ACR Meeting Abstracts

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Abstracts tagged "MicroRNA"

  • Abstract Number: 24 • 2018 ACR/ARHP Annual Meeting

    Rituximab Induces an Early Re-Assessment of the Immune and Vascular Systems in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Chary Lopez-Pedrera1, Irene Cecchi2, Nuria Barbarroja3, Alejandra Maria Patiño-Trives1, María Luque Tevar1, Laura Pérez Sánchez4, Alejandro Ibáñez-Costa1, Ivan Arias de la Rosa5, Yolanda Jiménez-Gómez3, Massimo Radin6, Rafaela Ortega-Castro3, M. Carmen Castro-Villegas7, Jerusalem Calvo-Gutierrez3, Alejandro Escudero-Contreras5, Maria Jose Cuadrado8, Savino Sciascia9, Eduardo Collantes Estevez1, Maria Ángeles Aguirre Zamorano1 and Carlos Perez-Sanchez3, 1IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 5Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 6Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 7Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 8Clinica Universidad de Navarra, Madrid, Spain, 9Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: While the role of Rituximab (RTX) in controlling the clinical manifestations of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) has been documented, the…
  • Abstract Number: 2128 • 2018 ACR/ARHP Annual Meeting

    The Effect of miRNA-21 Overexpression on the Aberrant T Follicular Helper Cells Differentiation in Systemic Lupus Erythematosus

    Ming Zhao1, Xiaofei Gao2, Jiali Wu3, Limin Liu1, Haijing Wu2 and Qianjin Lu1, 1Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China, 2The Second Xiangya Hospital of Central South University, Changsha, China, 3Department of Deramtology, The Second Xiangya Hospital of Central South University, Changsha, China

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by a large number of autoantibodies and multiple organs damage. T follicular helper(Tfh)…
  • Abstract Number: 109 • 2018 ACR/ARHP Annual Meeting

    Unique miRNA Signatures Detected in Extracellular Vesicles from Patients with Systemic Lupus Erythematous

    Ifeoma Okafor1, Nicholas A. Young2, Giancarlo R. Valiente3, Emily Schwarz1, Peter Harb1, Caitlin Henry1, William Willis2, Emily Sullivan4, Kyle Jablonski5, Lai-Chu Wu1, Naomi I. Maria6, Anne Davidson7, Elisha D.O. Roberson8 and Wael Jarjour9, 1Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 2Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 4The Ohio State Univeristy Wexner Medical Center, Columbus, OH, 5The Ohio State University Wexner Medical Center, Columbus, OH, 6Center for Autoimmunnity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, 7Feinstein Institute for Medical Research, Manhasset, NY, 8Depts. of Medicine and Genetics, Division of Rheumatology, Washington University, St. Louis, MO, 9Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Recent studies have identified distinct changes in cellular miRNA (miR) expression associated with systemic lupus erythematous (SLE). We have previously shown that toll-like receptor…
  • Abstract Number: 2816 • 2018 ACR/ARHP Annual Meeting

    Development of a Microrna Panel for Predicting Coronary Atherosclerosis in Rheumatoid Arthritis

    Michelle J. Ormseth1, Joseph F. Solus1, Quanhu Sheng1, Fei Ye1, Yan Guo1, Qiong Wu1, Annette M. Oeser1, Ryan Allen1, Paolo Raggi2, Kasey Vickers1 and C Michael Stein1, 1Vanderbilt University Medical Center, Nashville, TN, 2University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Small noncoding RNAs (sRNAs), such as microRNAs (miRNAs), regulate gene expression and can be used as biomarkers of disease. Patients with rheumatoid arthritis (RA)…
  • Abstract Number: 127 • 2018 ACR/ARHP Annual Meeting

    MiR-3606-3p Inhibits Systemic Sclerosis through Targeting TGF-β Receptor II

    Xiangguang Shi1, Qingmei Liu2, Wenzhen Tu3, Xueqian Mei1, Li Jin4, Wenyu Wu5 and Jiucun Wang4, 1State Key Laboratory of Genetic Engineering, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China, 2State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, Chile, 3Medicine, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shang hai, China, 4State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, 5Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China

    Background/Purpose: Though transforming growth factor-b (TGF-b) plays a fundamental role in the pathogenesis of SSc, the mechanism by which TGF-b signaling acts in SSc remains…
  • Abstract Number: 2840 • 2018 ACR/ARHP Annual Meeting

    MiR-125-b Is a Promising Biomarker for Giant Cell Arteritis in Patients with Negative Temporal Artery Biopsy Examination

    Tadeja Kuret1, Mojca Frank Bertoncelj2, Katja Lakota3,4, Snezna Sodin Semrl3,4, Saša Čučnik3,5, Matija Tomšič3,6 and Alojzija Hočevar1, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, 4University of Primorska, Faculty of Mathematics, Natural Science and Information Technology, Koper, Slovenia, 5University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia, 6Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    Background/Purpose: Giant cell arteritis (GCA) is a systemic vasculitis of large- and medium-sized arteries, diagnosed either with a temporal artery biopsy (TAB) histology or by…
  • Abstract Number: 172 • 2018 ACR/ARHP Annual Meeting

    Serum Chemokines and miRNA Levels and Its Association with Cumulative Organ Damage in Patients with Antiphospholipid Syndrome: A Bench to Bedside Study

    Laura-Aline Martinez-Martinez1, Fausto Sanchez-Muñoz2, Maya Jazmin Nastia Nicte Chacon-Perez2, Yaneli Juarez-Vicuña2, Nicole Mouneu Ornelas1, Anthony Beltran-Cortez2, Ricardo Alberto Venegas Yañez3, Julio Fonseca Basurto1, Evelyn Aranda Cano1, Mary Carmen Amigo4 and Luis M. Amezcua-Guerra1, 1Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 2Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 3Reumatologia, Instituto Nacional de Cardiología "Ignacio Chavez", Ciudad de México, Mexico, 4Rheumatology, Centro Medico ABC, Mexico, Mexico

    Background/Purpose: Recent evidence suggests that chemokines and miRNAs are involved in the pathogenesis of antiphospholipid syndrome (APS). However, the specific role of these molecules in…
  • Abstract Number: 1367 • 2017 ACR/ARHP Annual Meeting

    Circulating Microbial Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Michelle J. Ormseth1, Shilin Zhao2, Ryan Allen2, Joseph F. Solus2, Quanhu Sheng2, Yan Guo2, Fei Ye2, Marisol Ramirez2, Kasey Vickers2 and C Michael Stein2, 1Medicine, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs), such as microRNAs, are important regulators of biological processes and serve as important biomarkers of disease. We found that approximately half…
  • Abstract Number: 1710 • 2017 ACR/ARHP Annual Meeting

    Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells Enhances the Transition of Endothelial to Mesenchymal Cells (Endo-MT) Induced By TGFβ through Down-Regulating PI3/Akt Signaling Pathway By Targeting PIK3R2

    Yongqing Wang1, Shadia Nada2, Nezam Altorok2 and Bashar Kahaleh2, 1University of Toledo, Toledo, OH, 2Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: The accumulation of myofibroblasts in fibrotic tissue plays an important role in the pathogenesis of scleroderma (SSc) fibrosis. Recent studies have shown that myofibroblasts…
  • Abstract Number: 1729 • 2017 ACR/ARHP Annual Meeting

    Increased Serum Levels of Micro-RNA 30d and Micro-RNA 423-5p in 2 Independent Cohorts of Patients with Morphea

    Jorre S. Mertens1,2, Wiola Marut1, Cornelis P.J. Bekker1, Elke M.G.J. de Jong3 and Timothy R.D.J. Radstake1,4, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Dermatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Radboud University Medical Center, Nijmegen, Netherlands, 4Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose : Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. MicroRNAs (miRNAs) are a large family of highly conserved…
  • Abstract Number: 1764 • 2017 ACR/ARHP Annual Meeting

    Small RNA Sequencing Shows Differential Plasma Microrna Expression in Patients with ANCA-Associated Vasculitis: A Pilot Study

    Kevin Byram1, Joseph F. Solus1, Quanhu Sheng1, Yan Guo1, C Michael Stein1 and Michelle J. Ormseth2, 1Vanderbilt University Medical Center, Nashville, TN, 2Rheumatology, Vanderbilt Medical Center, Nashville, TN

    Background/Purpose: MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) that participate in post-transcriptional gene regulation. miRNAs have potential both as biomarkers for diagnosis and prognosis…
  • Abstract Number: 2150 • 2017 ACR/ARHP Annual Meeting

    Serum Microrna-1 Can be a Predictive Marker for Disease Activity of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease

    Yumiko Sugiyama, Ryusuke Yoshimi, Yosuke Kunishita, Daiga Kishimoto, Yohei Kirino and Hideaki Nakajima, Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: Although intensive immunosuppressive treatment are necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), the prognostic factors or disease activity indices for PM/DM have…
  • Abstract Number: 2187 • 2017 ACR/ARHP Annual Meeting

    Association of Circulating microRNAs with Prevalent and Incident Osteoarthritis in Women: The Ofely Study

    Jean-Charles Rousseau1, Marjorie Millet1, Martine Croset1, Elisabeth Sornay-Rendu2, Olivier Borel2 and Roland Chapurlat3, 1INSERM 1033, Lyon, France, 2INSERM 1033, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France, 3INSERM 1033, University of Lyon, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France

    Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
  • Abstract Number: 2326 • 2017 ACR/ARHP Annual Meeting

    Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis

    Zihua Hu1, Kaiyu Jiang2, Mark B. Frank3, Yanmin Chen2 and James Jarvis4, 1Center for Computational Research, University at Buffalo, Buffalo, NY, 2Pediatrics, University at Buffalo, Buffalo, NY, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY

    Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…
  • Abstract Number: 4 • 2017 ACR/ARHP Annual Meeting

    Downregulation of microRNAs in Plasmacytoid Dendritic Cells Is Associated with a Type I Interferon Signature in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Joel A.G. van Roon2,3, Ruth D.E. Fritsch-Stork4, Cornelis P.J. Bekker1, Aridaman Pandit1, Marzia Rossato5 and Timothy R.D.J. Radstake1, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: The most prominent alteration in the immune system of patients with SLE is a type I interferon (IFN) signature, which we recently also reported…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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