ACR Meeting Abstracts

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Abstracts tagged "macrophages"

  • Abstract Number: 0529 • ACR Convergence 2022

    Complex Relationships Between Inflammation and Clonal Hematopoiesis in Systemic Vasculitis

    Adrianna Jones1, Kristina Wells1, Fernanda Gutierrez-Rodrigues2, Cameron Rankin3, Wanxia Tsai3, Bhavisha Patel4, Kaitlin Quinn1, Dalton Hironaka2, Massimo Gadina5, Keith Sikora1, Neal Young2 and Peter Grayson6, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, 3NIAMS/NIH, Bethesda, MD, 4National Institutes of Health, Beltsville, MD, 5Translational Immunology Section, NIAMS, NIH, Bethesda, MD, 6National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is defined by somatic mutations in a set of genes commonly associated with myeloid neoplasms in an otherwise…
  • Abstract Number: 1666 • ACR Convergence 2022

    Differentiation of Injury-associated Macrophages in Lupus Kidneys Is Conserved in Humans and Lupus Mouse Models

    Paul Hoover1, David Lieb2, Stephen Li2, Chirag Raparia3, Accelerating Medicines Partnership SLE/RA4, Arnon Arazi5, Nir Hacohen2 and Anne Davidson6, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Cambridge, MA, 3Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Shoreham, NY, 4NIH, Bethesda, MD, 5Feinstein Institutes for Medical Research, Melrose, MA, 6Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Infiltrating monocytes acquire functions that support kidney remodeling in response to tissue damage in lupus nephritis. This process of monocyte differentiation has been difficult…
  • Abstract Number: 0554 • ACR Convergence 2022

    Loss of Synovial Tissue Macrophage Homeostasis Precedes Rheumatoid Arthritis Clinical Onset

    Megan Hanlon1, Mary Canavan2, conor Smith3, Achilleas Floudas4, Nuno Neto5, Qingxuan Song6, Phil Gallagher7, Ronan Mullan8, Conor Hurson9, Barry Moran5, Michael Monaghan5, Sunil Nagpal10, Douglas Veale11 and Ursula Fearon5, 1Molecular Rheumatology, Dublin, Ireland, 2Trinity College, Dublin, Ireland, 3bTrinity College Dublin, Dublin, Ireland, 4Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, 5Trinity College Dublin, Dublin, Ireland, 6Janssen Research and Development, LLC, Spring House, PA, 7St Vincent's University Hospital, Dublin, Ireland, 8Tallaght University Hospital, Dublin, Ireland, 9St Vincents University Hospital, Dublin, Ireland, 10Janssen Research, Collegeville, PA, 11St. Vincent's University Hospital, Blackrock, Dublin, Ireland

    Background/Purpose: Synovial-tissue macrophages significantly contribute to Rheumatoid Arthritis, yet the precise nature/function of macrophage subsets within the inflamed joint remains unexplored. Here we explore the…
  • Abstract Number: 1681 • ACR Convergence 2022

    Supernatants from Activated Macrophages Contain Citrullinated Vimentin and Induce Extracellular Matrix Deposition from Fibroblasts

    nozima Aripova1, Michael Duryee1, Eric Daubach1, carlos hunter1, Bryant England1, James O'Dell1, Ted Mikuls2 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Studies have shown that activated macrophages secrete several factors that promote human fibroblast-like synoviocyte (HFLS) activation, resulting in an invasive phenotype, that contributes to…
  • Abstract Number: 0596 • ACR Convergence 2022

    Neutrophil Extracellular Traps (NET) Trigger an Enhanced Pro-inflammatory Response in Macrophage Subpopulations in Rheumatoid Arthritis Patients via the Aryl Hydrocarbon Receptor (AhR) Pathway

    Dyhia Melbouci1, Sarra Seninet1, Marie-Christophe Boissier2, Elodie Segura3 and Patrice Decker1, 1University Sorbonne Paris Nord, Inserm UMR 1125, Li2P, Bobigny, France, 2INSERM UMR 1125, Sorbonne Paris Nord University,Rheumatology Dpt, APHP, GHUPSSD, Avicenne Hosp, Bobigny, France, 3U932 Inserm, Curie Institute, Paris, France

    Background/Purpose: Activated neutrophils (PMN) form neutrophil extracellular traps (NET), fibers of DNA and associated proteins expelled in the extracellular space. Increased NET formation has been…
  • Abstract Number: 1682 • ACR Convergence 2022

    Peptidyl Arginine Deiminase Expression and Macrophage Polarization Following Stimulation with Citrullinated and Malondialdehyde-acetaldehyde Modified Fibrinogen

    nozima Aripova1, Michael Duryee1, carlos hunter1, Bryant England1, Debra Romberger1, James O'Dell1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Post-translational modifications (PTM) of extracellular matrix proteins, such as fibrinogen, have been implicated in the pathogenesis of rheumatoid arthritis (RA). Citrullination, a type of…
  • Abstract Number: 0600 • ACR Convergence 2022

    Correlates Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Phenotypes: Data from the Accelerated Medicines Partnership

    Dana Weisenfeld1, Fan Zhang2, Laura Donlin3, Anna Jonsson1, William Apruzzese1, Debbie Campbell4, Ellen Gravallese5, Larry Moreland6, Susan Goodman3, Michael Brenner5, Soumya Raychaudhuri1, Andrew Filer7, Jennifer Anolik8, Vivian Bykerk3 and Katherine Liao1, 1Brigham and Women's Hospital, Boston, MA, 2University of Colorado, Aurora, CO, 3Hospital for Special Surgery, New York, NY, 4University of Rochester, Rochester, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6University of Colorado, Denver, CO, 7University of Birmingham, Birmingham, United Kingdom, 8University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Prior studies have characterized the diverse cell types in the RA synovium through a multi-center consortium incorporating RNA-seq data. Due to the novelty of…
  • Abstract Number: 1683 • ACR Convergence 2022

    Malondialdehyde-Acetaldehyde (MAA) Modified Matrix Gla Protein (MGP) Increases Citrullination by Human Macrophages

    Spencer Jones1, nozima Aripova1, Michael Duryee1, Austin Ragland1, Bryant England1, Ted Mikuls2 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Malondialdehyde and acetaldehyde, by-products of lipid peroxidation, react with free amino groups on proteins to form a stable post-translational modification (PTM), termed MAA. MAA…
  • Abstract Number: 0609 • ACR Convergence 2022

    Macrophage Response to MAA Modified Fibrinogen in the Presence of Peptidyl Arginine Deiminase Inhibitor

    nozima Aripova1, Michael Duryee1, carlos hunter1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The formation of citrullinated (CIT) proteins is catalyzed by a calcium-dependent peptidyl arginine deiminase (PAD). In rheumatoid arthritis (RA), synovial macrophages are main contributors…
  • Abstract Number: 1691 • ACR Convergence 2022

    Pentagalloyl Glucose Inhibits MSU-Induced Inflammation via Transforming Growth Factor-β-Activated Kinase 1 (TAK1)

    Paul Panipinto, Anil Singh, Farheen Sultan Shaikh and Salahuddin Ahmed, Washington State University, Spokane, WA

    Background/Purpose: Gout disease flares occur when primed macrophages interact with and phagocytose monosodium urate crystals (MSU), activating IL-1β via the NLRP3 inflammasome. Abrogation of inflammasome…
  • Abstract Number: 0614 • ACR Convergence 2022

    Post-translationally Modified Fibrinogen Activated Macrophages Drive the Expression of Fibrotic Genes in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    nozima Aripova1, Michael Duryee1, carlos hunter1, Eric Daubach1, Evan Ryan1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Cellular interactions between synovial macrophages and human fibroblast-like synoviocytes (HFLS) contribute to articular inflammation and fibrosis in rheumatoid arthritis (RA), leading to subsequent joint…
  • Abstract Number: 1695 • ACR Convergence 2022

    Dermatomyositis (DM) Macrophages Upregulate Genes Involved in the Remodeling of the Extracellular Matrix and Activate Keratinocytes in a Novel 3D Tissue Model of DM Skin Disease

    Zoe Chafouleas1, Angelique Cortez1, James Whitley1, Dorothea Barton1, Lin Brown1, Michael Whitfield2, Patricia pioli3 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Dartmouth Geisel School of Medicine, Department of Biomedical Data Science, Lebanon, NH, 3Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: With an incidence of 10 cases per million and lack of animal or ex vivo disease models, dermatomyositis (DM) remains a debilitating disease without…
  • Abstract Number: 0630 • ACR Convergence 2022

    Ferroptosis of CD163+ Tissue Infiltrating Macrophages in Lupus Nephritis

    Qi Cheng, Huaxiang Wu and Yan Du, The Second Affiliated Hospital Of Zhejiang University School Of Medicine, Hangzhou, China

    Background/Purpose: Lupus nephritis (LN) is one of the most common complications of systemic lupus erythematosus (SLE), with high morbidity and mortality. Despite a better understanding…
  • Abstract Number: 1730 • ACR Convergence 2022

    T Cell-Macrophage Interactions Play a Critical Role in a Mouse Model of Histidyl-tRNA Synthetase-Induced Myositis

    Daniel Reay1, Ying Wang2, Wael Jarjour3, Paula Clemens1 and Dana Ascherman4, 1University of Pittsburgh School of Medicine, Pittsburgh, PA, 2University of Miami Miller School of Medicine, Miami, FL, 3The Ohio State University, Columbus, OH, 4University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Histidyl-tRNA synthetase (HRS) is a key target of antigen-specific B and T cell responses in the anti-synthetase syndrome. Despite a clear role for aberrant…
  • Abstract Number: 0670 • ACR Convergence 2022

    A Short Allelic Epitope Coded by HLA-DRB1*03:01 Activates a Systemic Lupus Erythematosus Cell Aberration Cascade

    Bruna Miglioranza Scavuzzi1, Bhavneet Kaur1, Vincent Van Drongelen1, Raquel Mesquita-Ferrari2, Amr Sawalha3, Frederick Miller4 and Joseph Holoshitz1, 1University of Michigan, Ann Arbor, MI, 2Universidade Nove de Julho (UNINOVE), São Paulo, Brazil, 3University of Pittsburgh, Pittsburgh, PA, 4Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from an interaction of genetic, epigenetic, hormonal, environmental and immunoregulatory influences. It has been well…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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