ACR Meeting Abstracts

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Abstracts tagged "macrophages"

  • Abstract Number: 0669 • ACR Convergence 2020

    Calcium Pyrophosphate Crystal Deposition in Gouty Tophi

    Hang-Korng Ea1, Alan Gauffenic2, Quand Nguyen3, Nhu Pham3, Oceane Olivier2, Vincent Frochot4, Dominique Bazin5, Nghia Le3, Caroline Marty2, Agnès Ostertag2, Martine Cohen-Solal1, Jean-Denis Laredo6, Pascal Richette7 and Thomas Bardin8, 1Université de Paris, INSERM UMR 1132, BIOSCAR, AP-HP, DMU Locomoteur, Paris, France, 2Université de Paris, INSERM UMR 1132, BIOSCAR, Paris, France, 3Vien Gut Medical Center and French-Vietnamese research center on gout and chronic diseases, Ho Chi Ming, Vietnam, 4Hôpital Tenon, Service des explorations fonctionnelles multidisciplinaires, Sorbonne université, UMR_S1155, Paris, France, 5Institut de Chimie Physique, Université Paris-Saclay et CNRS - UMR8000, Orsay, France, 6AP-HP Université de Paris, Paris, 7Department of Rheumatology, Lariboisière Hospital, AP-HP Université de Paris, INSERM U1132, Paris, 8Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France

    Background/Purpose: The coexistence of calcium pyrophosphate (CPP) and monosodium urate crystals is rarely reported in gouty tophi. We investigated CPP crystal deposits in a series…
  • Abstract Number: 0738 • ACR Convergence 2020

    Systemic Administration of Novel Hydroxyl Dendrimers to Target Inflammation in Arthritic Tissues

    Jeffrey Cleland1, Rishi Sharma2, Minghao Sun3, Santiago Appiani La Rosa3 and Rangaramanujam M. Kannan4, 1Ashvattha Therapeutics, Inc, Redwood City, CA, 2Ashvattha Therapeutics, Baltimore, MD, 3Ashvattha Therapeutics, Inc, Baltimore, MD, 4Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: Chronic inflammation observed in arthritis and other autoimmune disorders is mediated primarily by pro-inflammatory reactive macrophages.  Systemic administration of anti-inflammatory agents does not selectively…
  • Abstract Number: 0787 • ACR Convergence 2020

    MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients

    Alessandra Nerviani1, Marie-Astrid Boutet1, Giulia Maria Ghirardi2, Gloria Lliso-Ribera2, Felice Rivellese1, Myles Lewis1, Michele Bombardieri2, Frances Humby2 and Costantino Pitzalis2, 1Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 2Queen Mary University of London, London, United Kingdom

    Background/Purpose: Despite valuable improvements in long-term clinical outcomes, a significant portion of rheumatoid arthritis (RA) patients still do not adequately respond to available treatments, and…
  • Abstract Number: 0839 • ACR Convergence 2020

    Single-Cell Transcriptomics of Mouse and Human Lupus Nephritis Identifies Conserved Myeloid Populations Across Species

    Paul Hoover1, Michael Peters2, David Lieb3, Rakesh Mishra4, Nir Hacohen2 and Anne Davidson5, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Boston, 3Broad Institute, Boston, MA, 4Feinstein Institute, Manhasset, NY, 5Northwell Health, New York

    Background/Purpose: We recently identified novel immune cell states in the kidneys of lupus nephritis patients (Arazi et al, Nature Immunology 2019). To determine the similarities…
  • Abstract Number: 0979 • ACR Convergence 2020

    The Identification of Shared and Unique Myeloid Cell States in Pre- and Post-nephritic Lupus Mouse Models, Sle.Yaa1 and NZBW

    Paul Hoover1, Michael Peters2, David Lieb3, Heather Geiger4, Rakesh Mishra5, Nir Hacohen2 and Anne Davidson6, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Boston, 3Broad Institute, Boston, MA, 4New York Genome Center, New York, NY, 5Feinstein Institute, Manhasset, NY, 6Northwell Health, New York

    Background/Purpose:Poor renal prognosis in lupus nephritis (LN) is associated with an abundance of renal macrophages and dendritic cells (DCs) but the role of these cells…
  • Abstract Number: 1531 • ACR Convergence 2020

    Characterization of Cytokine/chemokine Profile in Patient-derived M1/ M2 Macrophages to Identify Biomarkers for Genetically-defined Systemic Autoinflammatory Diseases

    Farzana Bhuyan1, Adriana Almeida de Jesus2, Kim Johnson3, Jacob Mitchell4, Yan Huang5 and Raphaela Goldbach-Mansky5, 1NIH, bhetesda, MD, 2Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 3NIH, NIAID, Bethesda, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 5NIH, Bethesda

    Background/Purpose: Genetic mutations in key regulatory molecules of the innate immune system cause autoinflammatory diseases through propagation of hyperinflammatory responses. Monocytes/ macrophages regulate inflammatory processes…
  • Abstract Number: 996 • 2019 ACR/ARP Annual Meeting

    The Role of Flip in Differentiation and Survival of Synovial Tissue Resident Macrophages

    Qi Huang1, Renee Doyle 1, Shang-Yang Chen 2, Alexander Misharin 3, Deborah Winter 4 and Richard Pope 5, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University Feinberg School of Medicine, chicago, 4Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, 5Northwestern University Feinberg School of Medicine, Division of Rheumatology, chicago, IL

    Background/Purpose: We previously identified that under homeostatic conditions Flip was necessary for macrophage (MΦ) survival.  The mechanisms responsible for the differentiation of monocyte-derived MΦs into…
  • Abstract Number: 1056 • 2019 ACR/ARP Annual Meeting

    Profibrotic Macrophage Activation in Systemic Sclerosis Is Dependent on the Mechanosensing MRTF-A Pathway

    Tricia Lim1, Kristina Krogmannova 1, Shiwen Xu 1, Bahja Ahmed Abdi 2, David Abraham 1, Christopher Denton 3 and Richard Stratton 1, 1University College London, London, United Kingdom, 2University College London, London, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom

    Background/Purpose: An M2-like alternative activation state of macrophages has been linked to the pathogenesis of several fibrotic disorders, including systemic sclerosis (SSc). MRTF-A is an…
  • Abstract Number: 1073 • 2019 ACR/ARP Annual Meeting

    Identification of Distinct Pro-Fibrotic Monocyte and Macrophage Subsets in Systemic Sclerosis

    Angela Tam1, Lauren Reinke-Breen 2, Glenda Trujillo 2, Shiwen Xu 1, Christopher Denton 3, David Abraham 1, Gabor Jarai 2 and Voon Ong 4, 1University College London, London, United Kingdom, 2Bristol-Myers Squibb, Pennington, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom, 4UCL Medical School, Royal Free Campus, London

    Background/Purpose: Chronic inflammation may modulate the balance of classical, intermediate and non-classical monocyte subsets (defined by CD14/CD16 expression)1.  Monocytes are heterogeneous and subsets can be…
  • Abstract Number: 2002 • 2019 ACR/ARP Annual Meeting

    Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts

    Samuel Finlay1, Stefano Alivernini 2, Aziza Elmesmari 3, Barbara Tolusso 2, Luca Petricca 2, Clara Di Mario 4, Annunziata Capacci 2, Andrew Filer 5, Gianfranco Ferraccioli 2, Iain McInnes 1, Elisa Gremese 2 and Mariola Kurowska-Stolarska 1, 1Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 3Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, 4Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, 5Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Background: A substantial proportion of Rheumatoid Arthritis patients do not respond to treatment and only a small proportion achieve sustained disease remission. We showed…
  • Abstract Number: 1011 • 2018 ACR/ARHP Annual Meeting

    Tissue Resident Macrophages Establish a Niche That Limits Monocyte to Macrophage Differentiation in Synovial Tissue during Homeostasis

    Qi Quan Huang1, Renee E. Doyle2, Alexander Misharin3, Shang-Yang Chen4, Deborah R. Winter5 and Richard M. Pope2, 1Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, 5Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Monocytes and Macrophages play critical roles in immune homeostasis and host defense. Recent studies identified that macrophages are highly heterogeneous in terms of location,…
  • Abstract Number: 1353 • 2018 ACR/ARHP Annual Meeting

    Autophagy Marker LC3 Accumulates in Immune-Mediated Necrotizing Myopathy Muscle Fibres

    Margherita Giannini1, Francesco Girolamo2, Anna Lia2, Angela Amati2, Luigi Serlenga2, Dario D'Abbicco3, Marilina Tampoia4, Maria Trojano2 and Florenzo Iannone1, 1D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, 2Department of Basic Medical Sciences, Neuroscience and Sense Organs, Unit of Neurophysiopathology, Policlinico Hospital, University of Bari, BARI, Italy, 3Institute of General Surgery ‘G Marinaccio’ (DETO), Policlinico Hospital, University of Bari, BARI, Italy, 4Laboratory of Clinical Pathology, University Hospital of Bari, BARI, Italy

    Background/Purpose: To investigate the expression of autophagy marker LC3, localization of macrophages and accumulation of misfolded proteins in myofibres of immune-mediated necrotizing myopathy (IMNM) muscle…
  • Abstract Number: 2043 • 2018 ACR/ARHP Annual Meeting

    Monocytes and Macrophages of Patients with Rheumatoid Arthritis Respond to Pathologically Increased Ionized Calcium with Proinflammatory Cytokine Production

    Supriya Murthy1, Elisabeth Jaeger1, Sebastian Jung1, Kathleen Friedrich2, Olga Seifert1, Christoph Baerwald1, Matthias Pierer1 and Manuela Rossol1, 1Department of Internal Medicine, Rheumatology, University of Leipzig, Leipzig, Germany, 2Department of Internal Medicine, Rheumatology, University of Leipzig, Germany, Leipzig, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and periarticular bone erosion. Bony erosions and cell necrosis might lead to a local…
  • Abstract Number: 840 • 2018 ACR/ARHP Annual Meeting

    The CCL21/CCR7 Axis Drives Vascular, Inflammatory and Destructive Remodeling in Rheumatoid Arthritis

    Katrien Van Raemdonck1,2, Karol Palasiewicz1,2, Sadiq Umar1,2 and Shiva Shahrara2, 1Jesse Brown VA Medical Center, Chicago, IL, 2Medicine, Division of Rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: The synovial tissue of rheumatoid arthritis (RA) patients exhibits abundant expression of CCL21, produced excessively by RA fibroblasts and macrophages. While CCR7 mediates CCL21-driven…
  • Abstract Number: 846 • 2018 ACR/ARHP Annual Meeting

    CD14 Deficiency Dampens Osteoclastogenesis and Alters Bone Remodeling in a Murine Model of Osteoarthritis

    Cheng Zhou1,2, Vu Nguyen2,3, Ryan Smalley2, Nisha Sambamurthy1,2, George R. Dodge2,4 and Carla Scanzello1,2, 1Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, 3University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 4Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

    Background/Purpose: Pathogenesis of osteoarthritis (OA) is accompanied by chronic inflammation evidenced by macrophage infiltration into the joint. CD14, is expressed by monocyte/macrophage lineage cells, and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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