ACR Meeting Abstracts

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Abstracts tagged "MicroRNA"

  • Abstract Number: 1860 • 2018 ACR/ARHP Annual Meeting

    Development and Validation of a Microrna Panel to Differentiate between Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Control Subjects

    Michelle J. Ormseth, Joseph F. Solus, Quanhu Sheng, Fei Ye, Qiong Wu, Yan Guo, Annette M. Oeser, Ryan Allen, Kasey Vickers and C Michael Stein, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: MicroRNAs (miRNAs) are short non-coding RNAs that regulate genes and have utility as disease biomarkers. Use of small RNA (sRNA) sequencing along with unbiased…
  • Abstract Number: 1931 • 2018 ACR/ARHP Annual Meeting

    Abundance of Plasma Microbial Small RNAs Are Predictive of Improvement in Disease Activity after DMARD Initiation for Rheumatoid Arthritis

    Michelle J. Ormseth1, Quanhu Sheng1, Shilin Zhao1, Joseph F. Solus1, Qiong Wu1, Ryan Allen1, Yan Guo1, Fei Ye1, Marisol Ramirez1, Kasey Vickers1, S. Louis Bridges Jr.2, Jeffrey R. Curtis3 and C Michael Stein1, 1Vanderbilt University Medical Center, Nashville, TN, 2Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Small RNAs (sRNAs) are important regulators of biological processes and are potential biomarkers of disease and drug response. We previously found that microbial sRNAs…
  • Abstract Number: 2044 • 2018 ACR/ARHP Annual Meeting

    Impaired microRNA Processing in Neutrophils from Rheumatoid Arthritis Patients Confers Their Pathogenic Profile. Modulation By Biological Therapies

    Ivan Arias de la Rosa1, Patricia Ruiz-Limon1, Carlos Perez-Sanchez2, Maria Carmen Abalos-Aguilera1, Yolanda Jiménez-Gómez2, Irene Cecchi3, Rafaela Ortega-Castro2, Miguel Angel Caracuel-Ruiz4, Jerusalem Calvo-Gutierrez2, Alejandro Escudero-Contreras1, Eduardo Collantes-Estévez2, Chary Lopez-Pedrera4 and Nuria Barbarroja2, 1Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 4IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain

    Background/Purpose: Neutrophils are the most abundant cells in synovial fluid, having all the features of activated cells in rheumatoid arthritis (RA), including prolonged cell survival,…
  • Abstract Number: 2053 • 2018 ACR/ARHP Annual Meeting

    Global Mirna Expression and Transcriptomic Profiling of Monocytes from RA Patients

    Marzena Ciechomska1, Krzysztof Bonek2, Piotr Gluszko2, Marzena Olesinska2, Bartosz Wojtas3, Vladimir Benes4 and Wlodzimierz Maslinski1, 1Department of Pathophysiology and Immunology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland, Warsaw, Poland, 2Department of Rheumatology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland, Warsaw, Poland, 3Nencki Institute of Experimental Biology, Warsaw, Poland, Warsaw, Poland, 4The European Molecular Biology Laboratory, Heidelberg, Germany, Heidelberg, Germany

    Background/Purpose: Infiltration of the synovium by mononuclear cells, including monocytes, is one of the main features of RA. Monocytes are the first immune cells which…
  • Abstract Number: 2073 • 2018 ACR/ARHP Annual Meeting

    Role of miRNA-21-5p As a Potential Biomarker for the Inflammation Pathway in Psoriatic Disease and Response to Methotrexate Treatment

    Rohan Machhar1, Justine Y. Ye2, Vinod Chandran2 and Dafna D Gladman3, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Toronto Psoriatic Arthritis Research Program, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis occurring in patients with psoriasis. miRNAs are small non coding RNAs whose main function, at a post…
  • Abstract Number: 2074 • 2018 ACR/ARHP Annual Meeting

    Micrornas Deregulation in Monocytes and T CD4 Lymphocytes from Patients with Axial Spondyloarthritis

    Olivier Fogel1, Andreas Bugge Tinggaard2, Maud Fagny1, Nelly Sigrist3, Elodie Roché3, Laurence Leclère3, Jean-François Deleuze4, Maxime Dougados5, Corinne Miceli-Richard6,7 and Jorg Tost1, 1Centre National de Recherche en Génomique Humaine, Institut François Jacob, CEA, Laboratory for Epigenetics and Environment, Evry, France, 2Aarhus University, Department of Biomedicine, Aarhus, Denmark, 3Laboratory for Epigenetics and Environment, Evry, France, 4Centre National de Recherche en Génomique Humaine, Evry, France, 5Paris Descartes University, Hôpital Cochin, Paris, France, 6Department of Immunology, Pasteur Institute, Immunoregulation Unit, Paris, France, 7Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France

    Background/Purpose: MicroRNAs have been shown to play a crucial role during innate or adaptive immune response. Deregulation of miRNAs has been described in several autoimmune…
  • Abstract Number: 2081 • 2018 ACR/ARHP Annual Meeting

    Dysregulated MiR-125a Promotes Joint Angiogenesis in Psoriatic Arthritis through Altered Bioenergetics

    Sarah M. Wade1, Nil Ohnesorge2, Hayley Mc-Loughlin1, Monika Biniecka1, Trudy McGarry3, Breandán Kennedy4, Douglas J. Veale2 and Ursula Fearon3, 1Department of Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 2Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 3Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 4Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland

    Background/Purpose: Psoriatic arthritis (PsA) is characterised by an early vascular phase essential for pannus growth, immune responses and disease progression. Recently, numerous studies have highlighted…
  • Abstract Number: 954 • 2017 ACR/ARHP Annual Meeting

    Microrna-21 Is a Critical Regulator of Autoimmunity through Promoting Effector and Metabolic Function of Pathogenic TH17 Cells

    Xiang Yu1 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, and Shanghai Jiao Tong University, Shanghai, China, 2Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, 3Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that causes mortality and morbidity worldwide. Recent studies suggest proinflammatory TH17 cells are key pathogenic…
  • Abstract Number: 972 • 2017 ACR/ARHP Annual Meeting

    JAK/STAT Mediated Inhibition of Mir-23a~24-2~27a Cluster Potentiates Activation of CD14+ Monocytes in Treatment-Resistant RA

    Marina Frleta-Gilchrist, Donna McIntyre, Aziza Elmesmari, Lynn Stewart, Derek Baxter, Mariola Kurowska-Stolarska, Derek Gilchrist and Iain B. McInnes, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: While emerging and existing treatments of RA allow better options and clinical outcomes for patients, studies informing drug resistant states and further clinical therapeutic…
  • Abstract Number: 1009 • 2017 ACR/ARHP Annual Meeting

    Novel Non-Coding RNAs Associated with Rheumatoid Arthritis in Asians By Gene-Based Testing

    Aleksander Lenert1 and David W. Fardo2, 1Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, 2Biostatistics, College of Public Health, University of Kentucky, Lexington, KY

    Background/Purpose: Rheumatoid arthritis (RA) is a complex genetics disease driven by multiple genetic contributors as evidenced by association with over 100 risk SNPs by GWAS.…
  • Abstract Number: 1336 • 2017 ACR/ARHP Annual Meeting

    Unique Role for miR429 in RA and Acute Model of Arthritis

    Jonatan Hervoso1, W. Alexander Stinson1, Yuxuan Du2, Sarah Arwani1, Ellen Cealey1, David A. Fox1 and M. Asif Amin1, 1Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, 2Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, MI

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by inflammation and subsequent infiltration of peripheral blood monocytes (MNs) into the synovial tissue (ST). Micro (mi)RNAs are non-coding…
  • Abstract Number: 1367 • 2017 ACR/ARHP Annual Meeting

    Circulating Microbial Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Michelle J. Ormseth1, Shilin Zhao2, Ryan Allen2, Joseph F. Solus2, Quanhu Sheng2, Yan Guo2, Fei Ye2, Marisol Ramirez2, Kasey Vickers2 and C Michael Stein2, 1Medicine, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs), such as microRNAs, are important regulators of biological processes and serve as important biomarkers of disease. We found that approximately half…
  • Abstract Number: 1710 • 2017 ACR/ARHP Annual Meeting

    Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells Enhances the Transition of Endothelial to Mesenchymal Cells (Endo-MT) Induced By TGFβ through Down-Regulating PI3/Akt Signaling Pathway By Targeting PIK3R2

    Yongqing Wang1, Shadia Nada2, Nezam Altorok2 and Bashar Kahaleh2, 1University of Toledo, Toledo, OH, 2Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: The accumulation of myofibroblasts in fibrotic tissue plays an important role in the pathogenesis of scleroderma (SSc) fibrosis. Recent studies have shown that myofibroblasts…
  • Abstract Number: 1729 • 2017 ACR/ARHP Annual Meeting

    Increased Serum Levels of Micro-RNA 30d and Micro-RNA 423-5p in 2 Independent Cohorts of Patients with Morphea

    Jorre S. Mertens1,2, Wiola Marut1, Cornelis P.J. Bekker1, Elke M.G.J. de Jong3 and Timothy R.D.J. Radstake1,4, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Dermatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Radboud University Medical Center, Nijmegen, Netherlands, 4Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose : Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. MicroRNAs (miRNAs) are a large family of highly conserved…
  • Abstract Number: 1764 • 2017 ACR/ARHP Annual Meeting

    Small RNA Sequencing Shows Differential Plasma Microrna Expression in Patients with ANCA-Associated Vasculitis: A Pilot Study

    Kevin Byram1, Joseph F. Solus1, Quanhu Sheng1, Yan Guo1, C Michael Stein1 and Michelle J. Ormseth2, 1Vanderbilt University Medical Center, Nashville, TN, 2Rheumatology, Vanderbilt Medical Center, Nashville, TN

    Background/Purpose: MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) that participate in post-transcriptional gene regulation. miRNAs have potential both as biomarkers for diagnosis and prognosis…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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