ACR Meeting Abstracts

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Abstracts tagged "Macrophage"

  • Abstract Number: 1197 • 2014 ACR/ARHP Annual Meeting

    Febuxostat Inhibits Monosodium Urate Crystal-Induced IL-1beta Secretion and Cell Death Via ROS- and Intracellular ATP-Dependent Pathways

    Johji Nomura1, Nathalie Busso2, Mizuho Tamura1, Tsunefumi Kobayashi1 and Alexander So3, 1Pharmaceutical Development Research Laboratories, Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Tokyo, Japan, 2Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland, 3Rheumatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland

    Background/Purpose: In gout, monosodium urate (MSU) crystals trigger acute inflammation. MSU has been reported to activate NLRP3 inflammasome via ROS-dependent pathways, which result in IL-1beta…
  • Abstract Number: 1199 • 2014 ACR/ARHP Annual Meeting

    Alarmins S100A8/S100A9 Aggravate Osteophyte Formation in Experimental Osteoarthritis and Predict Osteophyte Progression in EARLY Human Osteoarthritis in the Dutch Check Cohort

    Rik Schelbergen1, Wouter de Munter2, Martijn van den Bosch3, Floris Lafeber4, Annet Sloetjes3, Thomas Vogl5, Johannes Roth5, Peter M. van der Kraan6, Arjen B. Blom3, Wim B van den Berg3 and Peter L. van Lent3, 1Radboud university medical center, Nijmegen, Netherlands, 2Experimental rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Immunology, Institute of Immunology University of Muenster, Muenster, Germany, 6Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose The main pathological feature of osteoarthritis (OA) is degradation of the articular cartilage. Other important hallmarks include subclinical inflammation of the synovium and ectopic…
  • Abstract Number: 969 • 2014 ACR/ARHP Annual Meeting

    Caspase-8 Prevents Lung Fibrosis in a Murine SSc-like Disease Model By Preventing Macrophage Differentiation

    Alexander Misharin1, Carla M. Cuda2, Luisa Morales-Nebreda3, Gokhan Mutlu1, GR Scott Budinger3 and Harris R. Perlman4, 1Northwestern University, Chicago, IL, 2Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 4Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose Pulmonary fibrosis has emerged as the leading cause of death in patients with Systemic Sclerosis (SSc). Currently available therapies are only marginally effective in…
  • Abstract Number: 660 • 2014 ACR/ARHP Annual Meeting

    Microthrombotic Renal Vascular Lesions Are Associated to Increased Renal Inflammatory Infiltration in a Mouse Model of Lupus Nephritis

    María Galindo1, Elena Gonzalo-Gil2, Oscar Toldos3, Carmen García-Herrero2, Alicia Usategui1, Sonia Pérez-Yagüe4, Gabriel Criado5, Domingo F. Barber4 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Department of Rheumatology, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 3Servicio de Anatomia Patologica, Hospital 12 de Octubre, Madrid, Spain, 4Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain, 5Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain

    Background/Purpose In patients with lupus nephritis (LN), acute renal vascular and atherosclerotic lesions correlate with the degree of inflammation regardless the presence of antiphospholipid antibodies.…
  • Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting

    Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease

    Tsuyoshi Shirai1, Eric L. Matteson2, David G. Harrison3, Barbara B. Wallis4, Themistocles L. Assimes5, Jorg J. Goronzy6 and Cornelia M. Weyand1, 1Medicine, Stanford University School of Medicine, Stanford, CA, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, 4Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 5Stanford University School of Medicine, Stanford, CA, 6Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
  • Abstract Number: 327 • 2014 ACR/ARHP Annual Meeting

    AMPK Activation in Inflammatory Arthritis

    Monica Guma1, Yun Wang2 and Ru Liu-Bryan2, 1Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, 2UCSD/VAMC, La Jolla, CA

    Background/Purpose: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase involved in the regulation of cellular energy homeostasis. It is a central regulator of both…
  • Abstract Number: 76 • 2014 ACR/ARHP Annual Meeting

    Identification of Synovial Genes and Pathways Associated with Disease Progression in a Cohort of Early Symptomatic Osteoarthritis Patients Using a Transcriptomic Approach

    Arjen B. Blom1, Peter L. van Lent1, Martijn H. van den Bosch2, Hans Cats3, Frank H.J. van den Hoogen4, Floris P.J.G. Lafeber5, Wim B. van den Berg1 and Peter M. van der Kraan1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, 3Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, 4Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, 5Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: If and how the synovial activation that is observed in over 50% of osteoarthritis (OA) patients contributes to irreversible joint pathology, is not known.…
  • Abstract Number: 641 • 2013 ACR/ARHP Annual Meeting

    Vitamin D Increases The Number and Function Of Myeloid Angiogenic Cells In Systemic Lupus Erythematosus

    John A. Reynolds1, David W. Ray2, Terence O'Neill3, M. Yvonne Alexander4 and Ian N. Bruce5, 1Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, 2Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, 3Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 4Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, 5Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) have an increased prevalence of cardiovascular disease (CVD).  Vitamin D deficiency is common in SLE and an independent…
  • Abstract Number: 2902 • 2013 ACR/ARHP Annual Meeting

    Key Roles For Interferon and Macrophage Activation In Progressive Lung Fibrosis Associated With Systemic Sclerosis

    Romy Christmann1, Giuseppina Stifano2, Claudia Borges3, Carlos Carvalho4, Ronaldo Kairalla4, Edwin R. Parra5, Avrum Spira6, Robert W. Simms1, Percival Sampaio-Barros7, Vera L. Capelozzi5 and Robert Lafyatis1, 1Rheumatology, Boston University School of Medicine, Boston, MA, 2Rheumatology, Boston University Medical Center, Boston, MA, 3Rheumatology, CEUMA University, Sao Luis do Maranhao, Brazil, 4Pulmonology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, 5Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, 6Computational Biomedicine, Boston University School of Medicine, Boston, MA, 7Rheumatology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil

    Background/Purpose: Interstitial lung disease associate with Systemic Sclerosis(SSc-ILD) is one of the leading causes of mortality. We analyzed the gene expression of lung tissue in…
  • Abstract Number: 2744 • 2013 ACR/ARHP Annual Meeting

    Caspase 8 Modulates The Polarisome To Prevent Lung Fibrosis In a Murine Ssc-Like Disease Model

    Carla M. Cuda1, Alexander Misharin2, Gokhan Mutlu3, Luisa Morales-Nebreda4, GR Scott Budinger4 and Harris R. Perlman3, 1Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 3Northwestern University, Chicago, IL, 4Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Pulmonary fibrosis has emerged as the leading cause of death in patients with Systemic Sclerosis (SSc). Currently available therapies are only marginally effective in…
  • Abstract Number: 2745 • 2013 ACR/ARHP Annual Meeting

    Reshaping Inflammatory Macrophage Development and Functions by a Monosaccharide Analogue In Rheumatoid Arthritis

    Jun Li1, Hui-Chen Hsu2,3, PingAr Yang1, Qi Wu1, Bao Luo1, Amber L Rowse4, David M. Spalding5, James A Mobley6, S. Louis Bridges Jr.7 and John D. Mountz3,8, 1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Birmingham VA Medical Center, Birmingham, AL, 4Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, 6University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, 7University of Alabama at Birmingham, Birmingham, AL, 8Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Inflammatory macrophages (MΦs) play key roles in pathogenesis of rheumatoid arthritis (RA). Fucosylation, comprising the transfer of a fucose (6-Deoxy-L-galactose) to proteins, is regulated…
  • Abstract Number: 2235 • 2013 ACR/ARHP Annual Meeting

    Fas Signaling In Macrophages Promotes Chronicity In K/BxN Serum Transfer Induced Arthritis

    Qi Quan Huang1, Robert Birkett2, Renee E. Koessler1, Carla M. Cuda3, J.-P. Jin4, Harris R. Perlman5 and Richard M. Pope6, 1Medicine/Rheumatology, Northwestern University, Chicago, IL, 2Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, 3Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Physiology, Wayne State University, Detroit, MI, 5Northwestern University Feinberg School of Medicine, Chicago, IL, 6Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL

    Background/Purpose: A non-apoptotic role for Fas signaling has been implicated in the regulation of inflammation and innate immunity.  These studies were performed to elucidate the…
  • Abstract Number: 1764 • 2013 ACR/ARHP Annual Meeting

    Binding Of Apoptotic Fetal Cardiocytes By Anti-Ro Antibodies Stimulates uPA/uPAR- Dependent Macrophage Infiltration and M2 Type Phenotype

    Paraskevi Briasouli1, Savvas Pavlides2, Leslie Gold3, Mark Halushka4 and Jill P. Buyon5, 1Rheumatology, New York University Medical Center, New York, NY, 2New York University Medical Center, new York, NY, 3new York University Medical Center, new York, NY, 4Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD, 5Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: Organ injury induced by antibodies characteristic of Sjogren's Syndrome and Systemic Lupus Erythematosus, while varied in the adult and fetus, may share in common…
  • Abstract Number: 1730 • 2013 ACR/ARHP Annual Meeting

    Novel Role For Ly6C– Monocyte Subsets and Joint Macrophages In Mouse Model Of Rheumatoid Arthritis

    Alexander Misharin1, Carla M. Cuda2, Rana Saber3, Angelica K. Gierut4, G. Kenneth Haines III5, Steffen Jung6 and Harris R. Perlman7, 1Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 2Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/Rheumatology, Northwestern University, Chicago, IL, 4Rheumatology, Northwestern Med Faculty Found, Chicago, IL, 5Department of Pathology, Yale University, New Haven, CT, 6Immunology, Weizmann Institute, Rehovot, Israel, 7Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Monocytes and macrophages play a key role in the pathogenesis of rheumatoid arthritis. However, role of the individual subsets of monocytes and macrophages in…
  • Abstract Number: 1279 • 2013 ACR/ARHP Annual Meeting

    Anti-IL-6 Receptor Antibody Is Effective In Arthritis Regardless Of Obesity In Mouse Model

    Miho Suzuki, Hiroto Yoshida and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan

    Background/Purpose: Compared with non-obese patients, obese patients with rheumatoid arthritis (RA) reportedly experience worsening of symptoms [Arthritis Care Res (Hoboken). 2013; 65: 78-87] and do…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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