Abstracts tagged "microbiome"

Abstract Number: 0051 • ACR Convergence 2024
Impact of Tight Junction Proteins on Inflammatory Processes and Microbial Imbalance in Rheumatoid Arthritis
Arkaitz Mucientes¹, jose Manuel Lisbona-Montañez², Patricia Ruiz-Limón³, Sara Manrique-Arija⁴, Aimara García-Studer⁴, Fernando Ortiz-Márquez⁴, Natalia Mena Vázquez⁵ and Antonio Fernández-Nebro⁶, ¹IBIMA Plataforma BIONAND, Malaga, Andalucia, Spain, ²University of Malaga, Malaga, Andalucia, Spain, ³IBIMA, Instituto de Biomedicina de Málaga, Cordoba, Spain, ⁴Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, ⁵IBIMA, Málaga, Andalucia, Spain, ⁶Department of Rheumatology, Hospital Universitario de Málaga, Málaga, Andalucia, Spain
Background/Purpose: The etiology of Rheumatoid Arthritis (RA) is not fully understood. Recent studies point to intestinal permeability as an important factor in the establishment and…
Abstract Number: 2094 • ACR Convergence 2024
Cross-sectional Associations of Radiographic Multiple Joint Osteoarthritis and Pain with Demographic and Clinical Characteristics: Design of a Multi-modal Study in Human and Pet Dogs
Liubov Arbeeva¹, Kelly Johnson², Serena Savage-Guin³, Tessa Walker², Masataka Enomoto⁴, Christina Stevens⁴, Milja Koskinen⁴, Tracey Cole⁴, Savannah Aker⁴, Connor Thonen-Fleck⁴, Richard Loeser⁵, Jordan Renner², Duncan Lascelles⁶, Yvonne Golightly⁷ and Amanda Nelson⁸, ¹University of North Carolina, Chapel Hill, Carrboro, NC, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill,, Chapel Hill, NC, ⁴Translational Research in Pain and Comparative Pain Research and Education Center, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, ⁵University of North Carolina, Chapel Hill, NC, ⁶North Carolina State University, Raleigh, NC, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Multiple joint osteoarthritis (MJOA) is a progressive, highly prevalent disease affecting millions of Americans and as well as pet dogs. This preliminary analysis sought…
Abstract Number: 0053 • ACR Convergence 2024
Fasting Reduces an IL-17+/IFNg+ T Helper Cell-inducing Gut Pathobiont in Patients with Rheumatoid Arthritis
Márcia Pereira¹, Katja Stuhlträger², Natalie Scherff³, Anika Rajput Khokhar⁴, Sylvio Redanz¹, Hebah Ebid⁵, Bérénice Hansen⁵, Cédric C. Lacny⁵, Ulrike Löschberger², Stefan Bletz⁶, Jochen G. Schneider⁷, Paul Wilmes⁷, Christian S. Kessler⁴, Andreas Michalsen⁴, Alexander Mellmann³ and Martin Kriegel¹, ¹Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, ²Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Muenster, Germany, ³Institute of Hygiene, University Hospital Münster, Münster, Germany, Muenster, Germany, ⁴Institute of Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin, Germany, ⁵4University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg, ⁶Institute of Hygiene, University Hospital Münster, Germany, Muenster, Germany, ⁷University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg
Background/Purpose: The mucosal origins hypothesis suggests rheumatoid arthritis (RA) is triggered at mucosal sites in genetically predisposed hosts1. Animal models support that microbiota‐induced Th17 cells are…
Abstract Number: 2517 • ACR Convergence 2024
Skin Microbiome Shows Differences Between Pathergy Positive and Negative Patients with Behçet’s Syndrome
Betul Sarac¹, Ayse Kalkanci², Esra Kilic², Elif Ayca Sahin², Yesim Ozguler³ and Gulen Hatemi³, ¹Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey, ²Gazi University, Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey, ³Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey
Background/Purpose: Gut, oral and genital mucosa microbiome studies in Behçet’s syndrome have shown heterogeneous results including reduced bacterial diversity and decrease in butyrate-producing bacteria. A…
Abstract Number: 0066 • ACR Convergence 2024
Association Between Gut Microbiota, Inflammation, and Epigenetics in Rheumatoid Arthritis Patients
jose Manuel Lisbona-Montañez¹, Arkaitz Mucientes², Patricia Ruiz-Limón³, Gracia María Martín-Nuñez⁴, Rocio Redondo-Rodríguez⁴, Laura Cano-García⁴, Sara Manrique-Arija⁵, Isabel Moreno-Indias², Natalia Mena Vázquez⁶ and Antonio Fernández-Nebro⁷, ¹University of Malaga, Malaga, Andalucia, Spain, ²IBIMA Plataforma BIONAND, Malaga, Andalucia, Spain, ³IBIMA, Instituto de Biomedicina de Málaga, Cordoba, Spain, ⁴IBIMA Plataforma Bionand, Malaga, Spain, ⁵Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, ⁶IBIMA, Málaga, Andalucia, Spain, ⁷Department of Rheumatology, Hospital Universitario de Málaga, Málaga, Andalucia, Spain
Background/Purpose: The etiology of rheumatoid arthritis (RA) is not entirely known. Epigenetic modifications could be the link between genetic and environmental factors related to the…
Abstract Number: 2536 • ACR Convergence 2024
Trans-Disease Microbial Biomarkers of Protection and Pathogenesis in Autoimmune Conditions: Results from the AMP AIM Consortium
Kevin Bu¹, Rebecca Blank², Adam Cantor¹, Alba Boix-Amoros³, Jose Scher⁴ and Jose Clemente¹, and Accelerating Medicines Partnership and Immune-Mediated Diseases Network (AMP AIM), ¹Icahn School of Medicine at Mount Sinai, New York, NY, ²NYU, New York, NY, ³Icahn School of Medicine, New York, NY, ⁴New York University School of Medicine, New York, NY
Background/Purpose: Autoimmune and immune-mediated diseases (AIMDs) affect over 20 million Americans. Although AIMDs have distinct symptomatology, there is significant overlap in their treatment, suggesting overlap…
Abstract Number: 0073 • ACR Convergence 2024
Self or Bacteria-reactive Th17 Expand from Conventional and Regulatory T Cells in Parabacteroides Goldsteinii Gnotobiotic Arthritic SKG Mice, in Context of Interferon-driven Synovial Inflammatory Macrophages and Reduced Bacterial Immune Regulation
Benjamin Cai¹, Zewen Kelvin Tuong², Mark Morrison¹, Anne-Sophie Bergot¹ and Ranjeny Thomas³, ¹Frazer Institute, University of Queensland, Brisbane, Australia, ²Child Health Research Centre, University of Queensland, South Brisbane, Queensland, Australia, ³University of Queensland, Brisbane, Australia
Background/Purpose: In ankylosing spondylitis, spondyloarthritis (SpA) is often associated with gut inflammation. The strong genetic association with HLA-B27 and expanded CD8 TCR public clonotypes implicate…
Abstract Number: 2541 • ACR Convergence 2024
Probiotic Modulation of Gut Microbiota Mitigates Early Rheumatoid Arthritis Progression: Insights from Pre-Clinical Models
Tong Wu¹, Yanhong Li², Yubin Luo¹ and Yi Liu³, ¹West China Hospital, Sichuan University, Cheng Du, China (People's Republic), ²West China School of Medicine and West China Hospital, Sichuan University, Cheng Du, Sichuan, China, ³West China Hospital of Sichuan University, Chengdu, Sichuan, China
Background/Purpose: Rheumatoid arthritis (RA) progression, categorized by EULAR into six stages, includes pre-clinical RA (Pre-RA)[1], where mucosal surfaces are implicated as initiators of autoimmune responses…
Abstract Number: 0264 • ACR Convergence 2024
Clinical Value of Metagenomic Next-generation Sequencing in Patients with Connective Tissue Disease Co-infections: A Single-center Study from Southern Hospital in China
Yuan-Yuan Xiao¹, Ai-Ling Lu¹, Han-You Mo², Zhen-Dong He², Jia-Le Wen² and Xuan Yin¹, ¹Guilin Medical University, Guilin, China (People's Republic), ²The First Affiliated Hospital of Guangxi Medical University, Nanning, China (People's Republic)
Background/Purpose: Few studies have been reported on the use of metagenomic next-generation sequencing (mNGS) in patients with connective tissue disease (CTD) co-infections, and more relatively large-scale data…
Abstract Number: 2603 • ACR Convergence 2024
A Human Lupus Gut Pathobiont Accelerates Systemic Inflammation, Autoantibody Production and T Cell Dysregulation
Gregg Silverman¹ and Laurence Morel², ¹NYU Grossman School of Medicine, New York, NY, ²Joe R. & Teresa Lozano Long School of Medicine, San Antonio, TX
Background/Purpose: The mechanisms by which the gut microbiome contributes to autoimmune pathogenesis remain poorly understood. In lupus patients, more than ten-fold blooms of Ruminococcus gnavus…
Abstract Number: 0514 • ACR Convergence 2024
Efficacy, Safety and Mechanism of Butyrate in the Treatment of Rheumatoid Arthritis (RA)
Jing He¹, Naidi Wang², Yuhui Li³, Ruoyi Wang², Xiao Tan², Runzhi Zhufeng², Yipeng Han², Hao Li², Yuebo Jin² and Zhanguo Li⁴, ¹Rheumatology, Beijing, China, ²Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China, ³Peking University, BeiJing, China, ⁴People’s Hospital Peking University Health Sciences Centre, Beijing, China
Background/Purpose: This study aims to investigate the safety and efficacy of butyrate capsules in treating patients with rheumatoid arthritis (RA) and elucidate the underlying mechanisms.Methods:…
Abstract Number: 2685 • ACR Convergence 2024
Association Between Gastrointestinal Bacterial Species and Radiological Features of Systemic Sclerosis-Interstitial Lung Disease (SSc-ILD): A Multicenter Study from the SSc Microbiome Consortium Project
Arissa Young¹, Kristofer Andreasson², Swapna Joshi³, Jen Labus³, Andrea Low Hsiu Ling⁴, vanessa smith⁵, Zsuzsanna McMahan⁶, Antonia Valenzuela Vergara⁷, Susanna Proudman⁸, Grace Kim³, Gracijela Bozovic², Jonathan Goldin³, Ezinne Aja³, Jonathan Jacobs³ and Elizabeth Volkmann⁹, ¹UCLA, Los Angeles, CA, ²Lund University, Lund, Sweden, ³UCLA, Los Angeles, ⁴3Singapore General Hospital, Duke-NUS, Singapore, Singapore, ⁵Ghent University Hospital, Gent, Belgium, ⁶UTHealth Houston Division of Rheumatology, Houston, TX, ⁷Pontificia Universidad Catolica de Chile, Santiago, Chile, ⁸Royal Adelaide Hospital, Adelaide, Australia, ⁹University of California, Department of Medicine, Los Angeles, CA, USA, Los Angeles
Background/Purpose: Variations in gastrointestinal (GI) microbial communities may influence the development of lung diseases. Patients with SSc-ILD have a unique intestinal microbial signature. To further…
Abstract Number: 0812 • ACR Convergence 2024
A Human Gut Pathobiont Drives Platelet Activation with Microparticle Release and NETosis During Lupus Nephritis Flares
Abhimanyu Amarnani¹, Cristobal Rivera-Martinez¹, Marc Scherlinger², Doua Azzouz¹, Andy Lee¹, Kate Trujillo¹, MacIntosh Cornwell¹, Tyler Weinstein¹, Tatiana Borja³, Bharati Matta⁴, Sharon Chung⁵, Laura Cooney⁶, Uzair Chaudhary¹, Steven Medvedovsky¹, Peter Izmirly¹, Jill Buyon¹, Patrick Blanco⁷, Betsy Barnes⁸, Bhama Ramkhelawon¹, Kelly Ruggles⁹ and Gregg Silverman¹, ¹New York University Grossman School of Medicine, New York, NY, ²Strasbourg University Hospital, Strasbourg, France, ³Feinstein Institutes for Medical Research, New York, NY, ⁴The Feinstein Institutes for Medical Research, Manhasset, NY, ⁵University of California, San Francisco and Immune Tolerance Network, San Francsico, ⁶University of Michigan and Immune Tolerance Network, Ann Arbor, MI, ⁷UMR_CNRS 5164 Immunoconcept, BORDEAUX CEDEX, France, ⁸Feinstein Institutes for Medical Science, Manhasset, NY, ⁹NYU Grossman School of Medicine, Brooklyn, NY
Background/Purpose: SLE is a leading cause of premature death, often from severe complications including lupus nephritis (LN), especially in disadvantaged groups. Despite advances in treatment,…
Abstract Number: 2694 • ACR Convergence 2024
Associations Between Immune Checkpoint Molecules and Nasal Microbiome in ANCA-associated Vasculitis
Yoichi Nakayama¹, Mirei Shirakashi², Erika Furukawa³, Chikako Endo⁴, Tsuneo Sasai⁵, Yuya Tabuchi⁴, Ryosuke Hiwa⁵, Hideaki Tsuji⁵, Koji Kitagori⁶, Shuji Akizuki⁷, Ran Nakashima⁵, Kosaku Murakami³, Hajime Yoshifuji⁵ and Akio Morinobu⁸, ¹Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Hirakata-shi, Osaka-fu, Japan, ²Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, ³Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, ⁴Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan, ⁵Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁶Occupational Welfare Division, Agency for Health, Safety and Environment, Kyoto University,, Kyoto, Kyoto, Japan, ⁷Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto City, Japan, ⁸Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kyoto, Japan
Background/Purpose: Among patients with ANCA-associated vasculitis (AAV), several exhibit sinonasal involvement, especially in granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA). A recent…
Abstract Number: 0948 • ACR Convergence 2024
Neuronal Intestinal Dysplasia Due to Ncx Gene Deficiency Attenuates the Severity of Experimental Arthritis in Mice
Takayoshi Owada¹, Keiko Hatanaka², Ayae Tanaka², Kei Ikeda³, Hirokuni Hirata¹, Yasutsugu Fukushima¹, Kazuhiro Kurasawa² and Masafumi Arima², ¹Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan, ²Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi, Japan, ³Dokkyo Medical University, Mibu, Shimotsuga, Tochigi, Tochigi, Japan
Background/Purpose: Loss of bacterial diversity and increases of specific bacteria in the gut microbiota have been observed in inflammatory arthritis such as rheumatoid arthritis…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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