Abstracts tagged "metabolomics"

Abstract Number: 1415 • ACR Convergence 2022
Different Bioactive Lipid Profile Predicts Response to TNF or IL6 Inhibitors in Rheumatoid Arthritis: Result of the CorEvitas CERTAIN Comparative Effectiveness Study
Mona Alotaibi¹, Roxana Coras², Dimitrios Pappas³, Ted Mikuls⁴, Joel Kremer⁵, Geoffrey Thiele⁶, mohit jain¹ and Monica Guma⁷, ¹Department of Medicine, School of Medicine, University of California San Diego, San Diego, CA, ²University of California San Diego, San Diego, CA, ³CorEvitas, LLC, Waltham, MA, ⁴Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵The Corrona Research Foundation, Delray Beach, FL, ⁶University of Nebraska Medical Center, Omaha, NE, ⁷UCSD, La Jolla, CA
Background/Purpose: Circulating bioactive lipids can provide information about the pathogenesis of specific diseases and potentially help predict therapeutic response. Choosing the right biological therapy earlier…
Abstract Number: 1416 • ACR Convergence 2022
Bioactive Lipid Profiling Can Identify Dynamic Biomarkers in Response to Biologic Therapy Result of the CorEvitas CERTAIN Comparative Effectiveness Study
Roxana Coras¹, Mona Alotaibi², Dimitrios Pappas³, Joel Kremer⁴, Jeffrey Curtis⁵, Arthur Kavanaugh⁶, Ted Mikuls⁷, Geoffrey Thiele⁸, mohit jain² and Monica Guma⁹, ¹University of California San Diego, San Diego, CA, ²Department of Medicine, School of Medicine, University of California San Diego, San Diego, CA, ³CorEvitas, LLC, Waltham, MA, ⁴The Corrona Research Foundation, Delray Beach, FL, ⁵University of Alabama at Birmingham, Hoover, AL, ⁶University of California San Diego, La Jolla, CA, ⁷Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁸University of Nebraska Medical Center, Omaha, NE, ⁹UCSD, La Jolla, CA
Background/Purpose: Bioactive lipids comprise distinct classes of bioactive molecules with functions that are critical for joint disease, including regulation of not only inflammation but also…
Abstract Number: 1500 • ACR Convergence 2022
Investigating Serum Lipids Classifying Psoriatic Arthritis Disease Activity Using Solid Phase Microextraction – Liquid Chromatography – High-Resolution Mass Spectrometry
John Koussiouris¹, Nikita Looby², Max Kotlyar³, Vathany Kulasingam⁴, Igor Jurisica⁵ and Vinod Chandran⁶, ¹Department of Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute/ Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Department of Laboratory Medicine and Pathobiology, University of Toronto/ Division of Clinical Biochemistry, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada, ⁵Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network/ Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, ON, Canada, ⁶Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Psoriasis is an inflammatory skin disease that affects over 7.25 million Americans and 1.25 million Canadians. Approximately 25% of psoriasis patients, have an inflammatory…
Abstract Number: 1611 • ACR Convergence 2022
Putative Role of the Histidine and Tryptophan Biochemical Pathways in the Mode of Action of Upadacitinib in Patients with Ankylosing Spondylitis
Thierry Sornasse¹, Liang Li², Shuang Zhao², Xiaohang Wang², Fang Cai³, Yingtao Bi⁴, In-Ho Song⁵, Stephanie Wichuk⁶, Robert G. Lambert⁷ and Walter P Maksymowych⁸, ¹AbbVie, South San Francisco, CA, ²The Metabolomics Innovation Centre and Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ³AbbVie, Redwood City, CA, ⁴AbbVie, Inc, Worcester, MA, ⁵AbbVie, Inc., North Chicago, IL, ⁶University of Alberta, Edmonton, AB, Canada, ⁷Department of Medicine, Division of Rheumatology, University of Alberta, Edmonton, AB, Canada, ⁸Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Upadacitinib (UPA) 15 mg QD is efficacious in patients with active ankylosing spondylitis (AS) exhibiting inadequate responses to nonsteroidal anti-inflammatory drugs (NSAIDs-IR).1 We determined…
Abstract Number: L15 • ACR Convergence 2021
A Predictive Diagnostic Model for IgA Vasculitis Based on a Metabolomic Approach
Alexandre Boissais¹, Hélène Blasco², Patrick Emond³, Antoine Lefevre², Adrien Bigot⁴, denis Mulleman⁵, François Maillot⁴ and Alexandra Audemard-Verger⁴, ¹Medical University of Tours, Tours, France, ²Biochemistry and Molecular Biology Department, Tours, France, ³In vitro Nuclear Medicine Department, Tours, France, ⁴Department of Internal Medicine, Tours, France, ⁵Rheumatology Department, Tours, France
Background/Purpose: IgA vasculitis is a rare systemic disease that is life-threatening mainly due to digestive or renal involvement. To date, there is no reliable diagnostic…
Abstract Number: 1800 • ACR Convergence 2021
Altered Metabolic Profiles in the Transition from Psoriasis to Psoriatic Arthritis: A Longitudinal Analysis
Ananta Paine¹, Paul Brookes², Dongmei Li³, Somyaroop Bhattacharya⁴, Maria de la Luz Garcia-Hernandez¹ and Christopher Ritchlin¹, ¹Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, ²Department of Pharmacology & Physiology, University of Rochester Medical Center, Rochester, NY, ³Department of Clinical and Translational Research, University of Rochester Medical Center, Rochester, NY, ⁴Division of Neonatology, Department of Pediatrics, University of Rochester, Rochester, NY
Background/Purpose: The transition to psoriatic arthritis (PsA) occurs in 20-30% of psoriasis (Ps) patients, but the mechanisms underlying the emergence of musculoskeletal disease are not…
Abstract Number: 1892 • ACR Convergence 2021
Promotion of Autoimmune Arthritis via Tryptophan Metabolism and Production of the Bacterial-Derived Tryptophan Metabolite Indole
Brandon Trent¹, Meagan Chriswell², Widian Jubair¹ and Kristine Kuhn¹, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²UC Denver SOM, Denver, CO
Background/Purpose: Significant changes in gut bacterial richness and diversity occur during the development of inflammatory arthritis, in both murine models and human patients; however, the…
Abstract Number: 1929 • ACR Convergence 2021
Metabolomics Identifies Early Mechanisms of Atherogenic Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation
George Robinson¹, Kirsty Waddington¹, Junjie Peng¹, Anna Radziszewska¹, David Isenberg², Yiannis Ioannou¹, Ines Pineda-Torra¹, Coziana Ciurtin¹ and Elizabeth Jury¹, ¹University College London, London, United Kingdom, ²Centre for Rheumatology, University College London, London, United Kingdom
Background/Purpose: Cardiovascular disease (CVD) is a leading cause of mortality in patients with juvenile-onset systemic lupus erythematosus (JSLE) through atherosclerosis, the build-up of lipids and…
Abstract Number: 0027 • ACR Convergence 2021
Metabolomic Study of Rheumatoid Arthritis Using 1H Nuclear Magnetic Resonance (1H NMR)
Konstantina Tsezou, Dimitra Benaki, Katerina iliou, Emmanuel Mikros and Panayiotis Vlachoyiannopoulos, National and Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Rheumatoid arthritis (RA) remains a disease with high morbidity. Biologic agents revolutionized the therapy of RA, but they are withdrawn in 50% of patients…
Abstract Number: 0559 • ACR Convergence 2021
Targeting NNMT as a Novel Metabolic Approach to Treat Systemic Sclerosis
M.Asif Amin¹, Bo Shi², Pei-Suen Tsou¹, Swarna Bale¹, Phillip Campbell¹, Mikel Gurrea-Rubio¹, Mark Eckert³, Ernst Lengyel³, Johann Gudjonsson⁴ and Varga John¹, ¹University of Michigan, Ann Arbor, MI, ²Nothwestern university, Chicago, IL, ³University of chicago, Chicago, IL, ⁴Department of Dermatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Fibrosis, the hallmark of systemic sclerosis (SSc), is associated with metabolic and epigenetic alterations that are incompletely characterized. Our laboratory had previously implicated dysregulated…
Abstract Number: 0590 • ACR Convergence 2021
Association of Lipid Mediator Profiles and Development of Future Incident Inflammatory Arthritis in a High Risk, Anti-citrullinated Protein Antibody Positive Population
Lauren Vanderlinden¹, Elizabeth Bemis², Kristen Polinski³, Kristen Demoruelle⁴, Marie Feser⁵, Jennifer Seifert⁶, Ted Mikuls⁷, Michael Weisman⁸, Jane Buckner⁹, Kevin Deane¹⁰, Michael Clare-Salzler¹¹, V. Michael Holers¹² and Jill Norris¹³, ¹Colorado School of Public Health, Monument, CO, ²Colorado School of Public Health Anschutz Medical Campus, Aurora, CO, ³CSPH, Gaithersburg, CO, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵University of Colorado Denver, Aurora, CO, ⁶University of Colorado School of Medicine, Littleton, CO, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸Adjunct Professor of Medicine, Stanford University; Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁹Benaroya Research Institute at Virginia Mason, Seattle, WA, ¹⁰University of Colorado Denver, Denver, CO, ¹¹Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, ¹²University of Colorado, Denver, CO, ¹³Colorado School of Public Health, Aurora, CO
Background/Purpose: Lipid mediators are endogenously derived from the metabolism of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) and have important roles in promoting and resolving…
Abstract Number: 0860 • ACR Convergence 2021
Associations Between Tricarboxylic Acid Cycle Plasma Metabolites and Fatigue Phenotypes in Black Females with Systemic Lupus Erythematosus: An Untargeted Metabolomics Analysis
Laura Kimble¹, Arezou Khosroshahi¹, Glenna Brewster¹, Nicole Carlson¹, Ronald Eldridge¹ and Elizabeth Corwin², ¹Emory University, Atlanta, GA, ²Columbia University, New York, NY
Background/Purpose: Systemic lupus erythematosus (SLE) occurs predominantly in women and Black women have disproportionately poorer health outcomes across the trajectory of their disease compared to…
Abstract Number: 0943 • ACR Convergence 2021
Metabolomic Profiling of Synovial Tissue of Patients with Osteoarthritis
Jessica Murillo Saich¹, Roxana Coras², Robert Meyer³ and Monica Guma⁴, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ³San Diego VA Healthcare Service, La Jolla, CA, ⁴University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Increasing evidence indicates that osteoarthritis (OA) progression is mediated not simply by progressive degeneration of cartilage, but also by low-grade synovial inflammation (synovitis) that…
Abstract Number: 0948 • ACR Convergence 2021
Immunometabolism of Neutrophils in Antiphospholipid Syndrome (APS)
Ajay Tambralli¹, Alyssa Harbaugh², Shanea Estes², Srilakshmi Yalavarthi², Claire Hoy², Gautam Sule² and Jason Knight², ¹University of Michigan, Ypsilanti, MI, ²University of Michigan, Ann Arbor, MI
Background/Purpose: Neutrophil hyperactivity and neutrophil extracellular trap (NET) release (NETosis) appear to play roles in APS pathophysiology. Until recently, it was thought that neutrophils relied…
Abstract Number: 1091 • ACR Convergence 2021
Serum Metabolomic Profiling Identifies Potential Biomarkers in Arthritis in the Elderly
Martha Cedeno¹, Jessica Murillo Saich¹, Roxana Coras², Anahy Maria Brandy-Garcia³, Agueda Prior-Español⁴, Lourdes Mateo⁵, Melania Martinez-Morillo⁵ and Monica Guma⁶, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ³Hospital Germans Trias i Pujol, Badalona, Spain, ⁴Department of Rheumatology, Germans Trias i Pujol. University Hospital, Badalona, Spain, ⁵Department of Rheumatology, Germans Trias i Pujol. University Hospital, Barcelona, Spain, ⁶University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Elderly-onset RA (EORA) and polymyalgia rheumatica (PMR) are common rheumatic diseases in the elderly, but their pathogenesis is not yet fully understood. Seronegative EORAneg…

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