ACR Meeting Abstracts

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Abstracts tagged "macrophages"

  • Abstract Number: 1510 • 2014 ACR/ARHP Annual Meeting

    Blockade of TLR5 Ligation Is a Novel Strategy for RA Therapy  

    Seung-jae Kim1, Zhenlong Chen1, Abdul Essani2, Michael Volin3, Suncica Volkov1, William Swedler4, Shiva Arami2, Nadera J. Sweiss5 and Shiva Shahrara1, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2University of Illinois at Chicago, Chicago, IL, 3Microbiology & Immunology, Midwestern University, Downers Grove, IL, 4Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, 5internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: TLR5 expression is highly elevated in RA and CIA lining and sublining macrophages and endothelial cells compared to non-arthritic controls. Additionally, expression of TLR5…
  • Abstract Number: 1198 • 2014 ACR/ARHP Annual Meeting

    Prolactin Is Locally Produced in the Synovium of Patients with Inflammatory Arthritic Diseases and Promotes Macrophage Activation

    Man Wai Tang1, Samuel Garcia2, Danielle M. Gerlag3,4, Kris A. Reedquist5 and Paul P. Tak6,7, 1Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4GlaxoSmithKline, Cambridge, United Kingdom, 5Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 6Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 7University of Cambridge, Cambridge & GlaxoSmithKline, UK, Stevenage, United Kingdom

    Background/Purpose The sex hormone prolactin (PRL) has immunomodulatory properties, can be produced by immune cells, and elevated PRL serum levels have been reported in rheumatoid…
  • Abstract Number: 1151 • 2013 ACR/ARHP Annual Meeting

    Snapin Is Required For Functional Autophagy and Is Critical For Monocyte To Macrophage Differentiation

    Bo Shi1, Qiquan Huang2, Robert Birkett1, Renee E. Koessler3, Andrea Dorfleutner4, Christian Stehlik4 and Richard M. Pope5, 1Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/Rheumatology, Northwestern University, Chicago, IL, 4Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL

    Background/Purpose: Our recent data indicate that Snapin, a SNAP associated protein, is significantly increased in macrophages (MΦs) in rheumatoid arthritis (RA) synovial tissue and its…
  • Abstract Number: 530 • 2013 ACR/ARHP Annual Meeting

    Pattern Recognition Receptor Stimulated Cytokine Expression By Spondyloarthritis Patient Macrophages

    Yi-Ping Liu1, Ashley Bomkamp2, Jens Eickhoff3, Jack Schneck2, Mike Khan4 and Judith Smith5, 1Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, 2University of Wisconsin-Madison, Madison, WI, 3Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 4Cellular and Molecular Pathology, University of Wisconsin-Madison, Madison, WI, 5Pediatrics, University of Wisconsin-Madison, Madison, WI

    Background/Purpose: Spondyloarthritis (SpA) encompasses a group of chronic inflammatory conditions involving axial arthritis that includes ankylosing spondylitis (AS). GWAS studies in AS have implicated multiple…
  • Abstract Number: 882 • 2012 ACR/ARHP Annual Meeting

    Anti-Inflammatory Effects of Phosphodiesterase 4 Inhibition Are Mediated by Mitogen-Activated Protein Kinase Phosphatase-1

    Riku Korhonen, Tuija Hömmö, Mirka Laavola, Tiina Keränen, Mari Hämäläinen and Eeva Moilanen, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland

    Background/Purpose: MAP kinase phosphatase-1 (MKP-1) is a nuclear tyrosine/threonine phosphatase that limits p38 MAP kinase activity. MKP-1 KO mice display excessive inflammatory response, and exhibit…
  • Abstract Number: 733 • 2012 ACR/ARHP Annual Meeting

    Intra-Articular Injection of Adipose-Derived Stem Cells Inhibits Activation of the Synovium and Protects Against Cartilage Damage and Enthesophyte Formation in Murine Experimental Osteoarthritis

    Peter L.E.M. van Lent1, Menno C. ter Huurne2, Arjen B. Blom3, Rik Schelbergen3, Louis Casteilla4, Thomas Vogl5, Johannes Roth5, Roxane Blattes4, Christian Jorgensen6 and Wim B. van den Berg7, 1Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4STROMALab UPS/CNRS UMR5273, INSERM U1031, Toulouse, France, 5Institute of Immunology, University of Muenster, Munster, Germany, 6Department of therapy & Immuno-Rhumatology, Hospital Lapeyronie, Montpellier, France, 7Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: OA lesions are treated with mesenchymal stem cells aiming to enhance tissue repair by transformation to eg. chondrocytes.  Recently it has been shown that…
  • Abstract Number: 666 • 2012 ACR/ARHP Annual Meeting

    Leukadherin 1, a CR3 Mimetic, Negatively Regulates Toll Like Receptor (TLR) Dependent Inflammatory Responses via  Degradation of an Adaptor Protein

    Kristen Lee1, Joanne H. Reed2, Vineet Gupta3, Tejaskumar Patel2, Jill P. Buyon4 and Robert M. Clancy2, 1Rheumatology, NYU Langone Medical Center, New York, NY, 2Medicine, New York University School of Medicine, New York, NY, 3Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miami, FL 33136, U.S.A., Miami, FL, 4Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: Systemic Lupus Erythematosus is characterized by continuous and cyclic stimulation of the innate immune system by endogenous nucleic acids. Immune complexes of Ro60, ssRNA…
  • Abstract Number: 344 • 2012 ACR/ARHP Annual Meeting

    Non Classical Monocytes Are Required for Initiation Phase While Macrophages Are Necessary for the Resolution Phase in the K/BxN Murine of Inflammatory Arthritis

    Alexander V. Misharin1, G. Kenneth Haines III2 and Harris R. Perlman3, 1Medicine/Rheumatology, Northwestern University, Chicago, IL, 2Department of Pathology, Yale University, New Haven, CT, 3Feinberg School of Medicine, Northwestern University, Chicago, IL

    Background/Purpose: Monocytes and macrophages play an essential function in the pathogenesis of rheumatoid arthritis. However, monocytes and macrophages are a heterogenous population and thus the…
  • Abstract Number: 2526 • 2012 ACR/ARHP Annual Meeting

    Bruton′s Tyrosine Kinase and Calreticulin: A Novel Interaction with Implications for Inflammatory and Autoimmune Disease

    Jennifer C. Byrne1, Joan Ní Gabhann1, Kevin Stacey1, Barbara M. Coffey1, Eoghan M. McCarthy2, Warren Thomas3, Eamonn Molloy4, Grainne M. Kearns5 and Caroline Jefferies1, 1Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, 2Rheumatology, Beaumont Hospital, Dublin, Ireland, 3Molecular Medicine, Royal College of Surgeons in Ireland, Dublin 9, Ireland, 4Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 5Rheumatology Department, Beaumont Hospital, Dublin, Ireland

    Background/Purpose: Bruton’s Tyrosine Kinase (Btk) regulates innate immune responses downstream of multiple Toll-like receptors (TLRs), including TLR7. Given the role of TLR7 in driving type…
  • Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting

    IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA

    Nathan D. Chamberlain1, Seung-jae Kim2, Michael Volin3, Anjali Mehta2, Nadera J. Sweiss4 and Shiva Shahrara1, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2University of Illinois at Chicago, Chicago, IL, 3Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, 4internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…
  • Abstract Number: 2502 • 2012 ACR/ARHP Annual Meeting

    Neutrophil Extracellular Trap-Associated Protein Activation of the Inflammasome Is Enhanced in Lupus M1 Macrophages

    J. Michelle Kahlenberg1, Carolyne K. Smith2, Carmelo Carmona-Rivera1 and Mariana J. Kaplan3, 1Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann Arbor, MI, 3Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD

    Background/Purpose: Neutrophil extracellular traps (NETs) contain numerous bactericidal proteins and are an important defense mechanism against microorganisms.  Clearance of NETs is impaired in a subset…
  • Abstract Number: 131 • 2012 ACR/ARHP Annual Meeting

    Subclinical Arthritis Visualised by Positron Emission Tomography and Macrophage Targeting Precedes Clinical Flare in Rheumatoid Arthritis Patients in DAS28 Remission

    Y.Y.J. Gent1, A.E. Voskuyl1, N. Ahmadi2, N. Hoetjes3 and C.J. van der Laken1, 1Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 2Radiology, VU University Medical Center, Amsterdam, Netherlands, 3Nuclear Medicine & PET research, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Macrophages play an important role in the pathophysiology of Rheumatoid Arthritis (RA). Targeting of macrophages by (R)-[11C]PK11195 positron emission tomography (PET) has previously been successfully…
  • Abstract Number: 2152 • 2012 ACR/ARHP Annual Meeting

    Inhibition of Fucose Incorporation Abrogates the Development of Arthritis by Suppressing the Inflammatory Macrophage Development and TNF-α Production

    Jun Li1, Hui-Chen Hsu2, PingAr Yang1, Qi Wu1, David M. Spalding3, W. Winn Chatham4, Robert P. Kimberly5, S. Louis Bridges Jr.6 and John D. Mountz7, 1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Clinical Immunology and Rheum, University of Alabama at Birmingham, Birmingham, AL, 4University of Alabama at Birmingham, Birmingham, AL, 5Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 6Clinical Immunology & Rheum, University of Alabama at Birmingham, Birmingham, AL, 7Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL

    Background/Purpose: Fucosylation, catalyzed by fucosyltransferases (Futs), is an important glycosylation process involved in inflammation, cell death, and differentiation. We have observed an extremely high positive correlation…
  • Abstract Number: 2669 • 2012 ACR/ARHP Annual Meeting

    TLR7 Ligation Contributes to Monocyte Migration in Rheumatoid Arthritis

    Nathan D. Chamberlain1, Seung-jae Kim1, Michael Volin2, William Swedler3, Suncica Volkov1 and Shiva Shahrara1, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, 3Section of Rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: The aim of the study was to characterize the expression of TLR7 in rheumatoid arthritis (RA) peripheral blood (PB) cells and to examine the…
  • Abstract Number: 2157 • 2012 ACR/ARHP Annual Meeting

    Resveratrol Counters Pro-Atherogenic Effects of Systemic Lupus Erythematosus and Rheumatoid Arthritis Plasma On Cholesterol Efflux in Human Macrophages

    Allison B. Reiss1, Iryna Voloshyna1, Ofek Hai1, Michael J. Littlefield1, Elise Belilos2, Kristina B. Belostocki2, Lois A. Bonetti3, Gary C. Rosenblum2 and Steven E. Carsons4, 1Medicine, Winthrop University Hospital, Mineola, NY, 2Rheumatology, Winthrop University Hospital, Mineola, NY, 3Rheum & Immun, Winthrop University Hospital, Mineola, NY, 4Div of Rheumatology, Winthrop University Hospital, Mineola, NY

    Background/Purpose: Our group has demonstrated that resveratrol, a plant polyphenol, possesses atheroprotective properties, enhancing expression of reverse cholesterol transport (RCT) proteins. We have reported that Systemic…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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