Abstracts tagged "metabolomics and systemic lupus erythematosus (SLE)"

Abstract Number: 139 • 2018 ACR/ARHP Annual Meeting
Calcium/Calmodulin-Dependent Protein Kinase 4 Promotes GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus
Tomohiro Koga¹, Masataka Umeda², Yushiro Endo³, Toshimasa Shimizu², Remi Sumiyoshi³, Shinya Kawashiri³, Naoki Iwamoto², Kunihiro Ichinose⁴, Mami Tamai⁴, Tomoki Origuchi⁵, Hideki Nakamura² and Atsushi Kawakami², ¹Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Glycolysis is critical for T-cell effector functions, and increased glycolysis leads to autoimmunity. APT production by effector T cells is dependent on the mitochondria-independent…
Abstract Number: 704 • 2018 ACR/ARHP Annual Meeting
Metabolomics Analysis of Insulin Resistance in Mild/Inactive Non-Diabetic Systemic Lupus Erythematosus Women
Claudia Mendoza Pinto¹, Mario García-Carrasco², Gerardo Díaz-Merino³, Pamela Soto-Santillan⁴, Rossy Mejia-Ocampo⁵, Pamela Munguía-Realpozo³ and Alejandro Ruiz-Arguelles⁵, ¹Systemic Autoimmune Diseases Research Unit,, UMAE, HE CMN Manuel Ávila Camacho-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, Mexico, ²Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR Instituto Mexicano del Seguro Social, Puebla, Mexico, ³Systemic Autoimmune Diseases Research Unit,, Hospital de Especialidades UMAE CMN, Instituto Mexicano del Seguro Social, Puebla, Mexico, ⁴Systemic Autoimmune Diseases Research Unit, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico, ⁵Laboratorios Clínicos de Puebla, Puebla, Mexico
Background/Purpose: SLE patients present a higher prevalence of insulin resistance (IR) and metabolic syndrome (MetS) than age- and sex-matched healthy controls. Advances in technology are…
Abstract Number: 3058 • 2015 ACR/ARHP Annual Meeting
NMR-Based Metabolomics Provides New Insights into the Inflammatory Processes in Takayasu Arteritis
Ramnath Misra¹, Anupam Guleria², Durga Prasanna Misra¹, Avadesh Pratap³, Durgesh Dubey⁴, Atul Rawat⁴, Smriti Chaurasia³, C L Khetrapal⁴, Dinesh Kumar⁴ and Paul Bacon⁵, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Centre of Biomedical Research, Lucknow, India, ³S.G.P.G.I.M.S, Department of Clinical Immunology, Lucknow, India, ⁴Centre for Biomedical Research, Lucknow, India, ⁵Rheumatology, Birmingham Universit, Birmingham, United Kingdom
Background/Purpose: Takayasu Arteritis (TA), a large vessel disease of unknown aetiology, is the orphan of the inflammatory vasculitides with no evidence base for therapy. It…

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