Abstracts tagged "MicroRNA"

Abstract Number: 1860 • 2018 ACR/ARHP Annual Meeting
Development and Validation of a Microrna Panel to Differentiate between Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Control Subjects
Michelle J. Ormseth, Joseph F. Solus, Quanhu Sheng, Fei Ye, Qiong Wu, Yan Guo, Annette M. Oeser, Ryan Allen, Kasey Vickers and C Michael Stein, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: MicroRNAs (miRNAs) are short non-coding RNAs that regulate genes and have utility as disease biomarkers. Use of small RNA (sRNA) sequencing along with unbiased…
Abstract Number: 1931 • 2018 ACR/ARHP Annual Meeting
Abundance of Plasma Microbial Small RNAs Are Predictive of Improvement in Disease Activity after DMARD Initiation for Rheumatoid Arthritis
Michelle J. Ormseth¹, Quanhu Sheng¹, Shilin Zhao¹, Joseph F. Solus¹, Qiong Wu¹, Ryan Allen¹, Yan Guo¹, Fei Ye¹, Marisol Ramirez¹, Kasey Vickers¹, S. Louis Bridges Jr.², Jeffrey R. Curtis³ and C Michael Stein¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Small RNAs (sRNAs) are important regulators of biological processes and are potential biomarkers of disease and drug response. We previously found that microbial sRNAs…
Abstract Number: 2044 • 2018 ACR/ARHP Annual Meeting
Impaired microRNA Processing in Neutrophils from Rheumatoid Arthritis Patients Confers Their Pathogenic Profile. Modulation By Biological Therapies
Ivan Arias de la Rosa¹, Patricia Ruiz-Limon¹, Carlos Perez-Sanchez², Maria Carmen Abalos-Aguilera¹, Yolanda Jiménez-Gómez², Irene Cecchi³, Rafaela Ortega-Castro², Miguel Angel Caracuel-Ruiz⁴, Jerusalem Calvo-Gutierrez², Alejandro Escudero-Contreras¹, Eduardo Collantes-Estévez², Chary Lopez-Pedrera⁴ and Nuria Barbarroja², ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁴IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: Neutrophils are the most abundant cells in synovial fluid, having all the features of activated cells in rheumatoid arthritis (RA), including prolonged cell survival,…
Abstract Number: 2053 • 2018 ACR/ARHP Annual Meeting
Global Mirna Expression and Transcriptomic Profiling of Monocytes from RA Patients
Marzena Ciechomska¹, Krzysztof Bonek², Piotr Gluszko², Marzena Olesinska², Bartosz Wojtas³, Vladimir Benes⁴ and Wlodzimierz Maslinski¹, ¹Department of Pathophysiology and Immunology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland, Warsaw, Poland, ²Department of Rheumatology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland, Warsaw, Poland, ³Nencki Institute of Experimental Biology, Warsaw, Poland, Warsaw, Poland, ⁴The European Molecular Biology Laboratory, Heidelberg, Germany, Heidelberg, Germany
Background/Purpose: Infiltration of the synovium by mononuclear cells, including monocytes, is one of the main features of RA. Monocytes are the first immune cells which…
Abstract Number: 2073 • 2018 ACR/ARHP Annual Meeting
Role of miRNA-21-5p As a Potential Biomarker for the Inflammation Pathway in Psoriatic Disease and Response to Methotrexate Treatment
Rohan Machhar¹, Justine Y. Ye², Vinod Chandran² and Dafna D Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Psoriatic Arthritis Research Program, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis occurring in patients with psoriasis. miRNAs are small non coding RNAs whose main function, at a post…
Abstract Number: 2074 • 2018 ACR/ARHP Annual Meeting
Micrornas Deregulation in Monocytes and T CD4 Lymphocytes from Patients with Axial Spondyloarthritis
Olivier Fogel¹, Andreas Bugge Tinggaard², Maud Fagny¹, Nelly Sigrist³, Elodie Roché³, Laurence Leclère³, Jean-François Deleuze⁴, Maxime Dougados⁵, Corinne Miceli-Richard^6,7 and Jorg Tost¹, ¹Centre National de Recherche en Génomique Humaine, Institut François Jacob, CEA, Laboratory for Epigenetics and Environment, Evry, France, ²Aarhus University, Department of Biomedicine, Aarhus, Denmark, ³Laboratory for Epigenetics and Environment, Evry, France, ⁴Centre National de Recherche en Génomique Humaine, Evry, France, ⁵Paris Descartes University, Hôpital Cochin, Paris, France, ⁶Department of Immunology, Pasteur Institute, Immunoregulation Unit, Paris, France, ⁷Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: MicroRNAs have been shown to play a crucial role during innate or adaptive immune response. Deregulation of miRNAs has been described in several autoimmune…
Abstract Number: 2081 • 2018 ACR/ARHP Annual Meeting
Dysregulated MiR-125a Promotes Joint Angiogenesis in Psoriatic Arthritis through Altered Bioenergetics
Sarah M. Wade¹, Nil Ohnesorge², Hayley Mc-Loughlin¹, Monika Biniecka¹, Trudy McGarry³, Breandán Kennedy⁴, Douglas J. Veale² and Ursula Fearon³, ¹Department of Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ²Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ³Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ⁴Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland
Background/Purpose: Psoriatic arthritis (PsA) is characterised by an early vascular phase essential for pannus growth, immune responses and disease progression. Recently, numerous studies have highlighted…
Abstract Number: 954 • 2017 ACR/ARHP Annual Meeting
Microrna-21 Is a Critical Regulator of Autoimmunity through Promoting Effector and Metabolic Function of Pathogenic TH17 Cells
Xiang Yu¹ and Nan Shen^1,2,3, ¹Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, and Shanghai Jiao Tong University, Shanghai, China, ²Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that causes mortality and morbidity worldwide. Recent studies suggest proinflammatory TH17 cells are key pathogenic…
Abstract Number: 972 • 2017 ACR/ARHP Annual Meeting
JAK/STAT Mediated Inhibition of Mir-23a~24-2~27a Cluster Potentiates Activation of CD14+ Monocytes in Treatment-Resistant RA
Marina Frleta-Gilchrist, Donna McIntyre, Aziza Elmesmari, Lynn Stewart, Derek Baxter, Mariola Kurowska-Stolarska, Derek Gilchrist and Iain B. McInnes, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: While emerging and existing treatments of RA allow better options and clinical outcomes for patients, studies informing drug resistant states and further clinical therapeutic…
Abstract Number: 1009 • 2017 ACR/ARHP Annual Meeting
Novel Non-Coding RNAs Associated with Rheumatoid Arthritis in Asians By Gene-Based Testing
Aleksander Lenert¹ and David W. Fardo², ¹Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, ²Biostatistics, College of Public Health, University of Kentucky, Lexington, KY
Background/Purpose: Rheumatoid arthritis (RA) is a complex genetics disease driven by multiple genetic contributors as evidenced by association with over 100 risk SNPs by GWAS.…
Abstract Number: 1336 • 2017 ACR/ARHP Annual Meeting
Unique Role for miR429 in RA and Acute Model of Arthritis
Jonatan Hervoso¹, W. Alexander Stinson¹, Yuxuan Du², Sarah Arwani¹, Ellen Cealey¹, David A. Fox¹ and M. Asif Amin¹, ¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by inflammation and subsequent infiltration of peripheral blood monocytes (MNs) into the synovial tissue (ST). Micro (mi)RNAs are non-coding…
Abstract Number: 1367 • 2017 ACR/ARHP Annual Meeting
Circulating Microbial Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Michelle J. Ormseth¹, Shilin Zhao², Ryan Allen², Joseph F. Solus², Quanhu Sheng², Yan Guo², Fei Ye², Marisol Ramirez², Kasey Vickers² and C Michael Stein², ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small RNAs (sRNAs), such as microRNAs, are important regulators of biological processes and serve as important biomarkers of disease. We found that approximately half…
Abstract Number: 1710 • 2017 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells Enhances the Transition of Endothelial to Mesenchymal Cells (Endo-MT) Induced By TGFβ through Down-Regulating PI3/Akt Signaling Pathway By Targeting PIK3R2
Yongqing Wang¹, Shadia Nada², Nezam Altorok² and Bashar Kahaleh², ¹University of Toledo, Toledo, OH, ²Medicine/Rheumatology, University of Toledo, Toledo, OH
Background/Purpose: The accumulation of myofibroblasts in fibrotic tissue plays an important role in the pathogenesis of scleroderma (SSc) fibrosis. Recent studies have shown that myofibroblasts…
Abstract Number: 1729 • 2017 ACR/ARHP Annual Meeting
Increased Serum Levels of Micro-RNA 30d and Micro-RNA 423-5p in 2 Independent Cohorts of Patients with Morphea
Jorre S. Mertens^1,2, Wiola Marut¹, Cornelis P.J. Bekker¹, Elke M.G.J. de Jong³ and Timothy R.D.J. Radstake^1,4, ¹Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Dermatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Radboud University Medical Center, Nijmegen, Netherlands, ⁴Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose : Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. MicroRNAs (miRNAs) are a large family of highly conserved…
Abstract Number: 1764 • 2017 ACR/ARHP Annual Meeting
Small RNA Sequencing Shows Differential Plasma Microrna Expression in Patients with ANCA-Associated Vasculitis: A Pilot Study
Kevin Byram¹, Joseph F. Solus¹, Quanhu Sheng¹, Yan Guo¹, C Michael Stein¹ and Michelle J. Ormseth², ¹Vanderbilt University Medical Center, Nashville, TN, ²Rheumatology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) that participate in post-transcriptional gene regulation. miRNAs have potential both as biomarkers for diagnosis and prognosis…

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