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Abstracts tagged "meta-analysis and rheumatoid arthritis (RA)"

  • Abstract Number: 2483 • 2018 ACR/ARHP Annual Meeting

    Major Secular Trends of Patient Characteristics and Inclusion Criteria in RA Clinical Trials

    Andreas Kerschbaumer1, Bruno Bierbaumer2, Josef S. Smolen3 and Daniel Aletaha4, 1Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Independent, Munich, Germany, 3Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 4Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Rheumatoid arthritis (RA) is among the most intensively studied chronic inflammatory musculoskeletal diseases. Over the past two decades numerous new compounds have been tested…
  • Abstract Number: 1524 • 2018 ACR/ARHP Annual Meeting

    Malignancies and Serious Infections in Randomized Controlled Trials of Janus Kinase Inhibitors in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

    Maria A. Lopez-Olivo1, Jean Tayar2, Natalia Zamora3, Gregory Pratt4 and Maria Suarez-Almazor5, 1Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA, Houston, TX, 3Reumatologia, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, 4Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, 5Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA, Houston, TX

    Background/Purpose: Two JAK inhibitors are currently approved by different agencies worldwide for their use in patients with rheumatoid arthritis. The safety profile of these agents…
  • Abstract Number: 438 • 2017 ACR/ARHP Annual Meeting

    High Multi-Biomarker Disease Activity Score Is Associated with High Risk of Radiographic Progression in Six Cohorts

    Jeffrey R. Curtis1, Cecilie Heegaard Brahe2, Mikkel Østergaard3, Merete Lund Hetland2, Karen Hambardzumyan4, Saedis Saevarsdottir4, Xingbin Wang5, Eric H. Sasso5 and Tom W.J. Huizinga6, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 3Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 4Karolinska Institute and Karonlinska University Hospital, Stockholm, Sweden, 5Crescendo Bioscience Inc., South San Francisco, CA, 6Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The multi-biomarker disease activity (MBDA) test uses a validated algorithm with 12 serum protein biomarkers to assess disease activity in patients with RA. The…
  • Abstract Number: 1365 • 2017 ACR/ARHP Annual Meeting

    Correlation of the Multi-Biomarker Disease Activity Score with Composite Rheumatoid Arthritis Disease Activity Measures: A Systematic Review and Meta-Analysis

    Tate Johnson1, Kyle A. Register2, Cynthia Schmidt3, James R. O'Dell4, Ted R. Mikuls5, Kaleb Michaud1 and Bryant R. England6, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 3McGoogan Library of Medicine, University of Nebraska Medical Center, Omaha, NE, 4Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 5Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 6Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The regular assessment of disease activity is necessary to implement a treat-to-target management approach in RA. The Multi-Biomarker Disease Activity (MBDA) Score is a…
  • Abstract Number: 2395 • 2017 ACR/ARHP Annual Meeting

    Recommendations on the Management of Rheumatoid Arthritis in Patients with Cancer: A Systematic Review of Clinical Practice Guidelines and Consensus Statements

    Maria A. Lopez-Olivo1, Ines Colmegna2, Aliza Matusevich1, Susan Ruyu Qi3, Natalia Zamora1, Robin Sharma1, Gregory Pratt4 and Maria Suarez-Almazor1, 1Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, 2Division of Rheumatology, Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada, Montreal, QC, Canada, 3Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Montreal, QC, Canada, 4Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX

    Background/Purpose: To compare the recommendations of clinical practice guidelines (CPGs) and consensus statements (CSs) regarding the management of rheumatoid arthritis (RA) in patients with cancer.…
  • Abstract Number: 2429 • 2017 ACR/ARHP Annual Meeting

    Towards Precision Medicine in Rheumatoid Arthritis (RA): Trans-Ethnic Analysis and Prioritization of SNPs in the AFF3 Locus

    Vincent A. Laufer1, Maria I. Danila2, Richard J. Reynolds3, Leah C. Kottyan4, Kenneth Kaufman5, John B. Harley6, Carl D Langefeld7, Donna Arnett8 and S. Louis Bridges Jr.9, 1Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 6Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Wake Forest University, Winston Salem, NC, 8University of Kentucky College of Public Health, Lexington, KY, 9Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL

    Background/Purpose: Genetic variants in AFF3 have been associated with RA, including in our GWAS and ImmunoChip analyses of African-Americans (610 RA; 1543 controls). Likewise, an…
  • Abstract Number: 536 • 2016 ACR/ARHP Annual Meeting

    Precision Medicine in Rheumatoid Arthritis: Systematic Literature Review and Meta-Analysis on the Diagnostic Accuracy of Anti-CCP Tests for the Diagnosis of Rheumatoid Arthritis

    Gaia Gallo1, Barbara Mascialino1, Donna Fountain2, Kevin Cadwell2 and Sigrid Sjolander1, 1Immuno Diagnostics, Thermo Fisher Scientific, Uppsala, Sweden, Uppsala, Sweden, 2PHMR, Berkeley Works, Berkley Grove, London, London, United Kingdom

    Background/Purpose:  Biological markers are objective molecular indicators possessing diagnostic, prognostic and predictive utility. The detection of antibodies to cyclic citrullinated peptides (Anti-CCP) may occur long…
  • Abstract Number: 1490 • 2016 ACR/ARHP Annual Meeting

    Metabolic and Cardio-Vascular Benefits of Hydroxychloroquine in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

    Claire Rempenault1, Thomas Barnetche2, Jacques Morel3, Cédric Lukas4, Cécile Gaujoux-Viala5, Bernard Combe6 and Charlotte Hua7, 1Rheumatology, CHU Lapeyronie, University of Montpellier, France, 2Rheumatology Department, Pellegrin University Hospital, BORDEAUX, France, 3Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, 4Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, 5Rheumatology Department, University Hospital of Nîmes and EA2415, Montpellier University, Nîmes, France, 6Département Rhumatologie, Hôpital Lapeyronie, Montpellier, France, 7Department of Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France

    Background/Purpose: Cardiovascular disease (CVD) is the leading cause of mortality in rheumatoid arthritis (RA) patients. Hydroxychloroquine (HCQ) has been shown to improve major outcomes like…
  • Abstract Number: 1627 • 2016 ACR/ARHP Annual Meeting

    Network Meta-Analysis to Assess the Relative Efficacy of Sirukumab, an Anti–IL-6 Cytokine Monoclonal Antibody, in Combination Therapy for Patients with Active Rheumatoid Arthritis Despite Conventional Dmards

    Steve Peterson1, Maud Pacou2, Drifa Belhadi2, Suzy Van Sanden1, Thomas Webb1, Rita Ganguly3, Regina Kurrasch3, Ravi Rao3, Benjamin Hsu1, Kaiyin Fei1, Danuta Kielar1 and Rafael Alfonso3, 1Janssen Research & Development, LLC, Spring House, PA, 2Amaris, Paris, France, 3GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom

    Background/Purpose: Sirukumab is a human anti-interleukin-6 cytokine monoclonal antibody evaluated for the treatment of moderate to severe active rheumatoid arthritis (RA) and other diseases.  Our…
  • Abstract Number: 1676 • 2015 ACR/ARHP Annual Meeting

    Systematic Review and Network Meta-Analysis of Combination Treatments in Disease Modifying Anti-Rheumatic Drug Experienced Patients with Severe Rheumatoid Arthritis: Analysis of American College of Rheumatology Criteria Scores 20, 50, and 70: An Update

    Michelle E. Orme1, Charles Hawes2 and Stephen A. Mitchell3, 1ICERA consulting UK, Swindon, United Kingdom, 2Pfizer UK, Surrey, United Kingdom, 3Abacus International UK, Bicester, United Kingdom

    Background/Purpose: Biologic disease-modifying anti-rheumatic drugs (DMARDs) in combination with conventional DMARDs provide patients with severe rheumatoid arthritis (RA) and an inadequate response to conventional DMARDs…
  • Abstract Number: 500 • 2015 ACR/ARHP Annual Meeting

    Ofatumumab for Rheumatoid Arthritis: A Cochrane Systematic Review and Meta-Analysis

    Vidhu Anand1, Sachit Anand2, Sushil Garg3, Maria A. Lopez-Olivo4 and Jasvinder A. Singh5, 1University of Minnesota, Minneapolis, MN, 2All India Institute of Medical Sciences, New Delhi, India, 3The University of Minnesota, Minneapolis, MN, 4General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 5University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Ofatumumab is a unique anti-CD20 monoclonal antibody with its epitope more proximal and distinct from the epitope recognized by rituximab or by other anti-CD20…
  • Abstract Number: 1400 • 2014 ACR/ARHP Annual Meeting

    Risk of Venous Thromboembolic Events in Patients with Rheumatoid Arthritis: A Meta-Analysis of Observational Studies

    Michelle Avina1, Sally Choi2, Sharan Rai3, Hyon K. Choi4 and Mary De Vera3,5, 1Faculty of Sciences, Arthritis Research Centre of Canada/University of British Columbia, Richmond, BC, Canada, 2Arthritis Research Centre of Canada/University of British Columbia, Richmond, BC, Canada, 3Arthritis Research Centre of Canada, Richmond, BC, Canada, 4Boston University School of Medicine, Boston, MA, 5Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Venous thromboembolism (VTE), which includes both deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common vascular event after myocardial infarction…
  • Abstract Number: 499 • 2013 ACR/ARHP Annual Meeting

    Efficacy and Safety Of Infliximab Or Adalimumab Vs Abatacept In Patients With Rheumatoid Arthritis and An Inadequate Response To Methotrexate: Attest-Ample Network Randomized Trial

    Robin Christensen1, Simon Tarp1, Daniel Furst2, Lars E. Kristensen3 and Henning Bliddal4, 1Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, 2David Geffen School of Medicine, University of California, Los Angeles, CA, 3Rheumatology, Department of Clinical Sciences, Lund, Section of Rheumatology, Lund University, Lund, Sweden, 4Department of Rheumatology, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark

    Background/Purpose: Using combined data from the ATTEST [1] and AMPLE [2] study comparing infliximab and adalimumab with abatacept in patients with rheumatoid arthritis (RA), we…
  • Abstract Number: 894 • 2012 ACR/ARHP Annual Meeting

    Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts

    A. Krabben1, A. G. Wilson2, R. Knevel1, A. Zhernakova3, E. Brouwer3, E. Lindqvist4, T. Saxne4, G. Stoeken-Rijsbergen1, J. A. B. van Nies1, D. P. C. de Rooy1, T.W.J. Huizinga1, B. P. C. Koeleman5, R. E. M. Toes1, P. K. Gregersen6 and A. H. M. van der Helm-van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Infection & Immunity, University of Sheffield, Sheffield, United Kingdom, 3Rheumatology and Clinical Immunology, University of Groningen, University Medical Center, Groningen, Netherlands, 4Rheumatology, Lund University, Lund, Sweden, 5Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 6Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY

    Background/Purpose: The severity of RA is reflected by the severity of radiological joint destruction. It is highly variable between patients and up to 58% of…
  • Abstract Number: 1180 • 2012 ACR/ARHP Annual Meeting

    The Sex-Determining Region Y Box 6 Locus: Shared Genetic Susceptibility Between Rheumatoid Arthritis and Psychotic Disorder

    Tony R. Merriman1, Nicola Dalbeth2, Andrew Harrison3, John Highton4, Lisa K. Stamp5, Malcolm D. Smith6, Benedicte A. Lie7, Tore K. Kvien8, Timothy Radstake9, Marieke J.H. Coenen10, Barbara Franke11, Jasper Broen12, Piet Van Riel13, Pilar Barrera14, Sophia Steer15, Marilyn E. Merriman1, Amanda Phipps-Green1, Ruth Topless1, Mansour Zamanpoor16 and Wan Rohani Wan Tain17, 1Department of Biochemistry, University of Otago, Dunedin, New Zealand, 2Medicine, University of Auckland, Auckland, New Zealand, 3Rheumatology Unit, Hutt Hospital, Lower Hutt, New Zealand, 4Dept of Medicine, Univ of Otago Med Sch, Dunedin, New Zealand, 5Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand, 6Rheumatology Research Unit, Rheumatologist, Adelaide, Australia, 7Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway, 8Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 9Rheumatology, Radboud University Nijmegen Medical Centre, University Medical Center Utrecht, Nijmegen, Utrecht, Netherlands, 10Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 11Human Genetics (855), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 12Department of Rheumatology & Clinical Immunology, University Medical Center, Utrecht, Netherlands, 13Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 14Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 151 Sloane Ct East Flat 7, London, United Kingdom, 16University of Otago, Dunedin, New Zealand, 17Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Malaysia

    Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease and schizophrenia (SZ) is a common psychotic disorder. There is an established negative association between RA…
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