ACR Meeting Abstracts

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Abstracts tagged "macrophages"

  • Abstract Number: 1981 • ACR Convergence 2022

    Rho-GTPase Expression Recruits CD14+ Cells to Joints in Rheumatoid Arthritis and Predicts Good Response to JAK-inhibitor Treatment

    Eric Malmhäll-Bah1, Karin Andersson2, Nina Oparina2, Sofia Töyrä Silfverswärd3, Malin Erlandsson2 and Maria Bokarewa3, 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden, 3Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

    Background/Purpose: While examining arthritis development in GGTaseI-deficient mice, we found that hyperactive Rho-GTPases regulate the thymic egress of CD4+ T cells to the peripheral lymphoid…
  • Abstract Number: 0825 • ACR Convergence 2022

    Predicting Outcomes in Macrophage Activation Syndrome (MAS): A Retrospective Study on 43 Consecutive Patients with MAS

    Sumanth Madan1, Suma Balan1, MITHUN CHALAKKARAYIL BHAGAVALDAS2, Spoorthy DR1, Sudeep Rath1, Joslyn Thattil1, Amisha Shahul1 and Niveditha Kartha1, 1Amrita Institute of Medical Sciences, Kochi, India, 2Amrita Institute of Medical Sciences, Muvattupuzha, India

    Background/Purpose: Macrophage activation syndrome is a diagnosis along the spectrum of hemophagocytic lymphohistiocytosis (HLH) spectrum disorders. It is a rare, yet potentially fatal disease characterized…
  • Abstract Number: 2164 • ACR Convergence 2022

    Profibrotic Alveolar Macrophages as a Potential Biomarker in Systemic Sclerosis-associated Interstitial Lung Disease

    Nikolay Markov1, Karolina Senkow1, Anthony Esposito2, Jonathan Puchalski3, Mridu Gulati3, Erica Herzog3, Danielle Antin-Ozerkis4, Mary Carns5, Alyssa Williams6, Nic Page6, Alexander Misharin1 and Monique Hinchcliff7, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Brigham and Women's Hospital, Department of Medicine, Boston, MA, 3Yale School of Medicine, New Haven, CT, 4Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, 5Northwestern University Division of Rheumatology, Chicago, IL, 6Yale University, New Haven, CT, 7Yale School of Medicine, Westport, CT

    Background/Purpose: Interstitial lung disease (ILD) is a leading cause of death in patients with systemic sclerosis (SSc). Previously, profibrotic monocyte-derived alveolar macrophages (MoAM) expressing (SPP1,…
  • Abstract Number: 1119 • ACR Convergence 2022

    Investigating Macrophage Heterogeneity in the Esophagus and Lungs of SSc Patients

    Hadijat Makinde1, Carla Cuda1, Miranda Gurra1, Mary Carns2, Kathleen Aren2, Gaurav Gadhvi1, Salina Dominguez1, Jane Dematte3, Darren Brenner4, John Pandolfino5, G. R. Scott Budinger4, Deborah Winter6 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Northwestern University Division of Rheumatology, Chicago, IL, 3Northwestern University, Elmhurst, IL, 4Northwestern University Feinberg School of Medicine, Chicago, IL, 5Northwestern University, Feinberg School of Medicine, Wilmette, IL, 6Northwestern University, Skokie, IL

    Background/Purpose: Our group has made important contributions to an emerging understanding of monocytes and macrophages as central to SSc pathogenesis. There are numerous studies that…
  • Abstract Number: 2261 • ACR Convergence 2022

    Pain in Osteoarthritis – Identification of GPR34 and GPR150 as Novel Targets in the Dorsal Root Ganglia

    Matthew Wood1, Terese Geraghty2, David Thomas3, Alia Obeidat1, Jun Li2, Richard Miller4, Rachel Miller1 and Anne-Marie Malfait5, 1Rush University Medical Center, Chicago, IL, 2Rush University, Chicago, IL, 3University of Minnesota Internal Medicine Residency, St. Paul, MN, 4Northwestern University, Evaston, IL, 5Rush University, Oak Park, IL

    Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic pain worldwide. Currently available pain-alleviating therapies are often inadequate and associated with serious adverse effects, resulting…
  • Abstract Number: 1166 • ACR Convergence 2022

    Scleroderma Fibroblasts Induce Alternative Macrophage Activation via an ERK1/2-dependent Mechanism

    Taha Dinc1, Juan-Pablo Zertuche1, Fatima El Adili2, Maria Trojanowska3 and Andreea Bujor3, 1Boston University School of Medicine, Boston, MA, 2Boston University School of Medicine, Revere, MA, 3Boston University, Boston, MA

    Background/Purpose: Activation of the innate immune system in systemic sclerosis (SSc), with an increased number of profibrotic/alternatively-activated macrophages in affected tissues, is an important aspect…
  • Abstract Number: 1168 • ACR Convergence 2022

    Dermal Fibroblast-derived Exosomes Drive Profibrotic Macrophage Activation in Systemic Sclerosis

    Heetaek Yang1, Rajan Bhandari1, Noelle Kosarek2, Jonathan Garlick3, Michael Whitfield4 and Patricia Pioli1, 1Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Dartmouth Geisel School of Medicine, Lebanon, NH, 3Tufts University School of Dental Medicine, Boston, MA, 4Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Macrophage (MØ) activation derives from coordination of signals received in local tissue microenvironments. In prior studies, we demonstrated that cocultured MØs and fibroblasts from…
  • Abstract Number: 1169 • ACR Convergence 2022

    Downregulated Fli1 in Systemic Sclerosis Myeloid Cells Contributes to Enhanced Transendothelial Migration

    Pablo Weilg Espejo1, Taha Dinc2, Fatima El Adili3, Maria Trojanowska4 and Andreea Bujor4, 1Boston Medical Center, Chelsea, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Revere, MA, 4Boston University, Boston, MA

    Background/Purpose: The mononuclear phagocytic system in Systemic Sclerosis (SSc) is central to fibrogenesis and may contribute to fibrosis via enhanced monocyte migration into injured tissues…
  • Abstract Number: 1172 • ACR Convergence 2022

    Transcription Analysis of Macrophages Reveals Important Changes Induced by Systemic Sclerosis Fibroblasts

    Juan-Pablo Zertuche1, Taha Dinc2, Fatima El Adili3, Giovanni Ligresti1 and Andreea Bujor1, 1Boston University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Revere, MA

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune connective tissue disease characterized by immune system activation, endothelial dysfunction and widespread tissue fibrosis. Activation of the monocyte/macrophage…
  • Abstract Number: 0028 • ACR Convergence 2022

    Microenvironmental Stiffness Modulates Macrophage Responsiveness and Communication with Mesenchymal Stem Cells

    Sung Yeon Kim, Carla Scanzello, Robert Mauck and Edward Bonnevie, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The synovium envelopes the diarthodial joint and is composed of fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS). In healthy joints, the synovial cavity maintains…
  • Abstract Number: 1174 • ACR Convergence 2022

    Cellular Immunotherapy for Systemic Sclerosis

    Chanhyuk Park1, Rajan Bhandari2, Jason Gunn3, Timothy Sullivan2, Gretel Torres2, Joana Murad3, Michael Whitfield4 and Patricia Pioli2, 1Geisel School of Medicine at Dartmouth, West Lebanon, NH, 2Geisel School of Medicine at Dartmouth, Lebanon, NH, 3Celdara Medical, Lebanon, 4Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Pro-fibrotic macrophages (MØs) are implicated in the pathogenesis of systemic sclerosis (SSc). In prior work, we and others have shown that MØs derived from…
  • Abstract Number: 0148 • ACR Convergence 2022

    Dysferlin Associated Autoinflammatory Disease Causing Systemic Inflammation and Sterile Lung Abcesses Through Impaired Efferocytosis

    Farzana Bhuyan1, Adriana Almeida de Jesus2, Clinton Bradfield3, Mohammad Arif Rahman4, Andre Rastegar3, sundar ganesan3, Sachin Gaurav3, Sara Alehashemi3, Ronit Herzog5, Steven Holland3, Deborah Consilini6, Iain Fraser3 and Raphaela Goldbach-Mansky7, 1National Institutes of Health, Bethesda, MD, 2NIAID, NIH, Silver Spring, MD, 3NIAID, Bethesda, MD, 4NCI, Bethesda, MD, 5Langone Medical Center, New York, NY, 6Nemours Children's Hospital-Delaware, Wilmington, DE, 7NIAID, NIH, Rockville

    Background/Purpose: Using whole exome sequencing (WES), we identified a de novo mutation in DYSF encoding dysferlin in 2 unrelated patients with systemic inflammation and sterile…
  • Abstract Number: 1177 • ACR Convergence 2022

    Identification of a New Type of Pro-phagocytic Macrophages in Patients with Systemic Sclerosis

    Amela Hukara1, Tracy Tabib2, Michal Rudnik1, Oliver Distler3, Przemyslaw Blyszczuk1, Robert Lafyatis2 and Gabriela Kania1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 2Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 3Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland

    Background/Purpose: Phagocytosis is a crucial cellular process, which under certain immuno-pathological conditions can be activated in macrophages in an uncontrolled manner. Biomarker studies have implicated…
  • Abstract Number: 0302 • ACR Convergence 2021

    Loss of TAM Receptor Mer Contributes to Sjögren’s Syndrome–like Disease in Mice

    Richard Witas and Cuong Nguyen, University of Florida, Gainesville, FL

    Background/Purpose: Sjögren’s syndrome (SjS) is a chronic autoimmune disease primarily involving the exocrine glands where the involvement of the innate immune system is largely uncharacterized.…
  • Abstract Number: 0526 • ACR Convergence 2021

    Transcriptional Factor Profiling Denotes Specific Synovial Macrophage Heterogeneity

    Deborah Winter1, Carla Cuda2, Shang-Yang Chen2, Anna Montgomery3, Salina Dominguez2, Gaurav Gadhvi2 and Harris Perlman2, 1Northwestern University Division of Rheumatology, Chicago, IL, 2Northwestern University, Chicago, IL, 3UCL, Chicago, IL

    Background/Purpose: Macrophages are critical to the pathogenesis of rheumatoid arthritis(RA), but several distinct macrophage subpopulations co-exist in the synovium of joints. In steady-state, tissue-resident macrophages…
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