ACR Meeting Abstracts

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Abstracts tagged "Macrophage"

  • Abstract Number: 186 • 2016 ACR/ARHP Annual Meeting

    Impact of TLR Stimulation on Cytokine Production in Macrophage Subsets: TLR2 Stimulation Impairs Anti-Inflammatory Activity of M2 Macrophages

    Lilian Quero, Anke Gehringer and Diego Kyburz, Department of Biomedicine, Experimental Rheumatology, University of Basel, 4051 Basel, Switzerland

    Background/Purpose: Toll-like receptors (TLRs) have been shown to contribute to the inflammatory response in rheumatoid arthritis (RA). A number of TLRs have been found to…
  • Abstract Number: 2619 • 2016 ACR/ARHP Annual Meeting

    Sustained Suppression of Peripheral Biomarkers By Mavrilimumab but Not Golimumab in Anti-Tumor Necrosis Factor-Inadequate Responders: An Exploratory Analysis in the Phase IIb Earth Explorer 2 Clinical Trial

    Xiang Guo1, Shiliang Wang1, Anne C. Bay-Jensen2, Morten Asser Karsdal2, A Godwood3, Marius Albulescu3, D Close3, Patricia C. Ryan1, Lorin Roskos4 and Wendy White1, 1Translational Sciences, MedImmune, LLC, Gaithersburg, MD, 2Rheumatology, Nordic Bioscience, Herlev, Denmark, 3MedImmune, Cambridge, United Kingdom, 4MedImmune, LLC, Mountain View, CA

    Background/Purpose: Treatment of rheumatoid arthritis (RA) patients by anti-tumour necrosis factors (anti-TNFs), such as golimumab, has improved patient outcomes. However, unmet therapeutic needs exist for…
  • Abstract Number: 461 • 2016 ACR/ARHP Annual Meeting

    Involvement of CD163-Positive Macrophages in the Pathogenesis of Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Synovium of a Murine Model

    Shinjiro Kaieda1, Hiroaki Ida2 and Tomoaki Hoshino3, 1Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, 2Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, 3Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan

    Background/Purpose:  Synovial-lining macrophages play a crucial role in the onset and maintenance of joint inflammation in arthritis. CD68 and CD163 are commonly used markers of…
  • Abstract Number: 2626 • 2016 ACR/ARHP Annual Meeting

    Soluble CD206 Plasma Levels Decreases with Treatment and Reflects Anti-Tnfa Discontinuation in Rheumatoid Arthritis

    Line Dam Heftdal1,2, Kristian Stengaard-Pedersen2, Merete Lund Hetland3,4, Kim Hørslev-Petersen5, Peter Junker6, Mikkel Østergaard4,7, Malene Hvid8,9, Bent Deleuran2,8,9, Holger Jon Møller8,10 and Stinne Greisen2,9, 1Department of Biomedicine, Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 3Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 4Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Copenhagen, Denmark, 5King Christian X's Hospital for Rheumatic Diseases,, University of Southern Denmark, Graasten, Denmark, 6Department of Rheumatology, Odense University Hospital, Odense, Denmark, 7Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 8Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 9Department of Biomedicine, Aarhus University, Aarhus, Denmark, 10Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints and infiltration by activated macrophages. TNFa is a central…
  • Abstract Number: 1169 • 2015 ACR/ARHP Annual Meeting

    Crossregulatory Mechanisms Between Synovial Fibroblasts and Macrophages Relevant in RA Pathogenesis

    Jennifer Ding1, Lionel B. Ivashkiv2 and Laura T. Donlin1, 1Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 2Medicine, Hospital for Special Surgery, New York, NY

    Background/Purpose: Macrophages and synovial fibroblasts function as key drivers of inflammation in rheumatoid arthritis (RA). We have developed a co-culture system that aims to define…
  • Abstract Number: 1401 • 2015 ACR/ARHP Annual Meeting

    Is There Any Difference Between Autoimmune or Hemato-Oncology Etiology of Macrophage Activation Syndrome?

    César Antonio Egües Dubuc, Miren Uriarte Ecenarro, Nerea Errazquin Aguirre, Olga Maiz Alonso, Iñaki Hernando Rubio and Joaquin Maria Belzunegui Otano, Rheumatology, Donostia University Hospital, Donostia, Spain

    Background/Purpose: Macrophage activation syndrome (MAS) is a group of diseases, especially autoimmune (AI) and hemato-oncology (HO). So it will be interesting to find any clinical…
  • Abstract Number: 1402 • 2015 ACR/ARHP Annual Meeting

    Development of Systemic Juvenile Idiopathic Arthritis Manifestations Following Remission of Hemophagocytic Lymphohistiocytosis

    Baruch Goldberg1, Eyal Muscal2, Marietta De Guzman3 and Carl Allen4, 1Pediatric Rheumatology, Texas Children's Hospital, Houston, TX, 2Pediatric Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 3Pediatric Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 4Pediatric Hematology and Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose:       Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal pathologic inflammatory process resulting from impaired immune function due to inherited gene mutations or secondary to…
  • Abstract Number: 1625 • 2015 ACR/ARHP Annual Meeting

    Role of Macrophages in the Cardiovascular Disease Associated to Rheumatoid Arthritis: Effects of ANTI-CCPS in the Phenotypic Switching and the Insulin Signalling

    Patricia Ruiz-Limon, Yolanda Jiménez Gómez, Carlos Perez-Sanchez, MariCarmen Abalos-Aguilera, M.Ángeles Aguirre Zamorano, Jerusalem Calvo-Gutierrez, Rafaela Ortega, Eduardo Collantes-Estévez, Alejandro Escudero-Contreras, Chary Lopez-Pedrera and Nuria Barbarroja, IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain

    Background/Purpose: Macrophages play a key role in the pathogenesis of the rheumatoid arthritis (RA). Under certain stimulus conditions these cells are able to switch their…
  • Abstract Number: 1679 • 2015 ACR/ARHP Annual Meeting

    Vicm Is a Novel Biomarker of Macrophage Activity Evaluated in a Phase IIb Clinical Trial of Mavrilimumab

    Anne C. Bay-Jensen1, Xiang Guo2, Joachim Høg Mortensen1, Morten Asser Karsdal1 and Wendy White2, 1Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Translational Sciences, MedImmune, LLC, Gaithersburg, MD

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease driven by chronic inflammation, upheld by sustained recruitment and infiltration of leucocytes, especially macrophages. Mavrilimumab is a…
  • Abstract Number: 1682 • 2015 ACR/ARHP Annual Meeting

    Suppression of Chronic Arthritis By a Novel Nuclear Factor of Activated T-Cell 5 (NFAT5) Inhibitor

    Wan-Uk Kim1, Eun-Jin Han2, Chong-Hyeon Yoon3, Ki-Jo Kim4, Seung-Ah Yoo5, Bong Ki Hong5 and Saseong Lee5, 1Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, 2Institute of Bone & Joint Disease, The Catholic University of Korea, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 4St. Mary's Hospital, Seoul, South Korea, 5Institute of Bone and Joint Diseases, The Catholic University of Korea, Seoul, South Korea

    Background/Purpose: We reported that nuclear factor of activated T-cells 5 (NFAT5), originally identified as an osmo-protective transcription factor, has a critical role in the pathogenesis…
  • Abstract Number: 1767 • 2015 ACR/ARHP Annual Meeting

    Noninvasive Assessment of Macrophage Activation in Experimental Glomerulonephritis Using Optical Imaging with Near-Infrared Light Serves As a Surrogate of Disease Activity

    Sebastian Braehler1, Dongyue Huang2, Matthew Cheung2, Walter Akers3 and Alfred Kim2, 1Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, 2Rheumatology, Washington University School of Medicine, Saint Louis, MO, 3Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO

    Background/Purpose: Glomerulonephritis (GN) represents a major cause of morbidity & mortality. The standard for diagnosing GN is through renal biopsy, but this is not performed…
  • Abstract Number: 1778 • 2015 ACR/ARHP Annual Meeting

    Disease Progression Is Altered By Moderate Exercise and Social Stress in a Murine Model of Lupus Nephritis

    Jeffrey Hampton1, Nicholas A. Young2, Sudha Agarwal3, Saba Aqel3, Kendra Jones3, Lai-Chu Wu2,4, Nicole Powell5, John Sheridan5, Michael Bruss3 and Wael N. Jarjour2, 1Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, 2Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Biological Chemistry and Pharmacology, The Ohio State University College of Medicine, Columbus, OH, 5Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose:  Chronic inflammation is pathognomonic of autoimmune diseases and contributes to organ damage.  Our group has previously shown that moderate daily exercise reduces systemic inflammation…
  • Abstract Number: 2135 • 2015 ACR/ARHP Annual Meeting

    miRNA-223 Delivery to Synovial Fibroblasts Via Monocyte-Derived Extracellular Vesicles Promotes Their Proliferation

    Florian M.P. Meier1, Derek S. Gilchrist1, Derek Baxter2, Diane Vaughan1, Margaret Mullin3, David W. McCarey4, Pawel Herzyk5, Julie Galbraith5, Donna McIntyre1, Russka Shumnalieva6, Ulf Müller-Ladner7, Iain B. McInnes8 and Mariola Kurowska-Stolarska1, 1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 2Department of Rheumatology, University Hospital Ayr, Ayr, United Kingdom, 3School of Life Sciences, University of Glasgow, Glasgow, United Kingdom, 4Glasgow Royal Infirmary, Glasgow, United Kingdom, 5Polyomics Facility, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom, 6Department of Internal Medicine, Clinic of Rheumatology, Sofia, Bulgaria, 7Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 8Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Recently, it was shown that extracellular vesicles (EV) convey microRNAs (miR) from platelets to endothelial cells1and regulate recipient cell gene expression. Interaction of synovial…
  • Abstract Number: 2548 • 2015 ACR/ARHP Annual Meeting

    M-CSF-R Is a Critical Determinant for the Differentiation of Classical to Non-Classical Monocytes

    Philip J. Homan1, Alexander Misharin1, Carla Cuda2, Salina Dominguez2, Rana Saber2, Fu-Nien Tsai3 and Harris R. Perlman4, 1Medicine-Rheumatology, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL, 3Medicine, Rhuematology, Northwestern University, Chicago, IL, 4Feinberg School of Medicine, Northwestern University, Chicago, IL

    Background/Purpose: Colony-stimulating factors (CSF) are simply defined as haemotopoitec growth factors. However, CSFs have been implicated to have additional functions in various autoimmune diseases. Specifically…
  • Abstract Number: 2569 • 2015 ACR/ARHP Annual Meeting

    Regulation of SIRT1 Maybe a Perfect Strategy in Treatment of Rheumatoid Arthritis

    Sang-Yeob Lee1, Sung Won Lee2, Won Tae Chung2, Jae Ho Bae3, So Youn Park4 and Chi Dae Kim4, 1Division of Rheumatology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea, 2Rheumatology, Dong-A University Hospital, Busan, South Korea, 3Biochemistry, Pusan national university, Yong -San, South Korea, 4Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea

    Background/Purpose: Monocyte may differentiate to osteoclasts in bone and macrophages in joint. so, blocking of monocyte differentiation maybe effective target in RA (rheumatoid arthritis) treatment.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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