Mediation Archives - ACR Meeting Abstracts

Abstract Number: 1947 • ACR/ARHP Annual Meeting 2018
Do Changes in Pain Sensitization and Depressive Symptoms Mediate the Effect of Extreme Weight Loss on Knee Pain Improvement?
S. Reza Jafarzadeh¹, Tuhina Neogi¹, Joshua J. Stefanik², Margaret M. Clancy¹, Jing-Sheng Li³ and David T. Felson¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Department of Physical Therapy, University of Delaware, Newark, DE, ³College of Health and Rehabilitation Sciences: Sargent College, Boston University, Boston, MA
Background/Purpose: We previously showed that the one-year effects of weight loss on knee pain reduction were not mediated by changes in structural features of osteoarthritis…
Abstract Number: 663 • ACR/ARHP Annual Meeting 2018
Relative Contributions of Improvements in the Psoriasis Area and Severity Index (PASI) and Disease Activity Index for Psoriatic Arthritis (DAPSA) to Improvements in Quality of Life and Function in Patients with Psoriatic Arthritis
Alexis Ogdie¹, Prashanth Sunkureddi², Baojin Zhu³, Aubrey Spraberry⁴, William Malatestinic⁴, Yan Dong⁴ and David Shrom³, ¹University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Clear Lake Rheumatology Center, Nassau Bay, TX, ³LRL, Eli Lilly and Company, Indianapolis, IN, ⁴Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous inflammatory condition characterized by the clinical domains of arthritis, enthesitis, dactylitis, spondylitis, and psoriasis. While it is known…
Abstract Number: 2209 • ACR/ARHP Annual Meeting 2017
Leptin and Adiponectin Mediate the Association between Body Mass Index and Hand and Knee Osteoarthritis
F.P.B. Kroon¹, A. Veenbrink¹, R. de Mutsert², A.W. Visser¹, Saskia le Cessie³, F.R. Rosendaal² and M. Kloppenburg^1,2, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Associations between obesity and osteoarthritis (OA) in non-weight bearing joints suggest that systemic influences also contribute to OA. Systemically active substances secreted by adipose…
Abstract Number: 2208 • ACR/ARHP Annual Meeting 2016
Mediators of the Relationship Between Pain and Disability in the Distal Upper Limb
Daniel Whibley^1,2,3, Kathryn Remmes Martin^1,2,3, Karina Lovell⁴, Gareth T. Jones^1,2,3 and Arm Pain Trial Investigators, ¹Arthritis Research UK / MRC Centre for Musculoskeletal Health and Work, University of Aberdeen, Aberdeen, United Kingdom, ²Aberdeen Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, United Kingdom, ³Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom, ⁴School of Nursing, Midwifery and Social Work, University of Manchester, Manchester, United Kingdom
Background/Purpose: Disabling distal upper limb pain is common but relatively understudied. Fear avoidance (FA) models of disability have been empirically tested for back and lower…
Abstract Number: 3048 • ACR/ARHP Annual Meeting 2016
Pain Severity As a Mediator of the Effect of Depressive Symptoms on Physical Performance in Knee Osteoarthritis
Alan Rathbun¹, Michelle Shardell², Michelle S. Yau³, Mona Baumgarten⁴, Elizabeth Stuart⁵ and Marc Hochberg⁶, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Depression is a significant comorbidity of knee osteoarthritis (OA) that occurs in approximately 20% of OA patients. Depressive symptoms are associated with both subsequent…
Abstract Number: 452 • ACR/ARHP Annual Meeting 2015
Associations Between Arthritis Patient, Disease-Specific and Provider Characteristics and Medication Information Source Use
Lorie Geryk¹, Susan J. Blalock², Robert DeVellis³, Joanne M. Jordan³ and Delesha Carpenter⁴, ¹Division of Pharmaceutical Outcomes and Policy, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, ²Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ⁴Division of Pharmaceutical Outcomes and Policy, University of North Carolina Eshelman School of Pharmacy, Asheville, NC
Background/Purpose: Few studies have described how patient, disease-specific, and provider factors are associated with medication information source use among arthritis patients. We address this research…
Abstract Number: 2250 • ACR/ARHP Annual Meeting 2015
The Relationship Between Sex and Incident Knee Osteoarthritis Is Mediated By Shape
Barton L. Wise¹, Jingbo Niu², Yuqing Zhang³, Felix Liu⁴, Joyce H. Pang⁵, John A. Lynch⁶ and Nancy E. Lane⁷, ¹Department of Internal Medicine, UC Davis School of Medicine, Sacramento, CA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³BUSM, Boston, MA, ⁴University of California at San Francisco, San Francisco, CA, ⁵University of Nevada School of Medicine, Reno, NV, ⁶University of California San Francisco, San Francisco, CA, ⁷Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA
Background/Purpose: Incidence of knee osteoarthritis (OA) is higher in women than in men. We have previously shown that knee bone shape differs between men and…
Abstract Number: 2513 • ACR/ARHP Annual Meeting 2015
Contraception Use Amongst Women Ages 18-45 Taking Known Teratogenic Medications in an Academic Rheumatology Clinic
Rebecca Sadun, Nicholas Holdgate, Melissa Wells, Megan E. B. Clowse, Lisa Criscione-Schrieber, Stephen Balevic, Victoria Lackey, Samya Mohammad and Erica Peart, Rheumatology, Duke University Medical Center, Durham, NC

Background/Purpose: Patients with autoimmune diseases are often prescribed medications that are known to be teratogenic. Amongst women of child-bearing ages taking such medications, roughly half…
Abstract Number: 974 • ACR/ARHP Annual Meeting 2014
Obesity Paradox in Osteoarthritis Progression – What Effects Are We Measuring?
Qiong Louie-Gao¹, Hyon K. Choi², David T. Felson^1,3, Tuhina Neogi⁴, Uyen Sa D.T. Nguyen^5,6, Na Lu² and Yuqing Zhang², ¹Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ⁶Clinical Epidemiology Research &Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: While obesity is a well-established risk factor for incident knee osteoarthritis (OA), it has a null association with OA progression. Among various potential explanations…

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