Abstracts tagged "microbiome and rheumatoid arthritis (RA)"

Abstract Number: 82 • 2018 ACR/ARHP Annual Meeting
Analysis of Intestinal Microbiome Profile of Patients with Established Rheumatoid Arthritis and Healthy Controls
Natalia Mena-Vazquez¹, Isabel Moreno-Indias², Patricia Ruiz-Limon³, Marta Rojas-Gimenez⁴, Clara Fuego⁴, Sara Manrique-Arija⁴, Inmaculada Ureña-Garnica⁴, Francisco G. Jimenez-Nuñez⁴, Francisco Jose Tinahones² and Antonio Fernandez-Nebro⁵, ¹UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain., Malaga, Spain, ²Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, Spain, ³Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, ⁴UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain., Málaga, Spain, ⁵UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain
Background/Purpose: To describe the fecal microbiome profile in RA patients and analyze the mechanisms involved in the pathogenesis of RAMethods: Design: Controlled, observational, cross-sectional study…
Abstract Number: 1931 • 2018 ACR/ARHP Annual Meeting
Abundance of Plasma Microbial Small RNAs Are Predictive of Improvement in Disease Activity after DMARD Initiation for Rheumatoid Arthritis
Michelle J. Ormseth¹, Quanhu Sheng¹, Shilin Zhao¹, Joseph F. Solus¹, Qiong Wu¹, Ryan Allen¹, Yan Guo¹, Fei Ye¹, Marisol Ramirez¹, Kasey Vickers¹, S. Louis Bridges Jr.², Jeffrey R. Curtis³ and C Michael Stein¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Small RNAs (sRNAs) are important regulators of biological processes and are potential biomarkers of disease and drug response. We previously found that microbial sRNAs…
Abstract Number: 493 • 2017 ACR/ARHP Annual Meeting
Methotrexate Is an Antibacterial Drug Metabolized By Human Gut Bacteria
Renuka R. Nayak¹, Kye Stapleton-Gray², Colleen O'Loughlin³, Michael Fischbach⁴ and Peter J. Turnbaugh⁵, ¹Department of Medicine, Division of Rheumatology, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Carnegie Mellon University, Pittsburgh, PA, ³University of California, San Francisco, San Francisco, CA, ⁴Department of Bioengineering and Therapeutic Sciences,, University of California, San Francisco, San Francisco, CA, ⁵Microbiology and Immunology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology causing inflammation and irreversible damage in joints and other organs. Methotrexate (MTX) is first-line…
Abstract Number: 494 • 2017 ACR/ARHP Annual Meeting
The Oral Microbiome Is Altered in Patients with Rheumatoid Arthritis
Sheila Arvikar¹, Hatice Hasturk², Klemen Strle³, Daniel Nguyen⁴, Marcy B. Bolster⁵, Deborah Collier⁶, Alpdogan Kantarci² and Allen Steere¹, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ²Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴Forsyth, Cambridge, MA, ⁵Rheumatology, Allergy and Immunology, Endocrine Associates, Massachusetts General Hospital, Boston, MA, ⁶Rheumatology, Massachusetts General Hospital, Boston, MA
Background/Purpose: The mouth is the second most abundantly colonized mucosal surface in the human body. Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures,…
Abstract Number: 1367 • 2017 ACR/ARHP Annual Meeting
Circulating Microbial Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Michelle J. Ormseth¹, Shilin Zhao², Ryan Allen², Joseph F. Solus², Quanhu Sheng², Yan Guo², Fei Ye², Marisol Ramirez², Kasey Vickers² and C Michael Stein², ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small RNAs (sRNAs), such as microRNAs, are important regulators of biological processes and serve as important biomarkers of disease. We found that approximately half…
Abstract Number: 1204 • 2016 ACR/ARHP Annual Meeting
Methotrexate Is an Antibacterial Drug Metabolized By Human Gut Bacteria
Renuka R. Nayak^1,2, Colleen O'Loughlin³, Michael Fischbach⁴ and Peter J. Turnbaugh⁵, ¹Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, ²Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, ⁴Department of Bioengineering and Therapeutic Sciences,, University of California, San Francisco, San Francisco, CA, ⁵Microbiology and Immunology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology that causes inflammation and irreversible damage in joints and other organs. Methotrexate (MTX) is…
Abstract Number: 1921 • 2016 ACR/ARHP Annual Meeting
Evidence for Prevotella Copri As an Immune-Relevant Bacterium in Rheumatoid Arthritis
Annalisa Pianta¹, Sheila Arvikar¹, Klemen Strle¹, Elise E. Drouin², Qi Wang³, Catherine E. Costello³ and Allen C. Steere⁴, ¹Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁴Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Prevotella copri Methods: HLA-DR-presented peptides were identified directly from RA patients' synovial tissue or peripheral blood mononuclear cells (PBMC) by tandem mass spectrometry. P.…
Abstract Number: 2559 • 2016 ACR/ARHP Annual Meeting
Subgingival Microbiome Signatures in Patients with Established Rheumatoid Arthritis and Osteoarthritis
Ted R Mikuls¹, Clay Walker², Fang Qiu³, Fang Yu⁴, Geoffrey M. Thiele⁵ and Jeffrey Payne⁶, ¹Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ²College of Dentistry, University of Florida, Gainesville, FL, ³Biostatistics, University of Nebraska Medical Center, Omaha, NE, ⁴Public Health, University of Nebraska Medical Center, Omaha, NE, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶College of Dentistry, University of Nebraska Medical Center, Lincoln, NE
Background/Purpose: Periodontitis (PD) is an inflammatory disease of tissues supporting the teeth, caused by microorganisms that adhere to and grow along the tooth’s surface. …
Abstract Number: 3018 • 2016 ACR/ARHP Annual Meeting
The Analysis of Severity of Arthritis in the Intestinal Microbiota-Humanized Mice
Yuichi Maeda¹, Masato Matsushita², Masashi Narazaki³, Yukihiko Saeki^4,5, Atsushi Kumanogoh⁶ and Kiyoshi Takeda⁷, ¹Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, ²Rheumatology, Osaka Minami Medical Center, Osaka, Japan, ³Osaka University Graduate School of Medicine, Suita, Japan, ⁴Dept of Clinical research, Osaka-Minami Medical Ctr, Osaka, Japan, ⁵Dept of Clinical Research, Osaka-Minami Medical Center, Kawachinagano City, Japan, ⁶Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, ⁷Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita, Japan
Background/Purpose: Although various genetic factors have been implicated in susceptibility to rheumatoid arthritis (RA), environmental factors including smoking, periodontal disease and hormones are also necessary…
Abstract Number: 3144 • 2016 ACR/ARHP Annual Meeting
Role of the Gut Microbiome in Modulating Arthritis Progression in Mice
Xiao fei Liu¹, Qing hua Zou¹, Bing Zhong¹ and Yong fei Fang², ¹Southwest Hospital, Third Military Medical University, chongqing, China, ²Department of Rheumatology, Southwest Hospital, Third Military Medical University, chongqing, China
Abstract Background/Purpose: Genetics alone cannot explain most cases of rheumatoid arthritis (RA). Thus, investigating environmental factors such as the gut microbiota may provide new insights…
Abstract Number: 1733 • 2014 ACR/ARHP Annual Meeting
Immunomodulatory Effects of Dietary Non-Digestible Oligosaccharides in T Cell-Mediated Autoimmune Arthritis
Rebecca Rogier¹, Tom Ederveen², Anita Hartog³, Birgitte Walgreen⁴, Liduine van den Bersselaar¹, Monique M. Helsen¹, Paul Vos³, Johan Garssen^3,5, Linette Willemsen⁵, Wim B. van den Berg¹, Marije I. Koenders¹ and Shahla Abdollahi-Roodsaz⁶, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ³Danone Nutricia Research, Utrecht, Netherlands, ⁴Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁵Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, ⁶Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Accumulating evidence indicates the relevance of intestinal microbiota in shaping the immune response and supports its contribution to the development of autoimmune diseases. Prebiotic…

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