Abstracts tagged "microbiome and systemic sclerosis"

Abstract Number: 1117 • 2018 ACR/ARHP Annual Meeting
Characterization of the Esophageal Microbiome in Patients with Systemic Sclerosis (SSc)
Monica Espinoza¹, Bhaven K. Mehta¹, Yue Wang¹, Aileen Hoffmann², Mary A. Carns³, Noelle Kosarek¹, Tammara A. Wood⁴, Monique Hinchcliff⁵ and Michael L. Whitfield⁶, ¹Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁴Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁵Rheumatology, Northwestern University, Chicago, IL, ⁶Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis and inflammation. Multiple organ systems are affected including the skin, gastrointestinal tract, vasculature, and…
Abstract Number: 1712 • 2017 ACR/ARHP Annual Meeting
Microbial and Metabolic MULTI-Omic Correlations in Systemic Sclerosis Patients
Chiara Bellocchi¹, Alvaro Fernández-Ochoa², Gaia Montanelli¹, Barbara Vigone³, Alessandro Santaniello³, Christian Milani⁴, Rosa Quirantes-PIné², Isabel Borras Linares², Marco Ventura⁴, Antonio Segura Carretero², Marta Alarcón-Riquelme^5,6 and Lorenzo Beretta³, ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy, ²Department of Analytical Chemistry, University of Granada, Granada, Spain, ³Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁴Department of Life Sciences, Università degli studi di Parma, Parma, Italy, ⁵Centro de Genómica e Investigación Oncológica (GENYO), Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain, ⁶Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The gastro-intestinal tract (GIT) is frequently involved in Systemic sclerosis (SSc). Perturbation in the gut microbiota may affect the body well-being and function and…
Abstract Number: 1899 • 2016 ACR/ARHP Annual Meeting
The Intestinal Involvement in Systemic Sclerosis Is Characterized By a Peculiar Gut Microbiota
Silvia Bosello¹, Francesco Paroni Sterbini², Gerlando Natalello¹, Giovanni Canestrari¹, Federico Parisi¹, Maurizio Sanguinetti³ and Gianfranco Ferraccioli⁴, ¹Division of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ²Institute of Microbiology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ³Institute of Microbiology, Università Cattolica - Fondazione Policlinico Universitario A Gemelli, Rome, Italy, ⁴Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: Gastrointestinal involvement is recognized as a major cause of morbidity and mortality in systemic sclerosis (SSc). The pathophysiology is still unclear and includes impairment…
Abstract Number: 2015 • 2016 ACR/ARHP Annual Meeting
The Systemic Sclerosis Disease State Is Associated with Specific Alterations in Gastrointestinal Microbiota in Two Independent Cohorts
Elizabeth R. Volkmann¹, Anna-Maria Hoffmann-Vold², Yu-Ling Chang³, Jonathan Jacobs⁴, Philip J. Clements⁴, Martin Kummen², Johannes R. Hov², Kirsten Tillisch¹, Venu Lagishetty¹, Oyvind Midtvedt⁵, Øyvind Molberg⁵ and Jonathan Braun³, ¹University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Oslo University Hospital, Oslo, Norway, ³Pathology and Laboratory Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵Rheumatology, Oslo University Hospital, Oslo, Norway
Background/Purpose: A single center study demonstrated that systemic sclerosis (SSc) patients have a distinct colonic microbial consortium (based on lavage specimens) compared with healthy controls…
Abstract Number: 3129 • 2015 ACR/ARHP Annual Meeting
Integrative Analysis of the Colonic Microbiota in Systemic Sclerosis
Elizabeth R. Volkmann¹, Yu-Ling Chang², Nashla Barroso³, Daniel E. Furst³, Philip J. Clements¹, Alan Gorn⁴, Bennett Roth³, Jeffrey Conklin³, Terri Getzug³, Maomeng Tong², Jonathan Jacobs³ and Jonathan Braun², ¹Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Pathology and Laboratory Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA
Background/Purpose: Gastrointestinal tract (GIT) dysfunction is a leading cause of morbidity in patients with systemic sclerosis (SSc). However, the etiology of SSc-related lower GIT dysfunction…
Abstract Number: 1723 • 2014 ACR/ARHP Annual Meeting
Identification of the Microbiome As a Potential Trigger of Systemic Sclerosis By Metagenomic RNA-Sequencing of Skin Biopsies
Michael Johnson¹, Zhenghui Li¹, Michelle Dimon², Tammara A. Wood¹, Robert Lafyatis³, Sarah Arron² and Michael Whitfield⁴, ¹Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Dermatology, University of California, San Francisco, San Francisco, CA, ³Arthritis Center, Boston University, Boston, MA, ⁴Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Systemic sclerosis (SSc) is a rare and poorly understood systemic autoimmune disease that results in skin fibrosis and severe internal organ involvement. There…

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