Abstracts tagged "microbiome"

Abstract Number: 0032 • ACR Convergence 2025
Protein Language Model-Guided Homology Identifies Microbial Enzymes Linked to Fibrosis-Prone IgG4-RD and Crohn’s Disease
Kumar Thurimella¹, Ahmed Mohamed², Chenhao Li³, Tommi Vatanen⁴, Daniel Graham³, Roisin Owens⁵, Sabina Leanti La Rosa⁶, Damian Plichta³, Sergio Bacallado⁵ and Ramnik Xavier⁷, ¹University of Colorado School of Medicine, Aurora, CO, ²Broad Institute, Boston, ³Broad Institute, Cambridge, MA, ⁴University of Helsinki, Helsinki, Finland, ⁵University of Cambridge, Cambridge, United Kingdom, ⁶NMBU, As, Norway, ⁷Harvard Medical School, Boston, MA
Background/Purpose: Uncharacterized microbial enzymes in metagenomics are difficult to annotate, especially in fibrosis-prone conditions like IgG4-related disease (IgG4-RD) and Crohn’s disease (CD), where microbial carbohydrate…
Abstract Number: 2315 • ACR Convergence 2025
Alterations in the gut microbiome in ankylosing spondylitis and their correlation with disease activity
Hyemin Jeong¹, Eun-Jung Park² and Chan Hong Jeon¹, ¹Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea, ²National Medical Center, Seoul, Republic of Korea
Background/Purpose: The microbiome significantly influences immune dysfunction and gut dysbiosis in patients with ankylosing spondylitis (AS). This study seeks to define the distinct microbial characteristics…
Abstract Number: 0717 • ACR Convergence 2025
Circulating Bacterial sRNAs are Altered in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Christopher Xavier¹, Kevin Byram², Carol Langford³ and Michelle Ormseth⁴, ¹Meharry Medical College, Nashville, ²Vanderbilt University Medical Center, Nashville, TN, ³Cleveland Clinic, Moreland Hills, OH, ⁴Vanderbilt University Medical Center, Nashville
Background/Purpose: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (AAV) is an autoimmune disease causing small vessel inflammation. Underlying mechanisms of disease are unclear, but the human microbiota may…
Abstract Number: 0031 • ACR Convergence 2025
Meta-Analysis of Trans-Disease Microbial Biomarkers of Protection and Pathogenesis in Autoimmune Conditions: Results from the AMP AIM Consortium
Kevin Bu¹, Rebecca Blank², Alba Boix-Amoros³, Adam Cantor⁴, Jose Scher⁵ and Jose Clemente¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY, ²NYU Langone Health, New York, NY, ³Icahn School of Medicine, New York, NY, ⁴Icahn School of Medicine, New York, ⁵New York University School of Medicine, New York, NY
Background/Purpose: Autoimmune and immune-mediated diseases (AIMDs) affect over 20 million Americans. The sharp increase in prevalence of these disorders over recent decades suggests that factors…
Abstract Number: 2008 • ACR Convergence 2025
Exposure to Anaerobic Antibiotics and Risk of Gout Flares: Target Trial Emulation for the Potential Role of the Gut Microbiome in Gout and Chronic Kidney Disease (CKD)
Natalie McCormick¹, Sharan Rai², Chio Yokose³, leo lu⁴, Robert Terkeltaub⁵, Lama Nazzal⁶, Huilin Li⁶, Dylan Dodd⁷ and Hyon K. Choi⁸, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital/Harvard Medical School, Boston, MA, ³Massachusetts General Hospital, Waltham, MA, ⁴Arthritis Research Canada, Vancouver, BC, Canada, ⁵Retired, San Diego, CA, ⁶NYU Langone, New York, NY, ⁷Stanford University, Palo Alto, CA, ⁸MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA
Background/Purpose: As reported in Cell Press journals,1,2 intestinal commensal purine-degrading bacteria anaerobically degrade urate to anti-inflammatory short chain fatty acids, including butyrate, and thus may…
Abstract Number: 0712 • ACR Convergence 2025
Effects of Bacterial Secretome on Nasal Epithelial Cell Gene Expression in ANCA-Associated Vasculitis
A. Nikolai von Krusenstiern¹, Eleni Bouziani², Sokratis Apostolidis², Li Hui Tan², Swetha Rajagopal³, Nicholas Bolden², Paul J. Planet³, Dylan Curry³, Elliot Friedman³, Noam A. Cohen⁴ and Rennie Rhee², ¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Children’s Hospital of Philadelphia, Philadelphia, PA, ⁴University of Pennsylvania, Philadelphia
Background/Purpose: The nasal microbiome has been implicated as a contributor to relapse in ANCA-associated vasculitis (AAV). Previous research on nasal bacteria, particularly Staphylococcus aureus, has…
Abstract Number: 1855 • ACR Convergence 2025
Small Bowel Microbial Dysbiosis and Impaired Intestinal Absorptive Function in Systemic Sclerosis- A Single Center Prospective Study
Adam Edwinson¹, Elvira Lesmana², Thomas Guedens³, Ruben Mars³, Margaret Breen-Lyles⁴, Stephen Johnson³, Jun Chen³, Madhusudan Grover⁴ and Ashima Makol¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, USA, Rochester, MN, ³Mayo Clinic, Rochester, ⁴Mayo Clinic, Rochester, Rochester, MN
Background/Purpose: Systemic sclerosis (SSc) is characterized by peripheral vasculopathy and widespread fibrosis of skin and internal organs. Up to 90% of SSc patients report gastrointestinal…
Abstract Number: 0871 • ACR Convergence 2025
The gut microbiome shapes MTX pharmacology and is linked to treatment outcomes
Vanya Sofia Villa Soto¹, Diego Orellana², Erin Reilly³, Chloe Heath², Alexandra Degraeve², Mohana Mukherjee², darren Dumlao², Rebecca Blank⁴, steven Yu², Noah Perlmutter², Judith Ashouri², Jose Scher⁵, andrew Patterson³, Peter Turnbaugh² and Renuka Nayak⁶, ¹University of California, San Francisco, San Francics, CA, ²University of California, San Francisco, San Francisco, CA, ³Pennsylvania State University, University Park, PA, ⁴NYU Langone Health, New York, NY, ⁵New York University School of Medicine, New York, NY, ⁶University of California, San Francisco (UCSF), San Francisco, CA
Background/Purpose: Despite advances in targeted therapeutics, methotrexate (MTX) remains the first-line therapy in the treatment of rheumatoid arthritis (RA) and other inflammatory arthritides. However, more…
Abstract Number: 1835 • ACR Convergence 2025
Serum Zonulin As A Biomarker Of Renal Involvement In Systemic Lupus Erythematosus: Shedding Light On The Gut-Kidney Axis
Alessandra Milone¹, Giulio Forte², Alessia Salzillo², Barbara De Marino², Rosa Giacca², Francesco Ciccia³ and Daniele Mauro⁴, ¹University of Campania L. Vanvitelli, Naples, ²University of Campania L. Vanvitelli, Naples, Italy, ³Rheumatology Section, University of Campania L. Vanvitelli, Naples, Italy, Naples, Italy, ⁴University of Campania, Italy, Naples, Italy
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease in which lupus nephritis (LN) remains a major cause of morbidity and mortality. Zonulin, a…
Abstract Number: 0870 • ACR Convergence 2025
Same Model, Different Results: Vendor and Microbiome Influence Reproducibility in Collagen Induced Arthritis
Brenda Seymour¹, Brendan Allen² and Kristine Kuhn³, ¹University of Colorado School of Medicine, Denver, CO, ²University of Colorado School of Medicine, Aurora, CO, ³²⁰²² - ²⁰²³ / Adult/ University of Colorado, Aurora, CO
Background/Purpose: Although collagen-induced arthritis (CIA) in mice is a useful tool for studying inflammatory arthritis, it is a highly variable model with inconsistent disease severity…
Abstract Number: 1806 • ACR Convergence 2025
Sex differences in knee joint microbial DNA of C57BL/6 mice and the effect of cross-sex microbiome transplantation
Veera Durga Vaishnavi Kurra¹, Ausitn Lopez², Aleksander Szymczak³, Gabriella Dyson³, Pratibha Dube⁴, Padmaja Mehta-d'Souza² and Matlock Jeffries³, ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, Edmond, OK
Background/Purpose: Recent studies have suggested an association between the gut microbiome and osteoarthritis. We have previously shown that the joint microbiome is derived at least…
Abstract Number: 0800 • ACR Convergence 2025
Microbiota-Derived Indole Promotes Collagen-Induced Arthritis Type-17 Immunity through Intestinal Dendritic Cell Cytokine Production
Jing Jing Li¹, Sucai Liu², Brenda Seymour³, Brendan Allen², Le Yiphyo², Cassandra Levens¹ and Kristine Kuhn⁴, ¹Rheumatology, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO, ³University of Colorado School of Medicine, Denver, CO, ⁴²⁰²² - ²⁰²³ / Adult/ University of Colorado, Aurora, CO
Background/Purpose: One of the most substantial impacts of microbe-host interactions at the intestinal mucosa is the development of type 17 immunity. A Th17 signature has…
Abstract Number: 1794 • ACR Convergence 2025
OA-associated pain sensitivity is reduced in OA-protected MRL/MpJ mice, partially mediated by the gut microbiome, and transferable via microbiome transplantation
Gabriella Dyson¹, Montana Barrett¹, Nicholas Hanebutt¹, Aleksander Szymczak², Cindy Miranda Brawner¹, Pratibha Dube³, Ausitn Lopez¹, Padmaja Mehta-d'Souza¹ and Matlock Jeffries², ¹Oklahoma Medical Research Foundation, Oklahoma City, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Edmond, OK
Background/Purpose: MRL/MpJ (MRL) mice are protected from developing post-traumatic osteoarthritis (OA) histologic changes. We have previously shown the gut microbiome to play a key role…
Abstract Number: 0775 • ACR Convergence 2025
Increased Circulating Microbial Small RNA tDR-1 is Associated with Decreased Progression to Future Clinical Rheumatoid Arthritis In High Risk Individuals and Reduces In Vitro Type 1 Interferon Response Gene Expression
Anastasiia Phothisane¹, Tulsi Joishy², Carolina Ramirez-Becerra¹, Zuofei Wang², Qiong Wu³, Jennifer Seifert⁴, Marie Feser⁵, Jill Norris⁶, Kristen Demoruelle⁷, LauraKay Moss⁵, Kevin Deane⁸, V. Michael Holers⁹ and Michelle Ormseth², ¹Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, ³University of Virginia, Charlottesville, VA, ⁴University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, ⁵University of Colorado Anschutz Medical Campus, Aurora, CO, ⁶Colorado School of Public Health, Denver, CO, ⁷University of Colorado Anschutz Medical Campus, Golden, CO, ⁸University of Colorado Denver Anschutz Medical Campus, Aurora, CO, ⁹University of Colorado Anschutz Medical Campus, Aurora
Background/Purpose: Microbial small RNAs (sRNAs) can regulate human genes, often with anti-inflammatory effects. We previously showed that an increased plasma concentration of a tRNA-derived RNA…
Abstract Number: 1792 • ACR Convergence 2025
OA protection in African spiny (Acomys) mice is partially mediated by the gut microbiome and is transferrable to wild-type mice via microbiome transplantation
Gabriella Dyson¹, Montana Barrett¹, Nicholas Hanebutt¹, Aleksander Szymczak², Cindy Miranda Brawner¹, Pratibha Dube³, Padmaja Mehta-d'Souza¹, Ashley Siefert⁴ and Matlock Jeffries², ¹Oklahoma Medical Research Foundation, Oklahoma City, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Edmond, OK, ⁴University of Kentucky, Lexington, KY
Background/Purpose: Mounting evidence suggests that gut microbiome shifts may be associated with knee osteoarthritis (OA) development. We have previously shown that gut microbiome transplantation from…

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