ACR Meeting Abstracts

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Abstracts tagged "Macrophage"

  • Abstract Number: 1159 • 2013 ACR/ARHP Annual Meeting

    Exercise Suppresses Systemic Inflammation Via Inhibition Of NF-κB Activation In Monocytes

    Alisa Blazek1, Derrick Knapik2, Lai-Chu Wu3, Nicholas A. Young3, Wael N. Jarjour4 and Sudha Agarwal5, 1Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH, 2College of Medicine, The Ohio State University, Columbus, OH, 3Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 5Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Inflammation is integral to joint damage and bone erosion in rheumatoid arthritis.  We reported previously that physiologic levels of exercise are anti-inflammatory and suppress local…
  • Abstract Number: 1150 • 2013 ACR/ARHP Annual Meeting

    Differential Regulation Of IL-10 and Dusp1 Production By Kinases In The p38 MAPK Pathway

    Deepa Hammaker1, Katharyn Topolewski2 and G. S. Firestein3, 1MC 0656, UCSD School of Medicine, La Jolla, CA, 2UCSD School of Medicine, La Jolla, CA, 3Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: MAPK kinases MKK3 and MKK6 regulate p38 function in inflammatory diseases like rheumatoid arthritis (RA). Targeting MKK3 or MKK6 might be superior to traditional…
  • Abstract Number: 933 • 2013 ACR/ARHP Annual Meeting

    Characterizing The Expression and Function Of CCL28 and Its Corresponding Receptor CCR10 In The Pathogenesis Of RA

    Zhenlong Chen1, Seung-jae Kim1, Michael V. Volin2, Suncica Volkov1, William Swedler3, Nadera J. Sweiss4 and Shiva Shahrara1, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, 3Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, 4internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: This study was conducted to determine the expression pattern and function of CCL28 and its corresponding receptor CCR10 in the pathogenesis of rheumatoid arthritis…
  • Abstract Number: 823 • 2013 ACR/ARHP Annual Meeting

    Activation Of Liver X Receptors Inhibits Experimental Fibrosis By Interfering With Interleukin-6 Release From Macrophages

    Christian Beyer1, Jürgen Beer1, Katrin Palumbo-Zerr1, Pawel Zerr1, Alfiya Distler1, Clara Dees1, Louis E. Munoz1, Gerhard Krönke1, Oliver Distler2, Steve Anderson3, Georg A. Schett4 and Joerg H. W. Distler1, 1Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Lexicon Pharmaceuticals Inc., The Woodlands, TX, 4Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Liver X receptors (LXRs) are orphan nuclear receptors with emerging roles in metabolic and autoimmune diseases. Here, we investigated the role of LXRs in…
  • Abstract Number: 766 • 2013 ACR/ARHP Annual Meeting

    Cholesterol Accumulation By Synovial Lining Macrophages Results In Ectopic Bone Formation During Experimental Osteoarthritis

    Wouter de Munter1, Arjen B. Blom1, Monique M. Helsen1, Birgitte Walgreen1, Peter M. van Der Kraan1, Leo A. Joosten2, Wim B. van den Berg3 and Peter L. van Lent4, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, 3Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, 4Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Synovial macrophages have previously shown to play a significant role in the etiopathology of experimental collagenase-induced osteoarthritis (OA). In addition to production of pro-inflammatory…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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