Abstracts tagged "macrophages"

Abstract Number: 1510 • 2014 ACR/ARHP Annual Meeting
Blockade of TLR5 Ligation Is a Novel Strategy for RA Therapy
Seung-jae Kim¹, Zhenlong Chen¹, Abdul Essani², Michael Volin³, Suncica Volkov¹, William Swedler⁴, Shiva Arami², Nadera J. Sweiss⁵ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Microbiology & Immunology, Midwestern University, Downers Grove, IL, ⁴Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: TLR5 expression is highly elevated in RA and CIA lining and sublining macrophages and endothelial cells compared to non-arthritic controls. Additionally, expression of TLR5…
Abstract Number: 1198 • 2014 ACR/ARHP Annual Meeting
Prolactin Is Locally Produced in the Synovium of Patients with Inflammatory Arthritic Diseases and Promotes Macrophage Activation
Man Wai Tang¹, Samuel Garcia², Danielle M. Gerlag^3,4, Kris A. Reedquist⁵ and Paul P. Tak^6,7, ¹Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴GlaxoSmithKline, Cambridge, United Kingdom, ⁵Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁷University of Cambridge, Cambridge & GlaxoSmithKline, UK, Stevenage, United Kingdom
Background/Purpose The sex hormone prolactin (PRL) has immunomodulatory properties, can be produced by immune cells, and elevated PRL serum levels have been reported in rheumatoid…
Abstract Number: 1151 • 2013 ACR/ARHP Annual Meeting
Snapin Is Required For Functional Autophagy and Is Critical For Monocyte To Macrophage Differentiation
Bo Shi¹, Qiquan Huang², Robert Birkett¹, Renee E. Koessler³, Andrea Dorfleutner⁴, Christian Stehlik⁴ and Richard M. Pope⁵, ¹Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Our recent data indicate that Snapin, a SNAP associated protein, is significantly increased in macrophages (MΦs) in rheumatoid arthritis (RA) synovial tissue and its…
Abstract Number: 530 • 2013 ACR/ARHP Annual Meeting
Pattern Recognition Receptor Stimulated Cytokine Expression By Spondyloarthritis Patient Macrophages
Yi-Ping Liu¹, Ashley Bomkamp², Jens Eickhoff³, Jack Schneck², Mike Khan⁴ and Judith Smith⁵, ¹Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, ²University of Wisconsin-Madison, Madison, WI, ³Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, ⁴Cellular and Molecular Pathology, University of Wisconsin-Madison, Madison, WI, ⁵Pediatrics, University of Wisconsin-Madison, Madison, WI
Background/Purpose: Spondyloarthritis (SpA) encompasses a group of chronic inflammatory conditions involving axial arthritis that includes ankylosing spondylitis (AS). GWAS studies in AS have implicated multiple…
Abstract Number: 2526 • 2012 ACR/ARHP Annual Meeting
Bruton′s Tyrosine Kinase and Calreticulin: A Novel Interaction with Implications for Inflammatory and Autoimmune Disease
Jennifer C. Byrne¹, Joan Ní Gabhann¹, Kevin Stacey¹, Barbara M. Coffey¹, Eoghan M. McCarthy², Warren Thomas³, Eamonn Molloy⁴, Grainne M. Kearns⁵ and Caroline Jefferies¹, ¹Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ²Rheumatology, Beaumont Hospital, Dublin, Ireland, ³Molecular Medicine, Royal College of Surgeons in Ireland, Dublin 9, Ireland, ⁴Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ⁵Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: Bruton’s Tyrosine Kinase (Btk) regulates innate immune responses downstream of multiple Toll-like receptors (TLRs), including TLR7. Given the role of TLR7 in driving type…
Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting
IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA
Nathan D. Chamberlain¹, Seung-jae Kim², Michael Volin³, Anjali Mehta², Nadera J. Sweiss⁴ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…
Abstract Number: 2502 • 2012 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap-Associated Protein Activation of the Inflammasome Is Enhanced in Lupus M1 Macrophages
J. Michelle Kahlenberg¹, Carolyne K. Smith², Carmelo Carmona-Rivera¹ and Mariana J. Kaplan³, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Neutrophil extracellular traps (NETs) contain numerous bactericidal proteins and are an important defense mechanism against microorganisms. Clearance of NETs is impaired in a subset…
Abstract Number: 131 • 2012 ACR/ARHP Annual Meeting
Subclinical Arthritis Visualised by Positron Emission Tomography and Macrophage Targeting Precedes Clinical Flare in Rheumatoid Arthritis Patients in DAS28 Remission
Y.Y.J. Gent¹, A.E. Voskuyl¹, N. Ahmadi², N. Hoetjes³ and C.J. van der Laken¹, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Radiology, VU University Medical Center, Amsterdam, Netherlands, ³Nuclear Medicine & PET research, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Macrophages play an important role in the pathophysiology of Rheumatoid Arthritis (RA). Targeting of macrophages by (R)-[11C]PK11195 positron emission tomography (PET) has previously been successfully…
Abstract Number: 2152 • 2012 ACR/ARHP Annual Meeting
Inhibition of Fucose Incorporation Abrogates the Development of Arthritis by Suppressing the Inflammatory Macrophage Development and TNF-α Production
Jun Li¹, Hui-Chen Hsu², PingAr Yang¹, Qi Wu¹, David M. Spalding³, W. Winn Chatham⁴, Robert P. Kimberly⁵, S. Louis Bridges Jr.⁶ and John D. Mountz⁷, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Clinical Immunology and Rheum, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Clinical Immunology & Rheum, University of Alabama at Birmingham, Birmingham, AL, ⁷Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL
Background/Purpose: Fucosylation, catalyzed by fucosyltransferases (Futs), is an important glycosylation process involved in inflammation, cell death, and differentiation. We have observed an extremely high positive correlation…
Abstract Number: 2669 • 2012 ACR/ARHP Annual Meeting
TLR7 Ligation Contributes to Monocyte Migration in Rheumatoid Arthritis
Nathan D. Chamberlain¹, Seung-jae Kim¹, Michael Volin², William Swedler³, Suncica Volkov¹ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to characterize the expression of TLR7 in rheumatoid arthritis (RA) peripheral blood (PB) cells and to examine the…
Abstract Number: 2157 • 2012 ACR/ARHP Annual Meeting
Resveratrol Counters Pro-Atherogenic Effects of Systemic Lupus Erythematosus and Rheumatoid Arthritis Plasma On Cholesterol Efflux in Human Macrophages
Allison B. Reiss¹, Iryna Voloshyna¹, Ofek Hai¹, Michael J. Littlefield¹, Elise Belilos², Kristina B. Belostocki², Lois A. Bonetti³, Gary C. Rosenblum² and Steven E. Carsons⁴, ¹Medicine, Winthrop University Hospital, Mineola, NY, ²Rheumatology, Winthrop University Hospital, Mineola, NY, ³Rheum & Immun, Winthrop University Hospital, Mineola, NY, ⁴Div of Rheumatology, Winthrop University Hospital, Mineola, NY
Background/Purpose: Our group has demonstrated that resveratrol, a plant polyphenol, possesses atheroprotective properties, enhancing expression of reverse cholesterol transport (RCT) proteins. We have reported that Systemic…
Abstract Number: 1800 • 2012 ACR/ARHP Annual Meeting
Macrophages in Hypoxic Rheumatoid Joints Preferentially Express Hypoxia Inducible Transcription Factor-2
Sarah Aynsley¹, Ursula Fearon², Anthony G. Wilson¹ and Munitta Muthana³, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ³Infection and Immunity, University of sheffield, Sheffield, United Kingdom
Background/Purpose: In rheumatoid arthritis (RA), the influx of inflammatory cells as well as the aggressive proliferation of fibroblast-like synovial cells (FLS) outstrips the oxygen supply…
Abstract Number: 1801 • 2012 ACR/ARHP Annual Meeting
Biological Roles of C5orf30 in Rheumatoid Arthritis
Munitta Muthana¹, Sachin Khetan², Gbadebo Adeleke Adeleke³, Simon Tazzyman³, Sarah Aynsley¹, Fiona Morrow¹, Sarah Hawtree¹, Barbara Ciani⁴ and Anthony G. Wilson¹, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²Infection and immunity, Dr, Sheffield, United Kingdom, ³Infection and Immunity, Dr, Sheffield, United Kingdom, ⁴Chemistry, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first exon of an uncharacterized gene C5orf30. In addition, this variant is…
Abstract Number: 1454 • 2012 ACR/ARHP Annual Meeting
Characterization of Renal Mononuclear Phagocyte Populations in Murine SLE Nephritis
Ranjit Sahu¹, Ramalingam Bethunaickan² and Anne Davidson¹, ¹Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Macrophages and dendritic cells contribute to renal damage in chronic renal diseases including lupus nephritis. However owing to their multiple phenotypic and functional variations,…
Abstract Number: 1196 • 2012 ACR/ARHP Annual Meeting
Analysis of Gene Expression Patterns in Rheumatoid Arthritis (RA) Synovial Macrophages From Patients Undergoing Disease Flare
Karen L. Berg¹, Adedayo Hanidu¹, Jon Hill², Xiaoyu Jiang¹, Tom Freeman², Jennifer Swantek¹, Anna Yarlina³, George D. Kalliolias⁴, Lionel B. Ivashkiv⁵ and Gerald H. Nabozny¹, ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, ³Hospital for Special Surgery, New York, NY, ⁴Medicine, Hospital for Special Surgery, New York, NY, ⁵Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Synovial macrophages play a key role in RA pathogenesis. Their numbers are greatly increased in RA synovium, their phenotype is consistent with a pro-inflammatory…

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