Abstracts tagged "microbiome"

Abstract Number: 64 • 2018 ACR/ARHP Annual Meeting
Dietary Magnesium Modulates the Intestinal Microbiome and T Cell Subsets
Teresina Laragione¹, Carolyn Harris¹ and Percio S. Gulko², ¹Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Several studies have demonstrated that Magnesium (Mg) has a key role in the immune responses. Our previous studies showed that a short-term low Mg…
Abstract Number: 65 • 2018 ACR/ARHP Annual Meeting
Bacteria-Derived Indole Drives Autoimmune Arthritis By Altering B Cell Glycosylation of Autoantibodies
Widian Jubair¹, Erica Alexeev², Timothy Lemke³, Meagan Chriswell¹, Sean Colgan² and Kristine A Kuhn^1,2, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO, ³University of Colorado Denver, Aurora, CO
Background/Purpose: Ongoing studies in rheumatoid arthritis (RA) implicate intestinal dysbiosis of bacteria as a contributing factor, though the mechanism(s) by which bacteria influence disease is…
Abstract Number: 67 • 2018 ACR/ARHP Annual Meeting
Intestinal Inflammation and Netosis Associate with the Presence of Stool IgA ACPA in Subjects at-Risk for RA
Widian Jubair¹, Elizabeth A. Bemis², Yuko Okamoto³, Marie L. Feser³, Jennifer Seifert³, M. Kristen Demoruelle³, Jill M. Norris⁴, Kevin D. Deane³, V. Michael Holers⁵ and Kristine A Kuhn^1,6, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁴Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Rheumatology Division, University of Colorado Denver, Aurora, CO, ⁶Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and inflammation characterized by neutrophil extracellular trap (NET)osis have been detected at mucosal sites such as the lung and periodontium…
Abstract Number: 906 • 2018 ACR/ARHP Annual Meeting
Defining the Gut Microbiome in Patients with ANCA-Associated Vasculitis
Catherine E. Najem¹, Jung-Jin Lee², Ceylan Tanes², Antoine G. Sreih¹, Rennie L. Rhee¹, Abdallah Geara³, Hongzhe Li⁴, Kyle Bittinger², James D. Lewis⁵ and Peter A. Merkel^4,6, ¹Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Nephrology and Hypertension, University of Pennsylvania, Philadelphia, PA, ⁴Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, ⁵Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, ⁶Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose:Although a link between gut microbiome and autoimmune diseases has been suggested, there is a gap in the understanding of the gut microbiome in ANCA-associated…
Abstract Number: 394 • 2017 ACR/ARHP Annual Meeting
Female Tumor Necrosis Factor Transgenic Mice Have More Severe Arthritis Than Males and Supporessed Levels of Bifidobacterium Pseudolongum in Their Gut Microbiome
Emily Wu¹, Richard Bell², Alex Grier³, Steven Gill⁴, Edward Schwarz⁵ and Homaira Rahimi⁶, ¹Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ²Center for Musculoskelatal Research, University of Rochester, Rochester, NY, ³Rochester Genomics Center, University of Rochester, Rochester, NY, ⁴Genomics Research Center, University of Rochester, Rochester, NY, ⁵Orthopedeatrics, University of Rochester, Rochester, NY, ⁶Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) has an increased prevalence and severity in women compared to men, yet the underlying etiology of this sexual dimorphism is unknown.…
Abstract Number: 491 • 2017 ACR/ARHP Annual Meeting
Streptococcus Species Enriched in the Oral Cavity of RA Patients: A Persistent Source of Peptidoglycan-Polysaccharide Polymers Which Drive Disseminated Synovial Inflammation
Rabia Moentadj¹, Linda Rehaume², Paraic O Cuiv³, Kate Ormerod⁴, Muralidhara Maradana³, Vanessa Anne Lakis³, Mark Morrison², Philip Hugenholtz⁴, Helen Benham⁵, Kim-Anh Lê Cao⁶ and Ranjeny Thomas¹, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ³The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia, ⁵The University of Queensland Faculty of Medicine, Brisbane, Australia, ⁶School of Mathematics and Statistics, Centre for Systems Genomics, The University of Melbourne, Melbourne, Australia
Background/Purpose: In Rheumatoid Arthritis (RA), genetic predisposition and environmental risk factors promote dysbiosis of oral and fecal microbiota. We hypothesized that specific microbial taxa (operational…
Abstract Number: 569 • 2017 ACR/ARHP Annual Meeting
Is the Oral Microbiome Involved in the Pathogenesis of Sjogren’s Syndrome?
Taco A van der Meulen¹, Frans G.M. Kroese², S.C. Liefers², Arnau Vich Vila³, Hermie J.M. Harmsen⁴, Hendrika Bootsma², Fred K.L. Spijkervet¹ and Arjan Vissink⁵, ¹Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Gastroenterology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Environmental factors involved in the pathogenesis of primary Sjögren’s syndrome (pSS) are still largely unknown. The oral cavity is the microbial habitat closest to…
Abstract Number: 1326 • 2017 ACR/ARHP Annual Meeting
Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis
Lingshu Zhang^1,2, Pingfang Song², Xiaowei Zhang², Christina Metea², Matthew Schleisman², Lisa Karstens², Eric Leung², Jun Zhang³, Qiang Xu^2,4, Yi Liu⁵, Mark Asquith² and Cong-Qiu Chu^6,7, ¹Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, China, ²Oregon Health & Science University, Portland, OR, ³MD Anderson Cancer Center, Houston, TX, ⁴Guangzhou University of Chinese Medicine, Guangzhou, China, ⁵Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China, ⁶Rheumatology, Oregon Health & Science University, Portland, OR, ⁷Rheumatology, VA Portland Health Care System, Portland, OR
Background/Purpose: Acarbose, an alpha-glucosidase inhibitor anti-diabetic drug exhibited anti-arthritic effects. The mechanism that acarbose exerts its anti-arthritic effects is not fully understood. Since > 90%…
Abstract Number: 1574 • 2017 ACR/ARHP Annual Meeting
Gut Microbiota Perturbations in Reactive Arthritis
Julia Manasson¹, Nan Shen², Helga R. Garcia Ferrer^3,4, Carles Ubeda⁵, Isa Iraheta^3,4, Adriana Heguy⁶, Joan M. Von Feldt⁷, Luis R. Espinoza⁸, Abraham Garcia Kutzbach⁹, Leopoldo N. Segal¹⁰, Alexis Ogdie¹¹, Jose C. Clemente² and Jose U. Scher¹², ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Guatemalan Association against Rheumatic Diseases (AGAR), Guatemala City, Guatemala, ⁴Universidad Francisco Marroquin, Guatemala City, Guatemala, ⁵Institute for Research in Public Health, Valencia, Spain, ⁶Department of Pathology, New York University Genome Technology Center, New York University School of Medicine, New York, NY, ⁷Hospital of the University of Pennsylvania, Philadelphia, PA, ⁸Internal Medicine, LSU Health Sciences Center, New Orleans, LA, ⁹Internal Medicine, Rheumatology Unit (AGAR), Francisco Marroquin University, School of Medicine, Guatemala City, Guatemala, ¹⁰Department of Medicine, Division of Pulmonary and Critical Care, New York University School of Medicine, New York City, NY, ¹¹Division of Rheumatology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ¹²New York University School of Medicine, New York, NY
Background/Purpose: Reactive arthritis (ReA) is an inflammatory condition occurring several weeks after gastrointestinal (GI) or genitourinary (GU) infections. HLA-B27 positivity is considered a risk factor,…
Abstract Number: 1576 • 2017 ACR/ARHP Annual Meeting
IL-23 Promotes Fecal Microbiota Dysbiosis Associated with Susceptibility to Spondyloarthritis and Ileitis in ZAP-70 Mutant SKG Mice
Linda Rehaume¹, Nicholas Matigian¹, Kate Ormerod², Alicia Kang¹, Richard Linedale¹, Olga Zbarskaya¹, Kristine Kikly³, Joshua Daly², Nancy Lachner², Philip Hugenholtz², Mark Morrison¹, Kim-Anh Lê Cao⁴ and Ranjeny Thomas¹, ¹The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ²Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia, ³Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ⁴School of Mathematics and Statistics, Centre for Systems Genomics, The University of Melbourne, Melbourne, Australia
Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from SpA, or for people at-risk of disease…
Abstract Number: 1717 • 2017 ACR/ARHP Annual Meeting
Skin Commensal Bacteria Might Affect Wound Repair in SSc By Preventing Fibroblast Activation and By Provoking Chronic Inflammatory Reaction
Masaya Yokota¹, Janine Schniering¹, Oliver Distler² and Britta Maurer³, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Chronic digital ulcers (DU) due to peripheral microangiopathy are a major complication in systemic sclerosis (SSc). Chronic wounds are often enriched in bacteria without…
Abstract Number: 1737 • 2017 ACR/ARHP Annual Meeting
An Abundance of Butyrate-Producing Bacterium in the Intestine and Increased Foxp3 Gene Expression of T Cells in Patients with Relapsing Polychondritis
Jun Shimizu¹, Takao Kubota² and Noboru Suzuki³, ¹Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²The Japan Self Defense Forces Central Hospital, Tokyo, Japan, ³Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan
Background/Purpose: Helper T cell subsets including Th17 cells and regulatory T (Treg) cells play a role in the adaptive immune response. RORC and Foxp3 are…
Abstract Number: 924 • 2016 ACR/ARHP Annual Meeting
Intestinal Dysbiosis Influences Gut-Joint Lymphocyte Trafficking
Kristine Kuhn^1,2, Hanna Schulz², Jason Hendrickson² and Neha Ohri², ¹Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Intestinal microbiome studies in IBD and AS have shown significant bacterial dysbiosis (i.e., a substantial alteration of the individual species) in similar populations,…
Abstract Number: 1708 • 2016 ACR/ARHP Annual Meeting
Cutaneous Microbiota Features Distinguish Psoriasis from Psoriatic Arthritis
Julia Manasson¹, Soumya M. Reddy¹, Andrea L. Neimann², Leopoldo N. Segal³ and Jose U. Scher¹, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Department of Dermatology, New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Pulmonary and Critical Care, New York University School of Medicine, New York City, NY
Background/Purpose: Psoriasis (PsO) is a chronic immune-mediated skin condition affecting ~3% of adults worldwide. Up to a third of PsO patients go on to…
Abstract Number: 2522 • 2016 ACR/ARHP Annual Meeting
Pharmacomicrobiomics of Methotrexate: Baseline Intestinal Microbiota Correlates with Therapeutic Response
Carles Ubeda¹, Shahla Abdollahi-Roodsaz², Steven B. Abramson³ and Jose U. Scher⁴, ¹Institute for Research in Public Health, Valencia, Spain, ²Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research, NYU School of Medicine and NYU Hospital for Joint Diseases, New York, NY, ⁴New York University School of Medicine, New York, NY
Background/Purpose: Despite significant advances in the therapeutics of inflammatory arthritides, methotrexate (MTX) remains the mainstay of treatment for rheumatoid arthritis (RA) and related conditions worldwide.…

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