ACR Meeting Abstracts

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Abstracts tagged "MicroRNA"

  • Abstract Number: 127 • 2018 ACR/ARHP Annual Meeting

    MiR-3606-3p Inhibits Systemic Sclerosis through Targeting TGF-β Receptor II

    Xiangguang Shi1, Qingmei Liu2, Wenzhen Tu3, Xueqian Mei1, Li Jin4, Wenyu Wu5 and Jiucun Wang4, 1State Key Laboratory of Genetic Engineering, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China, 2State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, Chile, 3Medicine, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shang hai, China, 4State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, 5Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China

    Background/Purpose: Though transforming growth factor-b (TGF-b) plays a fundamental role in the pathogenesis of SSc, the mechanism by which TGF-b signaling acts in SSc remains…
  • Abstract Number: 2840 • 2018 ACR/ARHP Annual Meeting

    MiR-125-b Is a Promising Biomarker for Giant Cell Arteritis in Patients with Negative Temporal Artery Biopsy Examination

    Tadeja Kuret1, Mojca Frank Bertoncelj2, Katja Lakota3,4, Snezna Sodin Semrl3,4, Saša Čučnik3,5, Matija Tomšič3,6 and Alojzija Hočevar1, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, 4University of Primorska, Faculty of Mathematics, Natural Science and Information Technology, Koper, Slovenia, 5University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia, 6Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    Background/Purpose: Giant cell arteritis (GCA) is a systemic vasculitis of large- and medium-sized arteries, diagnosed either with a temporal artery biopsy (TAB) histology or by…
  • Abstract Number: 172 • 2018 ACR/ARHP Annual Meeting

    Serum Chemokines and miRNA Levels and Its Association with Cumulative Organ Damage in Patients with Antiphospholipid Syndrome: A Bench to Bedside Study

    Laura-Aline Martinez-Martinez1, Fausto Sanchez-Muñoz2, Maya Jazmin Nastia Nicte Chacon-Perez2, Yaneli Juarez-Vicuña2, Nicole Mouneu Ornelas1, Anthony Beltran-Cortez2, Ricardo Alberto Venegas Yañez3, Julio Fonseca Basurto1, Evelyn Aranda Cano1, Mary Carmen Amigo4 and Luis M. Amezcua-Guerra1, 1Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 2Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 3Reumatologia, Instituto Nacional de Cardiología "Ignacio Chavez", Ciudad de México, Mexico, 4Rheumatology, Centro Medico ABC, Mexico, Mexico

    Background/Purpose: Recent evidence suggests that chemokines and miRNAs are involved in the pathogenesis of antiphospholipid syndrome (APS). However, the specific role of these molecules in…
  • Abstract Number: 1008 • 2018 ACR/ARHP Annual Meeting

    Presence of a Specific Defect in M2 Polarization of Blood Monocytes from Patients with Rheumatoid Arthritis, Associated with Increased microRNA-155

    Audrey Paoletti1, Julien Rohmer2, Juliette Pascaud3, Bineta Oumouly1, Elodie Rivière3, Samuel Bitoun4, Gaetane Nocturne5 and Xavier Mariette6, 1U1184 IMVA, INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Internal medicine, France, Paris, France, 3Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, 4INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, 5INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 6Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France

    Background/Purpose: Macrophages contribute in situ to the RA pathogenesis. Two distinct states of polarization for macrophages have been recognized: the classically activated macrophage phenotype (M1),…
  • Abstract Number: 1025 • 2018 ACR/ARHP Annual Meeting

    MiR-146a a Key Player in Bone Metabolism

    Victoria Saferding1, Melanie Hofmann1, Julia S. Brunner2, Mihaela Militaru1, Antonia Puchner1, Silvia Hayer3, Gernot Schabbauer4, Melanie Timmen5, Richard Stange5, Josef S. Smolen6 and Stephan Blüml7, 1Medical University of Vienna, Austria, Vienna, Austria, 2Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, 3Waehringer Guertel 18-20 A-A09, Medical University of Vienna, Austria, Vienna, Austria, 4Vascular Biology and Thrombosis research, Medical University of Vienna, Vienna, Austria, 5Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, 6Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 7Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria

    Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
  • Abstract Number: 1460 • 2018 ACR/ARHP Annual Meeting

    Plasma Mir-146a-5p Associates with Beneficial Body Composition and Plasma Metabolic Profiles in Rheumatoid Arthritis

    Brian J. Andonian1, Ching-Heng Chou2, Virginia B. Kraus2, William E. Kraus3 and Kim M. Huffman4, 1Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, 2Duke Molecular Physiology Institute, Duke University, Durham, NC, 3Medicine, Duke University, Durham, NC, 4School of Medicine, Division of Rheumatology, Immunology and Molecular Physiology and Durham VA Medical Center, Duke University, Durham, NC

    Background/Purpose: In rheumatoid arthritis (RA), sarcopenic obesity is associated with significant cardiometabolic disease and mortality. Biomarkers of disease activity in RA and obesity are complicated…
  • Abstract Number: 1474 • 2018 ACR/ARHP Annual Meeting

    Circulating Transfer RNA-Derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Qiong Wu, Quanhu Sheng, Joseph F. Solus, Kasey Vickers, Ryan Allen, Shilin Zhao, Yan Guo, Fei Ye, C Michael Stein and Michelle J. Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs) are important gene regulators and markers of disease. Transfer RNA (tRNA)-derived sRNAs (tDRs), including tRNA fragments (tRFs) and halves (tRHs), are…
  • Abstract Number: 2150 • 2017 ACR/ARHP Annual Meeting

    Serum Microrna-1 Can be a Predictive Marker for Disease Activity of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease

    Yumiko Sugiyama, Ryusuke Yoshimi, Yosuke Kunishita, Daiga Kishimoto, Yohei Kirino and Hideaki Nakajima, Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: Although intensive immunosuppressive treatment are necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), the prognostic factors or disease activity indices for PM/DM have…
  • Abstract Number: 2187 • 2017 ACR/ARHP Annual Meeting

    Association of Circulating microRNAs with Prevalent and Incident Osteoarthritis in Women: The Ofely Study

    Jean-Charles Rousseau1, Marjorie Millet1, Martine Croset1, Elisabeth Sornay-Rendu2, Olivier Borel2 and Roland Chapurlat3, 1INSERM 1033, Lyon, France, 2INSERM 1033, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France, 3INSERM 1033, University of Lyon, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France

    Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
  • Abstract Number: 2326 • 2017 ACR/ARHP Annual Meeting

    Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis

    Zihua Hu1, Kaiyu Jiang2, Mark B. Frank3, Yanmin Chen2 and James Jarvis4, 1Center for Computational Research, University at Buffalo, Buffalo, NY, 2Pediatrics, University at Buffalo, Buffalo, NY, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY

    Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…
  • Abstract Number: 4 • 2017 ACR/ARHP Annual Meeting

    Downregulation of microRNAs in Plasmacytoid Dendritic Cells Is Associated with a Type I Interferon Signature in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Joel A.G. van Roon2,3, Ruth D.E. Fritsch-Stork4, Cornelis P.J. Bekker1, Aridaman Pandit1, Marzia Rossato5 and Timothy R.D.J. Radstake1, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: The most prominent alteration in the immune system of patients with SLE is a type I interferon (IFN) signature, which we recently also reported…
  • Abstract Number: 2338 • 2017 ACR/ARHP Annual Meeting

    Plasma Exosomes from Children with Juvenile Dermatomyositis Are Taken up By Human Aortic Endothelial Cells and Are Associated with Altered Gene Expression in Those Cells

    Kaiyu Jiang1, Zihua Hu2, Rie Karasawa3, Yanmin Chen1 and James Jarvis4, 1Pediatrics, University at Buffalo, Buffalo, NY, 2Center for Computational Research, University at Buffalo, Buffalo, NY, 3Institute of Medical Science, St. Marianna University School of Medicine, Japan, Kawasaki, Japan, 4Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY

    Background/Purpose: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and…
  • Abstract Number: 63 • 2017 ACR/ARHP Annual Meeting

    MiR-146a a Key Player in Bone Metabolism

    Victoria Saferding1, Melanie Hofmann1, Julia S. Brunner2, Antonia Puchner1, Melanie Timmen3, Richard Stange3, Josef S. Smolen4 and Stephan Blüml4, 1Medical University of Vienna, Austria, Vienna, Austria, 2Vascular Biology and Thrombosis research, Medical University of Vienna, Austria, Vienna, Austria, 3Institute for Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, 4Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria

    Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…
  • Abstract Number: 2434 • 2017 ACR/ARHP Annual Meeting

    Baseline Expressions of Cellular microRNA-31 and microRNA-10a Predict Remission and Low Disease Activity in Patients with Early Rheumatoid Arthritis after Six and Twelve Months of Therapy

    Veronika Hruskova1,2, Klara Prajzlerova3, Martin Komarc4, Lucia Vernerova1, Herman F Mann3, Maria Filkova3, Karel Pavelka3, Jiri Vencovsky3 and Ladislav Senolt3, 1Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 2Faculty of Science, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Department of Anthropometrics and Methodology, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by targeting messenger RNAs. The expression of miRNAs was demonstrated to differ between patients with rheumatoid arthritis (RA)…
  • Abstract Number: 180 • 2017 ACR/ARHP Annual Meeting

    Identification of a Functional Susceptible Variant in Distal Enhancer of Mir-146a By CRISPR-Cas9

    Guojun Hou1, Jing Zeng2, Yuanjia Tang3 and Nan Shen4,5, 1Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) &Shanghai Jiao Tong University School of Medicine (SJTUSM), ShangHai, China, 2Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Shanghai Institute of Rheumatology,Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 5The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH

    Background/Purpose: The majority of trait-associated SNPs occur in noncoding regions and are enriched in enhancers. GWAS have identified numerous genetic variants associated with Systemic Lupus…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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