Abstracts tagged "MicroRNA"

Abstract Number: 24 • 2018 ACR/ARHP Annual Meeting
Rituximab Induces an Early Re-Assessment of the Immune and Vascular Systems in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
Chary Lopez-Pedrera¹, Irene Cecchi², Nuria Barbarroja³, Alejandra Maria Patiño-Trives¹, María Luque Tevar¹, Laura Pérez Sánchez⁴, Alejandro Ibáñez-Costa¹, Ivan Arias de la Rosa⁵, Yolanda Jiménez-Gómez³, Massimo Radin⁶, Rafaela Ortega-Castro³, M. Carmen Castro-Villegas⁷, Jerusalem Calvo-Gutierrez³, Alejandro Escudero-Contreras⁵, Maria Jose Cuadrado⁸, Savino Sciascia⁹, Eduardo Collantes Estevez¹, Maria Ángeles Aguirre Zamorano¹ and Carlos Perez-Sanchez³, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ³Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁵Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁶Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁷Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁸Clinica Universidad de Navarra, Madrid, Spain, ⁹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: While the role of Rituximab (RTX) in controlling the clinical manifestations of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) has been documented, the…
Abstract Number: 2128 • 2018 ACR/ARHP Annual Meeting
The Effect of miRNA-21 Overexpression on the Aberrant T Follicular Helper Cells Differentiation in Systemic Lupus Erythematosus
Ming Zhao¹, Xiaofei Gao², Jiali Wu³, Limin Liu¹, Haijing Wu² and Qianjin Lu¹, ¹Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China, ²The Second Xiangya Hospital of Central South University, Changsha, China, ³Department of Deramtology, The Second Xiangya Hospital of Central South University, Changsha, China
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by a large number of autoantibodies and multiple organs damage. T follicular helper(Tfh)…
Abstract Number: 109 • 2018 ACR/ARHP Annual Meeting
Unique miRNA Signatures Detected in Extracellular Vesicles from Patients with Systemic Lupus Erythematous
Ifeoma Okafor¹, Nicholas A. Young², Giancarlo R. Valiente³, Emily Schwarz¹, Peter Harb¹, Caitlin Henry¹, William Willis², Emily Sullivan⁴, Kyle Jablonski⁵, Lai-Chu Wu¹, Naomi I. Maria⁶, Anne Davidson⁷, Elisha D.O. Roberson⁸ and Wael Jarjour⁹, ¹Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴The Ohio State Univeristy Wexner Medical Center, Columbus, OH, ⁵The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Center for Autoimmunnity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ⁷Feinstein Institute for Medical Research, Manhasset, NY, ⁸Depts. of Medicine and Genetics, Division of Rheumatology, Washington University, St. Louis, MO, ⁹Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Recent studies have identified distinct changes in cellular miRNA (miR) expression associated with systemic lupus erythematous (SLE). We have previously shown that toll-like receptor…
Abstract Number: 2816 • 2018 ACR/ARHP Annual Meeting
Development of a Microrna Panel for Predicting Coronary Atherosclerosis in Rheumatoid Arthritis
Michelle J. Ormseth¹, Joseph F. Solus¹, Quanhu Sheng¹, Fei Ye¹, Yan Guo¹, Qiong Wu¹, Annette M. Oeser¹, Ryan Allen¹, Paolo Raggi², Kasey Vickers¹ and C Michael Stein¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²University of Alberta, Edmonton, AB, Canada
Background/Purpose: Small noncoding RNAs (sRNAs), such as microRNAs (miRNAs), regulate gene expression and can be used as biomarkers of disease. Patients with rheumatoid arthritis (RA)…
Abstract Number: 127 • 2018 ACR/ARHP Annual Meeting
MiR-3606-3p Inhibits Systemic Sclerosis through Targeting TGF-β Receptor II
Xiangguang Shi¹, Qingmei Liu², Wenzhen Tu³, Xueqian Mei¹, Li Jin⁴, Wenyu Wu⁵ and Jiucun Wang⁴, ¹State Key Laboratory of Genetic Engineering, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China, ²State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, Chile, ³Medicine, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shang hai, China, ⁴State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, ⁵Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China
Background/Purpose: Though transforming growth factor-b (TGF-b) plays a fundamental role in the pathogenesis of SSc, the mechanism by which TGF-b signaling acts in SSc remains…
Abstract Number: 2840 • 2018 ACR/ARHP Annual Meeting
MiR-125-b Is a Promising Biomarker for Giant Cell Arteritis in Patients with Negative Temporal Artery Biopsy Examination
Tadeja Kuret¹, Mojca Frank Bertoncelj², Katja Lakota^3,4, Snezna Sodin Semrl^3,4, Saša Čučnik^3,5, Matija Tomšič^3,6 and Alojzija Hočevar¹, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, ⁴University of Primorska, Faculty of Mathematics, Natural Science and Information Technology, Koper, Slovenia, ⁵University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia, ⁶Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Background/Purpose: Giant cell arteritis (GCA) is a systemic vasculitis of large- and medium-sized arteries, diagnosed either with a temporal artery biopsy (TAB) histology or by…
Abstract Number: 172 • 2018 ACR/ARHP Annual Meeting
Serum Chemokines and miRNA Levels and Its Association with Cumulative Organ Damage in Patients with Antiphospholipid Syndrome: A Bench to Bedside Study
Laura-Aline Martinez-Martinez¹, Fausto Sanchez-Muñoz², Maya Jazmin Nastia Nicte Chacon-Perez², Yaneli Juarez-Vicuña², Nicole Mouneu Ornelas¹, Anthony Beltran-Cortez², Ricardo Alberto Venegas Yañez³, Julio Fonseca Basurto¹, Evelyn Aranda Cano¹, Mary Carmen Amigo⁴ and Luis M. Amezcua-Guerra¹, ¹Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ²Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ³Reumatologia, Instituto Nacional de Cardiología "Ignacio Chavez", Ciudad de México, Mexico, ⁴Rheumatology, Centro Medico ABC, Mexico, Mexico
Background/Purpose: Recent evidence suggests that chemokines and miRNAs are involved in the pathogenesis of antiphospholipid syndrome (APS). However, the specific role of these molecules in…
Abstract Number: 1367 • 2017 ACR/ARHP Annual Meeting
Circulating Microbial Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Michelle J. Ormseth¹, Shilin Zhao², Ryan Allen², Joseph F. Solus², Quanhu Sheng², Yan Guo², Fei Ye², Marisol Ramirez², Kasey Vickers² and C Michael Stein², ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small RNAs (sRNAs), such as microRNAs, are important regulators of biological processes and serve as important biomarkers of disease. We found that approximately half…
Abstract Number: 1710 • 2017 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells Enhances the Transition of Endothelial to Mesenchymal Cells (Endo-MT) Induced By TGFβ through Down-Regulating PI3/Akt Signaling Pathway By Targeting PIK3R2
Yongqing Wang¹, Shadia Nada², Nezam Altorok² and Bashar Kahaleh², ¹University of Toledo, Toledo, OH, ²Medicine/Rheumatology, University of Toledo, Toledo, OH
Background/Purpose: The accumulation of myofibroblasts in fibrotic tissue plays an important role in the pathogenesis of scleroderma (SSc) fibrosis. Recent studies have shown that myofibroblasts…
Abstract Number: 1729 • 2017 ACR/ARHP Annual Meeting
Increased Serum Levels of Micro-RNA 30d and Micro-RNA 423-5p in 2 Independent Cohorts of Patients with Morphea
Jorre S. Mertens^1,2, Wiola Marut¹, Cornelis P.J. Bekker¹, Elke M.G.J. de Jong³ and Timothy R.D.J. Radstake^1,4, ¹Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Dermatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Radboud University Medical Center, Nijmegen, Netherlands, ⁴Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose : Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. MicroRNAs (miRNAs) are a large family of highly conserved…
Abstract Number: 1764 • 2017 ACR/ARHP Annual Meeting
Small RNA Sequencing Shows Differential Plasma Microrna Expression in Patients with ANCA-Associated Vasculitis: A Pilot Study
Kevin Byram¹, Joseph F. Solus¹, Quanhu Sheng¹, Yan Guo¹, C Michael Stein¹ and Michelle J. Ormseth², ¹Vanderbilt University Medical Center, Nashville, TN, ²Rheumatology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) that participate in post-transcriptional gene regulation. miRNAs have potential both as biomarkers for diagnosis and prognosis…
Abstract Number: 2150 • 2017 ACR/ARHP Annual Meeting
Serum Microrna-1 Can be a Predictive Marker for Disease Activity of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease
Yumiko Sugiyama, Ryusuke Yoshimi, Yosuke Kunishita, Daiga Kishimoto, Yohei Kirino and Hideaki Nakajima, Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Although intensive immunosuppressive treatment are necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), the prognostic factors or disease activity indices for PM/DM have…
Abstract Number: 2187 • 2017 ACR/ARHP Annual Meeting
Association of Circulating microRNAs with Prevalent and Incident Osteoarthritis in Women: The Ofely Study
Jean-Charles Rousseau¹, Marjorie Millet¹, Martine Croset¹, Elisabeth Sornay-Rendu², Olivier Borel² and Roland Chapurlat³, ¹INSERM 1033, Lyon, France, ²INSERM 1033, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France, ³INSERM 1033, University of Lyon, E. Herriot Hospital, Hospices Civils de Lyon, Lyon, France
Background/Purpose: Sensitive and specific blood biomarkers to detect the initial stages of osteoarthritis (OA) and to predict the future development of the disease are not…
Abstract Number: 2326 • 2017 ACR/ARHP Annual Meeting
Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James Jarvis⁴, ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…
Abstract Number: 4 • 2017 ACR/ARHP Annual Meeting
Downregulation of microRNAs in Plasmacytoid Dendritic Cells Is Associated with a Type I Interferon Signature in Systemic Lupus Erythematosus and Antiphospholipid Syndrome
Lucas L. van den Hoogen¹, Joel A.G. van Roon^2,3, Ruth D.E. Fritsch-Stork⁴, Cornelis P.J. Bekker¹, Aridaman Pandit¹, Marzia Rossato⁵ and Timothy R.D.J. Radstake¹, ¹Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The most prominent alteration in the immune system of patients with SLE is a type I interferon (IFN) signature, which we recently also reported…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].