ACR Meeting Abstracts

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Abstracts tagged "matrix metalloproteinase (MMP)"

  • Abstract Number: 462 • 2016 ACR/ARHP Annual Meeting

    Selective Inhibition of MMP9 Using a Monoclonal Antibody As a Therapeutic Strategy for Rheumatoid Arthritis

    Sunhwa Kim1, Brian Carr1, Leah Tong1, Debi Jin1, Ruth Wang1, Derrek Marshall1, David Gossage2 and Victoria Smith1, 1Biology, Gilead Sciences, Inc., Foster city, CA, 2Biology, Gilead Sciences, Inc., foster city, CA

    Background/Purpose: Matrix metalloproteinase-9 (MMP9), highly expressed by infiltrating inflammatory cells, pannus tissue, and multinucleated cells in the synovium and subchondral bone tissue, including osteoclasts, participates…
  • Abstract Number: 2140 • 2016 ACR/ARHP Annual Meeting

    Phenotypic and Functional Characteristics of Exosomes Isolated from Human Osteoarthritis (OA) Synovial Fluid

    Geraldine M. McCarthy1, Dylan McGagh2, Clare C. Cunningham3, Emma M. Corr4, Louise Sullivan5, Fatima Haji6 and Aisling Dunne4, 1Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, 2School of Biochemistry & Immunology and School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 3School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, 4School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, 5Trinity Biomedical Sciences Institute, Trinity College Dublin, School of Biochemistry & Immunology and School of Medicine, Dublin 2, Ireland, 6Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland

    Background/Purpose: Exosomes are biologically active microvesicles derived from the endosomal membrane system understood to play a significant role in a wide range of inflammatory diseases.…
  • Abstract Number: 2995 • 2016 ACR/ARHP Annual Meeting

    WISP1/CCN4 Aggravates Experimental Osteoarthritis and Is Associated with Disease Progression in Early Osteoarthritis Patients

    Martijn H. van den Bosch1, Arjen B. Blom1, Azusa Maeda2, Tina Kilts2, Wim B. van den Berg3, Peter L. van Lent3, Marian F. Young2 and Peter M. van der Kraan1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2NIDCR/NIH, Bethesda, MD, 3Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose:  Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we described strongly increased expression of Wnt2b…
  • Abstract Number: 1142 • 2015 ACR/ARHP Annual Meeting

    Joint Specific Function of Synovial Fibroblasts – Integrating Positional Transcriptomes and Anatomic Patterns of Arthritis

    Mojca Frank Bertoncelj1, Michelle Trenkmann1, Kerstin Klein1, Emmanuel Karouzakis1, Christoph Kolling2, Andrew Filer3, Christopher Buckley4, Beat A. Michel1, Renate E. Gay1, Steffen Gay1 and Caroline Ospelt1, 1Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, 2Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, 3University of Birmingham, Birmingham, United Kingdom, 4University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom

    Background/Purpose: Synovial fibroblasts (SF) profoundly influence physiological and pathological processes in the joint such as reaction to inflammatory stimuli and production of extracellular matrix. We…
  • Abstract Number: 1170 • 2015 ACR/ARHP Annual Meeting

    The Alarmins S100A8/A9 Induce Canonical Wnt Signaling in Naïve Joints and Experimental OA

    Martijn H. van den Bosch1, Arjen Blom1, Rik Schelbergen2, Thomas Vogl3, Johannes Roth4, Wim van den Berg1, Peter van der Kraan1 and Peter van Lent1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Radboud university medical center, Nijmegen, Netherlands, 3Institute of Immunology, University of Muenster, Munster, Germany, 4Institute of Immunology, University of Münster, Münster, Germany

    Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we found increased expression of both the…
  • Abstract Number: 1982 • 2015 ACR/ARHP Annual Meeting

    Sonographic Scoring of the Synovial Components in the Shoulder Revealed That Shoulder Synovitis in PMR Patients Is Milder Than That in Elderly-Onset RA Patients with PMR-like Onset

    Takeshi Suzuki, Division of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo, Japan; Division of Rheumatology, Mitsui Memorial Hosipital, Tokyo, Japan

    Background/Purpose: Through the clinical experience, we noted that there seems to be differences not in the kind or the frequency but in the severity of…
  • Abstract Number: 3189 • 2015 ACR/ARHP Annual Meeting

    Enhancement of Mitochondrial Biogenesis Inhibits Cell Proliferation and MMP-3/RANKL Secretion in Rheumatoid Arthritis Fibroblast-like Synovial Cells and Joint Destruction in Arthritis Model Mice

    Takeshi Ueha1, Yoshitada Sakai1, Masayuki Morishita2, Toshihisa Maeda2, Koji Fukuda2, Miho Inoue2, Risa Harada2, Masaya Minoda2, Yasushi Miura3,4,5, Akira Hashiramoto6 and Masahiro Kurosaka1,4, 1Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 3Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 4Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 5Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, 6Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

    Background/Purpose: Joint destruction in rheumatoid arthritis (RA) progresses via the hyperproliferation of the synovium and secretion of MMP-3/RANKL from fibroblast-like synoviocytes (FLS). In tumors, we previously…
  • Abstract Number: 2925 • 2014 ACR/ARHP Annual Meeting

    Serum MMP-3 Predicts a Subgroup with No Radiographic Progression in Rheumatoid Arthritis Patients with Low-Dose Methotrexate (MTX) Monotherapy

    Kazuko Shiozawa1, Takashi Yamane2, Miki Murata1, Chihiro Tanaka1, Noriaki Yo2, Ryosuke Yoshihara1, Yasushi Tanaka1, Ken Tsumiyama3 and Shunichi Shiozawa4, 1The Rheumatic Diseases Center, Kohnan Kakogawa Hospital, Kakogawa, Japan, 2Kohnan Kakogawa Hospital, Kakogawa, Japan, 3Department of Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan, 4Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose: Studies have shown that treating rheumatoid patients with methotrexate (MTX) monotherapy initially and later providing an option to step up to combination therapy produces…
  • Abstract Number: 2223 • 2013 ACR/ARHP Annual Meeting

    Monitoring Of Active Matrix Metalloproteinase-3 Using

    Sung Jae Choi1, Young Ho Seo2, Young Ho Lee3, Jong Dae Ji1, Gwan Gyu Song4, Aeju Lee2 and Jae-Hoon Kim4, 1Rheumatology, Korea University Medical Center, Seoul, South Korea, 2Rheumatology, Korea University Medical center, Seoul, South Korea, 3Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, 4Div of Rheum, Dept of Int Med, Korea Univ College of Med, Seoul, South Korea

    Background/Purpose: Active matrix metalloproteinase-3 (MMP-3) is a prognostic marker of rheumatoid arthritis (RA). Recently, we developed the MMP-3 probe which can specifically detect an active…
  • Abstract Number: 1841 • 2013 ACR/ARHP Annual Meeting

    BAFF Induces Production of Matrix Metalloproteinase-9 By Peripheral Monocytes in Patients With Primary Sjögren’s Syndrome Through a Signaling Pathway That Involves NF-Kb and PI3 Kinase

    Keiko Yoshimoto1, Maiko Tanaka2, Masako Kojima2, Hideko Ogata2, Eriko Ishioka3, Ayumi Nishikawa2, Katsuya Suzuki1, Hideto Kameda1, Tohru Abe4 and Tsutomu Takeuchi5, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, 4Dept Int Med Saitama Med Ctr, Saitama Medical School, Kawagoe-shi Saitama, Japan, 5Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: B cell activating factor of the TNF family (BAFF) regulates proliferation, differentiation and survival of B cells, and plays a pivotal role in the…
  • Abstract Number: 1397 • 2013 ACR/ARHP Annual Meeting

    Changes In MMP In Fibroblast-Like Synoviocytes Following Adipogenesis

    Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose:   Fibroblast-like synovial cells (FLS) play important roles in the disease progression of RA. FLS produce cytokines and chemokines that contribute to chronic inflammation…
  • Abstract Number: 762 • 2013 ACR/ARHP Annual Meeting

    Inhibition Of TGF-Beta Signaling In Articular Chondrocytes Leads To OA-Like Pathological Defects and Pain-Related Behavior Change In Mice

    Jia Li1, Jie Shen2, Shan Li1, John Dickerson1, Jeffrey Kroin1, Hee-Jeong Im1 and Di Chen1, 1Rush University, Chicago, IL, 2University of Rochester, Rochester, NY

    Background/Purpose: TGF-β signaling plays an important role in chondrocyte differentiation and osteoarthritis (OA) pathogenesis.  However TGF-β downstream target genes and signaling mechanism in OA development…
  • Abstract Number: 2520 • 2012 ACR/ARHP Annual Meeting

    Suppressor of Cytokine Signaling 3 Is Reduced in Obese Patients with Osteoarthritis and Regulates Leptin Responses in Chondrocytes

    Anna Koskinen1, Katriina Vuolteenaho1, Riku Korhonen1, Teemu Moilanen2 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose: Leptin is an adipokine whose concentrations in circulation are proportional to body fat stores and body mass index (BMI). Initially leptin was discovered to…
  • Abstract Number: 1804 • 2012 ACR/ARHP Annual Meeting

    TNF-Like Protein 1A/Death Receptor 3 Pathway Regulates Osteoclastogenesis and Is Associated with Erosive Disease in Rheumatoid Arthritis

    Fraser L. Collins1, Michael D. Stone2, Rhian Goodfellow3, Ernest Choy4, Edward C. Wang5 and Anwen S. Williams6, 1Section of Rheumatology, Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, 2University Hospital Llandough, Cardiff & Vale University Health Board, Cardiff, United Kingdom, 3Section of Rheumatology, Cardiff University, Cardiff, ENGLAND, United Kingdom, 4Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom, 5Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, 6Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

    Background/Purpose: Bone erosion is a characteristic feature of inflammatory arthritides, such as rheumatoid arthritis (RA). Death Receptor 3 (DR3) and its only known ligand TNF-like…
  • Abstract Number: 1794 • 2012 ACR/ARHP Annual Meeting

    Matrix Metalloproteinase 3 and Acute Phase Proteins As Markers of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis

    Mahmood MTM Ally1, Bridget Hodkinson2, Pieter W.A Meyer1, Eustasius Musenge3, Mohammed Tikly4 and Ronald Anderson1, 1University of Pretoria, Pretoria, South Africa, 2Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, 3University of Witwatersrand, Johannesburg, South Africa, 4Rheumatology, Division of Rheumatology, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: Although matrix metalloproteinase-3 (MMP-3) is believed to be intimately involved in the immunopathogenesis of rheumatoid arthritis (RA), relatively little is known about its relationships…
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