ACR Meeting Abstracts

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Abstracts tagged "macrophages"

  • Abstract Number: 1478 • ACR Convergence 2021

    An Orphan Receptor and Osteoarthritis: Mouse Gpr34 Expression in Dorsal Root Ganglia After Partial Meniscectomy

    David Thomas1, Terese Geraghty2, Alia Obeidat2, Jun Li2, Rachel Miller2 and Anne-Marie Malfait3, 1University of Minnesota Internal Medicine Residency, St. Paul, MN, 2Rush University Medical Center, Chicago, IL, 3Rush University, Chicago, IL

    Background/Purpose: Osteoarthritis (OA) is one of the leading causes of musculoskeletal pain and disability. Worldwide, an estimated 303 million patients have clinically diagnosed OA, with…
  • Abstract Number: 1498 • ACR Convergence 2021

    Platelet Secreted LGALS3BP Induces a Pro-inflammatory Phenotype in Systemic Lupus Erythematosus

    Hanane EL Bannoudi1, MacIntosh Cornwell2, Elliot Luttrell-Williams2, Alexis Engel3, Christina Rolling1, Peter Izmirly4, H. Michael Belmont5, Kelly Ruggles2, Robert Clancy6, Jill Buyon5 and Jeffrey Berger2, 1NYU Langone Health, New York, NY, 2New York University, New York, NY, 3NYU Langone Health, New Yok, NY, 4New York University School of Medicine, New York, NY, 5NYU School of Medicine, New York, NY, 6NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex chronic heterogeneous autoimmune disease, which increases the risk of atherothrombosis. In addition to their well described role…
  • Abstract Number: 1575 • ACR Convergence 2021

    Urate Crystals Regulate a Distinct JNK-Dependent Metabolic and Inflammatory Response

    Anyan Cheng1, Isidoro Cobo1, Jessica Murillo Saich1, Roxana Coras2, Alyssa Torres3, Addison Lana1, Johannes Schlachetzki1, Ru Liu Bryan4, Robert Terkeltaub5, Elsa Sanchez-Lopez3, Christopher Glass1 and Monica Guma6, 1University of California San Diego, La Jolla, CA, 2University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, 3University of California San Diego, San Diego, CA, 4University of California San Diego and VASDHS, San Diego, CA, 5VA/UCSD, San Diego, CA, 6University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Although metabolic reprograming and its regulation in macrophages after TLR activation is well established, little is known about the regulation and the role of…
  • Abstract Number: 1891 • ACR Convergence 2021

    Variable Effects of Testosterone on Male versus Female Derived Macrophages in Inflammatory Arthritis

    Kiana Chen1, Xi Lin1, Lianping Xing2, H. Mark Kenney3, Richard Bell4, Edward Schwarz5 and Homaira Rahimi5, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester Medical Center, Webster, NY, 3University of Rochester Medical Center, Rochester, NY, 4Hospital for Special Surgery, New York, NY, 5University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that is female predominant. The TNF-transgenic (TNF-Tg) mouse model of RA also develops a sexually…
  • Abstract Number: 0302 • ACR Convergence 2021

    Loss of TAM Receptor Mer Contributes to Sjögren’s Syndrome–like Disease in Mice

    Richard Witas and Cuong Nguyen, University of Florida, Gainesville, FL

    Background/Purpose: Sjögren’s syndrome (SjS) is a chronic autoimmune disease primarily involving the exocrine glands where the involvement of the innate immune system is largely uncharacterized.…
  • Abstract Number: 0526 • ACR Convergence 2021

    Transcriptional Factor Profiling Denotes Specific Synovial Macrophage Heterogeneity

    Deborah Winter1, Carla Cuda2, Shang-Yang Chen2, Anna Montgomery3, Salina Dominguez2, Gaurav Gadhvi2 and Harris Perlman2, 1Northwestern University Division of Rheumatology, Chicago, IL, 2Northwestern University, Chicago, IL, 3UCL, Chicago, IL

    Background/Purpose: Macrophages are critical to the pathogenesis of rheumatoid arthritis(RA), but several distinct macrophage subpopulations co-exist in the synovium of joints. In steady-state, tissue-resident macrophages…
  • Abstract Number: 0540 • ACR Convergence 2021

    Behavioral Deficits May Precede Influx of Brain-Infiltrating Macrophages in Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Hadijat Makinde, Miranda Gurra, Yidan Wang, Sara Radecki and Carla Cuda, Northwestern University, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 0556 • ACR Convergence 2021

    Investigating the Heterogeneity of Skin Macrophages in Systemic Scleroderma

    Hadijat Makinde1, Salina Dominguez1, Monique Hinchcliff2, Deborah Winter3 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Yale School of Medicine, Westport, CT, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: The etiology and pathogenesis of systemic sclerosis (SSc) are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes…
  • Abstract Number: 1000 • ACR Convergence 2021

    Molecular Mechanism of Inhibition of CD38 in Attenuation of Monosodium Urate Crystal-induced Inflammatory Responses in Macrophages

    Huaping Qin1, Patricia Oliveira1, Tiffany Yan1, Robert Terkeltaub2 and Ru Liu Bryan3, 1University of California San Diego, La Jolla, CA, 2VA/UCSD, San Diego, CA, 3University of California San Diego and VASDHS, San Diego, CA

    Background/Purpose: CD38 can function as a degrading enzyme of nicotinamide adenine dinucleotide (NAD), a critical metabolic intermediate serving as enzyme cofactor in redox reactions and…
  • Abstract Number: 1001 • ACR Convergence 2021

    Exosomes Mediate a Cooperative Mechanism of Macrophage/Fibroblast Activation in Systemic Sclerosis

    Rajan Bhandari1, Heetaek Yang2, Noelle Kosarek3, Michael Whitfield4 and Patricia Pioli1, 1Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Geisel School of Medicine, Hanover, NH, 3Dartmouth Geisel School of Medicine, Hartford, VT, 4Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Prior work demonstrates that macrophages (MØs) from patients with Systemic Sclerosis (SSc) produce fibrotic and pro-inflammatory mediators and that cocultured MØs and SSc fibroblasts…
  • Abstract Number: 0071 • ACR Convergence 2020

    Significant Enrichment of Transcriptionally Distinct CD206+CD163+ Macrophage Population in Rheumatoid Arthritis Synovial Tissue

    Megan Hanlon1, Mary Canavan2, Qingxuan Song3, Candice Low4, Phil Gallagher5, Ronan Mullan6, Conor Hurson7, Sunil Nagpal8, Douglas Veale9 and Ursula Fearon2, 1Molecular Rheumatology, Trinity College Dublin, Dublin 2, Dublin, Ireland, 2Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 3Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 4EULAR Centre for Arthritis and Rheumatic diseases, St Vincents University Hospital, UCD, Dublin, Ireland, 5St Vincents University Hospital, UCD, Dublin, Ireland, 6Adelaide and Meath Hospital, Dublin, Dublin, Ireland, 7St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, 8Janssen Research & Development, Collegeville, PA, 9EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: Synovial tissue macrophages are an exquisitely plastic pool of innate cells that play a key role in RA disease progression. However, the precise nature,…
  • Abstract Number: 0072 • ACR Convergence 2020

    Characterizing Heterogeneity of Synovial Macrophages in Rheumatoid Arthritis Patients

    Shang-Yang Chen1, Yidan Wang2, Anna Montgomery2, Salina Dominguez2, Carla Cuda2, Gaurav Gadhvi1, Harris Perlman2 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). While they are potent producers of…
  • Abstract Number: 0669 • ACR Convergence 2020

    Calcium Pyrophosphate Crystal Deposition in Gouty Tophi

    Hang-Korng Ea1, Alan Gauffenic2, Quand Nguyen3, Nhu Pham3, Oceane Olivier2, Vincent Frochot4, Dominique Bazin5, Nghia Le3, Caroline Marty2, Agnès Ostertag2, Martine Cohen-Solal1, Jean-Denis Laredo6, Pascal Richette7 and Thomas Bardin8, 1Université de Paris, INSERM UMR 1132, BIOSCAR, AP-HP, DMU Locomoteur, Paris, France, 2Université de Paris, INSERM UMR 1132, BIOSCAR, Paris, France, 3Vien Gut Medical Center and French-Vietnamese research center on gout and chronic diseases, Ho Chi Ming, Vietnam, 4Hôpital Tenon, Service des explorations fonctionnelles multidisciplinaires, Sorbonne université, UMR_S1155, Paris, France, 5Institut de Chimie Physique, Université Paris-Saclay et CNRS - UMR8000, Orsay, France, 6AP-HP Université de Paris, Paris, 7Department of Rheumatology, Lariboisière Hospital, AP-HP Université de Paris, INSERM U1132, Paris, 8Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France

    Background/Purpose: The coexistence of calcium pyrophosphate (CPP) and monosodium urate crystals is rarely reported in gouty tophi. We investigated CPP crystal deposits in a series…
  • Abstract Number: 0738 • ACR Convergence 2020

    Systemic Administration of Novel Hydroxyl Dendrimers to Target Inflammation in Arthritic Tissues

    Jeffrey Cleland1, Rishi Sharma2, Minghao Sun3, Santiago Appiani La Rosa3 and Rangaramanujam M. Kannan4, 1Ashvattha Therapeutics, Inc, Redwood City, CA, 2Ashvattha Therapeutics, Baltimore, MD, 3Ashvattha Therapeutics, Inc, Baltimore, MD, 4Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: Chronic inflammation observed in arthritis and other autoimmune disorders is mediated primarily by pro-inflammatory reactive macrophages.  Systemic administration of anti-inflammatory agents does not selectively…
  • Abstract Number: 0787 • ACR Convergence 2020

    MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients

    Alessandra Nerviani1, Marie-Astrid Boutet1, Giulia Maria Ghirardi2, Gloria Lliso-Ribera2, Felice Rivellese1, Myles Lewis1, Michele Bombardieri2, Frances Humby2 and Costantino Pitzalis2, 1Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 2Queen Mary University of London, London, United Kingdom

    Background/Purpose: Despite valuable improvements in long-term clinical outcomes, a significant portion of rheumatoid arthritis (RA) patients still do not adequately respond to available treatments, and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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