Abstracts tagged "Macrophage"

Abstract Number: 1401 • 2015 ACR/ARHP Annual Meeting
Is There Any Difference Between Autoimmune or Hemato-Oncology Etiology of Macrophage Activation Syndrome?
César Antonio Egües Dubuc, Miren Uriarte Ecenarro, Nerea Errazquin Aguirre, Olga Maiz Alonso, Iñaki Hernando Rubio and Joaquin Maria Belzunegui Otano, Rheumatology, Donostia University Hospital, Donostia, Spain
Background/Purpose: Macrophage activation syndrome (MAS) is a group of diseases, especially autoimmune (AI) and hemato-oncology (HO). So it will be interesting to find any clinical…
Abstract Number: 1402 • 2015 ACR/ARHP Annual Meeting
Development of Systemic Juvenile Idiopathic Arthritis Manifestations Following Remission of Hemophagocytic Lymphohistiocytosis
Baruch Goldberg¹, Eyal Muscal², Marietta De Guzman³ and Carl Allen⁴, ¹Pediatric Rheumatology, Texas Children's Hospital, Houston, TX, ²Pediatric Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ³Pediatric Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁴Pediatric Hematology and Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal pathologic inflammatory process resulting from impaired immune function due to inherited gene mutations or secondary to…
Abstract Number: 1625 • 2015 ACR/ARHP Annual Meeting
Role of Macrophages in the Cardiovascular Disease Associated to Rheumatoid Arthritis: Effects of ANTI-CCPS in the Phenotypic Switching and the Insulin Signalling
Patricia Ruiz-Limon, Yolanda Jiménez Gómez, Carlos Perez-Sanchez, MariCarmen Abalos-Aguilera, M.Ángeles Aguirre Zamorano, Jerusalem Calvo-Gutierrez, Rafaela Ortega, Eduardo Collantes-Estévez, Alejandro Escudero-Contreras, Chary Lopez-Pedrera and Nuria Barbarroja, IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain
Background/Purpose: Macrophages play a key role in the pathogenesis of the rheumatoid arthritis (RA). Under certain stimulus conditions these cells are able to switch their…
Abstract Number: 1679 • 2015 ACR/ARHP Annual Meeting
Vicm Is a Novel Biomarker of Macrophage Activity Evaluated in a Phase IIb Clinical Trial of Mavrilimumab
Anne C. Bay-Jensen¹, Xiang Guo², Joachim Høg Mortensen¹, Morten Asser Karsdal¹ and Wendy White², ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease driven by chronic inflammation, upheld by sustained recruitment and infiltration of leucocytes, especially macrophages. Mavrilimumab is a…
Abstract Number: 1682 • 2015 ACR/ARHP Annual Meeting
Suppression of Chronic Arthritis By a Novel Nuclear Factor of Activated T-Cell 5 (NFAT5) Inhibitor
Wan-Uk Kim¹, Eun-Jin Han², Chong-Hyeon Yoon³, Ki-Jo Kim⁴, Seung-Ah Yoo⁵, Bong Ki Hong⁵ and Saseong Lee⁵, ¹Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ²Institute of Bone & Joint Disease, The Catholic University of Korea, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁴St. Mary's Hospital, Seoul, South Korea, ⁵Institute of Bone and Joint Diseases, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: We reported that nuclear factor of activated T-cells 5 (NFAT5), originally identified as an osmo-protective transcription factor, has a critical role in the pathogenesis…
Abstract Number: 1767 • 2015 ACR/ARHP Annual Meeting
Noninvasive Assessment of Macrophage Activation in Experimental Glomerulonephritis Using Optical Imaging with Near-Infrared Light Serves As a Surrogate of Disease Activity
Sebastian Braehler¹, Dongyue Huang², Matthew Cheung², Walter Akers³ and Alfred Kim², ¹Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, ²Rheumatology, Washington University School of Medicine, Saint Louis, MO, ³Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: Glomerulonephritis (GN) represents a major cause of morbidity & mortality. The standard for diagnosing GN is through renal biopsy, but this is not performed…
Abstract Number: 1778 • 2015 ACR/ARHP Annual Meeting
Disease Progression Is Altered By Moderate Exercise and Social Stress in a Murine Model of Lupus Nephritis
Jeffrey Hampton¹, Nicholas A. Young², Sudha Agarwal³, Saba Aqel³, Kendra Jones³, Lai-Chu Wu^2,4, Nicole Powell⁵, John Sheridan⁵, Michael Bruss³ and Wael N. Jarjour², ¹Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Biological Chemistry and Pharmacology, The Ohio State University College of Medicine, Columbus, OH, ⁵Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Chronic inflammation is pathognomonic of autoimmune diseases and contributes to organ damage. Our group has previously shown that moderate daily exercise reduces systemic inflammation…
Abstract Number: 660 • 2014 ACR/ARHP Annual Meeting
Microthrombotic Renal Vascular Lesions Are Associated to Increased Renal Inflammatory Infiltration in a Mouse Model of Lupus Nephritis
María Galindo¹, Elena Gonzalo-Gil², Oscar Toldos³, Carmen García-Herrero², Alicia Usategui¹, Sonia Pérez-Yagüe⁴, Gabriel Criado⁵, Domingo F. Barber⁴ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Department of Rheumatology, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Servicio de Anatomia Patologica, Hospital 12 de Octubre, Madrid, Spain, ⁴Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain, ⁵Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose In patients with lupus nephritis (LN), acute renal vascular and atherosclerotic lesions correlate with the degree of inflammation regardless the presence of antiphospholipid antibodies.…
Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting
Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease
Tsuyoshi Shirai¹, Eric L. Matteson², David G. Harrison³, Barbara B. Wallis⁴, Themistocles L. Assimes⁵, Jorg J. Goronzy⁶ and Cornelia M. Weyand¹, ¹Medicine, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁴Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
Abstract Number: 327 • 2014 ACR/ARHP Annual Meeting
AMPK Activation in Inflammatory Arthritis
Monica Guma¹, Yun Wang² and Ru Liu-Bryan², ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²UCSD/VAMC, La Jolla, CA
Background/Purpose: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase involved in the regulation of cellular energy homeostasis. It is a central regulator of both…
Abstract Number: 76 • 2014 ACR/ARHP Annual Meeting
Identification of Synovial Genes and Pathways Associated with Disease Progression in a Cohort of Early Symptomatic Osteoarthritis Patients Using a Transcriptomic Approach
Arjen B. Blom¹, Peter L. van Lent¹, Martijn H. van den Bosch², Hans Cats³, Frank H.J. van den Hoogen⁴, Floris P.J.G. Lafeber⁵, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ³Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: If and how the synovial activation that is observed in over 50% of osteoarthritis (OA) patients contributes to irreversible joint pathology, is not known.…
Abstract Number: 3003 • 2014 ACR/ARHP Annual Meeting
Am80 Ameliorates Bleomycin-Induced Dermal Fibrosis By Suppressing the Pro-Fibrotic Phenotype of Fibroblasts, Endothelial Cells, and Immune Cells
Tetsuo Toyama¹, Yoshihide Asano¹, Takehiro Takahashi¹, Ryosuke Saigusa¹, Yohei Ichimura¹, Takashi Taniguchi¹, Shinji Noda¹, Kaname Akamata¹, Shinichi Sato¹, Takafumi Kadono¹ and Koichi Shudo², ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Reseach Foundation ITSUU Laboratory, Tokyo, Japan
Background/Purpose: Am80 is a synthetic retinoid serving as an agonist for retinoic acid receptor α/β with chemical and pharmacological advantages over all-trans retinoic acid, such…
Abstract Number: 2952 • 2014 ACR/ARHP Annual Meeting
S100A9 Inhibitor Paquinimod (ABR-215757) reduces Joint Destruction in Experimental Osteoarthritis and Blocks Activating Effects of S100A9 in OA Synovium
Peter L. van Lent¹, Rik Schelbergen², Arjen B. Blom¹, Tomas Leanderson³, Helena Eriksson⁴ and Wim B. van den Berg⁵, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud university medical center, Nijmegen, Netherlands, ³Immunology Group, Lund University, Lund, Sweden, ⁴BioScience, Active Biotech AB, Lund, Sweden, ⁵Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Synovial activation is present in more than 50% of osteoarthritis (OA) patients and it is thought to be involved in the development of OA…
Abstract Number: 2127 • 2014 ACR/ARHP Annual Meeting
Subclinical Arthritis Is Detected By Macrophage Targeting and Positron Emission Tomography (PET) in Early RA Patients in Clinical Remission
Y.Y.J. Gent¹, M.M. ter Wee¹, D den Uyl¹, N. Ahmadi², W.F. Lems³, O.S. Hoekstra⁴, A.E. Voskuyl¹ and C.J. Van der Laken³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Radiology, VU University Medical Center, Amsterdam, Netherlands, ³Rheumatology, VU Medical Center, Amsterdam, Netherlands, ⁴Nuclear Medicine, VU Medical Center, Amsterdam, Netherlands
Background/Purpose: Recurrent flares in RA patients in complete remission (CR) are not an uncommon phenomenon. Studies with advanced imaging techniques have suggested that residual subclinical…
Abstract Number: 1714 • 2014 ACR/ARHP Annual Meeting
IL-6 Trans-Signalling Activates M2 Macrophage Polarisation and Mediates Fibrotic Response in Scleroderma
Rebecca Alade, Shiwen Xu, Korsa Khan, Angela Tam, Christopher P. Denton and Voon H. Ong, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom
Background/Purpose IL6 is a key mediator in activation of extracellular matrix (ECM) in scleroderma (SSc) fibroblasts and via its interplay with chemokines may modulate mononuclear…

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