Abstracts tagged "metabolomics"

Abstract Number: 2496 • 2019 ACR/ARP Annual Meeting
Serum Metabolomic Analysis of Psoriatic Arthritis Using Solid Phase Microextraction – Liquid Chromatography – High-Resolution Mass Spectrometry Identifies Putative Disease Activity Markers
Vinod Chandran¹, Nikita Looby ², Nathaly Reyes-Garces ², Rohan Machhar ³, Miao Yu ², Anna Roszkowska ², Janusz Pawliszyn ² and Vathany Kulasingam ⁴, ¹University Health Network, University of Toronto, Toronto, Canada, ²University of Waterloo, Waterloo, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: Disease activity in psoriatic arthritis (PsA) is often difficult to assess but drives treatment decisions, joint damage and long-term outcomes. We aimed to identify…
Abstract Number: 65 • 2018 ACR/ARHP Annual Meeting
Bacteria-Derived Indole Drives Autoimmune Arthritis By Altering B Cell Glycosylation of Autoantibodies
Widian Jubair¹, Erica Alexeev², Timothy Lemke³, Meagan Chriswell¹, Sean Colgan² and Kristine A Kuhn^1,2, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO, ³University of Colorado Denver, Aurora, CO
Background/Purpose: Ongoing studies in rheumatoid arthritis (RA) implicate intestinal dysbiosis of bacteria as a contributing factor, though the mechanism(s) by which bacteria influence disease is…
Abstract Number: 1060 • 2018 ACR/ARHP Annual Meeting
Variation in the Synovial Fluid Metabolome According to Disease Activity in Rheumatoid Arthritis
Joong Kyong Ahn¹, Jiwon Hwang², Jaejoon Lee³, Eun-Mi Koh³ and Hoon-Suk Cha³, ¹Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), ²Department of Internal Medicine, National Police Hospital, Seoul, Korea, Republic of (South), ³Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, inflammatory disease characterized by persistent inflammation and joint damage with a heterogeneous course and different pathogenic mechanisms. Metabolomics,…
Abstract Number: 1460 • 2018 ACR/ARHP Annual Meeting
Plasma Mir-146a-5p Associates with Beneficial Body Composition and Plasma Metabolic Profiles in Rheumatoid Arthritis
Brian J. Andonian¹, Ching-Heng Chou², Virginia B. Kraus², William E. Kraus³ and Kim M. Huffman⁴, ¹Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, ²Duke Molecular Physiology Institute, Duke University, Durham, NC, ³Medicine, Duke University, Durham, NC, ⁴School of Medicine, Division of Rheumatology, Immunology and Molecular Physiology and Durham VA Medical Center, Duke University, Durham, NC
Background/Purpose: In rheumatoid arthritis (RA), sarcopenic obesity is associated with significant cardiometabolic disease and mortality. Biomarkers of disease activity in RA and obesity are complicated…
Abstract Number: 1590 • 2018 ACR/ARHP Annual Meeting
Metabolomics Profile Predicts Carotid Atherosclerosis Progression in Psoriatic Disease
Lihi Eder¹, Paula Harvey², Paul Welsh³, Vinod Chandran⁴, Iain B. McInnes⁵, Richard J. Cook⁶, Dafna D Gladman⁷ and Naveed Sattar⁸, ¹Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, ²Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada, ³nstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ⁴Krembil Research Institute & University of Toronto, Toronto, ON, Canada, ⁵University of Glasgow, Glasgow, United Kingdom, ⁶Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁷Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁸Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Metabolomic profiling of patients with psoriatic disease (PsD) offers unparalleled opportunity to unravel the molecular and clinical interactions linking PsD with cardiovascular (CV) risk.…
Abstract Number: 1210 • 2017 ACR/ARHP Annual Meeting
Non-Responders to Total Joint Replacement Therapy in Osteoarthritis Patients and Novel Metabolic Markers
Guangju Zhai¹, Ming Liu², Quan Li¹, Andrew Furey¹, Weidong Zhang³, Sergei Likhodi¹, Edward Randell¹ and Proton Rahman⁴, ¹Memorial University of Newfoundland, St. John's, NF, Canada, ²Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ³Jilin University, Changchun, China, ⁴Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, and is the major source of joint pain and disability. The aim of the study…
Abstract Number: 1712 • 2017 ACR/ARHP Annual Meeting
Microbial and Metabolic MULTI-Omic Correlations in Systemic Sclerosis Patients
Chiara Bellocchi¹, Alvaro Fernández-Ochoa², Gaia Montanelli¹, Barbara Vigone³, Alessandro Santaniello³, Christian Milani⁴, Rosa Quirantes-PIné², Isabel Borras Linares², Marco Ventura⁴, Antonio Segura Carretero², Marta Alarcón-Riquelme^5,6 and Lorenzo Beretta³, ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy, ²Department of Analytical Chemistry, University of Granada, Granada, Spain, ³Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁴Department of Life Sciences, Università degli studi di Parma, Parma, Italy, ⁵Centro de Genómica e Investigación Oncológica (GENYO), Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain, ⁶Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The gastro-intestinal tract (GIT) is frequently involved in Systemic sclerosis (SSc). Perturbation in the gut microbiota may affect the body well-being and function and…
Abstract Number: 1451 • 2016 ACR/ARHP Annual Meeting
Glutamine Metabolism Plays a Crucial Role in the Pathogenesis of Rheumatoid Arthritis
Soshi Takahashi¹, Jun Saegusa², Ikuko Naka³, Kosaku Tsuda³, Takaichi Okano⁴, Kengo Akashi³, Sho Sendo², Yo Ueda³, Akira Onishi⁵, Yoshinori Kogata² and Akio Morinobu², ¹Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Many signaling pathways activated under inflammatory and hypoxic conditions have profound effects on intracellular metabolism to support cell growth and survival. Cancer cells consume…
Abstract Number: 574 • 2015 ACR/ARHP Annual Meeting
Metabolomic Profiling Predicts Outcome of Rituximab Therapy in Rheumatoid Arthritis
Shannon Sweeney¹, Arthur Kavanaugh², Alessia Lodi³, Bo Wang¹, David L. Boyle⁴, Stefano Tiziani⁵ and Monica Guma⁶, ¹University of Texas at Austin, Austin, TX, ²University of California San Diego, La Jolla, CA, ³nutritional Sciences, University of Texas at Austin, Austin, TX, ⁴Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁵Nutritional Sciences, University of Texas at Austin, Austin, TX, ⁶Pharmacology, University of California, San Diego, La Jolla, CA
Background/Purpose: We hypothesized that characterization of patients’ metabolic profiles, utilizing both high-resolution 1H-nuclear magnetic resonance (NMR) and mass spectrometry (MS), might help predict response to…
Abstract Number: 1256 • 2015 ACR/ARHP Annual Meeting
Gas Chromatography/Time-of-Flight-Mass Spectrometry-Based Metabolomic Profiling in Cultured Fibroblast-like Synoviocytes from Rheumatoid Arthritis
Joong Kyong Ahn¹, Sooah Kim², Jiwon Hwang¹, Jungyeon Kim², Young Hee Eun³, Hyemin Jeong⁴, Ji-Min Oh⁵, Hyungjin Kim³, Jaejoon Lee³, Eun-Mi Koh³, Kyoung Heon Kim² and Hoon-Suk Cha⁶, ¹Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Biotechnology, Korea University Graduate School, Seoul, South Korea, ³Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁵Anyang SAM Hospital, Anyang, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and hyperplasia. Fibroblast-like synoviocytes (FLS) in RA exhibit a tumor cell-like…
Abstract Number: 2097 • 2015 ACR/ARHP Annual Meeting
HLA-B27 Expression Profoundly Shapes the Host-Microbiota Metabolome
Mark Asquith¹, Patrick Stauffer², Sean Davin³, Stephen R. Planck⁴, Phoebe Lin⁵ and James T. Rosenbaum⁶, ¹OHSU, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Oregon Health and Science University, Portland, OR, ⁴Casey Eye Institute, Oregon Health & Science University, Portland, OR, ⁵Casey Eye Institute, Oregon Health and Science University, Portland, OR, ⁶Devers Eye Institute, Legacy Hospital system, Portland, OR
Background/Purpose: The intestinal microbiota plays a pivotal role in both host fitness and disease. Increasing evidence implicates microbial metabolites in the modulation of host immunity…
Abstract Number: 2701 • 2015 ACR/ARHP Annual Meeting
An Expansion of Rare Lineage Intestinal Microbes Characterize Rheumatoid Arthritis
Jun Chen¹, John M. Davis III², Eric L. Matteson³ and Veena Taneja⁴, ¹Health Sciences Research, Mayo Clinic, Rochesert, MN, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: The adaptive immune response in Rheumatoid arthritis (RA) is influenced by an interaction between host genetics and environment, particularly the host microbiome. To define…
Abstract Number: 2820 • 2015 ACR/ARHP Annual Meeting
Multi-Omics Studies of Gut Microbiota in Enthesitis-Related Arthritis Identify Diminished Microbial Diversity and Altered Typtophan Metabolism As Potential Factors in Disease Pathogenesis
Matthew L. Stoll¹, Landon S. Wilson², Stephen Barnes³, Ranjit Kumar⁴, Anna Genin⁵, Randy Q. Cron¹, Charles O. Elson⁶, Casey D Morrow⁷ and Elliot J. Lefkowitz⁸, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pharmicology / Toxicology, University of Alabama at Birmingham, Birmingham, AL, ³Pharmicology, University of Alabama at Birmingham, Birmingham, AL, ⁴Center for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, AL, ⁵Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁶Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ⁸Microbiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Children with enthesitis-related arthritis (ERA) and adults with spondyloarthritis are at risk for intestinal inflammation. We have previously shown altered microbiota in children with…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].