Mir-30b-5p, Mir-34a-5p, and Mir-431-3p Are Highly Expressed in the Plasma of Patients with Ankylosing Spondylitis
Background/Purpose: The role of miRNAs in immune and inflammatory diseases is increasing exponentially. miRNAs are present in the human plasma in stable form. We proposed…Abstract Number: 1672 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Activation of Canonical Wnt Signaling By Targeting LRP6 in Ankylosing Spondylitis
Background/Purpose: Aberrant regulation of the Wnt pathway is a key element in the pathogenesis of Ankylosing spondylitis (AS). We previously found that miR-29a was significantly…Abstract Number: 1750 • 2016 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-200a-3p, Targeting C-Terminal Binding Protein-2 (CtBP2), Is Involved in Hypoproduction of IL-2 in SLE-Derived T Cells
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease caused by genetic and epigenetic mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs, post-transcriptionally regulate the…Abstract Number: 1917 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Cells Produce Extracellular Vesicles That Incorporate PD-1 and microRNAs Targeting the PD-1 Pathway in Surrounding Cells
Background/Purpose: Programmed death-1 (PD-1) is a central marker of T cell exhaustion. Exhausted T cells are present in inflammatory conditions, where they fail to eliminate…Abstract Number: 77 • 2016 ACR/ARHP Annual Meeting
Integrated Analysis of Microrna and mRNA Expression Profiles Related to Cardiovascular Disease in Monocytes from Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome Patients
Background/Purpose: The interplay between miRNAs and their mRNA targets might constitute an important mechanism in the regulation of the proatherothrombotic status of SLE and APS…Abstract Number: 2063 • 2016 ACR/ARHP Annual Meeting
Identification of Microrna Predictive of Outcome in Lupus Nephritis
Background/Purpose: High dose corticosteroids such as cyclophosphamide are commonly used to treat lupus nephritis (LN). Although effective in preventing end stage renal disease (ESRD)…Abstract Number: 1168 • 2015 ACR/ARHP Annual Meeting
MiR125a-5p Mediates Angiogenic Mechanisms in Inflammatory Arthritis
Background/Purpose: MicroRNAs (miRNA) belong to a class of small, evolutionarily conserved, noncoding RNAs that function as post-transcriptional repressors of gene expression. An accumulating body of…Abstract Number: 1239 • 2015 ACR/ARHP Annual Meeting
Significant Impact of Microrna-Target Gene Networks on the Genetics of Rheumatoid Arthritis
Background/Purpose: MicroRNA (miRNA), a short endogenous noncoding RNA, has a major role in the degradation and translational repression of a specific gene through its binding…Abstract Number: 1244 • 2015 ACR/ARHP Annual Meeting
Extracellular MicroRNAs in Synovial Fluid Reveal a Marked Proliferative Signature in Patients with Antibiotic-Refractory Lyme Arthritis
Background/Purpose: Lyme arthritis (LA), caused by a tick-borne spirochete Borrelia burgdorferi, usually resolves appropriately with antibiotic treatment, called antibiotic-responsive LA. However, in some patients, arthritis…
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