Abstracts tagged "macrophages"

Abstract Number: 2002 • 2019 ACR/ARP Annual Meeting
Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts
Samuel Finlay¹, Stefano Alivernini ², Aziza Elmesmari ³, Barbara Tolusso ², Luca Petricca ², Clara Di Mario ⁴, Annunziata Capacci ², Andrew Filer ⁵, Gianfranco Ferraccioli ², Iain McInnes ¹, Elisa Gremese ² and Mariola Kurowska-Stolarska ¹, ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ³Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, ⁴Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, ⁵Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Background: A substantial proportion of Rheumatoid Arthritis patients do not respond to treatment and only a small proportion achieve sustained disease remission. We showed…
Abstract Number: 840 • 2018 ACR/ARHP Annual Meeting
The CCL21/CCR7 Axis Drives Vascular, Inflammatory and Destructive Remodeling in Rheumatoid Arthritis
Katrien Van Raemdonck^1,2, Karol Palasiewicz^1,2, Sadiq Umar^1,2 and Shiva Shahrara², ¹Jesse Brown VA Medical Center, Chicago, IL, ²Medicine, Division of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The synovial tissue of rheumatoid arthritis (RA) patients exhibits abundant expression of CCL21, produced excessively by RA fibroblasts and macrophages. While CCR7 mediates CCL21-driven…
Abstract Number: 846 • 2018 ACR/ARHP Annual Meeting
CD14 Deficiency Dampens Osteoclastogenesis and Alters Bone Remodeling in a Murine Model of Osteoarthritis
Cheng Zhou^1,2, Vu Nguyen^2,3, Ryan Smalley², Nisha Sambamurthy^1,2, George R. Dodge^2,4 and Carla Scanzello^1,2, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: Pathogenesis of osteoarthritis (OA) is accompanied by chronic inflammation evidenced by macrophage infiltration into the joint. CD14, is expressed by monocyte/macrophage lineage cells, and…
Abstract Number: 929 • 2018 ACR/ARHP Annual Meeting
Transcriptional Profiling of the Subcutaneous Rheumatoid Nodule: An Insight into Pathogenic Mechanisms and Cellular Content
Judith Marsman¹, Melanie J Millier¹, John Highton¹, Lisa K. Stamp² and Paul A Hessian¹, ¹Department of Medicine, University of Otago, Dunedin, New Zealand, ²University of Otago, Christchurch, New Zealand
Background/Purpose: Rheumatoid nodules are the most common cutaneous manifestation in patients with RA, often associated with longstanding and a more severe disease course. Paradoxically, therapy…
Abstract Number: 1011 • 2018 ACR/ARHP Annual Meeting
Tissue Resident Macrophages Establish a Niche That Limits Monocyte to Macrophage Differentiation in Synovial Tissue during Homeostasis
Qi Quan Huang¹, Renee E. Doyle², Alexander Misharin³, Shang-Yang Chen⁴, Deborah R. Winter⁵ and Richard M. Pope², ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, ⁵Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Monocytes and Macrophages play critical roles in immune homeostasis and host defense. Recent studies identified that macrophages are highly heterogeneous in terms of location,…
Abstract Number: 1353 • 2018 ACR/ARHP Annual Meeting
Autophagy Marker LC3 Accumulates in Immune-Mediated Necrotizing Myopathy Muscle Fibres
Margherita Giannini¹, Francesco Girolamo², Anna Lia², Angela Amati², Luigi Serlenga², Dario D'Abbicco³, Marilina Tampoia⁴, Maria Trojano² and Florenzo Iannone¹, ¹D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ²Department of Basic Medical Sciences, Neuroscience and Sense Organs, Unit of Neurophysiopathology, Policlinico Hospital, University of Bari, BARI, Italy, ³Institute of General Surgery ‘G Marinaccio’ (DETO), Policlinico Hospital, University of Bari, BARI, Italy, ⁴Laboratory of Clinical Pathology, University Hospital of Bari, BARI, Italy
Background/Purpose: To investigate the expression of autophagy marker LC3, localization of macrophages and accumulation of misfolded proteins in myofibres of immune-mediated necrotizing myopathy (IMNM) muscle…
Abstract Number: 2043 • 2018 ACR/ARHP Annual Meeting
Monocytes and Macrophages of Patients with Rheumatoid Arthritis Respond to Pathologically Increased Ionized Calcium with Proinflammatory Cytokine Production
Supriya Murthy¹, Elisabeth Jaeger¹, Sebastian Jung¹, Kathleen Friedrich², Olga Seifert¹, Christoph Baerwald¹, Matthias Pierer¹ and Manuela Rossol¹, ¹Department of Internal Medicine, Rheumatology, University of Leipzig, Leipzig, Germany, ²Department of Internal Medicine, Rheumatology, University of Leipzig, Germany, Leipzig, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and periarticular bone erosion. Bony erosions and cell necrosis might lead to a local…
Abstract Number: 174 • 2017 ACR/ARHP Annual Meeting
Transcriptional Profiling of Synovial Macrophages from RA Patients to Capture Disease Heterogeneity
Philip J. Homan¹, Arthur M. Mandelin II², Salina Dominguez¹, Emily Bacalao³, S. Louis Bridges Jr.⁴, Joan M. Bathon⁵, John Atkinson⁶, David Fox⁷, Eric L. Matteson⁸, Chris Buckley⁹, Costantino Pitzalis¹⁰, Deborah Parks¹¹, Laura Hughes¹², Laura Geraldino-Pardilla¹³, Robert Ike¹⁴, Kristine Phillips¹⁵, Kerry Wright¹⁶, Andrew Filer¹⁷, Stephen Kelly¹⁸, Eric M. Ruderman¹⁹, Carla Cuda¹, Hiam Abdala-Valencia³, Alexander Misharin³, G. R. Scott Budinger³, Richard M. Pope¹⁹, Harris Perlman²⁰ and Deborah R. WInter¹, ¹Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ⁵Division of Rheumatology, Columbia University Medical Center, New York, NY, ⁶Washington University in St. Louis, St. Louis, MO, ⁷Department of Medicine [Division of Rheumatology], University of Michigan Medical System, Ann Arbor, MI, ⁸Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁹University of Birmingham, Birmingham, United Kingdom, ¹⁰Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹¹Washington University School of Medicine in St. Louis, St. Louis, MO, ¹²University Alabama Birmingham, Birmingham, AL, ¹³Columbia University, New york, NY, ¹⁴Division of Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁵University of Michigan, Ann Arbor, MI, ¹⁶Rheumatology, Mayo Clinic, Rochester, MN, ¹⁷Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ¹⁸William Harvey Research Institute, London, United Kingdom, ¹⁹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²⁰Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine,, Chicago, IL
Background/Purpose: In a given patient with rheumatoid arthritis (RA), it is difficult to predict disease progression or identify to which treatments they will respond. Macrophages…
Abstract Number: 301 • 2017 ACR/ARHP Annual Meeting
MiR-221-3p Overexpression Impairs Anti-Inflammatory Activity of TLR4-Stimulated M2-Macrophages
Lilian Quero^1,2, Andre Tiaden^1,2 and Diego Kyburz^2,3, ¹Department of Biomedicine, Experimental Rheumatology, University of Basel, Basel, Switzerland, ²Rheumatology, University Hospital Basel, Basel, Switzerland, ³Department of Biomedicine, Experimental Rheumatology, University of Basel, 4051 Basel, Switzerland
Background/Purpose: MicroRNAs (miRNAs) have been shown to contribute to the inflammatory response in rheumatoid arthritis (RA) and several of these miRNAs have been found to…
Abstract Number: 1791 • 2017 ACR/ARHP Annual Meeting
TET1 Is an Important Transcriptional Activator of the Tnfa Locus in Macrophages
Emmanuel Karouzakis¹, Fangfang Sun², Agnieszka Pajak¹, Shuang Ye², Steffen Gay¹, Oliver Distler³ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Activated macrophages are found in the inflamed and hyperplastic synovial RA tissue. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…
Abstract Number: 2570 • 2017 ACR/ARHP Annual Meeting
The Functional Consequence of Human (hu)TLR8 on Macrophage Immunometabolism and Renal Inflammation in Murine Systemic Lupus Erythematosus
Naomi I. Maria¹, Megan Woods², Shani Martinez³, Weiqing Huang⁴ and Anne Davidson⁴, ¹Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ³Feinstein Institute for Medical Research, Manhasset, NY, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Infiltrating macrophages are one of the hallmarks of renal inflammation and kidney damage in lupus nephritis. Increasing evidence suggests the crucial role of cell-specific…
Abstract Number: 3175 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of MMF Clinical, Molecular, and Immunohistochemistry (IHC) Responses Shows SSc Patients Lose Their Inflammatory Signature and Rebound upon Treatment Cessation
Diana Toledo¹, Monique Hinchcliff², Jaclyn Taroni¹, Tammara A. Wood³, Jennifer Franks³, Sanjiv Shah⁴, Rishi Agrawal⁴, Lauren Beussink-Nelson⁴, Mary A. Carns⁵, Sofia Podlusky⁶, Patricia Pioli⁷ and Michael Whitfield³, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Northwestern University, Chicago, IL, ⁵Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁶Rheumatology Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁷Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: We previously showed patients in the inflammatory subset were most likely to demonstrate improvement in modified Rodnan Skin Score (mRSS) during mycophenolate mofetil (MMF)…
Abstract Number: 172 • 2016 ACR/ARHP Annual Meeting
S100A8/A9 Produced during Experimental Osteoarthritis Induces a Systemic Decrease in BM Monocytes and Increases Ly6C High Monocytes Locally in the Joint
Niels Cremers, Edwin Geven, Arjen Blom, Annet Sloetjes, Irene Di Ceglie, Stephanie van Dalen, Giuliana Ascone, Martijn van den Bosch and Peter van Lent, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In response to pro-inflammatory cytokines released locally during osteoarthritis (OA), such as the alarmins S100A8/A9, monocytes can be recruited from the bone marrow (BM)…
Abstract Number: 479 • 2016 ACR/ARHP Annual Meeting
Type II Collagen Secreted from Articular Chondrocytes Is Mainly Destroyed By Cathepsin S in RA Mice
Jinjun Zhao¹, Qin Huang², Hao Ren¹, Qingqing Ouyang¹ and Min Yang¹, ¹Nanfang Hospital，Southern Medical University, Guangzhou, China, ²Department of Rheumatology, Nanfang Hospital，Southern Medical University, Guangzhou, China
Background/Purpose: Mast cells have long been recognized to increase strikingly in number in the synovial membrane of rheumatoid arthritis（RA），accounting for 5% of the surface synovial…
Abstract Number: 2140 • 2016 ACR/ARHP Annual Meeting
Phenotypic and Functional Characteristics of Exosomes Isolated from Human Osteoarthritis (OA) Synovial Fluid
Geraldine M. McCarthy¹, Dylan McGagh², Clare C. Cunningham³, Emma M. Corr⁴, Louise Sullivan⁵, Fatima Haji⁶ and Aisling Dunne⁴, ¹Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ²School of Biochemistry & Immunology and School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ⁴School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, ⁵Trinity Biomedical Sciences Institute, Trinity College Dublin, School of Biochemistry & Immunology and School of Medicine, Dublin 2, Ireland, ⁶Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
Background/Purpose: Exosomes are biologically active microvesicles derived from the endosomal membrane system understood to play a significant role in a wide range of inflammatory diseases.…

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