Abstracts tagged "MicroRNA"

Abstract Number: 2150 • 2017 ACR/ARHP Annual Meeting
Serum Microrna-1 Can be a Predictive Marker for Disease Activity of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease
Yumiko Sugiyama, Ryusuke Yoshimi, Yosuke Kunishita, Daiga Kishimoto, Yohei Kirino and Hideaki Nakajima, Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Although intensive immunosuppressive treatment are necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), the prognostic factors or disease activity indices for PM/DM have…
Abstract Number: 2187 • 2017 ACR/ARHP Annual Meeting
Association of Circulating microRNAs with Prevalent and Incident Osteoarthritis in Women: The Ofely Study
Jean-Charles Rousseau¹, Marjorie Millet¹, Martine Croset¹, Elisabeth Sornay-Rendu², Olivier Borel² and Roland Chapurlat³, ¹INSERM 1033, Lyon, France, ²INSERM 1033, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France, ³INSERM 1033, University of Lyon, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France
Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
Abstract Number: 2326 • 2017 ACR/ARHP Annual Meeting
Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James Jarvis⁴, ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…
Abstract Number: 4 • 2017 ACR/ARHP Annual Meeting
Downregulation of microRNAs in Plasmacytoid Dendritic Cells Is Associated with a Type I Interferon Signature in Systemic Lupus Erythematosus and Antiphospholipid Syndrome
Lucas L. van den Hoogen¹, Joel A.G. van Roon^2,3, Ruth D.E. Fritsch-Stork⁴, Cornelis P.J. Bekker¹, Aridaman Pandit¹, Marzia Rossato⁵ and Timothy R.D.J. Radstake¹, ¹Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The most prominent alteration in the immune system of patients with SLE is a type I interferon (IFN) signature, which we recently also reported…
Abstract Number: 2338 • 2017 ACR/ARHP Annual Meeting
Plasma Exosomes from Children with Juvenile Dermatomyositis Are Taken up By Human Aortic Endothelial Cells and Are Associated with Altered Gene Expression in Those Cells
Kaiyu Jiang¹, Zihua Hu², Rie Karasawa³, Yanmin Chen¹ and James Jarvis⁴, ¹Pediatrics, University at Buffalo, Buffalo, NY, ²Center for Computational Research, University at Buffalo, Buffalo, NY, ³Institute of Medical Science, St. Marianna University School of Medicine, Japan, Kawasaki, Japan, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and…
Abstract Number: 63 • 2017 ACR/ARHP Annual Meeting
MiR-146a a Key Player in Bone Metabolism
Victoria Saferding¹, Melanie Hofmann¹, Julia S. Brunner², Antonia Puchner¹, Melanie Timmen³, Richard Stange³, Josef S. Smolen⁴ and Stephan Blüml⁴, ¹Medical University of Vienna, Austria, Vienna, Austria, ²Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, ³Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁴Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria
Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
Abstract Number: 2434 • 2017 ACR/ARHP Annual Meeting
Baseline Expressions of Cellular microRNA-31 and microRNA-10a Predict Remission and Low Disease Activity in Patients with Early Rheumatoid Arthritis after Six and Twelve Months of Therapy
Veronika Hruskova^1,2, Klara Prajzlerova³, Martin Komarc⁴, Lucia Vernerova¹, Herman F Mann³, Maria Filkova³, Karel Pavelka³, Jiri Vencovsky³ and Ladislav Senolt³, ¹Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ²Faculty of Science, Charles University, Prague, Czech Republic, Prague, Czech Republic, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁴Department of Anthropometrics and Methodology, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by targeting messenger RNAs. The expression of miRNAs was demonstrated to differ between patients with rheumatoid arthritis (RA)…
Abstract Number: 180 • 2017 ACR/ARHP Annual Meeting
Identification of a Functional Susceptible Variant in Distal Enhancer of Mir-146a By CRISPR-Cas9
Guojun Hou¹, Jing Zeng², Yuanjia Tang³ and Nan Shen^4,5, ¹Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) &Shanghai Jiao Tong University School of Medicine (SJTUSM), ShangHai, China, ²Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Shanghai Institute of Rheumatology,Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ⁵The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose: The majority of trait-associated SNPs occur in noncoding regions and are enriched in enhancers. GWAS have identified numerous genetic variants associated with Systemic Lupus…
Abstract Number: 2435 • 2017 ACR/ARHP Annual Meeting
Circulating Mirnas As Potential Biomarkers of Cardiovascular Disease in Rheumatoid Arthritis Patients
Chary Lopez-Pedrera¹, Nuria Barbarroja¹, Patricia Ruiz-Limon², Ivan Arias de la Rosa², Maria Carmen Abalos-Aguilera², Yolanda Jiménez-Gómez¹, Rafaela Ortega-Castro¹, Eduardo Collantes-Estévez¹, Alejandro Escudero-Contreras², Raquel Lopez-Mejías³, Miguel Angel González-Gay³ and Carlos Perez-Sanchez¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Extracellular microRNAs, circulating in the bloodstream and extracellular space, have been proposed as attractive candidates as both diagnostic and prognostic biomarkers in various diseases,…
Abstract Number: 301 • 2017 ACR/ARHP Annual Meeting
MiR-221-3p Overexpression Impairs Anti-Inflammatory Activity of TLR4-Stimulated M2-Macrophages
Lilian Quero^1,2, Andre Tiaden^1,2 and Diego Kyburz^2,3, ¹Department of Biomedicine, Experimental Rheumatology, University of Basel, Basel, Switzerland, ²Rheumatology, University Hospital Basel, Basel, Switzerland, ³Department of Biomedicine, Experimental Rheumatology, University of Basel, 4051 Basel, Switzerland
Background/Purpose: MicroRNAs (miRNAs) have been shown to contribute to the inflammatory response in rheumatoid arthritis (RA) and several of these miRNAs have been found to…
Abstract Number: 2436 • 2017 ACR/ARHP Annual Meeting
MiR-146a Upregulates the TLR4/NF-κb Signaling Pathway to Promote Cytokine Expression and Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Yuan-hao Wu^1,2, Wei Liu¹, Lei Zhang³, Bin Xue³, Yi Wang³, Xiao-ya Liu³, Yang Ji⁴, Ran Duan³, Yue Cai³ and Bo Zhang³, ¹Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, ²Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China, ³First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, ⁴The 272nd Hospital of Chinese People's Liberation Army, Tianjin, China
Background/Purpose: To investigate the role of miR-146a in the activation of toll-like receptor-4 (TLR4)/ nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, and…
Abstract Number: 579 • 2017 ACR/ARHP Annual Meeting
Circulating MiR-145 As a Marker of Therapeutic Response to Anti-TNF Therapy in Patients with Ankylosing Spondylitis
Klára Prajzlerová¹, Veronika Hruskova¹, Martin Komarc², Šárka Forejtová¹, Karel Pavelka³, Jiri Vencovsky³, Ladislav Senolt³ and Maria Filkova¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Department of Anthropometrics and Methodology, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: The altered expression of miRNAs contributes to the pathophysiology of inflammatory conditions. In addition, circulating miRNAs may serve as promising therapeutic and prognostic biomarkers.…
Abstract Number: 2655 • 2017 ACR/ARHP Annual Meeting
Contribution of Monocytes to Circulating microRNAs Related to Cardiovascular Disease in Systemic Lupus Erythematosus. Effects of In Vivo Treatment with Rituximab
Carlos Perez-Sanchez¹, Irene Cecchi², Massimo Radin³, Maria Ángeles Aguirre Zamorano¹, Patricia Ruiz-Limon⁴, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera⁴, Ivan Arias de la Rosa⁴, Eduardo Collantes-Estévez¹, Maria Jose Cuadrado⁵, Savino Sciascia⁶ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ³Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁴Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: Despite emerging data on disease-specific associations for various blood- and plasma-derived miRNAs, consensus is lacking as to whether a cellular, extracellular, or a mixed…
Abstract Number: 138 • 2017 Pediatric Rheumatology Symposium
Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James Jarvis⁴, ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…
Abstract Number: 56 • 2016 ACR/ARHP Annual Meeting
A Systems Biology Approach to Investigating Beneficial Effects of Endurance Exercise in Myositis Patients
Jessica Boehler^1,2, Marshall Hogarth³, Matthew Barberio³, Svetlana Ghimbovschi², Kristy Brown^1,2, Li Alemo Munters⁴, Ingela Loell⁴, Yi-Wen Chen^2,5, Helene Alexanderson⁶, Ingrid E. Lundberg⁷ and Kanneboyina Nagaraju^5,8, ¹Department of Integrative Systems Biology, The George Washington University, Washingtion, DC, ²Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, ³Research Center for Genetic Medicine, Children's National Medical Center, Washingtion, DC, ⁴Karolinska University Hospital, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Sweden, Stockholm, Sweden, ⁵Department of Integrative Systems Biology, The George Washington University, Washington, DC, ⁶Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Research Center for Genetic Medicine, Children’s National Medical Center, Washington, DC
Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) are skeletal muscle disorders characterized by proximal muscle weakness and inflammation. Recent studies have suggested that endurance exercise improves…

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