Abstracts tagged "MicroRNA"

Abstract Number: 1034 • 2016 ACR/ARHP Annual Meeting
Microrna-146a Controls Local Bone Destruction By Regulating Fibroblast Induced Osteoclastogenesis in Inflammatory Arthritis
Victoria Saferding¹, Antonia Puchner², Eliana Goncalves-Alves³, Melanie Hofmann³, Julia Brunner⁴, Emine Sahin⁴, Silvia Hayer⁵, Philippe Georgel⁶, Marije M. Koenders⁷, Gernot Schabbauer⁴, Josef S. Smolen⁸, Günter Steiner⁹, Kurt Redlich³ and Stephan Blüml¹⁰, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Vascular Biology and Thrombosis research, Medical University of Vienna, Vienna, Austria, ⁵Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Vienna, Austria, ⁶Centre de Recherche en Immunologie et Hématologie, Université de Strasbourg, Strasbourg, France, ⁷Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁸Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁹Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ¹⁰Internal Medicine 3; Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: MicroRNA (MiR-) 146a plays an important role in the regulation of the innate immune response and has also been shown to suppress cancer development…
Abstract Number: 2414 • 2016 ACR/ARHP Annual Meeting
Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms
Thuy Do¹, Rachel Tan², Mark Bennett², Mario Medvedovic², Nan Shen³, Sherry Thornton¹, Alexei Grom¹ and Grant Schulert⁴, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…
Abstract Number: 1197 • 2016 ACR/ARHP Annual Meeting
Certain Serum Micro-RNAs Are Associated with Osteoarthritis
Jean-Charles Rousseau¹, Elisabeth Sornay-Rendu¹, Olivier Borel¹ and Roland Chapurlat², ¹INSERM UMR 1033, Lyon, France, ²Service de Rhumatologie et Pathologie Osseuse, Hôpital Edouard Herriot, INSERM UMR 1033 and Université de Lyon and Hospices Civils de Lyon, Lyon, France
Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
Abstract Number: 2713 • 2016 ACR/ARHP Annual Meeting
Differentially Expressed Microrna As Candidate Biomarker for Disease Activity in Ankylosing Spondylitis
Marina N. Magrey¹, Abdul Haseeb² and Tariq M Haqqi², ¹Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Differentially Expressed MicroRNA as candidate Biomarker for Disease Activity in Ankylosing Spondylitis Background/Purpose: MicroRNAs (miRNAs) have evolved as a novel class of biomarkers We proposed…
Abstract Number: 1568 • 2016 ACR/ARHP Annual Meeting
Microrna-17 Suppresses TNF-α Signaling By Reducing TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts
Nahid Akhtar¹, Anil Singh² and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Washington State University, College of Pharmacy, Spokane, WA
Background/Purpose: TNF-α is a major cytokine implicated in rheumatoid arthritis (RA) and its expression has shown to be regulated at transcriptional and posttranscriptional levels.…
Abstract Number: 2997 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Curtails Synovitis in the Development of Knee Osteoarthritis By Disrupting VEGF
Feng-Sheng Wang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Intensive synovitis is a prominent feature that progressively aggravated excessive fibrosis reactions relative to joint stiffness in the pathogenesis of osteoarthritis (OA). MicroRNA-29a (miR-29a)…
Abstract Number: 1578 • 2016 ACR/ARHP Annual Meeting
Functional Screening of Micrornas Using the Inhibitor Library Identified Micrornas to Regulate Expression of MMP-3 and IL-6 in Rheumatoid Arthritis Synovial Fibroblasts
Fumitaka Mizoguchi, Hisanori Hasegawa and Hitoshi Kohsaka, Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Background/Purpose: Synovial fibroblasts play crucial roles in the pathogenesis of rheumatoid arthritis (RA). They secrete proteinases and proinflammatory cytokines to damage the synovial tissues in…
Abstract Number: 3219 • 2016 ACR/ARHP Annual Meeting
Altered microRNA Expression Pattern in Synovial and Blood Neutrophils in Rheumatoid Arthritis Reveals the Pathogenic Profile of These Cells. Effect of Biological Therapies
Nuria Barbarroja¹, Ivan Arias de la Rosa¹, Carlos Perez-Sanchez¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera², Miguel Angel Caracuel-Ruiz³, Jerusalem Calvo-Gutierrez¹, Rafaela Ortega-Castro¹, Eduardo Collantes-Estévez¹, Alejandro Escudero-Contreras¹, Chary Lopez-Pedrera¹ and Patricia Ruiz-Limon², ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain
Background/Purpose: MicroRNAs (miRNA) have recently emerged as a new class of modulators of gene expression, regulating inflammation, degradation of extracellular matrix and invasive behavior of the…
Abstract Number: 1579 • 2016 ACR/ARHP Annual Meeting
Small Rnaseq Reveals Different Plasma miRNA Signature in Patients with RA and SLE: A Pilot Study
Michelle J. Ormseth¹, Joseph F. Solus², Yan Guo³, Quanhu Sheng³, Ryan Allen³, Kasey C. Vickers³ and C Michael Stein³, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, ³Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: MicroRNAs (miRNAs) are ~22-nt RNAs that post-transcriptionally regulate gene expression and serve as biomarkers of many disease states. Most previous plasma miRNA studies in…
Abstract Number: 3232 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Micro-RNA 130a and Micro-RNA 708 in Type-1 Classical Dendritic Cells of Patients with Primary SS Indicates Their Dysregulation
Maarten R. Hillen^1,2, Sofie L.M. Blokland^1,2, Elena Chouri^1,2, Ana Lopes^1,2, Aike A. Kruize², Marzia Rossato^1,2, Timothy R.D.J. Radstake^1,2 and Joel A.G. van Roon^1,2, ¹Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: cDespite the fact that especially cDC1s are candidate key players in the activation of local T and B-cells in pSS, they have rarely been…
Abstract Number: 1655 • 2016 ACR/ARHP Annual Meeting
Plasma microRNA Expression Profiles in Ankylosing Spondylitis Patients
Pilar Font-Ugalde¹, Carlos Perez-Sanchez¹, Chary Lopez-Pedrera¹, M. Carmen Castro-Villegas², Maria Carmen Abalos-Aguilera³, Patricia Ruiz-Limon³, Nuria Barbarroja¹, Ivan Arias de la Rosa³, Rafaela Ortega-Castro¹, Alejandro Escudero-Contreras³, Eduardo Collantes-Estévez¹ and Yolanda Jiménez-Gómez¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: MicroRNAs (miRNAs) are a group of single-stranded non-coding RNAs of 20-25 nucleotides in length that can potentially regulate every aspect of cellular function. Recent…
Abstract Number: 1666 • 2016 ACR/ARHP Annual Meeting
Micrornas Mir-30b-5p, Mir-34a-5p, and Mir-431-3p Are Highly Expressed in the Plasma of Patients with Ankylosing Spondylitis
Abdul Haseeb¹, Tariq M. Haqqi¹ and Marina N. Magrey², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH
Background/Purpose: The role of miRNAs in immune and inflammatory diseases is increasing exponentially. miRNAs are present in the human plasma in stable form. We proposed…
Abstract Number: 1035 • 2015 ACR/ARHP Annual Meeting
Synovium-Derived microRNAs Inhibit Bone Formation in Rheumatoid Arthritis
Ellen M. Gravallese¹, Yukiko Maeda², Nicholas H Farina³, Paul Fanning⁴ and Jane Lian³, ¹Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Department of Biochemistry, University of Vermont, Burlington, VT, ⁴Department of Orthopedics, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Articular bone erosion in rheumatoid arthritis (RA) is a consequence of synovial inflammation that leads to disability for patients. Cells within the synovium secrete…
Abstract Number: 2994 • 2015 ACR/ARHP Annual Meeting
The Global Microrna Profile of Systemic Sclerosis Whole Skin/Dermal Fibroblasts and the Role of the Xq26.3 miRNA Cluster As a TGF-b Pathway Positive Feedback Mechanism
Gloria Salazar¹, John Hagan², Minghua Wu³, Xinjian Guo⁴, Xiaodong Zhou⁴, Julio Charles¹, Maureen D Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²Neurosurgery, University of Texas at Houston, Houston, TX, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Internal Medicine, University of Texas Medical School at Houston, Houston, TX
Background/Purpose: MicroRNA (miRNA) are critical gene regulators that frequently play central roles in disease. Here, we report the miRNA expression signatures of systemic sclerosis (SSc)…
Abstract Number: 1131 • 2015 ACR/ARHP Annual Meeting
A Histone Deacetylase Inhibitor SAHA Induce MCPIP1 Expression and Suppress IL-6 Expression By Upregulating Cebpα Expression and Downregulating the Expression of Mir-9 in Human OA Chondrocytes
Mohammad Shahidul Makki¹ and Tariq Haqqi², ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Histone deacetylase inhibitors (HDACi) are a class of compounds that inhibits the histone deacetylase activity. MCPIP1 is a negative regulator of IL-6 expression…

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