ACR Meeting Abstracts

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Abstracts tagged "metabolomics"

  • Abstract Number: 0860 • ACR Convergence 2021

    Associations Between Tricarboxylic Acid Cycle Plasma Metabolites and Fatigue Phenotypes in Black Females with Systemic Lupus Erythematosus: An Untargeted Metabolomics Analysis

    Laura Kimble1, Arezou Khosroshahi1, Glenna Brewster1, Nicole Carlson1, Ronald Eldridge1 and Elizabeth Corwin2, 1Emory University, Atlanta, GA, 2Columbia University, New York, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) occurs predominantly in women and Black women have disproportionately poorer health outcomes across the trajectory of their disease compared to…
  • Abstract Number: 0943 • ACR Convergence 2021

    Metabolomic Profiling of Synovial Tissue of Patients with Osteoarthritis

    Jessica Murillo Saich1, Roxana Coras2, Robert Meyer3 and Monica Guma4, 1University of California San Diego, La Jolla, CA, 2University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, 3San Diego VA Healthcare Service, La Jolla, CA, 4University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Increasing evidence indicates that osteoarthritis (OA) progression is mediated not simply by progressive degeneration of cartilage, but also by low-grade synovial inflammation (synovitis) that…
  • Abstract Number: 0948 • ACR Convergence 2021

    Immunometabolism of Neutrophils in Antiphospholipid Syndrome (APS)

    Ajay Tambralli1, Alyssa Harbaugh2, Shanea Estes2, Srilakshmi Yalavarthi2, Claire Hoy2, Gautam Sule2 and Jason Knight2, 1University of Michigan, Ypsilanti, MI, 2University of Michigan, Ann Arbor, MI

    Background/Purpose: Neutrophil hyperactivity and neutrophil extracellular trap (NET) release (NETosis) appear to play roles in APS pathophysiology. Until recently, it was thought that neutrophils relied…
  • Abstract Number: 1091 • ACR Convergence 2021

    Serum Metabolomic Profiling Identifies Potential Biomarkers in Arthritis in the Elderly

    Martha Cedeno1, Jessica Murillo Saich1, Roxana Coras2, Anahy Maria Brandy-Garcia3, Agueda Prior-Español4, Lourdes Mateo5, Melania Martinez-Morillo5 and Monica Guma6, 1University of California San Diego, La Jolla, CA, 2University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, 3Hospital Germans Trias i Pujol, Badalona, Spain, 4Department of Rheumatology, Germans Trias i Pujol. University Hospital, Badalona, Spain, 5Department of Rheumatology, Germans Trias i Pujol. University Hospital, Barcelona, Spain, 6University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Elderly-onset RA (EORA) and polymyalgia rheumatica (PMR) are common rheumatic diseases in the elderly, but their pathogenesis is not yet fully understood. Seronegative EORAneg…
  • Abstract Number: 0970 • ACR Convergence 2020

    Oxylipins Profiles During the Earliest Phases of Rheumatoid Arthritis: Associations with Clinical Stage and Treatment Outcomes

    Roxana Coras1, Javier Rodríguez-Carrio2, Mercedes Alperi-López3, Patricia López4, Catalina Ulloa5, Francisco J Ballina-García3, Aaron M Armando6, Oswald Quehenberger1, Monica Guma7 and Ana Suárez4, 1University of California San Diego, La Jolla, CA, 2Department of Functional Biology, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain/Bone and Mineral Research Unit, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Spain, Oviedo, 3Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, Oviedo, 4Department of Functional Biology, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain, Oviedo, 5Bone and Mineral Research Unit, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Spain, Oviedo, 6Department of Pharmacology, School of Medicine, University of California, San Diego, USA, San Diego, 7Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Altered eicosanoids have been linked to rheumatoid arthritis (RA), suggesting an enhanced metabolization. Eicosanoid metabolism forms a complex network, involving different pathways and mediators,…
  • Abstract Number: 0991 • ACR Convergence 2020

    Pathogenic, Glycolytic PD-1+ B Cells Accumulate in the Hypoxic RA Joint

    Achilleas Floudas1, Nuno Neto2, Viviana Marzaioli3, Kieran Murray4, Barry Moran5, Michael Monaghan6, Candice Low7, Ronan Mullan8, Navin Rao9, Vinod Krishna9, Sunil Nagpal10, Douglas Veale11 and Ursula Fearon3, 1Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, 2Department of Mechanical and Manufacturing Engineering, Dublin, Dublin, Ireland, 3Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 4Saint Vincent's University Hospital, Dublin 4, Dublin, Ireland, 5Trinity Biomedical Sciences Institute, Dublin, Ireland, 6Department of Mechanical and Manufacturing Engineering, Dublin, Ireland, 7EULAR Centre for Arthritis and Rheumatic diseases, St Vincents University Hospital, UCD, Dublin, Ireland, 8Adelaide and Meath Hospital, Dublin, Dublin, Ireland, 9Janssen R&D, Spring House, PA, 10Janssen Research & Development, Collegeville, PA, 11EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: Rheumatoid arthritis (RA) often has a progressive and debilitating course, with significant impact on the patient’s quality of life. Despite the long-known association with…
  • Abstract Number: 0996 • ACR Convergence 2020

    Bacteria-Derived Indole Drives Autoimmune Arthritis by Altering B Cell Glycosylation of Autoantibodies

    Brandon Trent1, Meagan Chriswell2, Widian Jubair3 and Kristine Kuhn1, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2UC Denver SOM, Denver, CO, 3University of Colorado Denver, Denver, CO

    Background/Purpose: Background: Dysbiosis of gut bacterial communities in rheumatoid arthritis (RA) is a noted phenomenon in both murine models and human patients; however, the mechanisms…
  • Abstract Number: 1008 • ACR Convergence 2020

    Assessing Improved Risk Prediction of Seropositive Rheumatoid Arthritis by Environmental, Genetic, and Preclinical Plasma Metabolite Factors

    Karen Costenbader1, Jeffrey Sparks2, Elizabeth Karlson3, Kazuki Yoshida4, Jing Cui5, Susan Malspeis6 and Lilia Bouzit7, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 5Brigham Women's Hospital, Boston, MA, 6Brigham and Women's Hospital, Boston, 7Harvard Chan School of Public Health, Boston, MA

    Background/Purpose: Recent research has advanced the understanding of associations between environmental, genetic, and metabolic factors and rheumatoid arthritis (RA), introducing potential to improve risk prediction.…
  • Abstract Number: 1092 • ACR Convergence 2020

    NMR-Based Serum Metabolomics, Is It Different in Clinico-Serological Clusters of Idiopathic Inflammatory Myositis?

    Naveen R1, Anupam Guleria2, Dinesh Kumar2, Umesh Kumar2, Anamika Anuja1, Vikas Agarwal3 and Latika Gupta4, 1Sanjay Gandhi Post graduate institute of medical sciences, Lucknow, Uttar Pradesh, India, 2Centre of Biomedical Research, Sanjay Gandhi post graduate institute of medical sciences, Lucknow, Uttar Pradesh, India, 3Sanjay Gandhi Post Graduate Institute of Medical Sciences, LUCKNOW, India, 4Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

    Background/Purpose: Idiopathic inflammatory myositis (IIM) are rare and heterogenous. Myositis specific antibodies (MSA) show mutual exclusivity and identify specific clinical phenotypes1. Most biomarker studies are…
  • Abstract Number: 1221 • ACR Convergence 2020

    Evaluation of Methotrexate Efficacy and Exploration of Metabolites Associated with Disease Activity in Collagen-induced Arthritis Mouse Model

    Yu Kyoung Cho1 and Ryan Funk1, 1UNIVERSITY OF KANSAS, Kansas City, KS

    Background/Purpose: Methotrexate (MTX) is cornerstone of therapy for rheumatoid arthritis. However, response to MTX is variable and unpredictable among patients. Therefore, there is a critical…
  • Abstract Number: 1517 • ACR Convergence 2020

    Metabolic Regulation of Type 3 Innate Lymphoid Cells by Intestinal Bacteria-Derived Indoles in Ankylosing Spondylitis

    Adam Berlinberg1, Adam Lefferts2, Emilie Regner3, Andrew Stahly4 and Kristine Kuhn4, 1University of Colorado, Denver, CO, 2University of Colorado, Anschutz Medical Campus, Denver, CO, 3University of California San Francisco, San Francisco, CA, 4University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Intestinal microbial dysbiosis, intestinal inflammation, and Th17 immunity are all linked to the pathophysiology of ankylosing spondylitis (AS); however, the mechanisms linking them remain…
  • Abstract Number: 1849 • ACR Convergence 2020

    Identification of New Associations Between Psoriatic Arthritis and the Gut Microbiota. the Mi-PART, a Phenomic Study

    Jesus Miguens Blanco1, Uma Selvarajah1, Zhigang Lui1, Benjamin Mullish1, James Alexander1, Julie McDonald2, Sonya Abraham1 and Julian Marchesi1, 1Imperial College London, London, United Kingdom, 2Imperial College London, London

    Background/Purpose: Perturbations of the gut microbiota have been associated with Psoriatic Arthritis (PsA), a chronic inflammatory disease. We aim to test the microbiome-metabolic interface of…
  • Abstract Number: 0031 • ACR Convergence 2020

    Metabolomics Profiling Predicts Outcome of Tocilizumab in Rheumatoid Arthritis

    Jessica Murillo-Saich1, Cesar Diaz-Torne2, M. Angeles Ortiz2, Roxana Coras1, Arthur Kavanaugh3, Hector Corominas2, Silvia Vidal2 and Monica Guma4, 1University of California San Diego, La Jolla, CA, 2Institut Rec. Hospital de la Santa Creu I Sant Pau., Barcelona, Spain, 3Division of Rheumatology, Allergy, & Immunology, University of California San Diego Medical School, San Diego, CA, 4Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Metabolomics may provide information about the activity and severity of specific diseases and  potentially help discriminate between diseases. Choosing the right biological therapy earlier…
  • Abstract Number: 1994 • ACR Convergence 2020

    Rheumatoid Arthritis Improvement After Exposure to an Anti-Inflammatory “ITIS” Diet Is Associated with Changes of Gut Microbiome and Systemic Metabolome

    Roxana Coras1, Cameron Martino2, Julia Gauglitz3, Anupriya Tripathi3, Alan Jarmusch4, Francesca Cedola5, Marta Fernandez Bustamante6, Meritxall Agustín-Perez7, Maram Alharthi8, Susan Lee8, Abha Singh8, Soo In Choi8, Tania Rivera8, Katherine Nguyen8, Tatyana Shekhtman9, Tiffany Holt10, Shahrokh Golshan11, Rob Knight3, Pieter Dorrestein12 and Monica Guma13, 1University of California San Diego, La Jolla, CA, 2Bioinformatics and Systems Biology, University of California San Diego, San Diego, 3University of California San Diego, San Diego, 4Univesity of California San Diego, San Diego, 5Hospital Policlinico Tor Vergata, Rome, Italy, 6Departement of Medicine, Division of Rheumatology, University of California San Diego, San Diego, 7Department of Medicine, University of California San Diego, San Diego, San Diego, 8Department of Medicine, Division of Rheumatology, University of California San Diego, San Diego, 9Department of Psychiatry, University of California, San Diego, San Diego, 10Center for Integrative Nutrition, University of California San Diego, San Diego, 11Department of Psychiatry, University of California San Diego, San Diego, CA, USA, San Diego, 12Department of Pharmacology and Pediatrics, University of California San Deigo, San Diego, 13Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: A new dimension has been added to the link between diet and health, the gut microbiome. Of particular interest is the influence of diet…
  • Abstract Number: 0318 • ACR Convergence 2020

    Oxylipin Profile Is Associated with Skin Disease and Enthesitis in Psoriatic Disease

    Roxana Coras1, Arthur Kavanaugh2, Angela Kluzniak3, Dustina Holt3, Amy Weilgosz3, Oswald Quehenberger1, Christopher Ritchlin4 and Monica Guma5, 1University of California San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy, & Immunology, University of California San Diego Medical School, San Diego, CA, 3University of Rochester Medical Center, New York, NY, 4Department of Medicine, University of Rochester Medical Center, Rochester, NY, 5Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Psoriatic arthritis (PsA), a systemic inflammatory disease, occurs in about 25% of patients with psoriasis (PsO). At present, there are no biomarkers that reliably…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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