ACR Meeting Abstracts

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Abstracts tagged "Magnetic resonance imaging (MRI)"

  • Abstract Number: 1232 • ACR Convergence 2022

    Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis

    Greg Gilles1, Arjun Vohra1, Chelsea Caruso1, Dagoberto Robles1, Mihra Taljanovic1, Jeffrey Duryea2, Erin Ashbeck1, Edward Bedrick3 and Kent Kwoh4, 1University of Arizona Arthritis Center, Tucson, AZ, 2Brigham and Women's Hospital, Boston, MA, 3Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, 4University of Arizona, Tucson, AZ

    Background/Purpose: Effusion-synovitis (ES) on knee MRI has been identified as an important biomarker of OA. Semi-automated software methods offer objective measurements of ES volume on…
  • Abstract Number: 2204 • ACR Convergence 2022

    Interosseous Tendon Inflammation in the Hands: A Novel Feature of Developing Rheumatoid Arthritis? Results from a Large MRI Study in Clinically Suspect Arthralgia

    Bastiaan van Dijk1, Hanna van Steenbergen1, Monique Reijnierse2, Sarah J.H. Khidir2, Lambertus Wisse1, Marco deRuiter1 and Annette van der Helm-van Mil3, 1Leiden University Medical Centre (LUMC), Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: Inflammation around the tendons of hand interosseous muscles (interosseous tendon inflammation; ITI) on MRI was recently reported for the first time in rheumatoid arthritis…
  • Abstract Number: 0213 • ACR Convergence 2021

    Quantitative Assessment of Volumetric Change in Hip Effusion Using Artificial Intelligence in Patients with Osteoarthritis of the Hip

    Jacob Jaremko1, Banafshe Felfeliyan2, Abhilash Hareendranathan1, Bashiar Thejeel1, Vanessa Quinn-Laurin1, Mikkel Ostergaard3, Philip Conaghan4, Robert Lambert1, Janet Ronsky2 and Walter Maksymowych1, 1University of Alberta, Edmonton, AB, Canada, 2University of Calgary, Calgary, AB, Canada, 3Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Accurate quantification of hip effusion volume may aid effective OA management as synovitis of the hip has been associated with pain and structural damage…
  • Abstract Number: 0901 • ACR Convergence 2021

    Low Dose Dual Energy CT Scan for the Detection of Bone Marrow Edema and Erosions in Axial Spondyloarthritis

    Jonathan Chan1, Savvas Nicolaou1, Yet Yen Yan2, Mahomed Osman3, Hugue Ouellette1 and Sabeena Jalal4, 1University of British Columbia, Vancouver, BC, Canada, 2Changi General Hospital, Singapore, 3Queensland X-ray, Brisbane, Australia, 4Harvard School of Public Health, Boston, USA, Boston, MA

    Background/Purpose: Bone marrow edema (BME) and erosions of the sacroiliac (SI) joints are key imaging features in the diagnosis of axial spondyloarthritis (axSpA). MRI with…
  • Abstract Number: 0216 • ACR Convergence 2021

    Distribution of Medial Femur and Tibia Cartilage Volume Change over 48 Months on MRI: Comparison Among Kellgren-Lawrence Grades

    Rebecca Amesbury1, Hedieh Ragati Haghi1, Todd Laffaye1, Rebekah Stein1, Erin Ashbeck2, C. Kent Kwoh3, Alexander Mathiessen1 and Jeffrey Duryea1, 1Brigham and Women's Hospital, Boston, MA, 2University of Arizona Arthritis Center, Tucson, AZ, 3University of Arizona College of Medicine, Tuscon, AZ

    Background/Purpose: Semi-automated Local Area Cartilage Segmentation (LACS) software uses two robust coordinate systems to measure cartilage change in focused regions in the femur and tibia.…
  • Abstract Number: 0903 • ACR Convergence 2021

    Scoring MRI Structural Lesions in Sacroiliac Joints of Patients with Axial Spondyloarthritis: How Many Slices Are Optimal?

    Walter Maksymowych1, Ulrich Weber2, Xenofon Baraliakos3, Pedro Machado4, Susanne Pedersen5, Joachim Sieper6, Stephanie Wichuk7, Denis Poddubnyy8, Martin Rudwaleit9, Désirée van der Heijde10, Robert Landewé11, Joel Paschke12, Mikkel Ostergaard13 and Robert Lambert7, 1Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada, 2Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, 3Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 4Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 5Rigshospitalet, Center for Arthritis Research, Glostrup, Denmark, 6Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 7University of Alberta, Edmonton, AB, Canada, 8Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 9University of Bielefeld, Klinikum Bielefeld, Bielefeld, Germany, 10Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, 11Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam, Netherlands; Zuyderland MC, Heerlen, Netherlands, 12CARE Arthritis, Edmonton, AB, Canada, 13Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark

    Background/Purpose: There is no international consensus on the optimal number of slices for evaluation of MRI structural lesions in the SIJ. An “all slice” method…
  • Abstract Number: 0217 • ACR Convergence 2021

    The OMERACT Knee Inflammation MRI Scoring System: Validation of Quantitative Methodologies and Tri-compartmental Overlays by Comparison with the MRI Osteoarthritis Knee Score

    Walter Maksymowych1, Jacob Jaremko2, Susanne Pedersen3, Iris Eshed4, Ulrich Weber5, Paul Bird6, Andrew McReynolds2, Stephanie Wichuk2, Joel Paschke7 and Robert Lambert2, 1Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada, 2University of Alberta, Edmonton, AB, Canada, 3Rigshospitalet, Center for Arthritis Research, Glostrup, Denmark, 4Sheba Medical Center, Ramat Gan, Israel, 5Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, 6University of New South Wales, Sydney, Australia, 7CARE Arthritis, Edmonton, AB, Canada

    Background/Purpose: Bone marrow lesions (BML) and synovitis on MRI are independently associated with the severity and progression of osteoarthritis (OA) and randomized controlled trials have…
  • Abstract Number: 0904 • ACR Convergence 2021

    Data-driven Definitions Based on Inflammatory Lesions for a Positive MRI of the Spine Consistent with Axial Spondyloarthritis

    Walter Maksymowych1, Robert Lambert2, Xenofon Baraliakos3, Susanne Pedersen4, Iris Eshed5, Ulrich Weber6, Pedro Machado7, Manouk de Hooge8, Joachim Sieper9, Stephanie Wichuk2, Denis Poddubnyy10, Martin Rudwaleit11, Robert Landewé12, Désirée van der Heijde13 and Mikkel Ostergaard14, 1Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada, 2University of Alberta, Edmonton, AB, Canada, 3Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 4Rigshospitalet, Center for Arthritis Research, Glostrup, Denmark, 5Sheba Medical Center, Ramat Gan, Israel, 6Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, 7Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 8Ghent University Hospital, Ghent, Belgium, 9Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 10Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 11University of Bielefeld, Klinikum Bielefeld, Bielefeld, Germany, 12Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam, Netherlands; Zuyderland MC, Heerlen, Netherlands, 13Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, 14Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark

    Background/Purpose: The ASAS definition of a positive MRI for inflammation in the spine (ASAS-MRI+) is intended for classification of patients as having axSpA but is…
  • Abstract Number: 0219 • ACR Convergence 2021

    Intra-Articular Mineralization on Knee CT and Risk of Cartilage Loss: The Multicenter Osteoarthritis Study

    Jean Liew1, John Lynch2, Ali Guermazi1, Mohamed Jarraya3, David Felson1, Na Wang1, Cora Lewis4, James Torner5, Michael Nevitt6 and Tuhina Neogi7, 1Boston University, Boston, MA, 2University of California San Francisco, San Francisco, CA, 3Massachusetts General Hospital, Boston, MA, 4University of Alabama Birmingham, Birmingham, AL, 5University of Iowa, Iowa City, IA, 6University of California San Francisco, Orinda, CA, 7Boston University School of Medicine, Boston, MA

    Background/Purpose: Intra-articular (IA) mineralization due to crystal deposition may contribute to OA pathology through inflammation, release of pro-catabolic factors, or altered cartilage biomechanical properties. Prior…
  • Abstract Number: 0905 • ACR Convergence 2021

    Artificial Neural Network for the Recognition of Active Inflammatory Changes Compatible with Axial Spondyloarthritis on Magnetic Resonance Imaging of Sacroiliac Joints

    Denis Poddubnyy1, Janis Vahldiek2, Lisa Adams2, Torsten Diekhoff2, Fabian Proft2, Mikhail Protopopov2, Judith Rademacher2, Valeria Rios Rodriguez2, Murat Torgutalp2, Stefan Niehues2 and Keno Bressem2, 1Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 2Charité University Medicine Berlin, Berlin, Germany

    Background/Purpose: Active inflammatory changes in sacroiliac joints (SIJ) compatible with axial spondyloarthritis - axSpA (first of all, subchondral bone marrow edema – BME / osteitis)…
  • Abstract Number: 0230 • ACR Convergence 2021

    Fatigue and Inflammation in Rheumatoid Arthritis Are Already Disconnected Before Clinical Arthritis Develops

    Sarah J.H. Khidir1, Annette H.M van der Helm-van Mil1 and Elise van Mulligen2, 1Leiden University Medical Center, Leiden, Netherlands, 2Erasmus Medical Center, Rotterdam, Netherlands

    Background/Purpose: Fatigue is disabling and common in Rheumatoid Arthritis (RA); the causation of fatigue in RA is multidimensional and only partially explained by inflammation. The…
  • Abstract Number: 0921 • ACR Convergence 2021

    Effect of Secukinumab on Radiographic Progression and Inflammation in Sacroiliac Joints and Spine in Patients with Non-radiographic Axial Spondyloarthritis: 2-year Imaging Outcomes from a Phase III Randomized Trial

    Juergen Braun1, Ricardo Blanco2, Helena Marzo-Ortega3, Lianne Gensler4, Filip Van den Bosch5, Stephen Hall6, Hideto Kameda7, Denis Poddubnyy8, Marleen van de Sande9, Désirée van der Heijde10, Tingting Zhuang11, Anna Stefanska12, Aimee Readie11, Hanno Richards13 and Atul Deodhar14, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2Hospital University Marqués de Valdecilla, IDIVAL, Division of Rheumatology, Santander, Spain, 3NIHR Leeds Biomedical Research Centre and University of Leeds, Leeds, United Kingdom, 4Department of Rheumatology, University of California San Francisco, San Francisco, CA, 5Dept. of Rheumatology - Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, 6Emeritus Research and Monash University, Melbourne, Australia, Melbourne, Australia, 7Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan, 8Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 9Amsterdam UMC, University of Amsterdam, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, 10Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, 11Novartis Pharmaceuticals Corporation, East Hanover, NJ, 12Novartis Ireland Limited, Dublin, Ireland, Dublin, Ireland, 13Novartis Pharma AG, Basel, Switzerland, 14Oregon Health & Science University, Portland, OR

    Background/Purpose: Axial spondyloarthritis (axSpA) is characterized by inflammation of the sacroiliac joints (SIJ) and the spine. Secukinumab (SEC) treatment was clinically efficacious and reduced SIJ…
  • Abstract Number: 0305 • ACR Convergence 2021

    Artificial Neural Networks Approaches to Predict Myocardial Fibrosis in Primary Sjögren Syndrome Patients Without Cardiac Symptoms

    Hitomi Kobayashi1, Yasuyuki Kobayashi2, Atsuma Nishiwaki1, Isamu Yokoe1, Haraoka Masaki3, Eichi Takaya3, Yousuke Nagasawa1, Noboru Kitamura1, Masami Takei1 and Hideki Nakamura1, 1Nihon University School of Medicine, Itabashi, Japan, 2St. Marianna University School of Medicine, kowasaki, Japan, 3St. Marianna University School of Medicine, Kawaski, Japan

    Background/Purpose: A recent meta-analysis of cardiovascular diseases demonstrated that the odds of heart failure (HF) was more than 2.54-fold higher in primary Sjögren syndrome (pSS)…
  • Abstract Number: 0930 • ACR Convergence 2021

    Effect of Tofacitinib on Spinal Vertebral Body and Posterolateral Element Inflammation and Structural Lesions Using the Canada-Denmark MRI Scoring System in Patients with Ankylosing Spondylitis: Results from a Phase 2 Study

    Mikkel Ostergaard1, Joseph Wu2, Lara Fallon3, Sarah P Sherlock4, Cunshan Wang2, Dona L Fleishaker2, Keith S Kanik2 and Walter Maksymowych5, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark, 2Pfizer Inc, Groton, CT, 3Pfizer Canada, Montréal, QC, Canada, 4Pfizer Inc, Cambridge, MA, 5Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada

    Background/Purpose: The Canada-Denmark (CANDEN) MRI scoring system enables detailed anatomy-based evaluation of inflammatory and structural lesions in spinal vertebral bodies and posterior elements in patients…
  • Abstract Number: 0364 • ACR Convergence 2021

    Dose Tapering of TNF Inhibitors in Patients with Axial Spondyloarthritis in Routine Care – 2-year Clinical and MRI Outcomes and Predictors of Successful Tapering

    Marie Wetterslev1, Stylianos Georgiadis2, Inge Juul Sørensen3, Susanne Juhl Pedersen2, Sara Nysom Christiansen4, Merete Lund Hetland1, Cecilie Heegaard Brahe2, Mads Bakkegaard5, Anne Duer6, Mikael Boesen7, Kasper Kjærulf Gosvig8, Jakob Møllenbach Møller8, Niels Steen Krogh9, Bente Jensen5, Ole Rintek Madsen5, Jan Christensen5, Annette Hansen5, Jesper Nørregaard5, Henrik Røgind5 and Mikkel Ostergaard10, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 3Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 4Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 5Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 6Department of Radiology, Rigshospitalet, Glostrup, Copenhagen, Denmark, 7Department of Radiology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, 8Department of Radiology, Herlev and Gentofte Hospital, Copenhagen, Denmark, 9ZiteLab ApS, Copenhagen, Denmark, Frederiksberg, Denmark, 10Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark

    Background/Purpose: In a 2-year follow-up study of patients with axial spondyloarthritis (axSpA) in clinical remission who tapered Tumor Necrosis Factor inhibitor (TNFi) treatment according to…
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