Abstracts tagged "microbiome"

Abstract Number: 2806 • 2015 ACR/ARHP Annual Meeting
Bacterial Skin Microbiome in Psoriatic Arthritis Ã¢â‚¬â€œ Pilot Data from Psoriatic Plaques on Dry Skin Sites from Patients with Psoriasis (PsC) and Psoriatic Arthritis (PsA)
Madhura Castelino¹, Stephen Eyre², Mauro Tutino², John Moat³, Paul Martin², Umer Ijaz⁴, Christopher Quince⁵, Pauline Ho¹, Mathew Upton⁶ and Anne Barton^1,7, ¹NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ³Microbiology and Virology Unit, University of Manchester, Manchester, United Kingdom, ⁴School of Engineering, University of Glasgow, Glasgow, United Kingdom, ⁵Warwick Medical School, University of Warwick, Coventry, United Kingdom, ⁶Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, United Kingdom, ⁷Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University Of Manchester, Manchester, United Kingdom
Background/Purpose: In complex traits like psoriasis (PsC) and psoriatic arthritis (PsA) interactions between genetics and environmental factors are thought to result in the development of…
Abstract Number: 2817 • 2015 ACR/ARHP Annual Meeting
The Microbiome of Reactive Arthritis in a Guatemalan Cohort
Alexis Ogdie-Beatty¹, Carles Ubeda², Helga Raquel Garcia Ferrer³, Joan Von Feldt⁴, A Garcia Kutzbach⁵ and Jose U. Scher⁶, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Institute for Research in Public Health, Valencia, Spain, ³Society for Worldwide Med Exchange, North Bay Village, FL, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Internal Medicine, Rheumatology Unit (AGAR), Francisco Marroquin University, School of Medicine, Guatemala City, Guatemala, ⁶Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Reactive arthritis (ReA) is an inflammatory arthritis that typically follows infection. Several agents microbial agents have been implicated, particularly Shigella, Salmonella, Campylobacter in the…
Abstract Number: 2823 • 2015 ACR/ARHP Annual Meeting
Gut Inflammation in HLA-B27 Transgenic Rats Alters the Monocyte Compartment and Its Osteoclastogenic Potential
C. Ansalone, L. Utriainen, S. W. F. Milling and C. S. Goodyear, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Human HLA-B27 and β2-microglobulin transgenic rats (B27 rats), an animal model for spondyloarthropathies, spontaneously develop inflammatory colitis and bone loss. We have previously demonstrated…
Abstract Number: 2740 • 2014 ACR/ARHP Annual Meeting
Microbiota Modulate Intraepithelial Lymphocyte Presence and Function
Kristine A. Kuhn and Sean P. Colgan, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Microbiome studies in autoimmune diseases including rheumatoid arthritis and inflammatory bowel disease demonstrate alterations in relative abundance of specific bacterial species (dysbiosis). The immunologic…
Abstract Number: 622 • 2014 ACR/ARHP Annual Meeting
Gut Microbiota Variations Correlate with Disease Activity in Spondyloarthritis (SpA) and Rheumatoid Arthritis (RA)
Julien Tap^1,2, Jad Abou-Ghantous¹, Ariane Leboime³, Roula Said Nahal³, Philippe Langella¹, Henri-Jean Garchon⁴, Gilles Chiocchia⁵, Jean-Pierre Furet¹ and Maxime Breban^3,4, ¹UMR INRA-AgroParisTech 1319, Equipe ProbiHote, MICALIS Institute, National Institute for Agronomical research (INRA), Jouy-en-Josas, France, ²Metagenopolis, INRA, Jouy-en-Josas, France, ³Service de Rhumatologie, Hopital Ambroise Pare, Boulogne-Billancourt, France, ⁴INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ⁵Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France
Background/Purpose Inflammatory bowel diseases (IBD) are associated with changes in microbiota which may be responsible for sustained gut inflammation and/or a consequence of it. Whether…
Abstract Number: 618 • 2014 ACR/ARHP Annual Meeting
A Gender Bias in Gut Microbiota of SKG Mice Colonized with a Limited Bacterial Consortium Associated with Severity of Spondyloarthritis and Ileitis Triggered By Beta-Glucan
Linda Rehaume, Olga Zbarskaya, Alicia Kang, Helen Benham, Paraic O Cuiv, Mark Morrison and Ranjeny Thomas, University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose Beta-glucan (curdlan)-treated BALB/c ZAP-70W163C(SKG) mutant mice develop IL-23-dependent spondyloarthritis, and curdlan promotes ileitis in SKG mice housed under specific pathogen-free (SPF) but not germ-free…
Abstract Number: 88 • 2014 ACR/ARHP Annual Meeting
Microbiomes of Inflammatory and Non-Inflammatory Thoracic Aortic Aneurysms
Pauline Funchain*^1,2,3, Gary S. Hoffman*⁴, Lars Svensson⁵, Eric Roselli⁵, Gosta Pettersson⁶, Douglas Johnston⁶, Edward Soltesz⁶, Ritu Chakravarti⁷, Alison Clifford⁸ and Charis Eng², ¹Genomic Medicine Institute, Lerner Research Institute, Cleveland, OH, ²Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, ³Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, ⁴Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁵Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁶Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁷Lerner Research Institure, Cleveland Clinic, Cleveland, OH, ⁸Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Aortitis may occur in the context of multifocal large and medium-sized vessel diseases such as giant cell arteritis (GCA) or Takayasu arteritis (TAK) and…
Abstract Number: 1165 • 2013 ACR/ARHP Annual Meeting
Systems Approach To The Study Of the Microbiome and Inflammatory Pathways In Oral Ulcer Tissue From Patients With Active Behςet’s Syndrome (BS)
Cailin Sibley¹, Gulen Hatemi², Yusuf Yazici³, Yin Liu⁴, Steve Brooks⁵, Hasan Yazici⁶ and Raphaela Goldbach-Mansky⁷, ¹Office of the Clinical Director, NIH / NIAMS, Bethesda, MD, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ⁵NIAMS/NIH, Bethesda, MD, ⁶Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ⁷Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: Behcet's syndrome (BS) exhibits features of both innate and acquired immunity. Oral ulceration is the cardinal lesion which usually precedes other manifestations. Despite the…

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