Abstract Number: 3175 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of MMF Clinical, Molecular, and Immunohistochemistry (IHC) Responses Shows SSc Patients Lose Their Inflammatory Signature and Rebound upon Treatment Cessation
Background/Purpose: We previously showed patients in the inflammatory subset were most likely to demonstrate improvement in modified Rodnan Skin Score (mRSS) during mycophenolate mofetil (MMF)…Abstract Number: 793 • 2015 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Promote the Generation of CD206+ Macrophage and Increase Its Phagocytic Activity in Systemic Lupus Erythematosus
Background/Purpose: Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) have been confirmed to exert therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits…Abstract Number: 1033 • 2015 ACR/ARHP Annual Meeting
Novel Ligand-Independent Peptide Inhibitors of Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) and T Cell Receptor (TCR): Efficacy in a Collagen-Induced Arthritis Model Suggests New Targeted Treatment for Rheumatoid Arthritis
Background/Purpose: Macrophages and T cells are central to the pathophysiology of autoimmune diseases. Synovial macrophages, synovial fibroblasts and infiltrating T lymphocytes are the most abundant…Abstract Number: 2151 • 2015 ACR/ARHP Annual Meeting
Inhibition of Myeloid-Associated Gene Expression in Skin Biopsy Samples of Systemic Sclerosis Patients Treated with Tocilizumab
Background/Purpose: Systemic sclerosis (SSc) is a progressive, debilitating disease with limited treatment options. IL-6 has been implicated in disease pathogenesis. Tocilizumab (TCZ), an IL-6Rα inhibitor,…Abstract Number: 2875 • 2014 ACR/ARHP Annual Meeting
Macrophage Expression of Hypoxia-Inducible Factor-2 Alpha Promotes Rheumatoid Arthritis Progression
Background/Purpose Hypoxia exists in many diseased tissues including arthritic joints, atherosclerotic plaques and malignant tumours. Macrophages accumulate in these hypoxic sites where they possess broad…Abstract Number: 2175 • 2014 ACR/ARHP Annual Meeting
Macrophages from the Synovium of Active Rheumatoid Arthritis Exhibit an Activin a- Dependent Pro-Inflammatory Profile
Background/Purpose: Synovial macrophages are key effector cells in rheumatoid arthritis (RA), where they are a major source of pro-inflammatory cytokines and contribute to the cartilage…Abstract Number: 1510 • 2014 ACR/ARHP Annual Meeting
Blockade of TLR5 Ligation Is a Novel Strategy for RA Therapy
Background/Purpose: TLR5 expression is highly elevated in RA and CIA lining and sublining macrophages and endothelial cells compared to non-arthritic controls. Additionally, expression of TLR5…Abstract Number: 1198 • 2014 ACR/ARHP Annual Meeting
Prolactin Is Locally Produced in the Synovium of Patients with Inflammatory Arthritic Diseases and Promotes Macrophage Activation
Background/Purpose The sex hormone prolactin (PRL) has immunomodulatory properties, can be produced by immune cells, and elevated PRL serum levels have been reported in rheumatoid…Abstract Number: 530 • 2013 ACR/ARHP Annual Meeting
Pattern Recognition Receptor Stimulated Cytokine Expression By Spondyloarthritis Patient Macrophages
Background/Purpose: Spondyloarthritis (SpA) encompasses a group of chronic inflammatory conditions involving axial arthritis that includes ankylosing spondylitis (AS). GWAS studies in AS have implicated multiple…Abstract Number: 1151 • 2013 ACR/ARHP Annual Meeting
Snapin Is Required For Functional Autophagy and Is Critical For Monocyte To Macrophage Differentiation
Background/Purpose: Our recent data indicate that Snapin, a SNAP associated protein, is significantly increased in macrophages (MΦs) in rheumatoid arthritis (RA) synovial tissue and its…Abstract Number: 1800 • 2012 ACR/ARHP Annual Meeting
Macrophages in Hypoxic Rheumatoid Joints Preferentially Express Hypoxia Inducible Transcription Factor-2
Background/Purpose: In rheumatoid arthritis (RA), the influx of inflammatory cells as well as the aggressive proliferation of fibroblast-like synovial cells (FLS) outstrips the oxygen supply…Abstract Number: 1801 • 2012 ACR/ARHP Annual Meeting
Biological Roles of C5orf30 in Rheumatoid Arthritis
Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first exon of an uncharacterized gene C5orf30. In addition, this variant is…Abstract Number: 1454 • 2012 ACR/ARHP Annual Meeting
Characterization of Renal Mononuclear Phagocyte Populations in Murine SLE Nephritis
Background/Purpose: Macrophages and dendritic cells contribute to renal damage in chronic renal diseases including lupus nephritis. However owing to their multiple phenotypic and functional variations,…Abstract Number: 1196 • 2012 ACR/ARHP Annual Meeting
Analysis of Gene Expression Patterns in Rheumatoid Arthritis (RA) Synovial Macrophages From Patients Undergoing Disease Flare
Background/Purpose: Synovial macrophages play a key role in RA pathogenesis. Their numbers are greatly increased in RA synovium, their phenotype is consistent with a pro-inflammatory…Abstract Number: 1078 • 2012 ACR/ARHP Annual Meeting
Prolactin Is Increased in Responders to Anti-TNFá Treatment and the Role of the Prolactin Receptor in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is the most common rheumatic disease which mainly affects women. In the last decade, it is known that prolactin (PRL) is…
ACR Meeting Abstracts