Abstracts tagged "Macrophage"

Abstract Number: 1197 • 2014 ACR/ARHP Annual Meeting
Febuxostat Inhibits Monosodium Urate Crystal-Induced IL-1beta Secretion and Cell Death Via ROS- and Intracellular ATP-Dependent Pathways
Johji Nomura¹, Nathalie Busso², Mizuho Tamura¹, Tsunefumi Kobayashi¹ and Alexander So³, ¹Pharmaceutical Development Research Laboratories, Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Tokyo, Japan, ²Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland, ³Rheumatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
Background/Purpose: In gout, monosodium urate (MSU) crystals trigger acute inflammation. MSU has been reported to activate NLRP3 inflammasome via ROS-dependent pathways, which result in IL-1beta…
Abstract Number: 1199 • 2014 ACR/ARHP Annual Meeting
Alarmins S100A8/S100A9 Aggravate Osteophyte Formation in Experimental Osteoarthritis and Predict Osteophyte Progression in EARLY Human Osteoarthritis in the Dutch Check Cohort
Rik Schelbergen¹, Wouter de Munter², Martijn van den Bosch³, Floris Lafeber⁴, Annet Sloetjes³, Thomas Vogl⁵, Johannes Roth⁵, Peter M. van der Kraan⁶, Arjen B. Blom³, Wim B van den Berg³ and Peter L. van Lent³, ¹Radboud university medical center, Nijmegen, Netherlands, ²Experimental rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Immunology, Institute of Immunology University of Muenster, Muenster, Germany, ⁶Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose The main pathological feature of osteoarthritis (OA) is degradation of the articular cartilage. Other important hallmarks include subclinical inflammation of the synovium and ectopic…
Abstract Number: 969 • 2014 ACR/ARHP Annual Meeting
Caspase-8 Prevents Lung Fibrosis in a Murine SSc-like Disease Model By Preventing Macrophage Differentiation
Alexander Misharin¹, Carla M. Cuda², Luisa Morales-Nebreda³, Gokhan Mutlu¹, GR Scott Budinger³ and Harris R. Perlman⁴, ¹Northwestern University, Chicago, IL, ²Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Pulmonary fibrosis has emerged as the leading cause of death in patients with Systemic Sclerosis (SSc). Currently available therapies are only marginally effective in…
Abstract Number: 660 • 2014 ACR/ARHP Annual Meeting
Microthrombotic Renal Vascular Lesions Are Associated to Increased Renal Inflammatory Infiltration in a Mouse Model of Lupus Nephritis
María Galindo¹, Elena Gonzalo-Gil², Oscar Toldos³, Carmen García-Herrero², Alicia Usategui¹, Sonia Pérez-Yagüe⁴, Gabriel Criado⁵, Domingo F. Barber⁴ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Department of Rheumatology, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Servicio de Anatomia Patologica, Hospital 12 de Octubre, Madrid, Spain, ⁴Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain, ⁵Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose In patients with lupus nephritis (LN), acute renal vascular and atherosclerotic lesions correlate with the degree of inflammation regardless the presence of antiphospholipid antibodies.…
Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting
Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease
Tsuyoshi Shirai¹, Eric L. Matteson², David G. Harrison³, Barbara B. Wallis⁴, Themistocles L. Assimes⁵, Jorg J. Goronzy⁶ and Cornelia M. Weyand¹, ¹Medicine, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁴Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
Abstract Number: 327 • 2014 ACR/ARHP Annual Meeting
AMPK Activation in Inflammatory Arthritis
Monica Guma¹, Yun Wang² and Ru Liu-Bryan², ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²UCSD/VAMC, La Jolla, CA
Background/Purpose: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase involved in the regulation of cellular energy homeostasis. It is a central regulator of both…
Abstract Number: 76 • 2014 ACR/ARHP Annual Meeting
Identification of Synovial Genes and Pathways Associated with Disease Progression in a Cohort of Early Symptomatic Osteoarthritis Patients Using a Transcriptomic Approach
Arjen B. Blom¹, Peter L. van Lent¹, Martijn H. van den Bosch², Hans Cats³, Frank H.J. van den Hoogen⁴, Floris P.J.G. Lafeber⁵, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ³Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: If and how the synovial activation that is observed in over 50% of osteoarthritis (OA) patients contributes to irreversible joint pathology, is not known.…
Abstract Number: 641 • 2013 ACR/ARHP Annual Meeting
Vitamin D Increases The Number and Function Of Myeloid Angiogenic Cells In Systemic Lupus Erythematosus
John A. Reynolds¹, David W. Ray², Terence O'Neill³, M. Yvonne Alexander⁴ and Ian N. Bruce⁵, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) have an increased prevalence of cardiovascular disease (CVD). Vitamin D deficiency is common in SLE and an independent…
Abstract Number: 2902 • 2013 ACR/ARHP Annual Meeting
Key Roles For Interferon and Macrophage Activation In Progressive Lung Fibrosis Associated With Systemic Sclerosis
Romy Christmann¹, Giuseppina Stifano², Claudia Borges³, Carlos Carvalho⁴, Ronaldo Kairalla⁴, Edwin R. Parra⁵, Avrum Spira⁶, Robert W. Simms¹, Percival Sampaio-Barros⁷, Vera L. Capelozzi⁵ and Robert Lafyatis¹, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, CEUMA University, Sao Luis do Maranhao, Brazil, ⁴Pulmonology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁵Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁶Computational Biomedicine, Boston University School of Medicine, Boston, MA, ⁷Rheumatology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Background/Purpose: Interstitial lung disease associate with Systemic Sclerosis(SSc-ILD) is one of the leading causes of mortality. We analyzed the gene expression of lung tissue in…
Abstract Number: 2744 • 2013 ACR/ARHP Annual Meeting
Caspase 8 Modulates The Polarisome To Prevent Lung Fibrosis In a Murine Ssc-Like Disease Model
Carla M. Cuda¹, Alexander Misharin², Gokhan Mutlu³, Luisa Morales-Nebreda⁴, GR Scott Budinger⁴ and Harris R. Perlman³, ¹Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: Pulmonary fibrosis has emerged as the leading cause of death in patients with Systemic Sclerosis (SSc). Currently available therapies are only marginally effective in…
Abstract Number: 2745 • 2013 ACR/ARHP Annual Meeting
Reshaping Inflammatory Macrophage Development and Functions by a Monosaccharide Analogue In Rheumatoid Arthritis
Jun Li¹, Hui-Chen Hsu^2,3, PingAr Yang¹, Qi Wu¹, Bao Luo¹, Amber L Rowse⁴, David M. Spalding⁵, James A Mobley⁶, S. Louis Bridges Jr.⁷ and John D. Mountz^3,8, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Birmingham VA Medical Center, Birmingham, AL, ⁴Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, ⁶University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Inflammatory macrophages (MΦs) play key roles in pathogenesis of rheumatoid arthritis (RA). Fucosylation, comprising the transfer of a fucose (6-Deoxy-L-galactose) to proteins, is regulated…
Abstract Number: 2235 • 2013 ACR/ARHP Annual Meeting
Fas Signaling In Macrophages Promotes Chronicity In K/BxN Serum Transfer Induced Arthritis
Qi Quan Huang¹, Robert Birkett², Renee E. Koessler¹, Carla M. Cuda³, J.-P. Jin⁴, Harris R. Perlman⁵ and Richard M. Pope⁶, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ³Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Physiology, Wayne State University, Detroit, MI, ⁵Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: A non-apoptotic role for Fas signaling has been implicated in the regulation of inflammation and innate immunity. These studies were performed to elucidate the…
Abstract Number: 1764 • 2013 ACR/ARHP Annual Meeting
Binding Of Apoptotic Fetal Cardiocytes By Anti-Ro Antibodies Stimulates uPA/uPAR- Dependent Macrophage Infiltration and M2 Type Phenotype
Paraskevi Briasouli¹, Savvas Pavlides², Leslie Gold³, Mark Halushka⁴ and Jill P. Buyon⁵, ¹Rheumatology, New York University Medical Center, New York, NY, ²New York University Medical Center, new York, NY, ³new York University Medical Center, new York, NY, ⁴Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD, ⁵Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Organ injury induced by antibodies characteristic of Sjogren's Syndrome and Systemic Lupus Erythematosus, while varied in the adult and fetus, may share in common…
Abstract Number: 1730 • 2013 ACR/ARHP Annual Meeting
Novel Role For Ly6C^– Monocyte Subsets and Joint Macrophages In Mouse Model Of Rheumatoid Arthritis
Alexander Misharin¹, Carla M. Cuda², Rana Saber³, Angelica K. Gierut⁴, G. Kenneth Haines III⁵, Steffen Jung⁶ and Harris R. Perlman⁷, ¹Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern Med Faculty Found, Chicago, IL, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Immunology, Weizmann Institute, Rehovot, Israel, ⁷Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Monocytes and macrophages play a key role in the pathogenesis of rheumatoid arthritis. However, role of the individual subsets of monocytes and macrophages in…
Abstract Number: 1279 • 2013 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Is Effective In Arthritis Regardless Of Obesity In Mouse Model
Miho Suzuki, Hiroto Yoshida and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Compared with non-obese patients, obese patients with rheumatoid arthritis (RA) reportedly experience worsening of symptoms [Arthritis Care Res (Hoboken). 2013; 65: 78-87] and do…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].