Abstracts tagged "macrophages"

Abstract Number: 344 • 2012 ACR/ARHP Annual Meeting
Non Classical Monocytes Are Required for Initiation Phase While Macrophages Are Necessary for the Resolution Phase in the K/BxN Murine of Inflammatory Arthritis
Alexander V. Misharin¹, G. Kenneth Haines III² and Harris R. Perlman³, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Department of Pathology, Yale University, New Haven, CT, ³Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Monocytes and macrophages play an essential function in the pathogenesis of rheumatoid arthritis. However, monocytes and macrophages are a heterogenous population and thus the…
Abstract Number: 2526 • 2012 ACR/ARHP Annual Meeting
Bruton′s Tyrosine Kinase and Calreticulin: A Novel Interaction with Implications for Inflammatory and Autoimmune Disease
Jennifer C. Byrne¹, Joan Ní Gabhann¹, Kevin Stacey¹, Barbara M. Coffey¹, Eoghan M. McCarthy², Warren Thomas³, Eamonn Molloy⁴, Grainne M. Kearns⁵ and Caroline Jefferies¹, ¹Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ²Rheumatology, Beaumont Hospital, Dublin, Ireland, ³Molecular Medicine, Royal College of Surgeons in Ireland, Dublin 9, Ireland, ⁴Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ⁵Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: Bruton’s Tyrosine Kinase (Btk) regulates innate immune responses downstream of multiple Toll-like receptors (TLRs), including TLR7. Given the role of TLR7 in driving type…
Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting
IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA
Nathan D. Chamberlain¹, Seung-jae Kim², Michael Volin³, Anjali Mehta², Nadera J. Sweiss⁴ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…
Abstract Number: 2502 • 2012 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap-Associated Protein Activation of the Inflammasome Is Enhanced in Lupus M1 Macrophages
J. Michelle Kahlenberg¹, Carolyne K. Smith², Carmelo Carmona-Rivera¹ and Mariana J. Kaplan³, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Neutrophil extracellular traps (NETs) contain numerous bactericidal proteins and are an important defense mechanism against microorganisms. Clearance of NETs is impaired in a subset…
Abstract Number: 131 • 2012 ACR/ARHP Annual Meeting
Subclinical Arthritis Visualised by Positron Emission Tomography and Macrophage Targeting Precedes Clinical Flare in Rheumatoid Arthritis Patients in DAS28 Remission
Y.Y.J. Gent¹, A.E. Voskuyl¹, N. Ahmadi², N. Hoetjes³ and C.J. van der Laken¹, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Radiology, VU University Medical Center, Amsterdam, Netherlands, ³Nuclear Medicine & PET research, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Macrophages play an important role in the pathophysiology of Rheumatoid Arthritis (RA). Targeting of macrophages by (R)-[11C]PK11195 positron emission tomography (PET) has previously been successfully…
Abstract Number: 2152 • 2012 ACR/ARHP Annual Meeting
Inhibition of Fucose Incorporation Abrogates the Development of Arthritis by Suppressing the Inflammatory Macrophage Development and TNF-α Production
Jun Li¹, Hui-Chen Hsu², PingAr Yang¹, Qi Wu¹, David M. Spalding³, W. Winn Chatham⁴, Robert P. Kimberly⁵, S. Louis Bridges Jr.⁶ and John D. Mountz⁷, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Clinical Immunology and Rheum, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Clinical Immunology & Rheum, University of Alabama at Birmingham, Birmingham, AL, ⁷Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL
Background/Purpose: Fucosylation, catalyzed by fucosyltransferases (Futs), is an important glycosylation process involved in inflammation, cell death, and differentiation. We have observed an extremely high positive correlation…
Abstract Number: 2669 • 2012 ACR/ARHP Annual Meeting
TLR7 Ligation Contributes to Monocyte Migration in Rheumatoid Arthritis
Nathan D. Chamberlain¹, Seung-jae Kim¹, Michael Volin², William Swedler³, Suncica Volkov¹ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to characterize the expression of TLR7 in rheumatoid arthritis (RA) peripheral blood (PB) cells and to examine the…
Abstract Number: 2157 • 2012 ACR/ARHP Annual Meeting
Resveratrol Counters Pro-Atherogenic Effects of Systemic Lupus Erythematosus and Rheumatoid Arthritis Plasma On Cholesterol Efflux in Human Macrophages
Allison B. Reiss¹, Iryna Voloshyna¹, Ofek Hai¹, Michael J. Littlefield¹, Elise Belilos², Kristina B. Belostocki², Lois A. Bonetti³, Gary C. Rosenblum² and Steven E. Carsons⁴, ¹Medicine, Winthrop University Hospital, Mineola, NY, ²Rheumatology, Winthrop University Hospital, Mineola, NY, ³Rheum & Immun, Winthrop University Hospital, Mineola, NY, ⁴Div of Rheumatology, Winthrop University Hospital, Mineola, NY
Background/Purpose: Our group has demonstrated that resveratrol, a plant polyphenol, possesses atheroprotective properties, enhancing expression of reverse cholesterol transport (RCT) proteins. We have reported that Systemic…

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