ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "MicroRNA"

  • Abstract Number: 2435 • 2017 ACR/ARHP Annual Meeting

    Circulating Mirnas As Potential Biomarkers of Cardiovascular Disease in Rheumatoid Arthritis Patients

    Chary Lopez-Pedrera1, Nuria Barbarroja1, Patricia Ruiz-Limon2, Ivan Arias de la Rosa2, Maria Carmen Abalos-Aguilera2, Yolanda Jiménez-Gómez1, Rafaela Ortega-Castro1, Eduardo Collantes-Estévez1, Alejandro Escudero-Contreras2, Raquel Lopez-Mejías3, Miguel Angel González-Gay3 and Carlos Perez-Sanchez1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

    Background/Purpose: Extracellular microRNAs, circulating in the bloodstream and extracellular space, have been proposed as attractive candidates as both diagnostic and prognostic biomarkers in various diseases,…
  • Abstract Number: 301 • 2017 ACR/ARHP Annual Meeting

    MiR-221-3p Overexpression Impairs Anti-Inflammatory Activity of TLR4-Stimulated M2-Macrophages

    Lilian Quero1,2, Andre Tiaden1,2 and Diego Kyburz2,3, 1Department of Biomedicine, Experimental Rheumatology, University of Basel, Basel, Switzerland, 2Rheumatology, University Hospital Basel, Basel, Switzerland, 3Department of Biomedicine, Experimental Rheumatology, University of Basel, 4051 Basel, Switzerland

    Background/Purpose: MicroRNAs (miRNAs) have been shown to contribute to the inflammatory response in rheumatoid arthritis (RA) and several of these miRNAs have been found to…
  • Abstract Number: 2436 • 2017 ACR/ARHP Annual Meeting

    MiR-146a Upregulates the TLR4/NF-κb Signaling Pathway to Promote Cytokine Expression and Synovial Fibroblast Proliferation in Rheumatoid Arthritis

    Yuan-hao Wu1,2, Wei Liu1, Lei Zhang3, Bin Xue3, Yi Wang3, Xiao-ya Liu3, Yang Ji4, Ran Duan3, Yue Cai3 and Bo Zhang3, 1Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, 2Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China, 3First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, 4The 272nd Hospital of Chinese People's Liberation Army, Tianjin, China

    Background/Purpose: To investigate the role of miR-146a in the activation of toll-like receptor-4 (TLR4)/ nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, and…
  • Abstract Number: 579 • 2017 ACR/ARHP Annual Meeting

    Circulating MiR-145 As a Marker of Therapeutic Response to Anti-TNF Therapy in Patients with Ankylosing Spondylitis

    Klára Prajzlerová1, Veronika Hruskova1, Martin Komarc2, Šárka Forejtová1, Karel Pavelka3, Jiri Vencovsky3, Ladislav Senolt3 and Maria Filkova1, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Department of Anthropometrics and Methodology, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: The altered expression of miRNAs contributes to the pathophysiology of inflammatory conditions. In addition, circulating miRNAs may serve as promising therapeutic and prognostic biomarkers.…
  • Abstract Number: 2655 • 2017 ACR/ARHP Annual Meeting

    Contribution of Monocytes to Circulating microRNAs Related to Cardiovascular Disease in Systemic Lupus Erythematosus. Effects of In Vivo Treatment with Rituximab

    Carlos Perez-Sanchez1, Irene Cecchi2, Massimo Radin3, Maria Ángeles Aguirre Zamorano1, Patricia Ruiz-Limon4, Nuria Barbarroja1, Yolanda Jiménez-Gómez1, Maria Carmen Abalos-Aguilera4, Ivan Arias de la Rosa4, Eduardo Collantes-Estévez1, Maria Jose Cuadrado5, Savino Sciascia6 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 4Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 5Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, 6Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: Despite emerging data on disease-specific associations for various blood- and plasma-derived miRNAs, consensus is lacking as to whether a cellular, extracellular, or a mixed…
  • Abstract Number: 954 • 2017 ACR/ARHP Annual Meeting

    Microrna-21 Is a Critical Regulator of Autoimmunity through Promoting Effector and Metabolic Function of Pathogenic TH17 Cells

    Xiang Yu1 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, and Shanghai Jiao Tong University, Shanghai, China, 2Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, 3Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that causes mortality and morbidity worldwide. Recent studies suggest proinflammatory TH17 cells are key pathogenic…
  • Abstract Number: 972 • 2017 ACR/ARHP Annual Meeting

    JAK/STAT Mediated Inhibition of Mir-23a~24-2~27a Cluster Potentiates Activation of CD14+ Monocytes in Treatment-Resistant RA

    Marina Frleta-Gilchrist, Donna McIntyre, Aziza Elmesmari, Lynn Stewart, Derek Baxter, Mariola Kurowska-Stolarska, Derek Gilchrist and Iain B. McInnes, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: While emerging and existing treatments of RA allow better options and clinical outcomes for patients, studies informing drug resistant states and further clinical therapeutic…
  • Abstract Number: 1009 • 2017 ACR/ARHP Annual Meeting

    Novel Non-Coding RNAs Associated with Rheumatoid Arthritis in Asians By Gene-Based Testing

    Aleksander Lenert1 and David W. Fardo2, 1Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, 2Biostatistics, College of Public Health, University of Kentucky, Lexington, KY

    Background/Purpose: Rheumatoid arthritis (RA) is a complex genetics disease driven by multiple genetic contributors as evidenced by association with over 100 risk SNPs by GWAS.…
  • Abstract Number: 1336 • 2017 ACR/ARHP Annual Meeting

    Unique Role for miR429 in RA and Acute Model of Arthritis

    Jonatan Hervoso1, W. Alexander Stinson1, Yuxuan Du2, Sarah Arwani1, Ellen Cealey1, David A. Fox1 and M. Asif Amin1, 1Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, 2Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, MI

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by inflammation and subsequent infiltration of peripheral blood monocytes (MNs) into the synovial tissue (ST). Micro (mi)RNAs are non-coding…
  • Abstract Number: 1367 • 2017 ACR/ARHP Annual Meeting

    Circulating Microbial Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Michelle J. Ormseth1, Shilin Zhao2, Ryan Allen2, Joseph F. Solus2, Quanhu Sheng2, Yan Guo2, Fei Ye2, Marisol Ramirez2, Kasey Vickers2 and C Michael Stein2, 1Medicine, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs), such as microRNAs, are important regulators of biological processes and serve as important biomarkers of disease. We found that approximately half…
  • Abstract Number: 1710 • 2017 ACR/ARHP Annual Meeting

    Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells Enhances the Transition of Endothelial to Mesenchymal Cells (Endo-MT) Induced By TGFβ through Down-Regulating PI3/Akt Signaling Pathway By Targeting PIK3R2

    Yongqing Wang1, Shadia Nada2, Nezam Altorok2 and Bashar Kahaleh2, 1University of Toledo, Toledo, OH, 2Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: The accumulation of myofibroblasts in fibrotic tissue plays an important role in the pathogenesis of scleroderma (SSc) fibrosis. Recent studies have shown that myofibroblasts…
  • Abstract Number: 1729 • 2017 ACR/ARHP Annual Meeting

    Increased Serum Levels of Micro-RNA 30d and Micro-RNA 423-5p in 2 Independent Cohorts of Patients with Morphea

    Jorre S. Mertens1,2, Wiola Marut1, Cornelis P.J. Bekker1, Elke M.G.J. de Jong3 and Timothy R.D.J. Radstake1,4, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Dermatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Radboud University Medical Center, Nijmegen, Netherlands, 4Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose : Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. MicroRNAs (miRNAs) are a large family of highly conserved…
  • Abstract Number: 1764 • 2017 ACR/ARHP Annual Meeting

    Small RNA Sequencing Shows Differential Plasma Microrna Expression in Patients with ANCA-Associated Vasculitis: A Pilot Study

    Kevin Byram1, Joseph F. Solus1, Quanhu Sheng1, Yan Guo1, C Michael Stein1 and Michelle J. Ormseth2, 1Vanderbilt University Medical Center, Nashville, TN, 2Rheumatology, Vanderbilt Medical Center, Nashville, TN

    Background/Purpose: MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) that participate in post-transcriptional gene regulation. miRNAs have potential both as biomarkers for diagnosis and prognosis…
  • Abstract Number: 138 • 2017 Pediatric Rheumatology Symposium

    Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis

    Zihua Hu1, Kaiyu Jiang2, Mark B. Frank3, Yanmin Chen2 and James Jarvis4, 1Center for Computational Research, University at Buffalo, Buffalo, NY, 2Pediatrics, University at Buffalo, Buffalo, NY, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY

    Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…
  • Abstract Number: 1578 • 2016 ACR/ARHP Annual Meeting

    Functional Screening of Micrornas Using the Inhibitor Library Identified Micrornas to Regulate Expression of MMP-3 and IL-6 in Rheumatoid Arthritis Synovial Fibroblasts

    Fumitaka Mizoguchi, Hisanori Hasegawa and Hitoshi Kohsaka, Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: Synovial fibroblasts play crucial roles in the pathogenesis of rheumatoid arthritis (RA). They secrete proteinases and proinflammatory cytokines to damage the synovial tissues in…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
  • 5
  • …
  • 9
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology