ACR Meeting Abstracts

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Abstracts tagged "microbiome"

  • Abstract Number: 1171 • ACR Convergence 2024

    Differences in Microbiome Profiles Based on Pain Severity and Inflammatory Biomarkers in Acute Low Back Pain

    Rebecca Fillipo1, Michael Brown2, Jason Arnold2, Colleen Burke3, Stephanie Danyluk2, Kelley Seebeck2 and Adam Goode2, 1Duke University School of Medicine, Durham, NC, 2Duke University, Durham, NC, 3Duke University School of Medicine, Chapel Hill, NC

    Background/Purpose: Low Back Pain (LBP) is highly prevalent, with up to 25% of individuals experiencing LBP each year, with as many as 32% transitioning to…
  • Abstract Number: 1350 • ACR Convergence 2024

    Relationship Between Salivary and Stool Microbiome with Disease Activity and Vascular Function in Patients with Rheumatoid Arthritis

    Tulsi Joishy, Sheau-Chiann Chen, Qiong Wu and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting the joints that is associated with increased cardiovascular risk. Environmental factors play a crucial role…
  • Abstract Number: 1395 • ACR Convergence 2024

    Effects of Butyrate Supplementation in Modulation of Gut Microbiome and Its Metabolites in New Onset Rheumatoid Arthritis

    Rebecca Blank1, Alba Boix-Amoros2, Erin Reilly3, Kevin Bu4, Ian Cunningham5, Renuka Nayak6, Andrew Patterson7, Jose Clemente4 and Jose Scher8, 1NYU, New York, NY, 2Icahn School of Medicine, New York, NY, 3Penn State, State Park, PA, 4Icahn School of Medicine at Mount Sinai, New York, NY, 5NYU Langone Health, New York, NY, 6University of California, San Francisco (UCSF), San Francisco, CA, 7Penn State University, State College, PA, 8New York University School of Medicine, New York, NY

    Background/Purpose: The gut microbiome and its metabolites are dysregulated in RA and other immune-mediated inflammatory diseases. However, the significance of this observation and its implications…
  • Abstract Number: 1572 • ACR Convergence 2024

    Associations Between the Gut Microbiota, Ultra-Processed Food Intake, and Gastrointestinal Tract Symptoms in Patients with Systemic Sclerosis

    Ju Young Lee1, Swapna Joshi2, Arissa Young3, Jen Labus2, Zsuzsanna McMahan4, Ezinne Aja2, Jonathan Jacobs2 and Elizabeth Volkmann5, 1David Geffen School of Medicine, UCLA, Los Angeles, CA, 2UCLA, Los Angeles, 3UCLA, Los Angeles, CA, 4UTHealth Houston Division of Rheumatology, Houston, TX, 5University of California, Department of Medicine, Los Angeles, CA, USA, Los Angeles

    Background/Purpose: Alterations in the gastrointestinal (GI) microbiome (i.e., dysbiosis) are a feature of systemic sclerosis (SSc) [1]. Diet is a known modifier of the GI…
  • Abstract Number: 1585 • ACR Convergence 2024

    Characterization of the Fecal Metabolome in Early Systemic Sclerosis

    Arissa Young1, Kristofer Andreasson2, Jen Labus3, Nedas Matulianos4, Blake Wilde1, Jonathan Jacobs3, Heather Christofk4 and Elizabeth Volkmann5, 1UCLA, Los Angeles, CA, 2Lund University, Lund, Sweden, 3UCLA, Los Angeles, 4University of California Los Angeles, Los Angeles, CA, 5University of California, Department of Medicine, Los Angeles, CA, USA, Los Angeles

    Background/Purpose: Previous studies have shown that alterations in gut microbiota are present early in systemic sclerosis (SSc) (Andréasson et al. 2022) and are associated with…
  • Abstract Number: 1708 • ACR Convergence 2024

    Unveiling the Uterine-Joint Axis: Dysbiosis and Subclinical Uterine Inflammation in Female Axial Spondyloarthritis Pathogenesis

    Daniele Mauro1, Matteo Vecellio2, Anne-Sophie Bergot3, Eva Schmid4, Giulio Forte5, Alessia Stingo6, Alessia Salzillo5, Aldo Pastore7, Paolo Aretini7, Francesca Di Lorenzo7, Antonio ciancio5, Ilenia Pantano5, Gabriele Saccone8, Fulvio Zullo9, carlo Maurizio Montecucco10, Aroldo Rizzo11, Georg Schett12, Ranjeny Thomas13, Mario Zaiss14 and Francesco Ciccia15, 1University of Campania, Italy, Naples, Naples, Italy, 2Fondazione Pisana per la Scienza ONLUS, Pisa, Italy, 3Frazer Institute, University of Queensland, Brisbane, Australia, 4Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Rheumatology and Immunology, Erlangen, Erlangen, Germany, 5University of Campania L. Vanvitelli, Naples, Italy, 6University of Campania L. Vanvitelli, Nasples, Italy, 7Fondazione Pisana per la Scienza ONLUS, Giuliano Terme, Italy, 8University Federico II of Naples, Naples, Italy, 9University of Catanzaro, Catanzaro, Italy, 10Unit of Rheumatology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy, 11Azienda Ospedaliera Ospedali riuniti Villa Sofia Cervello,, Palermo, Italy, 12Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 13University of Queensland, Brisbane, Australia, 14Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universittsklinikum Erlangen, Erlangen, Germany; 2 Deutsches Zentrum für Immuntherapie (DZI), Erlangen, Germany, 15Università degli studi della Campania Luigi Vanvitelli, Naples, Italy

    Background/Purpose: Numerous studies exploring gender differences in axial spondyloarthritis (AxSpA) have noted that women exhibit distinct disease manifestations. Yet, a definitive pathophysiological distinction of these diverse…
  • Abstract Number: 0012 • ACR Convergence 2024

    Dichotomous Expression of CXCR3 and CCR9 and Relationship to Intestinal Permeability in B Cells in Rheumatoid Arthritis

    Ken Yasaka, Ruoqiao Wang, Nida Pellett, Daria Krenitsky, Juilee Thakar and Jennifer Anolik, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: The gut is a key mucosal tissue that can impact the immune system and contribute to systemic inflammation in the setting of increased intestinal…
  • Abstract Number: 1851 • ACR Convergence 2024

    Aberrant Tfh Cells Generated by Th17 Cell Plasticity in the Gut Promote Autoimmune Arthritis

    Joyce Wu, The Ohio State University, Columbus, OH

    Background/Purpose: Much remains unknown regarding T follicular helper 17 (Tfh17) cells in autoimmunity. We previously showed, and here ask why, egress of gut segmented filamentous…
  • Abstract Number: 0034 • ACR Convergence 2024

    Arthritogenic Subdoligranulum (S. Dido 7) Is Increased in Individuals At-Risk for and with Early RA and Decreases over Time During Development of Inflammatory Arthritis

    Lyndsey Cole1, Sucai Liu2, Brendan Allen2, Marie Feser3, Kristen Demoruelle4, Kevin Deane5, Michael Holers3 and Kristine Kuhn6, 1University of Colorado School of Medicine, Centennial, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4University of Colorado Anschutz Medical Campus, Golden, CO, 5University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 6University of Colorado, Aurora, CO

    Background/Purpose: Subdoligranulum didolesgii, S. dido 7, is present in a subset of individuals who are at-risk for RA (termed ‘ARI’) and who have clinical RA,…
  • Abstract Number: 2092 • ACR Convergence 2024

    Remote-Delivered Tai Chi and Gut Microbiota in Osteoarthritis: A Randomized Mechanistic Trial

    Chenchen Wang1, Timothy McAlindon2, Meghan Short1, Mei Chung3, Ye Chen1, Albert Tai1 and Honorine Ward1, 1Tufts Medical Center, Boston, MA, 2University of Massachusets, Worchester, MA, 3Tufts Medical Center, Brighton, MA

    Background/Purpose: Previous studies show that Tai Chi achieves clinical improvement for osteoarthritis (OA) through multiple pathways. There is evidence for interaction of the gut microbiota…
  • Abstract Number: 0051 • ACR Convergence 2024

    Impact of Tight Junction Proteins on Inflammatory Processes and Microbial Imbalance in Rheumatoid Arthritis

    Arkaitz Mucientes1, jose Manuel Lisbona-Montañez2, Patricia Ruiz-Limón3, Sara Manrique-Arija4, Aimara García-Studer4, Fernando Ortiz-Márquez4, Natalia Mena Vázquez5 and Antonio Fernández-Nebro6, 1IBIMA Plataforma BIONAND, Malaga, Andalucia, Spain, 2University of Malaga, Malaga, Andalucia, Spain, 3IBIMA, Instituto de Biomedicina de Málaga, Cordoba, Spain, 4Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, 5IBIMA, Málaga, Andalucia, Spain, 6Department of Rheumatology, Hospital Universitario de Málaga, Málaga, Andalucia, Spain

    Background/Purpose: The etiology of Rheumatoid Arthritis (RA) is not fully understood. Recent studies point to intestinal permeability as an important factor in the establishment and…
  • Abstract Number: 2094 • ACR Convergence 2024

    Cross-sectional Associations of Radiographic Multiple Joint Osteoarthritis and Pain with Demographic and Clinical Characteristics: Design of a Multi-modal Study in Human and Pet Dogs

    Liubov Arbeeva1, Kelly Johnson2, Serena Savage-Guin3, Tessa Walker2, Masataka Enomoto4, Christina Stevens4, Milja Koskinen4, Tracey Cole4, Savannah Aker4, Connor Thonen-Fleck4, Richard Loeser5, Jordan Renner2, Duncan Lascelles6, Yvonne Golightly7 and Amanda Nelson8, 1University of North Carolina, Chapel Hill, Carrboro, NC, 2Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill,, Chapel Hill, NC, 4Translational Research in Pain and Comparative Pain Research and Education Center, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 5University of North Carolina, Chapel Hill, NC, 6North Carolina State University, Raleigh, NC, 7University of Nebraska Medical Center, Omaha, NE, 8University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Multiple joint osteoarthritis (MJOA) is a progressive, highly prevalent disease affecting millions of Americans and as well as pet dogs. This preliminary analysis sought…
  • Abstract Number: 0053 • ACR Convergence 2024

    Fasting Reduces an IL-17+/IFNg+ T Helper Cell-inducing Gut Pathobiont in Patients with Rheumatoid Arthritis

    Márcia Pereira1, Katja Stuhlträger2, Natalie Scherff3, Anika Rajput Khokhar4, Sylvio Redanz1, Hebah Ebid5, Bérénice Hansen5, Cédric C. Lacny5, Ulrike Löschberger2, Stefan Bletz6, Jochen G. Schneider7, Paul Wilmes7, Christian S. Kessler4, Andreas Michalsen4, Alexander Mellmann3 and Martin Kriegel1, 1Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, 2Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Muenster, Germany, 3Institute of Hygiene, University Hospital Münster, Münster, Germany, Muenster, Germany, 4Institute of Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin, Germany, 54University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg, 6Institute of Hygiene, University Hospital Münster, Germany, Muenster, Germany, 7University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg

    Background/Purpose: The mucosal origins hypothesis suggests rheumatoid arthritis (RA) is triggered at mucosal sites in genetically predisposed hosts1. Animal models support that microbiota‐induced Th17 cells are…
  • Abstract Number: 2517 • ACR Convergence 2024

    Skin Microbiome Shows Differences Between Pathergy Positive and Negative Patients with Behçet’s Syndrome

    Betul Sarac1, Ayse Kalkanci2, Esra Kilic2, Elif Ayca Sahin2, Yesim Ozguler3 and Gulen Hatemi3, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey, 2Gazi University, Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey, 3Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey

    Background/Purpose: Gut, oral and genital mucosa microbiome studies in Behçet’s syndrome have shown heterogeneous results including reduced bacterial diversity and decrease in butyrate-producing bacteria. A…
  • Abstract Number: 0066 • ACR Convergence 2024

    Association Between Gut Microbiota, Inflammation, and Epigenetics in Rheumatoid Arthritis Patients

    jose Manuel Lisbona-Montañez1, Arkaitz Mucientes2, Patricia Ruiz-Limón3, Gracia María Martín-Nuñez4, Rocio Redondo-Rodríguez4, Laura Cano-García4, Sara Manrique-Arija5, Isabel Moreno-Indias2, Natalia Mena Vázquez6 and Antonio Fernández-Nebro7, 1University of Malaga, Malaga, Andalucia, Spain, 2IBIMA Plataforma BIONAND, Malaga, Andalucia, Spain, 3IBIMA, Instituto de Biomedicina de Málaga, Cordoba, Spain, 4IBIMA Plataforma Bionand, Malaga, Spain, 5Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, 6IBIMA, Málaga, Andalucia, Spain, 7Department of Rheumatology, Hospital Universitario de Málaga, Málaga, Andalucia, Spain

    Background/Purpose: The etiology of rheumatoid arthritis (RA) is not entirely known. Epigenetic modifications could be the link between genetic and environmental factors related to the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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