Abstracts tagged "meta-analysis"

Abstract Number: 1389 • 2015 ACR/ARHP Annual Meeting
A Meta-Analysis of the Prevalence of the Ocular Manifestations in All Inflammatory Rheumatic Diseases
Jacqueline Hayworth¹ and Janet E. Pope², ¹Medicine, University of Western Ontario and U of Toronto, Toronto, ON, Canada, ²University of Western Ontario, London, ON, Canada
Background/Purpose: Many inflammatory rheumatic diseases (IRD) are associated with ocular involvement. The prevalence of these complications is not fully known. This meta-analysis was performed to…
Abstract Number: 1781 • 2015 ACR/ARHP Annual Meeting
Comparative Efficacy and Safety of Tacrolimus, Mycophenolate Mofetil, and Cyclophosphamide As Induction Therapy for Lupus Nephritis: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
Young Ho Lee and Gwan Gyu Song, Rheumatology, Korea University Medical Center, Seoul, South Korea
Background/Purpose: Cyclophosphamide (CYC) regimens improved renal outcomes, and have long been considered the gold standard for inducing renal remission and preventing renal flares in proliferative…
Abstract Number: 1833 • 2015 ACR/ARHP Annual Meeting
Musculoskeletal Complications of Systemic Lupus Erythematosus: Risk Factors for and Prevalence of Avascular Necrosis and Osteoporosis
Maeve Gamble¹ and Janet E. Pope², ¹Medicine, University of Western Ontario, London, ON, Canada, ²University of Western Ontario, London, ON, Canada
Background/Purpose: Osteoporosis (OP) and avascular necrosis (AVN) are well-recognized musculoskeletal complications of systemic lupus erythematosus (SLE) and cause morbidity. Steroid therapy and the underlying disease…
Abstract Number: 2475 • 2015 ACR/ARHP Annual Meeting
Association Between Fibromyalgia and Suicidal Risk: A Systematic Review and Meta-Analysis
Sikarin Upala¹ and Anawin Sanguankeo², ¹Internal Medicine, Bassett Medical Center, Cooperstown, NY, ²Bassett Medical Center, Cooperstown, NY
Background/Purpose: Chronic pain conditions are related poor overall health, economic burden, and mental disorders including suicidal ideation (SI), suicide attempts (SA), and completed suicides. Fibromyalgia…
Abstract Number: 2370 • 2014 ACR/ARHP Annual Meeting
Management of Perioperative Tumor Necrosis Factor α Inhibitors in Rheumatoid Arthritis Undergoing Arthroplasty: A Systematic Review and Meta-Analysis
Susan M. Goodman¹, Indu Menon², Rie Smethurst³, Paul Christos⁴ and Vivian P. Bykerk¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, NY, NY, ³Education - Academic Training, Hospital for Special Surgery, NY, NY, ⁴Healthcare Policy and Research, Weill Cornell Medical College, NY, NY
Background/Purpose: Tumor Necrosis Factor α inhibitors (TNFi) are widely used in patients with RA (Rheumatoid Arthritis) undergoing orthopedic surgery, yet its optimal perioperative management is…
Abstract Number: 1074 • 2014 ACR/ARHP Annual Meeting
A Meta-Analysis of the Risk of Venous Thromboembolism in Inflammatory Rheumatic Diseases
Jason J Lee¹ and Janet E. Pope², ¹Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, ²St Joseph Health Care, London, ON, Canada
Background/Purpose: We performed a meta-analysis investigating the risk of developing deep vein thrombosis (DVT) and/or pulmonary embolisms (PE) in patients with inflammatory arthritis, vasculitis, and…
Abstract Number: 875 • 2014 ACR/ARHP Annual Meeting
Treatment-Related Outcomes in Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: A Pooled Analysis of 12 Randomized Controlled Trials
Rennie L. Rhee¹, Nicole B. Gabler², Amy Praestgaard², Peter A. Merkel³ and Steven M. Kawut⁴, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA, ⁴Pulmonary and Critical Care, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Recent studies have shown that therapies for pulmonary arterial hypertension (PAH) improve exercise capacity, but subgroup analyses suggest that these therapies may be less…
Abstract Number: 747 • 2014 ACR/ARHP Annual Meeting
Systemic Sclerosis Patients with Antitopoisomerase Antibodies Showed Significant Association with CCR6 Polymorphisms
Javier Martin¹, Eguzkine Ochoa², Jose Ezequiel Martin¹, Shervin Assassi³, Lorenzo Beretta⁴, Patricia Carreira⁵, Carmen Pilar Simeon⁶, Eugénie Koumakis⁷, Philippe Dieude⁸, Yannick Allanore⁹, Francisco J. García-Hernández¹⁰, Gerard Espinosa¹¹, Ivan Castellvi Barranco¹², Luis Trapiella¹³, Luis Rodriguez Rodriguez¹⁴, Miguel A González-Gay¹⁵, María-Victoria Egurbide¹⁶, Luis Saez¹⁷, José Luis Callejas¹⁸, JA Vargas-Hitos¹⁹, Nicolas Hunzelmann²⁰, Gabriela Riemekasten²¹, Torsten Witte²², Jörg HW Distler²³, Alexander Kreuter²⁴, Claudio Lunardi²⁵, Alessandro Santaniello²⁶, Filemon K. Tan³, Frank C. Arnett³, Paul Shiels²⁷, Ariane L. Herrick²⁸, Jane Worthington²⁹, Madelon C. Vonk³⁰, Bobby P.C. Koeleman³¹, T.R.D.J. Radstake³² and Maureen Mayes³³, ¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²Immunology, Instituto de Parasitología y Biomedicina Lopez Neyra (IPBLN-CSIC), Granada, Spain, ³Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴Via Francesco Sforza 28, Ospedale Maggiore Policlinico, Milano, Italy, ⁵Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, ⁶Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain, ⁷Rheumatology A department, Cochin Hospital, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁸Rhumatologie, Hopital Bichat Claude Bernard, Paris, France, ⁹Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France, ¹⁰Internal Medicine, Hospital Virgen del Rocío, Sevilla, Spain, ¹¹Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Barcelona, Spain, ¹²Hosp. De Sta. Creu i S. Pau, Vilafranca del Pened, Spain, ¹³Department of Internal Medicine,, Hospital Universitario Central de Asturias, Asturias, Spain, ¹⁴Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ¹⁶Autoimmune Disease Research Unit, Service of Internal Medicine,, Hospital de Cruces, UPV/EHU, Barakaldo, Spain, Barakaldo, Spain, ¹⁷Unidad de Enfermedades Autoinmunes, Servicio de Medicina Interna, Hospital Miguel Servet, Zaragoza, Spain, ¹⁸Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain, ¹⁹Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain, ²⁰Department of Dermatology, University of Cologne, Cologne, Germany, ²¹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ²²Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ²³Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²⁴Department of Dermatology, Venereology, and Allergologie, HELIOS St. Elisabeth Hospital, Oberhausen, Germany, ²⁵Department of Medicine, Università degli Studi di Verona, Verona, Italy, ²⁶Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²⁷University of Glasgow, Glasgow, United Kingdom, ²⁸Musculoskeletal Research Group, School of Translational Medicine, Manchester Academic Health Science Centre, Salford Royal Hospital, University of Manchester., Salford, United Kingdom, ²⁹Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ³⁰Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³¹Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ³²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³³Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX
Background/Purpose: Systemic sclerosis (SSc), also known as scleroderma, is an inflammatory autoimmune disease characterized by fibrosis of the skin and internal organs, vascular damage and…
Abstract Number: 673 • 2014 ACR/ARHP Annual Meeting
A Comparison of Rheumatoid Arthritis and Systemic Lupus Erythematosus Trial Design: Ways to Improve Positive Trials in Systemic Lupus Erythematosus
Amy Miles¹ and Janet E. Pope², ¹Medicine, University of Western Ontario and U of Toronto, London, ON, Canada, ²St Joseph Health Care, London, ON, Canada
Background/Purpose: Recent SLE RCTs were examined and compared to rheumatoid arthritis (RA) RCT to suggest modifications to SLE RCTs that could improve the future success…
Abstract Number: 477 • 2014 ACR/ARHP Annual Meeting
Leflunomide Use Is Not Associated with an Increased Risk of Lung Disease in Rheumatoid Arthritis: A Meta-Analysis of Randomised Controlled Trials
Richard Conway¹, Candice Low², Robert J. Coughlan¹, Martin O'Donnell³ and John J. Carey¹, ¹Rheumatology, Galway University Hospitals, Galway, Ireland, ²Medicine, St. James Hospital, Dublin, Ireland, ³Clinical Research Facility, Galway University Hospitals, Galway, Ireland
Background/Purpose Leflunomide is an effective treatment for rheumatoid arthritis. An association between pulmonary adverse events, in particular interstitial lung disease, and leflunomide use has been…
Abstract Number: 2772 • 2014 ACR/ARHP Annual Meeting
The Use of Imaging in the Diagnosis of Polymyalgia Rheumatica: Systematic Literature Review and Meta-Analysis
Sarah Mackie¹, Gouri Koduri², Catherine L. Hill^3,4, Andrew Hutchings⁵, Richard J. Wakefield⁶, Bhaskar Dasgupta⁷ and Jeremy Wyatt⁸, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ²Rheumatology, York Teaching Hospital NHS Foundation Trust, York, United Kingdom, ³Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia, ⁴Discipline of Medicine, University of Adelaide, Adelaide, Australia, ⁵Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁶NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁷Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁸Leeds Insitute of Health Sciences, University of Leeds, Leeds, United Kingdom
Background/Purpose ACR/EULAR provisional classification criteria for polymyalgia rheumatica (PMR) incorporate musculoskeletal ultrasound of shoulder and hip (bursitis and synovitis given equal weight). Our objective was…
Abstract Number: 2537 • 2014 ACR/ARHP Annual Meeting
Diagnostic Accuracies of Sialography and Salivary Ultrasonography in Sjogren’s Syndrome Patients: A Meta-Analysis
Young Ho Lee¹ and Gwan Gyu Song², ¹Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, ²Div of Rheum, Dept of Int Medicine, Guro Hospital, Korea Univ College of Medicine, Seoul, South Korea
Background/Purpose Ultrasonography (US) may come to replace conventional invasive examinations in clinical practice. However, the diagnostic accuracy of salivary US has not been clearly compared…
Abstract Number: 2501 • 2014 ACR/ARHP Annual Meeting
Indirect Comparison of Tocilizumab and Tofacitinib in Patients with Rheumatoid Arthritis
Stacey Chang¹, Laura Sawyer¹ and Fred Dejonckheere², ¹Symmetron Limited, London, United Kingdom, ²F. Hoffmann-La Roche, Basel, Switzerland
Background/Purpose: Tocilizumab (TCZ) is a recombinant, humanized, monoclonal antibody directed against the cytokine interleukin-6 receptor, and tofacitinib (Tofa) is an oral, synthetic, disease-modifying antirheumatic drug…
Abstract Number: 2433 • 2014 ACR/ARHP Annual Meeting
Efficacy of Ketoprofen Vs Ibuprofen and Diclofenac for Treating Pain in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Fabiola Atzeni^1,2, Alessandra Monguzzi³, Elisabetta Grillo³, Luigi Lanata³ and Piercarlo Sarzi-Puttini², ¹V Giovanni Battista Grassi 74, Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ²Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ³Medical Department, Dompé SpA, Milan, Italy
Background/Purpose: Patients with rheumatic diseases, including rheumatoid arthritis (RA), describe symptoms such as pain and stiffness as important factors affecting their quality of life. The…
Abstract Number: 2443 • 2014 ACR/ARHP Annual Meeting
A New Meta-Analysis on Safety of Ketoprofen Vs Ibuprofen and Diclofenac: Risk and Benefit of Nsaids Beyond Efficacy Meta-Analysis
P. Sarzi-Puttini¹, F. Atzeni¹, Luigi Lanata², Alessandra Monguzzi² and Michela Bagnasco², ¹Rheumatology Unit, L. Sacco University Hospital of Milan, Milan, Italy, ²Medical Department, Dompé SpA, Milan, Italy
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for management of mild-to-moderate pain, chronic inflammatory and degenerative joint diseases. Among NSAIDs, ketoprofen, ibuprofen and diclofenac…

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