Abstracts tagged "magnetic resonance imaging (MRI) and rheumatoid arthritis (RA)"

Abstract Number: 1172 • 2014 ACR/ARHP Annual Meeting
Assessing the Validity and Reliability of a Novel MRI Semi-Automated Algorithm for Quantifying Bone Loss in the Hand
Matthew Jessome¹, Isabel Rodrigues², Michael Tomizza², Joshua Barbosa², Melissa XP. Koh¹, Karen Beattie³, William G. Bensen³, Raja Bobba³, Alfred Cividino³, Patrick D. Emond³, Karen Finlay⁴, Chris Gordon³, Lawrence Hart³, George Ioannidis³, Erik Jurriaans⁴, Maggie Larche³, Arthur Lau³, Naveen Parasu⁴, Ruben Tavares³, Stephen Tytus³, Hao Wu² and Jonathan D. Adachi^2,3, ¹Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁴Radiology, Hamilton Health Sciences, Hamilton, ON, Canada
Background/Purpose Efficient and accurate evaluation of erosive damage to the MCP joints in RA patients is desirable in both clinical trials and clinical practice. The…
Abstract Number: 355 • 2014 ACR/ARHP Annual Meeting
Increased Left Ventricular Mass Index and Decreased Ejection Fraction Are Associated with Disease Activity in Rheumatoid Arthritis Patients without Cardiac Symptoms; Comparison Between Non-Biologic and Biologic Dmards Treatment Groups, Using a Cardiac Magnetic Resonance Imaging
Hitomi Kobayashi¹, Yasuyuki Kobayashi², Atsuma Nishiwaki³, Hirotake Inomata¹, Noboru Kitamura¹, Hidetake Shiraiwa³, Takamasa Nozaki³, Natsumi Ikumi⁴ and Masami Takei⁵, ¹Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ²Radiology, St.Marianna University School of Medicine, Kawasaki, Japan, ³Nihon University School of Medicine, Tokyo, Japan, ⁴Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ⁵Dept of Med Rheumatology, Nihon University School of Medicine, Itabashi Tokyo, Japan
Background/Purpose Patients with rheumatoid arthritis (RA) experience an excess risk of congestive heart failure (CHF), but effects of disease-modifying anti-rheumatic drugs (DMARDs) on cardiac structure…
Abstract Number: 1974 • 2013 ACR/ARHP Annual Meeting
Assessing Validity Of Low Field Magnetic Resonance Imaging (MRI) for Joint Inflammation and Damage In Wrist/Hand Rheumatoid Arthritis (RA) – A Systematic Literature Review (SLR)
OM Troum¹, OL Pimienta¹, TG Woodworth², O Morgacheva³, V Ranganath⁴ and Daniel Furst⁵, ¹Keck School of Medicine, University of Southern California, Los Angeles, CA, ²Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA, ³Medicine/Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA, ⁴Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁵David Geffen School of Medicine, University of California, Los Angeles, CA
Background/Purpose: Radiographic scoring of erosions and joint space narrowing (JSN) of the hand/wrist is standard to evaluate RA joint damage for regulatory approval of DMARDs;…
Abstract Number: 1967 • 2013 ACR/ARHP Annual Meeting
Computer-Aided and Manual Quantifications Of MRI Synovitis, Bone Edema, Erosion and Semi-Quantitative Cartilage Loss In Rheumatoid Arthritis
Haitao Yang^1,2, Julien Rivoire¹, Michael Hoppe¹, John B. Imboden³, Thomas M Link⁴ and Xiaojuan Li⁴, ¹Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, ²Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, ³Department of Medicine, Division of Rheumatology, UCSF, San Francisco, CA, ⁴Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA
Background/Purpose: Early diagnosis and early detection of therapeutic response within the so called “window of opportunity” in rheumatoid arthritis (RA) are essential for superior clinical…
Abstract Number: 1619 • 2012 ACR/ARHP Annual Meeting
Quantification of Bone Marrow Edema by Using Magnetic Resonance Imaging for the Assessment of Neck Pain Only Marginally Reflects Clinical Evaluation in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Xenofon Baraliakos¹, Frank Heldmann², Ravi Suppiah³, Fiona M. McQueen⁴ and Jürgen Braun², ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, ⁴Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Despite the differences in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS), neck pain is a frequent clinical symptom in both diseases…
Abstract Number: 1620 • 2012 ACR/ARHP Annual Meeting
Early Magnetic Resonance Imaging Measures Independently Predict 1- and 2- Year X-Ray Progression: Results From a Large Clinical Trial
Joshua Baker¹, Mikkel Østergaard², Paul Emery³, Elizabeth C. Hsia⁴, J. D. Lu⁵, Daniel Baker⁴ and Philip G. Conaghan⁶, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ³Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁴Janssen Research & Development, LLC., Spring House, PA, ⁵Janssen Research & Development, LLC/U of Penn, Spring House/Phila, PA, ⁶University of Leeds, Leeds, United Kingdom
Early MRI Measures Independently Predict 1- and 2- year X-ray Progression: Results from a Large Clinical TrialBackground/Purpose: Early predictors of progression in structural joint…
Abstract Number: 1050 • 2012 ACR/ARHP Annual Meeting
Assessment of Validity of Magnetic Resonance Imaging Measures of Joint Inflammation and Damage in Rheumatoid Arthritis Wrist/Hand – a Systematic Literature Review
TG Woodworth¹, O. Morgacheva², OM Troum³, OL Pimienta⁴, P. Maranian⁵, V.K. Ranganath⁵ and Daniel Furst⁵, ¹Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA, ²Medicine/Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA, ³Medicine, USC Keck School of Medicine, Santa Monica, CA, ⁴Keck School of Medicine, University of Southern California, Los Angeles, CA, ⁵Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA
Background/Purpose: Limitation of x-ray joint damage is a key indicator of therapeutic efficacy in rheumatoid arthritis (RA). Although magnetic resonance imaging (MRI) is increasingly used…
Abstract Number: 1018 • 2012 ACR/ARHP Annual Meeting
Reliability of the Early Erosions in Rheumatoid Arthritis Software When Quantifying Bone Loss
Melissa XP. Koh¹, Joshua WJ. Barbosa¹, Ruben Tavares², Stephen Tytus², Patrick Emond³, Chris Gordon², George Ioannidis⁴, Karen A. Beattie⁵, William G. Bensen⁶, Raja S. Bobba⁷, Alfred A. Cividino⁵, Lawrence E. Hart⁸, Maggie Larche⁷, Arthur N. Lau⁹ and Jonathan D. Adachi¹⁰, ¹Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³Medical Physics, McMaster University, Hamilton, ON, Canada, ⁴St Josephs Hospital, McMaster University, Hamilton, ON, Canada, ⁵Medicine, McMaster University, Hamilton, ON, Canada, ⁶Department of Medicine, Division of Rheumatology, St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada, ⁷Rheumatology, McMaster University, Hamilton, ON, Canada, ⁸Medicine (Rheumatology), St. Joseph's Health Care, Hamilton, ON, Canada, ⁹Rheumatology and Clinical Epidemiology, Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ¹⁰St. Joseph's Health Care and McMaster University, Hamilton, ON, Canada
Background/Purpose: Instruments designed to determine the clinical relevance of bone erosions captured by magnetic resonance imaging (MRI) in rheumatoid arthritis (RA) patients have been set-back…
Abstract Number: 1019 • 2012 ACR/ARHP Annual Meeting
Visualization of Cartilage in High-Resolution Magnetic Resonance Imaging Is a New Imaging Biomarker for the Quantification of Joint Damage in Rheumatoid Arthritis
Barbara Herz¹, Stephanie Finzel¹, Andreas Albrecht¹, Juergen Rech², Matthias Englbrecht¹, Goetz Welsch³ and Georg Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Traumatic Surgery, Department of Traumatic Surgery, University Clinic of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Recent achievements in Magnetic Resonance Imaging (MRI) have been the gradient-echo-based T1-delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) focussing on the detection of proteoglycan content…
Abstract Number: 1020 • 2012 ACR/ARHP Annual Meeting
Location of Erosions At the Metatarsophalangeal Joints in Patients with Rheumatoid Arthritis
Heidi J. Siddle¹, Richard J. Hodgson², Andrew J. Grainger³, Anthony C. Redmond⁴, Richard J. Wakefield⁴ and Philip S. Helliwell⁵, ¹Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit and The Leeds Teaching Hospitals Trusts, Leeds, United Kingdom, ⁴Division of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁵PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose: The forefoot is described as the most common site of symptoms in the foot and ankle of patients with rheumatoid arthritis (RA). Pressure under…
Abstract Number: 2488 • 2012 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging Substudy in a Phase 2b Dose-Ranging Study of Baricitinib, an Oral Janus Kinase 1/Janus Kinase 2 Inhibitor, in Combination with Traditional Disease-Modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis
Charles G. Peterfy¹, Paul Emery², Mark C. Genovese³, Edward Keystone⁴, Peter Taylor⁵, Pierre-Yves Berclaz⁶, Julie C. DiCarlo¹, Chin H. Lee⁶, Douglas E. Schlichting⁶, Scott D. Beattie⁶, Monica E. Luchi⁷ and William Macias⁶, ¹Spire Sciences LLC, Kentfield, CA, ²Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ³Division of Rheumatology, Stanford University, Palo Alto, CA, ⁴University of Toronto, Toronto, ON, Canada, ⁵NDORMS, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ⁶Eli Lilly and Company, Indianapolis, IN, ⁷E361/309, Incyte Corporation, Wilmington, DE
Background/Purpose: Baricitinib (formerly, LY3009104/ INCB028050 ) is a novel, oral inhibitor of JAK1 and JAK2 in the JAK-STAT pathway. Primary results of this phase 2b…
Abstract Number: 2135 • 2012 ACR/ARHP Annual Meeting
Trabecular Bone Texture parameters are Correlated with Magnetic Resonance Imaging (MRI) bone Edema At Hand and Wrist in Active Rheumatoid Arthritis (RA)
Thao Pham¹, Sophie Trijau¹, Roland Chapurlat², Damien Loeuille³, Thierry Schaeverbeke⁴, Christian Roux⁵, Claude-Laurent Benhamou⁶, Olivier Vittecoq⁷, Jean Sibilia⁸, Frederic Mistretta⁹ and Cécile Hacquard-Bouder¹⁰, ¹Rheumatology Department, Sainte Marguerite Hospital, Marseille, France, ²Hôpital Edouard Herriot, Lyon, France, ³Rheumatology, CHU Brabois, Vandoeuvre les Nancy, France, ⁴Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, ⁵Rheumatology, Paris Descartes University, Paris, France, ⁶Centre Hospitalier Régional d'Orléans, Orleans, France, ⁷Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France, ⁸Rheumatology, CHU Hautepierre, Strasbourg, France, ⁹Lyon, France, ¹⁰Abbott France, Rungis, France
Background/Purpose: In RA, bone marrow edema (BME) is predictive of erosive progression. Bone erosions are assumed to appear through activation of local bone resorption mechanisms,…
Abstract Number: 2112 • 2012 ACR/ARHP Annual Meeting
Combination of Magnetic Resonance Imaging (MRI)-Proven Osteitis with 2010 RA Classification Criteria Improves the Diagnostic Probability of Rheumatoid Arthritis (RA)
Mami Tamai¹, Yoshikazu Nakashima¹, Takahisa Suzuki¹, Yoshiro Horai², Akitomo Okada², Junko Kita², Shin-ya Kawashiri³, Naoki Iwamoto², Kunihiro Ichinose⁴, Kazuhiko Arima², Hideki Nakamura⁵, Tomoki Origuchi⁶, Masataka Uetani⁷, Kiyoshi Aoyagi⁸, Katsumi Eguchi⁹ and Atsushi Kawakami³, ¹Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁶Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Radiology and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁸Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁹Sasebo City General Hospital, Sasebo, Nagasaki, Japan
Background/Purpose: In the articles of 2010 rheumatoid arthritis (RA) classification criteria, it is stated that additional evidence of joint injury from other imaging techniques such…
Abstract Number: 1617 • 2012 ACR/ARHP Annual Meeting
Whole-Body Magnetic Resonance Imaging of Disease Manifestations in Axial and Peripheral Joints and Entheses in Rheumatoid Arthritis Patients
Mette Bjørndal Axelsen¹, Anne Duer², Iris Eshed³, Jakob M. Møller⁴, Susanne Juhl Pedersen¹ and Mikkel Østergaard⁵, ¹Depart of Rheumatology RM, Glostrup Hospital, Copenhagen, Denmark, ²Department of Radiology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark, ³Department of Radiology, Sheba Medical Center, Tel Hashomer, Israel, ⁴Department of Radiology, Copenhagen University Hospital in Herlev, Copenhagen, Denmark, ⁵Copenhagen University Hospital Glostrup, Copenhagen, Denmark
Background/Purpose: To investigate the ability of whole-body magnetic resonance imaging (WBMRI) to visualize synovitis, bone marrow edema and erosions in patients with rheumatoid arthritis (RA)…

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