Abstract Number: 2157 • 2012 ACR/ARHP Annual Meeting
Resveratrol Counters Pro-Atherogenic Effects of Systemic Lupus Erythematosus and Rheumatoid Arthritis Plasma On Cholesterol Efflux in Human Macrophages
Background/Purpose: Our group has demonstrated that resveratrol, a plant polyphenol, possesses atheroprotective properties, enhancing expression of reverse cholesterol transport (RCT) proteins. We have reported that Systemic…Abstract Number: 1800 • 2012 ACR/ARHP Annual Meeting
Macrophages in Hypoxic Rheumatoid Joints Preferentially Express Hypoxia Inducible Transcription Factor-2
Background/Purpose: In rheumatoid arthritis (RA), the influx of inflammatory cells as well as the aggressive proliferation of fibroblast-like synovial cells (FLS) outstrips the oxygen supply…Abstract Number: 1801 • 2012 ACR/ARHP Annual Meeting
Biological Roles of C5orf30 in Rheumatoid Arthritis
Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first exon of an uncharacterized gene C5orf30. In addition, this variant is…Abstract Number: 1454 • 2012 ACR/ARHP Annual Meeting
Characterization of Renal Mononuclear Phagocyte Populations in Murine SLE Nephritis
Background/Purpose: Macrophages and dendritic cells contribute to renal damage in chronic renal diseases including lupus nephritis. However owing to their multiple phenotypic and functional variations,…Abstract Number: 1196 • 2012 ACR/ARHP Annual Meeting
Analysis of Gene Expression Patterns in Rheumatoid Arthritis (RA) Synovial Macrophages From Patients Undergoing Disease Flare
Background/Purpose: Synovial macrophages play a key role in RA pathogenesis. Their numbers are greatly increased in RA synovium, their phenotype is consistent with a pro-inflammatory…Abstract Number: 1078 • 2012 ACR/ARHP Annual Meeting
Prolactin Is Increased in Responders to Anti-TNFá Treatment and the Role of the Prolactin Receptor in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is the most common rheumatic disease which mainly affects women. In the last decade, it is known that prolactin (PRL) is…Abstract Number: 1057 • 2012 ACR/ARHP Annual Meeting
A Specific Inhibitor of Spleen Tyrosine Kinase, PRT062607, Is a Potent Modulator of Innate Immune Cell Function
Background/Purpose: Tumor Necrosis Factor-α (TNF-α) is an essential component of the inflammatory stimuli leading to rheumatoid arthritis (RA). Therapeutics targeting TNF-α are the standard of…Abstract Number: 901 • 2012 ACR/ARHP Annual Meeting
Colony-Stimulating Factor (CSF) Receptor 1 Blockade Overcomes Overlapping Effects of M-CSF and Interleukin-34 On Myeloid Differentiation and Gene Expression to Reduce Inflammation in Human and Murine Models of Rheumatoid Arthritis
Background/Purpose: Disease activity and response to therapy in RA correlates with changes in synovial macrophage numbers and their products. M-CSF or IL-34 stimulation of their…Abstract Number: 880 • 2012 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 8 Regulates BAFF Production in Murine Macrophages and Is a Nexus for Cross Talk Between IFN-γ and TGF-β
Background/Purpose: Lupus is a systemic autoimmune disease that can lead to severe end-organ damage characterized by unabated inflammation and aberrant tissue repair. Macrophage dysregulation plays…Abstract Number: 882 • 2012 ACR/ARHP Annual Meeting
Anti-Inflammatory Effects of Phosphodiesterase 4 Inhibition Are Mediated by Mitogen-Activated Protein Kinase Phosphatase-1
Background/Purpose: MAP kinase phosphatase-1 (MKP-1) is a nuclear tyrosine/threonine phosphatase that limits p38 MAP kinase activity. MKP-1 KO mice display excessive inflammatory response, and exhibit…Abstract Number: 733 • 2012 ACR/ARHP Annual Meeting
Intra-Articular Injection of Adipose-Derived Stem Cells Inhibits Activation of the Synovium and Protects Against Cartilage Damage and Enthesophyte Formation in Murine Experimental Osteoarthritis
Background/Purpose: OA lesions are treated with mesenchymal stem cells aiming to enhance tissue repair by transformation to eg. chondrocytes. Recently it has been shown that…Abstract Number: 666 • 2012 ACR/ARHP Annual Meeting
Leukadherin 1, a CR3 Mimetic, Negatively Regulates Toll Like Receptor (TLR) Dependent Inflammatory Responses via Degradation of an Adaptor Protein
Background/Purpose: Systemic Lupus Erythematosus is characterized by continuous and cyclic stimulation of the innate immune system by endogenous nucleic acids. Immune complexes of Ro60, ssRNA…Abstract Number: 344 • 2012 ACR/ARHP Annual Meeting
Non Classical Monocytes Are Required for Initiation Phase While Macrophages Are Necessary for the Resolution Phase in the K/BxN Murine of Inflammatory Arthritis
Background/Purpose: Monocytes and macrophages play an essential function in the pathogenesis of rheumatoid arthritis. However, monocytes and macrophages are a heterogenous population and thus the…
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