ACR Meeting Abstracts

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Abstracts tagged "Mesenchymal stem cells"

  • Abstract Number: 0861 • ACR Convergence 2024

    Stem Cell Function and Capsule Tissue Composition Are Associated with Symptoms, Joint Range of Motion and Radiographic Severity in People with Knee Osteoarthritis

    T Mark Campbell1, Robert Feibel2, Jeff Dilworth3, Odette Laneuville4 and Guy Trudel5, 1Bruyère Research Institute, Ottawa, ON, Canada, 2The Ottawa Hospital, Ottawa, ON, Canada, 3University of Wisconsin, Madison, WI, 4University of Ottawa, Ottawa, ON, Canada, 5Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Background/Purpose: Osteoarthritis is a common and debilitating condition without cure. Increased OA severity is associated with lost range of motion (ROM) in the affected joint.…
  • Abstract Number: 1990 • ACR Convergence 2024

    Human Umbilical Cord Mesenchymal Stem Cell-derived Microvesicles Alleviate Pulmonary Fibrosis by Inhibiting Monocyte-macrophage Migration Through ERK1/2 Signaling-mediated Suppression of CCL2 Expression

    Xiuping Liang, West China Hospital, Sichuan University, Cheng Du Shi, Sichuan, China

    Background/Purpose: Pulmonary fibrosis (PF) is a disease with high morbidity and mortality rates, but effective treatment options extremely limited. Mesenchymal stem cells (MSCs) and their…
  • Abstract Number: 2271 • ACR Convergence 2024

    Intra-Articular Injection of Human Bone Marrow-Derived Mesenchymal Stem Cells in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial

    Jennifer Lee1 and Ji Hyeon Ju2, 1seoul st mary's hospital, Seoul, South Korea, 2Seoul St MAry's hospital, Seoul, Republic of Korea

    Background/Purpose: To assess the impact of a single intra-articular (IA) injection of bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with knee osteoarthritis (OA).Methods: This…
  • Abstract Number: 2290 • ACR Convergence 2024

    Umbilical Cord-derived Mesenchymal Stem Cells Suppress Sjogren’s Syndrome Pathology

    Yukitomo Hagiwara1, Goh Murayama2, Taiga Kuga2, Yujin Nishioka2, Takumi Saito2, Yu Yamaji2, Tomoko Miyashita2, Makio Kusaoi3, Ken Yamaji2 and Naoto Tamura2, 1Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan, 2Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan

    Background/Purpose: Primary Sjögren's syndrome (pSS) is characterized by lymphocytic infiltration of the salivary and lacrimal glands, leading to functional loss and gradually causing dry mouth…
  • Abstract Number: 0277 • ACR Convergence 2024

    Mesenchymal Stem Cells Derived from Human Bone Marrow Ameliorate Monosodium Urate Crystal-induced Inflammation

    Jennifer Lee1 and Ah Young Choi2, 1seoul st mary's hospital, Seoul, South Korea, 2The Cactholic University of Korea, Seoul, Republic of Korea

    Background/Purpose: Mesenchymal stem cells (MSCs) have anti-inflammatory properties and have been implicated in several inflammatory diseases. Acute gout is initiated by IL-1β produced by monosodium…
  • Abstract Number: 0534 • ACR Convergence 2024

    Patient Reported Outcomes and Disease Activity from a Phase 1 Double-Blind Randomized Clinical Trial of Allogeneic Mesenchymal Stem Cells in Early Rheumatoid Arthritis

    Alexandre Matar1, Maya Breitman2, Tracey Bonfield3, Maricela Haghiac4, Jane Reese3, Emma Barnboym5, Steven Lewis6, Hillard Lazarus7 and Nora Singer8, 1MetroHealth, Westlake, OH, 2MetroHealth Medical Center,Case Western Reserve University School of Medicine, Cleveland, OH, 3Case Western Reserve University, Cleveland, OH, 4Metrohealth Medical Center, Cleveland, OH, 5The MetroHealth System, Cleveland, OH, 6Case Western University, MetroHealth, Cleveland, OH, 7Case Western Reserve University/University Hospitals, Cleveland, OH, 8MetroHealth System at Case Western Reserve University School of Medicine, Cleveland, OH

    Background/Purpose: Mesenchymal stem (stromal) cells (MSCs) constitute an emerging therapeutic strategy for several human diseases. Small non-randomized studies have shown that MSCs may be a…
  • Abstract Number: 0871 • ACR Convergence 2023

    Mitochondrial Transfer Functionally Restores the Human Osteoarthritis (OA) Chondrocyte, Is Protective Against Oxidative Stress and Improves OA in a Clinical Model of Disease

    Fernando Figueroa1, Angela Court2, Patricia Luz Crawford2, Ana Maria Vega Letter2, Francesca Velarde2, Cynthia Garcia2 and Maroun Khoury2, 1IMPACT, Santiago de Chile, Chile, 2IMPACT, Santiago, Chile

    Background/Purpose: Osteoarthrosis (OA) is a leading cause of pain, disability and early mortality, with no disease modifying treatments. Mitochondrial dysfunction is a known driver of…
  • Abstract Number: 1724 • ACR Convergence 2023

    Human Embryonic Stem Cell-derived Mesenchymal Stem Cells Attenuates Experimental Pulmonary Fibrosis Through Mitochondria Transfer Mediated Anti-apoptotic and Immunomodulatory Effects

    Hanna Lee1, Suhee Kim2, Mingyo Kim2, Ok-Yi Jeong3 and Sang-Il Lee2, 1Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, South Korea, 2Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine and Hospital, JinJu, South Korea, 3Division of Rheumatology, Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea

    Background/Purpose: Interstitial lung disease (ILD) is a serious condition characterized by inflammation and fibrosis in the lung interstitium. The important subtypes of ILD include idiopathic…
  • Abstract Number: 1991 • ACR Convergence 2023

    Therapeutic Efficacy of Intra Articular Injection of Human Bone Marrow Derived Mesenchymal Stem Cells in Knee Osteoarthritis; Randomized, Double-blind, Placebo-controlled Clinical Trial

    Ji Won Yang, Bong-Woo Lee, Jennifer Lee and Ji Hyeon Ju, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Background/Purpose: Osteoarthritis (OA) is severe and intractable musculoskeletal disease that eventually leads to joint failure and pain due to inflammation and joint injury. Mesenchymal stem…
  • Abstract Number: 2496 • ACR Convergence 2023

    HXB-319, a New Generation Mesenchymal Stromal Cell (MSC) Therapy, Alleviates Neutrophilic Inflammation, and End-organ Damage in Pulmonary Renal Syndromes by Inducing FoxP3+ Tregs, and by Promoting TNFα-stimulated gene-6 (TSG-6) over Expression

    Hulya Bukulmez1, Adrienne Dennis1, Jane Reese-Koc2, Scott Sieg2 and Steven Emancipator2, 1MetroHealth Medical Center, Department of Pediatrics, Cleveland, OH, 2Case Western Reserve University, Cleveland, OH

    Background/Purpose: Mesenchymal stromal cells (MSCs) have been shown to be safe therapies in more than 100 human clinical trials. However, MSCs clinical efficacy is variable,…
  • Abstract Number: 0030 • ACR Convergence 2022

    Fluidic Shear Stress Reduces TNFα-mediated Cartilage Damage in a 3D Model of Degenerative Joint Disease

    Alexandra Damerau1, Duc Ha Do Nguyen1, Christina Lubahn1, Thomas Leeuw2, Timo Gaber3 and Frank Buttgereit3, 1Charité-Universitätsmedizin Berlin, Berlin, Germany, 2Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany, 3Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany

    Background/Purpose: Degenerative joint diseases such as osteoarthritis (OA) ultimately result in the breakdown of cartilage. The exact underlying mechanisms of cause and progression of OA…
  • Abstract Number: 1369 • ACR Convergence 2021

    Adipose Tissue-Derived Stromal Vascular Fraction Plus Fat Grafts for Hand Therapy in Patients with Systemic Sclerosis. a Randomized Controlled Clinical Trial

    Martín Iglesias1, Iván Torre-Villalvazo1, Armando Tovar-Palacio1, Alejandro Zentella-Dehesa1, Patricia Butrón-Gandarillas1, Marta Durand-Carbajal1, Erik Torre-Anaya2, Martha Guevara2 and Tatiana Rodriguez-Reyna2, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico

    Background/Purpose: Adipose tissue-derived Stromal Vascular Fraction (ADSVF) has been proposed as regenerative treatment for hand deformities and digital ulcer healing in patients with Systemic Sclerosis…
  • Abstract Number: 1440 • ACR Convergence 2021

    Targeting Endogenous Mesenchymal Stromal Cell Response to Interferong in Sjӧgren’s Syndrome

    Sara McCoy, Ilya Gurevic, Maxwell Parker and Jacques Galipeau, University of Wisconsin, Madison, WI

    Background/Purpose: Sjӧgren’s syndrome (SS) is a systemic autoimmune disease that is associated with a lymphoma risk 14-fold that of the general population. Greater focal lymphocytic…
  • Abstract Number: 1502 • ACR Convergence 2021

    Longitudinal Changes in B Cell Subsets in Patients in the Mesenchymal Stromal Cell Trial in Lupus: Analysis of the First Cohort

    Diane Kamen1, S Sam Lim2, Scott Jenks3, Regina Bugrovosky3, Aisha Hill3, Chungwen Wei3, Cristina Drenkard3, Kenneth Kalunian4, Ummara Shah5, Mariko Ishimori6, Rosalind Ramsey-Goldman7, Saira Sheikh8, Mary Alison Mahieu7, Daniel Wallace9, Ellen Goldmuntz10 and Gary Gilkeson1, 1Medical University of South Carolina, Charleston, SC, 2Department of Medicine, Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, 3Emory University, Atlanta, GA, 4UC San Diego, La Jolla, CA, 5University of Rochester, Rochester, NY, 6Cedars-Sinai Health System, Los Angeles, CA, 7Northwestern University, Chicago, IL, 8University of North Carolina, Chapel Hill, NC, 9Attune Health, Beverly Hills, CA, 10National Institutes of Health, Bethesda, MD

    Background/Purpose: Recent advances allow expanded identification of B cell subtypes of pathogenic potential in lupus. Of particular interest are IgD- CD27- double negative (DN2) B…
  • Abstract Number: 1709 • ACR Convergence 2021

    Long-term Safety of a Single Infusion of Human Umbilical Cord Blood-derived Mesenchymal Stem Cell Therapy in Rheumatoid Arthritis: The 5-year Follow-up of the Phase I Clinical Trial

    Min Jung Kim1, Eun Hye Park2 and Kichul Shin3, 1Seoul Metropolitan Government–Seoul National University Boramae Medical Center, Seoul, Republic of Korea, 2Chung-Ang University Hospital, Seoul, Republic of Korea, 3Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea

    Background/Purpose: Mesenchymal stem cell (MSC) therapy represents a promise for the treatment of autoimmune diseases due to its potent immunomodulatory effect. We investigated the long-term…
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