Abstracts tagged "microbiome"

Abstract Number: 2643 • ACR Convergence 2025
Microbiome Signatures in RA Treatment: Personalizing Methotrexate Therapy
Rahul Bodkhe¹, Kai Trepka¹, Diego Orellana¹, Rebecca Blank², Peter Turnbaugh³, Jose Scher⁴ and Renuka Nayak⁵, ¹University of California San Francisco, San Francisco, CA, ²NYU Langone Health, New York, NY, ³University of California, San Francisco, San Francisco, CA, ⁴New York University School of Medicine, New York, NY, ⁵University of California, San Francisco (UCSF), San Francisco, CA
Background/Purpose: Rheumatoid arthritis (RA) is a common systemic autoimmune disease that targets the joints, causing persistent pain and swelling. Oral methotrexate (MTX) remains first-line therapy…
Abstract Number: 1338 • ACR Convergence 2025
Short-Chain Fatty Acids and Their Gut Microbial Metabolic Pathways Distinguish Rheumatoid Arthritis in Discordant Monozygotic Twins
Rebecca Blank¹, Kevin Bu², Xinyuan Zhang³, Weixi Chen⁴, Ian Cunningham⁴, jeremy sokolove⁵, Lauren Lahey⁶, Adriana Heguy⁴, Rhina Medina⁴, Carles Ubeda⁷, Renuka Nayak⁸, Jiyuan Hu⁴, Adam Cantor⁹, Jakleen Lee⁹, Frances Williams¹⁰, Jose Clemente² and Jose Scher¹¹, ¹NYU Langone Health, New York, NY, ²Icahn School of Medicine at Mount Sinai, New York, NY, ³Kings College London, London, United Kingdom, ⁴NYU Grossman School of Medicine, New York, ⁵odyssey, Berwyn, PA, ⁶Stanford, Palo Alto, ⁷Fisabio, Madrid, ⁸University of California, San Francisco (UCSF), San Francisco, CA, ⁹Icahn School of Medicine, New York, ¹⁰Kings College London, London, ¹¹New York University School of Medicine, New York, NY
Background/Purpose: Although genetic factors have been identified in the pathogenesis of RA, the concordance rate in monozygotic (MZ) twins is low, suggesting that other factors…
Abstract Number: 0400 • ACR Convergence 2025
Recent Antibiotic Exposure and Response to Treatment of Juvenile Idiopathic Arthritis
Daniel Horton¹, Charu Verma², Sanika Rege², Alicia Iizuka², Matthew Iozzio³, Dawn Koffman³, Stephen Crystal⁴, Amy Davidow⁵, Tobias Gerhard², Lauren Parlett⁶, Carlos Rose⁷ and Brian Strom⁸, ¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Rutgers Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA, New Brunswick, NJ, ³Rutgers Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA, New Brunswick, ⁴Rutgers Center for Health Services Research, Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, ⁵New Jersey Medical School, Newark, NJ, ⁶Carelon Research, Inc, Wilmington, DE, ⁷Thomas Jefferson University, Wilmington, DE, ⁸Rutgers Biomedical and Health Sciences, New Brunswick
Background/Purpose: Juvenile idiopathic arthritis (JIA), the most common pediatric rheumatic disease, has been tied to microbiome disruption (dysbiosis). Dysbiosis in adults with arthritis affects response…
Abstract Number: 2639 • ACR Convergence 2025
Gut Microbiome Signatures Forecast Clinical Response to Methotrexate in Treatment-Naïve Early Rheumatoid Arthritis
VINOD GUPTA¹, Adam Koller¹, Benjamin Hur¹, Marissa Bailey¹, Kara Delger², Elena myasoedova¹, Vanessa Kronzer¹, John Davis¹ and Jaeyun Sung¹, ¹Mayo Clinic, ROCHESTER, MN, ²Mayo Clinic, St Charles, MN
Background/Purpose: Oral methotrexate (MTX) is the cornerstone treatment for newly diagnosed rheumatoid arthritis (RA), yet up to 50% of patients do not respond adequately. Early…
Abstract Number: 1329 • ACR Convergence 2025
Relationship Between Circulating Bacterial Small RNAs, Methotrexate Response, and Microbiome in New Onset Rheumatoid Arthritis
Carolina Ramirez-Becerra¹, Tulsi Joishy², Sheau-Chiann Chen², Marisol Ramirez-Solano², Quanhu Sheng², Peter Turnbaugh³, Carles Ubeda⁴, Renuka Nayak⁵, Rebecca Blank⁶, Jose Scher⁷ and Michelle Ormseth², ¹Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, ³University of California, San Francisco, San Francisco, CA, ⁴Fisabio, Madrid, ⁵University of California, San Francisco (UCSF), San Francisco, CA, ⁶NYU Langone Health, New York, NY, ⁷New York University School of Medicine, New York, NY
Background/Purpose: Microbiome and microbial products are possible contributors and predictors to methotrexate (MTX) response variability. Bacterial small RNAs (sRNAs) are found in human plasma and…
Abstract Number: 0322 • ACR Convergence 2025
Metabolites Reflective of the Gut Microbiome Relate to Future Incident Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Shike Xu², Timothy McAlington³, John Haran⁴, Julieann Patarini⁴ and Bing Lu⁵, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²University of Connecticut Health Center, Farmington, CT, ³UMass Chan School of Medicine, Arlington, MA, ⁴UMass Chan Medical School, Worcester, MA, ⁵UConn Health Center, Newton, MA
Background/Purpose: Numerous cross-sectional and animal studies have linked an altered gut microbiome to osteoarthritis (OA). Human studies are needed to explore the association between the…
Abstract Number: 2622 • ACR Convergence 2025
Oral Microbiome Dysbiosis and Oral-gut Microbial Network Disruption in Hand Osteoarthritis: Data from the Xiangya Osteoarthritis Study
Jiatian Li¹, Yadan Xiao², Tuo Yang¹, david Hunter³, Weiya Zhang⁴, Michael Doherty⁴, Yuqing Zhang⁵, Zidan Yang¹, Yilun Wang¹, Dongxing Xie¹, Changjun Li¹, Wei Li¹, Zeqin Wen¹, Chao Zeng¹, Guanghua Lei¹ and Jie Wei¹, ¹Xiangya Hospital, Central South University, Changsha, Hunan, China (People's Republic), ²Xiangya School of Public Health, Central South University, Changsha, Hunan, China (People's Republic), ³Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ⁴School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁵Massachusetts General Hospital, Quincy, MA
Background/Purpose: The oral microbiome plays a critical role in modulating systemic inflammation and maintaining immune homeostasis, partly through its interactions with the gut microbiome. Although…
Abstract Number: 1119 • ACR Convergence 2025
Microbial activation of cytotoxic CD8⁺ T cells promotes skin immune-related adverse events in patients treated with immune checkpoint inhibitors
Shady Younis¹, Suman Acharya¹, Gayathri Swaminathan¹, Heidi Wong¹, Hannah Kim¹, Alec Eschholz¹, Subramanya Hegde², Andrew McKnight³, William Robinson⁴ and Lisa Zaba¹, ¹Stanford University, Stanford, CA, ²Sanofi US, New Jersey, MA, ³Sanofi US, Cambridge, MA, ⁴Stanford University, Palo Alto, CA
Background/Purpose: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their use is often limited by immune-related adverse events (irAEs), particularly in barrier tissues such…
Abstract Number: 0101 • ACR Convergence 2025
Enrichment of putative bacteria-reactive gut-derived IL-17+ tissue resident memory helper T cells in arthritic ankles in the SKG mouse model of spondyloarthritis
Benjamin Cai¹, Megan Soon², Zewen Kelvin Tuong², Mark Morrison², Anne-Sophie Bergot³ and Ranjeny Thomas⁴, ¹Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia, ²Frazer Institute, The University of Queensland, Brisbane, Australia, ³Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia, ⁴Frazer Institute, University of Queensland, Brisbane, Queensland, Australia
Background/Purpose: In spondyloarthropathy (SpA), arthritis is often associated with gut inflammation. The strong genetic association with HLA-B27 implicates involvement of T cells, but how gut…
Abstract Number: 2590 • ACR Convergence 2025
Translating findings on urate-metabolizing bacterial genes and urate levels at the human population level: a gut microbiome analysis of three independent cohorts of men and women
Sharan Rai¹, Natalie McCormick², Xochitl Morgan³, Matthew Nayor⁴, Robert Terkeltaub⁵, Dylan Dodd⁶, Lama Nazzal⁷, Huilin Li⁷, Gary Curhan⁸, Curtis Huttenhower³ and Hyon K. Choi⁹, ¹Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Harvard T.H. Chan School of Public Health, Boston, ⁴Boston University, Boston, ⁵Retired, San Diego, CA, ⁶Stanford University, Palo Alto, CA, ⁷NYU Langone, New York, NY, ⁸Brigham and Women's Hospital, Boston, ⁹MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA
Background/Purpose: Approximately 21% of US adults have hyperuricemia, the causal precursor for gout. Human cells do not degrade urate (due to uricase gene inactivation). However,…
Abstract Number: 1032 • ACR Convergence 2025
Exploring the role of the gut microbiome in gout: Prospective analysis of dietary fiber intake and the risk of gout
Sharan Rai¹, Natalie McCormick², Chio Yokose³, Robert Terkeltaub⁴, Dylan Dodd⁵, Lama Nazzal⁶, Huilin Li⁶, Qi Sun⁷ and Hyon K. Choi⁸, ¹Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Massachusetts General Hospital, Waltham, MA, ⁴Retired, San Diego, CA, ⁵Stanford University, Palo Alto, CA, ⁶NYU Langone, New York, NY, ⁷Harvard T.H. Chan School of Public Health, Boston, ⁸MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA
Background/Purpose: The role of the gut microbiome has been increasingly implicated in the pathogenesis of gout. For instance, gout patients have shown depletions of bacteria…
Abstract Number: 0088 • ACR Convergence 2025
Imbalance of Inflammation-Regulating Microorganisms and Predicted Metabolomic Pathways Associates With Disease Evolution in Individuals At-Risk for Rheumatoid Arthritis
Lyndsey Cole¹, Brendan Allen², Sucai Liu², Marie Feser³, Le Yi Phyo², LauraKay Moss², Daniel Frank², J. Kirk Harris², Kristen Demoruelle⁴, Kevin Deane⁵, V. Michael Holers⁶ and Kristine Kuhn⁷, ¹University of Colorado School of Medicine, Centennial, CO, ²University of Colorado School of Medicine, Aurora, CO, ³University of Colorado Anschutz Medical Campus, Aurora, CO, ⁴University of Colorado Anschutz Medical Campus, Golden, CO, ⁵University of Colorado Denver Anschutz Medical Campus, Aurora, CO, ⁶University of Colorado Anschutz Medical Campus, Aurora, ⁷²⁰²² - ²⁰²³ / Adult/ University of Colorado, Aurora, CO
Background/Purpose: The mucosal origins hypothesis of RA proposes that immune responses to microorganisms at mucosal sites (e.g. intestine) lead to systemic inflammation and autoimmunity. Little…
Abstract Number: 2589 • ACR Convergence 2025
Multi-omics Integration Reveals Gut Microbiota–Metabolite Dysregulation in Gout with Metabolic Syndrome
Yuanpiao Ni¹, Fanxin Zeng², Yufeng Qing³ and Quanbo Zhang³, ¹Affiliated Hospital Of North Sichuan Medical College, Nanchong, Sichuan, China (People's Republic), ²Dazhou Central Hospital, Dazhou, Sichuan, China (People's Republic), ³The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China (People's Republic)

Background/Purpose: Gout is a metabolic disorder driven by abnormalities in urate metabolism and chronic inflammation. Recent studies suggest that gout is not limited to joint…
Abstract Number: 0938 • ACR Convergence 2025
Short Term Antibiotic Treatment Improves the Neurobehavioral Phenotype of MRL/lpr Mice
Melodie Zaknoun¹, Doaa Tehawey¹, Baruh Polis¹ and Chaim Putterman², ¹Azrieli Faculty of Medicine, Safed, Israel, ²Albert Einstein College of Medicine, Safed, Israel
Background/Purpose: Neuropsychiatric lupus (NPSLE) is a common and prognostically significant manifestation of SLE, affecting 20-40% of lupus patients. The ACR identified 19 clinical syndromes associated…
Abstract Number: 0054 • ACR Convergence 2025
Microbial Cues Promote Arthritis and Alter T Cell Selection in SKG Mice
Astha Patel¹, Steven yu¹, Yuka Nakao¹, Mohana Mukherjee¹, Diego Orellana², Jose Scher³, Peter Turnbaugh¹, Renuka Nayak⁴ and Judith Ashouri¹, ¹University of California, San Francisco, San Francisco, CA, ²University of California San Francisco, San Francisco, CA, ³New York University School of Medicine, New York, NY, ⁴University of California, San Francisco (UCSF), San Francisco, CA
Background/Purpose: Dysbiosis of the gut microbiota has been linked to rheumatoid arthritis (RA), but it remains unclear whether these microbial alterations are causal or secondary…

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