Abstract Number: 127 • 2018 ACR/ARHP Annual Meeting
MiR-3606-3p Inhibits Systemic Sclerosis through Targeting TGF-β Receptor II
Background/Purpose: Though transforming growth factor-b (TGF-b) plays a fundamental role in the pathogenesis of SSc, the mechanism by which TGF-b signaling acts in SSc remains…Abstract Number: 2840 • 2018 ACR/ARHP Annual Meeting
MiR-125-b Is a Promising Biomarker for Giant Cell Arteritis in Patients with Negative Temporal Artery Biopsy Examination
Background/Purpose: Giant cell arteritis (GCA) is a systemic vasculitis of large- and medium-sized arteries, diagnosed either with a temporal artery biopsy (TAB) histology or by…Abstract Number: 172 • 2018 ACR/ARHP Annual Meeting
Serum Chemokines and miRNA Levels and Its Association with Cumulative Organ Damage in Patients with Antiphospholipid Syndrome: A Bench to Bedside Study
Background/Purpose: Recent evidence suggests that chemokines and miRNAs are involved in the pathogenesis of antiphospholipid syndrome (APS). However, the specific role of these molecules in…Abstract Number: 1008 • 2018 ACR/ARHP Annual Meeting
Presence of a Specific Defect in M2 Polarization of Blood Monocytes from Patients with Rheumatoid Arthritis, Associated with Increased microRNA-155
Background/Purpose: Macrophages contribute in situ to the RA pathogenesis. Two distinct states of polarization for macrophages have been recognized: the classically activated macrophage phenotype (M1),…Abstract Number: 1025 • 2018 ACR/ARHP Annual Meeting
MiR-146a a Key Player in Bone Metabolism
Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…Abstract Number: 1460 • 2018 ACR/ARHP Annual Meeting
Plasma Mir-146a-5p Associates with Beneficial Body Composition and Plasma Metabolic Profiles in Rheumatoid Arthritis
Background/Purpose: In rheumatoid arthritis (RA), sarcopenic obesity is associated with significant cardiometabolic disease and mortality. Biomarkers of disease activity in RA and obesity are complicated…Abstract Number: 1474 • 2018 ACR/ARHP Annual Meeting
Circulating Transfer RNA-Derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Background/Purpose: Small RNAs (sRNAs) are important gene regulators and markers of disease. Transfer RNA (tRNA)-derived sRNAs (tDRs), including tRNA fragments (tRFs) and halves (tRHs), are…Abstract Number: 2150 • 2017 ACR/ARHP Annual Meeting
Serum Microrna-1 Can be a Predictive Marker for Disease Activity of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease
Background/Purpose: Although intensive immunosuppressive treatment are necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), the prognostic factors or disease activity indices for PM/DM have…Abstract Number: 2187 • 2017 ACR/ARHP Annual Meeting
Association of Circulating microRNAs with Prevalent and Incident Osteoarthritis in Women: The Ofely Study
Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…Abstract Number: 2326 • 2017 ACR/ARHP Annual Meeting
Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis
Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…Abstract Number: 4 • 2017 ACR/ARHP Annual Meeting
Downregulation of microRNAs in Plasmacytoid Dendritic Cells Is Associated with a Type I Interferon Signature in Systemic Lupus Erythematosus and Antiphospholipid Syndrome
Background/Purpose: The most prominent alteration in the immune system of patients with SLE is a type I interferon (IFN) signature, which we recently also reported…Abstract Number: 2338 • 2017 ACR/ARHP Annual Meeting
Plasma Exosomes from Children with Juvenile Dermatomyositis Are Taken up By Human Aortic Endothelial Cells and Are Associated with Altered Gene Expression in Those Cells
Background/Purpose: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and…Abstract Number: 63 • 2017 ACR/ARHP Annual Meeting
MiR-146a a Key Player in Bone Metabolism
Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…Abstract Number: 2434 • 2017 ACR/ARHP Annual Meeting
Baseline Expressions of Cellular microRNA-31 and microRNA-10a Predict Remission and Low Disease Activity in Patients with Early Rheumatoid Arthritis after Six and Twelve Months of Therapy
Background/Purpose: MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by targeting messenger RNAs. The expression of miRNAs was demonstrated to differ between patients with rheumatoid arthritis (RA)…Abstract Number: 180 • 2017 ACR/ARHP Annual Meeting
Identification of a Functional Susceptible Variant in Distal Enhancer of Mir-146a By CRISPR-Cas9
Background/Purpose: The majority of trait-associated SNPs occur in noncoding regions and are enriched in enhancers. GWAS have identified numerous genetic variants associated with Systemic Lupus…
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