Abstracts tagged "magnetic resonance imaging (MRI) and systemic lupus erythematosus (SLE)"

Abstract Number: 2044 • 2015 ACR/ARHP Annual Meeting
Axonal Dysfunction in Childhood-Onset Systemic Lupus Erythematosus. Association with Neuropsychiatric Manifestations and Disease Activity
Renan Frittoli¹, Mariana Postal², Karina Pelicari², Nailu Sinicato³, Aline Tamires Lapa⁴, Fernando Peres¹, Fernando Cendes⁵, Roberto Marini Sr.⁶, Gabriela Castellano⁷, Leticia Rittner⁸ and Simone Appenzeller², ¹State University of Campinas, Campinas, Brazil, ²Medicine, State University of Campinas, Campinas, Brazil, ³pEDIATRICS, State University of Campinas, Campinas, Brazil, ⁴Rua Alexandre Fleming, Fcm09-Baraogeraldo, Campinas, Brazil, ⁵Neurology, State University of Campinas, Campinas, Brazil, ⁶Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, ⁷Medical Physics, State University of Campinas, Campinas, Brazil, ⁸Electrical Engineering, State University of Campinas, Campinas, Brazil
Background/Purpose: Involvement of the central nervous system is frequently observed in childhood-onset SLE patients (cSLE). Proton magnetic spectroscopy (1H-MRS) is an important non-invasive method of…
Abstract Number: 2958 • 2015 ACR/ARHP Annual Meeting
Vitamin D, Cognition and Cerebral Structural Abnormalities in Childhood- Onset Systemic Lupus Erythematosus
Nailu A. Sinicato¹, Mariana Postal², Aline Tamires Lapa², Bruna B Siqueira³, Karina Pelicari², Paula T Fernades³, Roberto Marini Sr.⁴ and Simone Appenzeller⁵, ¹Pediatrics, State University of Campinas, Campinas, Brazil, ²Medicine, State University of Campinas, Campinas, Brazil, ³State University of Campinas, Campinas, Brazil, ⁴Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, ⁵Division of Rheumatology, Faculty of Medical Science, State University of Campinas, São Paulo, Brazil
Background/Purpose: About 16-95% of SLE patients have vitamin D insufficiency. Vitamin D levels, especially vitamin D deficiency, are associated with cognitive performance in adults. We…
Abstract Number: 3123 • 2015 ACR/ARHP Annual Meeting
Evidence of Altered Blood Brain Barrier Permeability in Systemic Lupus Erythematosus Using Magnetic Resonance Imaging
Gaurav Gulati¹, Jordan T. Jones², Mekibib Altaye³, Jamie Meyers Eaton⁴, Kasha Wiley², Mark DiFrancesco⁵ and Hermine I. Brunner⁶, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Biostatistics and Epidemiology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁴Division of Pediatric Rheumatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁵Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Neurocognitive dysfunction is a common manifestation of childhood-onset Systemic Lupus Erythematosus (cSLE). Murine models suggest that loss of the blood-brain barrier (BBB) integrity allows…
Abstract Number: 3126 • 2015 ACR/ARHP Annual Meeting
Biomarkers Associated with Hyperintense White Matter Lesions in Systemic Lupus Erythematosus
Mariana Postal, Aline Tamires Lapa, Karina O. Peliçari, Nailu A. Sinicato, Fernando A. Peres, Angela C. Gomes, Lilian TL Costallat, Fernando Cendes and Simone Appenzeller, Medicine, State University of Campinas, Campinas, Brazil
Background/Purpose: Cytokines and neuronal injury markers act as crucial mediators in the bidirectional signaling between the immune system and the brain and may be biomarkers…
Abstract Number: 2659 • 2014 ACR/ARHP Annual Meeting
Neurofilament H Is Associated with White Matter Lesions in Childhood-Onset Systemic Lupus Erythematosus
Aline T. Lapa¹, Mariana Postal¹, Nailu A. Sinicato¹, Lucas Ferreti Silveira², Fernando Cendes³, Roberto Marini⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Campinas, Brazil, ³Neurology, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose Imaging findings in systemic lupus erythematosus (SLE) patients are diverse; and diffuse or regional atrophy and white matter hyperintensities (WMH) have been described in…
Abstract Number: 2657 • 2014 ACR/ARHP Annual Meeting
Brain Gray and White Matter Volume Losses and Their Associations with Glucocorticoid Use in Patients with Newly Diagnosed Systemic Lupus Erythematosus (SLE) – a Prospective MR Study
Anselm Mak¹, Roger CM Ho², Hanying Tng³ and Juan Zhou³, ¹Medicine, National University of Singapore, Singapore, Singapore, ²Psychological Medicine, National University of Singapore, Singapore, Singapore, ³Center for Cognitive Neuroscience, Duke-NUS Graduate Medical School, Singapore, Singapore
Background/Purpose Data suggest that cerebral atrophy occurs in patients with SLE as early as within 9 months after disease onset. We aimed to address (1)…
Abstract Number: 2641 • 2014 ACR/ARHP Annual Meeting
Cardiac Magnetic Resonance Imaging in Systemic Lupus Erythematosus
Alexa Meara¹, Namrata Dhillon², Kimberly Fisher³, Paul Jensen⁴ and Stacy P. Ardoin⁵, ¹Internal Medicine/Rheumatology, The Ohio State University, Columbus, OH, ²University of Pittsburgh Medical Center, Pittsburgh, PA, ³Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Internal Medicine/Pediatrics, The Ohio State University, Nationwide Children's Hospital, Columbus, OH, ⁵Pediatric & Adult Rheumatology, Ohio State University College of Medicine, Columbus, OH
Background/Purpose Cardiac complications of SLE are common and include both acute and chronic manifestations: pericarditis, myocarditis, valvular disease, pulmonary hypertension, atherosclerosis, ischemic and non-ischemic cardiomyopathy. …
Abstract Number: 1622 • 2014 ACR/ARHP Annual Meeting
Th1 and Th2 Cytokines Are Associated with Cerebral Atrophy in Systemic Lupus Erythematosus
Mariana Postal¹, Aline T. Lapa¹, Karina de Oliveira Peliçari², Nailu A. Sinicato¹, Fernando Augusto Peres¹, Wesley Geraldo Ferreira², Roberto Marini², Lilian Costallat³, Fernando Cendes⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Campinas, Brazil, ³Medicine, State University of Campinas, Campinas, United Kingdom, ⁴Neurology, State University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose Cerebral atrophy has been described to occur in systemic lupus erythematosus (SLE) with variable frequency. The pathophysiology of central nervous system (CNS) involvement in…

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