Abstracts tagged "metabolomics"

Abstract Number: 1929 • ACR Convergence 2021
Metabolomics Identifies Early Mechanisms of Atherogenic Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation
George Robinson¹, Kirsty Waddington¹, Junjie Peng¹, Anna Radziszewska¹, David Isenberg², Yiannis Ioannou¹, Ines Pineda-Torra¹, Coziana Ciurtin¹ and Elizabeth Jury¹, ¹University College London, London, United Kingdom, ²Centre for Rheumatology, University College London, London, United Kingdom
Background/Purpose: Cardiovascular disease (CVD) is a leading cause of mortality in patients with juvenile-onset systemic lupus erythematosus (JSLE) through atherosclerosis, the build-up of lipids and…
Abstract Number: 0027 • ACR Convergence 2021
Metabolomic Study of Rheumatoid Arthritis Using 1H Nuclear Magnetic Resonance (1H NMR)
Konstantina Tsezou, Dimitra Benaki, Katerina iliou, Emmanuel Mikros and Panayiotis Vlachoyiannopoulos, National and Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Rheumatoid arthritis (RA) remains a disease with high morbidity. Biologic agents revolutionized the therapy of RA, but they are withdrawn in 50% of patients…
Abstract Number: 0559 • ACR Convergence 2021
Targeting NNMT as a Novel Metabolic Approach to Treat Systemic Sclerosis
M.Asif Amin¹, Bo Shi², Pei-Suen Tsou¹, Swarna Bale¹, Phillip Campbell¹, Mikel Gurrea-Rubio¹, Mark Eckert³, Ernst Lengyel³, Johann Gudjonsson⁴ and Varga John¹, ¹University of Michigan, Ann Arbor, MI, ²Nothwestern university, Chicago, IL, ³University of chicago, Chicago, IL, ⁴Department of Dermatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Fibrosis, the hallmark of systemic sclerosis (SSc), is associated with metabolic and epigenetic alterations that are incompletely characterized. Our laboratory had previously implicated dysregulated…
Abstract Number: 0590 • ACR Convergence 2021
Association of Lipid Mediator Profiles and Development of Future Incident Inflammatory Arthritis in a High Risk, Anti-citrullinated Protein Antibody Positive Population
Lauren Vanderlinden¹, Elizabeth Bemis², Kristen Polinski³, Kristen Demoruelle⁴, Marie Feser⁵, Jennifer Seifert⁶, Ted Mikuls⁷, Michael Weisman⁸, Jane Buckner⁹, Kevin Deane¹⁰, Michael Clare-Salzler¹¹, V. Michael Holers¹² and Jill Norris¹³, ¹Colorado School of Public Health, Monument, CO, ²Colorado School of Public Health Anschutz Medical Campus, Aurora, CO, ³CSPH, Gaithersburg, CO, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵University of Colorado Denver, Aurora, CO, ⁶University of Colorado School of Medicine, Littleton, CO, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸Adjunct Professor of Medicine, Stanford University; Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁹Benaroya Research Institute at Virginia Mason, Seattle, WA, ¹⁰University of Colorado Denver, Denver, CO, ¹¹Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, ¹²University of Colorado, Denver, CO, ¹³Colorado School of Public Health, Aurora, CO
Background/Purpose: Lipid mediators are endogenously derived from the metabolism of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) and have important roles in promoting and resolving…
Abstract Number: 0680 • ACR Convergence 2020
Sustained Treat to Target Uric Acid Lowering Therapy Markedly Lowers Fatty Acids Levels in Gout Patients
Monica Guma¹, Roxana Coras², Ru Liu-Bryan³ and Robert Terkeltaub⁴, ¹Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA, ²University of California San Diego, La Jolla, CA, ³Department of Medicine, VAMC/University of California San Diego, San Diego, ⁴VA Medical Center/UC San Diego, San Diego, CA
Background/Purpose: Though hyperuricemia is implicated in cardiovascular disease, the metabolic syndrome, and type 2 diabetes in both gout and in asymptomatic patients, the core metabolism…
Abstract Number: 0747 • ACR Convergence 2020
Isotope-Labeling-LC-MS-based Metabolic Profiling of Multiple Serum Sample Sets for the Discovery of High-confidence Rheumatoid Arthritis Biomarkers
Xiaohang Wang¹, Wei Han¹, Liang Li¹, Stephanie Wichuk², Edna Hutchings³, Rana Dadashova³, Joel Paschke³ and Walter Maksymowych², ¹Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³CARE Arthritis, Edmonton, AB, Canada
Background/Purpose: Early diagnosis of rheumatoid arthritis (RA) is hampered by suboptimal accuracy of currently available serological biomarkers. In this work, we applied a high-performance chemical…
Abstract Number: 0842 • ACR Convergence 2020
mTOR Signaling Pathway Blockade and Rab4 Expression Affects Metabolism of Lupus T Cells
Tamas Faludi¹, Nick Huang¹, Manuel Duarte¹, Joshua Lewis¹ and Andras Perl¹, ¹SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Pro-inflammatory T-cell development underlies the pathogenesis of systemic lupus erythematosus (SLE). Activation of the mechanistic target of rapamycin (mTOR) plays a central role in…
Abstract Number: 0844 • ACR Convergence 2020
Rab4A Regulates Glomerulonephritis and Tryptophan Metabolism in Sle1.2.3. Lupus-prone Mice via Recycling of CD98
Brandon Wyman¹, Nick Huang¹, Zhiwei Lai¹, Mark Haas², Manuel Duarte¹, Joshua Lewis¹ and Andras Perl¹, ¹SUNY Upstate Medical University, Syracuse, NY, ²Cedars-Sinai, Los Angeles, CA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with an incompletely understood etiology. Previous work has identified Rab4A, a small GTPase responsible for endosomal…
Abstract Number: 0970 • ACR Convergence 2020
Oxylipins Profiles During the Earliest Phases of Rheumatoid Arthritis: Associations with Clinical Stage and Treatment Outcomes
Roxana Coras¹, Javier Rodríguez-Carrio², Mercedes Alperi-López³, Patricia López⁴, Catalina Ulloa⁵, Francisco J Ballina-García³, Aaron M Armando⁶, Oswald Quehenberger¹, Monica Guma⁷ and Ana Suárez⁴, ¹University of California San Diego, La Jolla, CA, ²Department of Functional Biology, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain/Bone and Mineral Research Unit, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Spain, Oviedo, ³Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, Oviedo, ⁴Department of Functional Biology, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain, Oviedo, ⁵Bone and Mineral Research Unit, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Spain, Oviedo, ⁶Department of Pharmacology, School of Medicine, University of California, San Diego, USA, San Diego, ⁷Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Altered eicosanoids have been linked to rheumatoid arthritis (RA), suggesting an enhanced metabolization. Eicosanoid metabolism forms a complex network, involving different pathways and mediators,…
Abstract Number: 0991 • ACR Convergence 2020
Pathogenic, Glycolytic PD-1+ B Cells Accumulate in the Hypoxic RA Joint
Achilleas Floudas¹, Nuno Neto², Viviana Marzaioli³, Kieran Murray⁴, Barry Moran⁵, Michael Monaghan⁶, Candice Low⁷, Ronan Mullan⁸, Navin Rao⁹, Vinod Krishna⁹, Sunil Nagpal¹⁰, Douglas Veale¹¹ and Ursula Fearon³, ¹Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, ²Department of Mechanical and Manufacturing Engineering, Dublin, Dublin, Ireland, ³Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, ⁴Saint Vincent's University Hospital, Dublin 4, Dublin, Ireland, ⁵Trinity Biomedical Sciences Institute, Dublin, Ireland, ⁶Department of Mechanical and Manufacturing Engineering, Dublin, Ireland, ⁷EULAR Centre for Arthritis and Rheumatic diseases, St Vincents University Hospital, UCD, Dublin, Ireland, ⁸Adelaide and Meath Hospital, Dublin, Dublin, Ireland, ⁹Janssen R&D, Spring House, PA, ¹⁰Janssen Research & Development, Collegeville, PA, ¹¹EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland
Background/Purpose: Rheumatoid arthritis (RA) often has a progressive and debilitating course, with significant impact on the patient’s quality of life. Despite the long-known association with…
Abstract Number: 0996 • ACR Convergence 2020
Bacteria-Derived Indole Drives Autoimmune Arthritis by Altering B Cell Glycosylation of Autoantibodies
Brandon Trent¹, Meagan Chriswell², Widian Jubair³ and Kristine Kuhn¹, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²UC Denver SOM, Denver, CO, ³University of Colorado Denver, Denver, CO
Background/Purpose: Background: Dysbiosis of gut bacterial communities in rheumatoid arthritis (RA) is a noted phenomenon in both murine models and human patients; however, the mechanisms…
Abstract Number: 1008 • ACR Convergence 2020
Assessing Improved Risk Prediction of Seropositive Rheumatoid Arthritis by Environmental, Genetic, and Preclinical Plasma Metabolite Factors
Karen Costenbader¹, Jeffrey Sparks², Elizabeth Karlson³, Kazuki Yoshida⁴, Jing Cui⁵, Susan Malspeis⁶ and Lilia Bouzit⁷, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁵Brigham Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital, Boston, ⁷Harvard Chan School of Public Health, Boston, MA
Background/Purpose: Recent research has advanced the understanding of associations between environmental, genetic, and metabolic factors and rheumatoid arthritis (RA), introducing potential to improve risk prediction.…
Abstract Number: 1092 • ACR Convergence 2020
NMR-Based Serum Metabolomics, Is It Different in Clinico-Serological Clusters of Idiopathic Inflammatory Myositis?
Naveen R¹, Anupam Guleria², Dinesh Kumar², Umesh Kumar², Anamika Anuja¹, Vikas Agarwal³ and Latika Gupta⁴, ¹Sanjay Gandhi Post graduate institute of medical sciences, Lucknow, Uttar Pradesh, India, ²Centre of Biomedical Research, Sanjay Gandhi post graduate institute of medical sciences, Lucknow, Uttar Pradesh, India, ³Sanjay Gandhi Post Graduate Institute of Medical Sciences, LUCKNOW, India, ⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Background/Purpose: Idiopathic inflammatory myositis (IIM) are rare and heterogenous. Myositis specific antibodies (MSA) show mutual exclusivity and identify specific clinical phenotypes1. Most biomarker studies are…
Abstract Number: 1221 • ACR Convergence 2020
Evaluation of Methotrexate Efficacy and Exploration of Metabolites Associated with Disease Activity in Collagen-induced Arthritis Mouse Model
Yu Kyoung Cho¹ and Ryan Funk¹, ¹UNIVERSITY OF KANSAS, Kansas City, KS
Background/Purpose: Methotrexate (MTX) is cornerstone of therapy for rheumatoid arthritis. However, response to MTX is variable and unpredictable among patients. Therefore, there is a critical…
Abstract Number: 1517 • ACR Convergence 2020
Metabolic Regulation of Type 3 Innate Lymphoid Cells by Intestinal Bacteria-Derived Indoles in Ankylosing Spondylitis
Adam Berlinberg¹, Adam Lefferts², Emilie Regner³, Andrew Stahly⁴ and Kristine Kuhn⁴, ¹University of Colorado, Denver, CO, ²University of Colorado, Anschutz Medical Campus, Denver, CO, ³University of California San Francisco, San Francisco, CA, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Intestinal microbial dysbiosis, intestinal inflammation, and Th17 immunity are all linked to the pathophysiology of ankylosing spondylitis (AS); however, the mechanisms linking them remain…

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