ACR Meeting Abstracts

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Abstracts tagged "Metabolism"

  • Abstract Number: 77 • 2019 ACR/ARP Annual Meeting

    Flux Analysis Reveals Influence of Rab4 Expression on Mitochondrial and Pentose Phosphate Pathway Metabolism of Lupus T Cells

    Tamas Faludi1, Nick Huang 1, Manuel Duarte 2, Joshua Lewis 2 and Andras Perl 3, 1Upstate Medical University, Syracuse, NY, 2Upstate Medical University, Syracuse, 3SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: HRES-1/Rab4 is a small GTPase enzyme which regulates endosomal trafficking. The protein is overexpressed in T cells of SLE patients (J Immunol. February 15,…
  • Abstract Number: 1043 • 2019 ACR/ARP Annual Meeting

    The Metabolic Intermediate Alpha-Ketoglutarate Suppresses the TGFβ-driven Profibrotic Responses of Dermal Fibroblasts

    Blaž Burja1, Gabriela Kania 2, Matija Tomšič 3, Tea Janko 3, Snezna Sodin-Semrl 3, Oliver Distler 4, Katja Lakota 3 and Mojca Frank-Bertoncelj 5, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, LJUBLJANA, Slovenia, 4Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 5University Hospital Zürich, Zürich, Switzerland

    Background/Purpose: Metabolic perturbations are emerging as drivers of fibroblast activation in fibrosis. Transcriptomic analyses have shown the enrichment of glycolysis and suppression of tricarboxylic acid…
  • Abstract Number: 2014 • 2019 ACR/ARP Annual Meeting

    Loss-of-function of the DNA Repair Nuclease MRE11A Induces Mitochondrial Failure and Tissue Inflammation in Rheumatoid Arthritis

    Yinyin Li 1, Yi Shen 1, Ke Jin 1, Zhenke Wen 1, Wenqiang Cao 1, Bowen Wu 1, Ru Wen 1, Lu Tian 1, Gerald Berry 1, Jorg Goronzy 1 and Cornelia Weyand1, 1Stanford University, Stanford, CA

    Background/Purpose: Patients with rheumatoid arthritis (RA) accumulate tissue-invasive, pro-inflammatory CD4+ T cells. Such T cells are metabolically reprogrammed, favoring cytokine production, lipogenesis and membrane formation…
  • Abstract Number: 2814 • 2019 ACR/ARP Annual Meeting

    Methionine Commits Immunometabolism and Epigenetic Regulation of BACH2 Loci in B Cells, Resulting in Biases Toward Plasmablast Differentiation in the Pathogenesis of SLE

    Mingzeng Zhang1, Shigeru Iwata 1, Maiko Hajime 1, Naoaki Ohkubo 1, Yasuyuki Todoroki 2, Hiroko Miyata 2, Jie Fan 2, Shingo Nakayamada 1, Kaoru Yamagata 1 and Yoshiya Tanaka 3, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan, 2The First Department of Internal Medicine, University of Occupational & Environmental Health Kitakyushu, Japan, Kitakyushu, Japan, 3University of Occupational and Environmental Health Japan, Kitakyushu, Japan

    Background/Purpose: Amino acids play an important role in various metabolic processes. However, the role of amino acid metabolism in the regulation of human B cell…
  • Abstract Number: 2817 • 2019 ACR/ARP Annual Meeting

    Lysosomal Placement of the Energy Sensors AMPK and mTORC1 Controls Tissue Inflammation in Rheumatoid Arthritis

    Zhenke Wen 1, Ke Jin 1, Yinyin Li 1, Bowen Wu 1, Jorg Goronzy 1 and Cornelia Weyand1, 1Stanford University, Stanford, CA

    Background/Purpose: CD4 T cells from patients with rheumatoid arthritis (RA) are metabolically reprogrammed, diverting glucose away from glycolysis towards the production of biosynthetic precursors. Several…
  • Abstract Number: 24 • 2019 ACR/ARP Annual Meeting

    Role of Trained Immunity in the Pathogenesis of Erdheim-Chester Disease

    Giulio Cavalli1, Riccardo Biavasco 1, Marina Ferrarini 2, Elisabetta Ferrero 2, Eugenio Montini 2, Simone Cenci 2, Cardaci Simone 2 and Lorenzo Dagna 1, 1Vita-Salute San Raffaele University, Milan, Italy, 2IRCCS San Raffaele Hospital, Milan, Italy

    Background/Purpose: Erdheim-Chester disease (ECD) is a chronic inflammatory disease characterized by infiltration of bone and other tissues by foamy macrophages. These cells exhibit activating mutations…
  • Abstract Number: 1015 • 2018 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Peripheral CD14+ Monocytes Are Hyper-Inflammatory, Hyper-Glycolytic and Retain a Memory Bias Toward M1 Macrophages

    Trudy McGarry1, Megan M. Hanlon2, Clare C. Cunningham3, Douglas J. Veale4 and Ursula Fearon5, 1St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, 2Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 3Molecular Rheumatology, Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 4Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 5Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Myeloid cells with a monocyte/macrophages phenotype are present in large numbers in the rheumatoid arthritis (RA) joint, significantly contributing to disease. This study aimed…
  • Abstract Number: 1037 • 2018 ACR/ARHP Annual Meeting

    Develop an in Vitro Model to Test the Different Behavior of mtDNA in OA and Healthy Patients, Based on Mitochondrial Activity and Metabolic Response

    Mercedes Fernandez Moreno1, Andrea Dalamao-Fernandez2, Tamara Hermida-Gómez3, Jenny Lund4, Arild Rustan4, Maria Eugenia Vazquez Mosquera5, Sara Relaño-Fernandez6, Ignacio Rego-Pérez5 and Francisco J Blanco7, 1Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), Spain. CIBER-BBN, Madrid, Spain, 2Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A CORUÑA, Spain, 3Rheumatology, INIBIC. Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. CIBER-BBN., A Coruña, Spain, 4Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Norway, Oslo, Norway, 5Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 6Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 7Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo HospitalarioUniversitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain

    Background/Purpose: Mitochondrial dysfunction is well documented in OA and has the capacity to alter chondrocyte function and viability, contributing to cartilage degeneration. Several studies have…
  • Abstract Number: 1040 • 2018 ACR/ARHP Annual Meeting

    The Potential Role of Choline Kinase Alpha in Osteoarthritis

    Roxana Coras1,2, Liang-Yu Chen3, Elsa Sanchez-Lopez4, Martin Lotz5, Ru Liu-Bryan1,3 and Monica Guma1,2, 1Medicine, University of California San Diego, La Jolla, CA, 2Medicine, Autonomous University of Barcelona, Bellatera, Spain, 3VA San Diego Healthcare System, San Diego, CA, 4University of California San Diego, La Jolla, CA, 5Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA

    Background/Purpose: Osteoarthritis (OA) is the most common joint disease and a leading cause of disability. Cartilage degeneration is the central characteristic of OA, and low-grade…
  • Abstract Number: 2034 • 2018 ACR/ARHP Annual Meeting

    Increased Invasive Capacity and Metabolic Activity in Synovial Fibroblasts from Children with Downs Arthropathy Compared to Juvenile Idiopathic Arthritis

    Sharon Ansboro1, Charlene Foley2, Monika Biniecka3, Emma MacDermott4, Douglas J. Veale5, Ronan Mullan6, Orla G Killeen7 and Ursula Fearon8, 1Molecular Rheumatology, Trinty College Dublin, Dublin, Ireland, 2Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland, 3Department of Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 4Our Lady's Children's Hospital, Crumlin, Dublin, Ireland, 5Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 6Department of Rheumatology,, Tallaght Hospital, Dublin, Ireland, 7National Centre for Paediatric Rheumatology, Dublin, Ireland, 8Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Downs Arthropathy (DA) is an inflammatory joint condition affecting children with Down syndrome, which is under-recognised, has a delayed diagnoses, resulting in chronic disability.…
  • Abstract Number: 2570 • 2017 ACR/ARHP Annual Meeting

    The Functional Consequence of Human (hu)TLR8 on Macrophage Immunometabolism and Renal Inflammation in Murine Systemic Lupus Erythematosus

    Naomi I. Maria1, Megan Woods2, Shani Martinez3, Weiqing Huang4 and Anne Davidson4, 1Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, 2Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, 3Feinstein Institute for Medical Research, Manhasset, NY, 4Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: Infiltrating macrophages are one of the hallmarks of renal inflammation and kidney damage in lupus nephritis. Increasing evidence suggests the crucial role of cell-specific…
  • Abstract Number: 2572 • 2017 ACR/ARHP Annual Meeting

    Rab4a Control over Glycolytic Metabolism and T-Cell Lineage Specification Protects from Intra-Alveolar Hemorrhage in Mouse Model of SLE

    Nick Huang1, Zachary Oaks2, Sarah Blair2, Thomas Winans2, Zhi-Wei Lai1, Katalin Banki3 and Andras Perl1, 1Medicine, SUNY Upstate Medical University, Syracuse, NY, 2SUNY Upstate Medical University, Syracuse, NY, 3Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease that involves all organs of the body. Without a known cure, a detailed understanding…
  • Abstract Number: 478 • 2016 ACR/ARHP Annual Meeting

    Evaluation of the Relationship Between Methotrexate Polyglutamation and Efficacy in the Collagen-Induced Arthritis Mouse Model

    Rakesh Singh1, Leon van Haandel2, Paul Kiptoo3, Mara L Becker4, Teruna Siahaan3 and Ryan Funk5, 1Department of Pharmacy Practice, University of Kansas Medical Center, Kansas City, KS, 22401 Gillham Road, Children's Mercy Hospitals and Clinics, Kansas City, MO, 3Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, 4Rheumatology, Children's Mercy Kansas City, Kansas City, MO, 5University of Kansas Medical Center, Kansas City, KS

    Background/Purpose: Polyglutamate metabolites of methotrexate (MTX) are believed to represent the pharmacologically active form of the drug and have been proposed as a biomarker to…
  • Abstract Number: 1571 • 2016 ACR/ARHP Annual Meeting

    Altered Bioenergetics, Mitochondrial Function and Pro-Inflammatory Pathways in RA Synovium in Response to Tofacitinib

    Carl Orr1, Trudy McGarry2, Monika Biniecka3, Jennifer McCormick4, Ursula Fearon5 and Douglas J. Veale1, 1Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, 2St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, 3St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 4Department of Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 5Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland

    Background/Purpose:  Rheumatoid arthritis (RA) is a chronic joint disease, characterised by synovial inflammation and destruction of articular cartilage/bone. The Janus-Kinase and Signal Transducer and Activator…
  • Abstract Number: 2570 • 2016 ACR/ARHP Annual Meeting

    Pyruvate Regulates Reactive Oxygen Species (ROS) Production, Dysfunction and Aberrant Metabolism of Mitochondria in Fibroblast-like Synoviocytes of Rheumatoid Arthritis

    Jeong Yeon Kim1,2, Shin Eui Kang2,3, Hyun Jung Yoo3,4, Ji Soo Park1, Eun Young Lee2, Eun Bong Lee2 and Yeong Wook Song3,4, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of, 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

    Background/Purpose:  In rheumatoid arthritis (RA), fibroblast-like synoviocyte (FLS) is a key component of invasive synovium and mediates inflammation and destruction of joint. Recently, change of…
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