Abstracts tagged "Macrophage"

Abstract Number: 2060 • 2016 ACR/ARHP Annual Meeting
Bim Suppresses the Development of SLE By Limiting Macrophage Inflammatory Responses
FuNien Tsai¹, Carla Cuda², Harris R. Perlman³, Philip J. Homan⁴, Salina Dominguez², Alexander Shaffer³, George Kenneth Haines III⁵ and Jack Hutcheson⁶, ¹Medicine-Rheumatology, Northwestern University-Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, IL, ³Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Medicine-Rheumatology, Northwestern University, Chicago, IL, ⁵Mount Sinai, New York, NY, ⁶UT Southwestern, Dallas, TX
Background/Purpose: The Bcl-2 family guards the mitochondrial apoptotic pathway. Among numerous Bcl-2 antagonists, only the loss of Bim in mice leads to the development of…
Abstract Number: 2109 • 2016 ACR/ARHP Annual Meeting
Immunoprofiling of Bruton’s Tyrosine Kinase (Btk)/Tec Family Kinase Inhibitors Indicate Activities Beyond Btk in Immunocyte Function
Jolanta Kosek¹, Lori Capone², Mary Adams¹, Eun Mi Hur¹, Peter H. Schafer³ and Garth Ringheim¹, ¹Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, ²Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: CC-292, CC-90008, and ibrutinib are covalent Btk/Tec family kinase inhibitors that block Btk activity by binding with high affinity to the adenosine triphosphate (ATP)…
Abstract Number: 2145 • 2016 ACR/ARHP Annual Meeting
The Modulation of Macrophage Polarization By SIRT1 Maybe New Target Therapy in Rheumatoid Arthritis
Sang-Yeob Lee¹, Won Tae Chung², Sung Won Lee³, So Youn Park⁴ and Bae Jae Ho⁵, ¹Cell Biology, Dong -A university, South Korea, Pusan, South Korea, ²Rheumatology, Dong-A University Hospital, Busan, South Korea, ³Dong-A university,Busan, South Korea, Pusan, South Korea, ⁴Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea, ⁵department of biochemistry, medical college, Pusan National University,, MD, PhD, Gyeongsangnam-do, South Korea
Background/Purpose: The polarization of macrophages was the expressed to M1/M2 phenotype by various stimuli or environment signals. The M1 macrophage was pro-inflammatory phenotype and was…
Abstract Number: 2267 • 2016 ACR/ARHP Annual Meeting
AMP-Activated Protein Kinase: A Target for Methotrexate in Macrophages
Cornelia Cudrici¹, Martin Pelletier² and Richard M. Siegel³, ¹NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ²Infectious and immune diseases Centre Hospitalier de l'Université Laval (CHUL) Québec, Québec, QC, Canada, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD
Background/Purpose: Methotrexate (MTX) remains a cornerstone of treatment in multiple forms of inflammatory arthritis, lupus and vasculitis. The anti-inflammatory effects of MTX are more likely…
Abstract Number: 20 • 2015 ACR/ARHP Annual Meeting
Role of the Epigenetic Regulator EZH2 in Proinflammatory Macrophage Polarization and Signaling in Rheumatoid Arthritis
Michelle Trenkmann¹, Eimear Linehan², Mary Canavan³, Douglas J. Veale⁴ and Ursula Fearon¹, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ²St. Vincent's University Hospital Dublin, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ³St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ⁴St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: In rheumatoid arthritis (RA), synovial tissue macrophages (MΦ) are inherently involved in disease pathogenesis by producing inflammatory mediators and matrix-destructive enzymes. Depending on their…
Abstract Number: 2814 • 2015 ACR/ARHP Annual Meeting
IL-10 May Mitigate Cardiovascular Risk in Psoriatic Arthritis Via an Anti-Atherosclerotic Effect on Cellular Cholesterol Transport
Lucas McCaffrey¹, Iryna Voloshyna², Michael J. Littlefield², Eduard Zhurov³, Steven E. Carsons⁴, Elise Belilos⁵, Kristina Belostocki⁶, Lois Bonetti⁷, Gary Rosenblum⁶ and Allison B. Reiss², ¹Medicine, Division of Rheumatology, Winthrop-University Hospital, Mineola, NY, ²Medicine, Winthrop University Hospital, Mineola, NY, ³Winthrop-University Hospital, Mineola, NY, ⁴Rheumatology, Allergy and Immunology, Winthrop University Hospital, Mineola, NY, ⁵Winthrop University Hospital, Mineola, NY, ⁶Rheumatology, Winthrop University Hospital, Mineola, NY, ⁷Rheum & Immun, Winthrop University Hospital, Mineola, NY
Background/Purpose: The increased risk of major adverse cardiovascular events (MACE) in patients who suffer from systemic inflammatory conditions such as Rheumatoid Arthritis (RA), Systemic Lupus…
Abstract Number: 795 • 2015 ACR/ARHP Annual Meeting
High Mobility Group Box-1 (HMGB1) Affects Macrophage Polarization and Phagocytosis in Systemic Lupus Erythematosus Patients
Fleur Schaper¹, Gerda Horst¹, Karina de Leeuw¹, Hendrika Bootsma¹, Pieter C Limburg², Peter Heeringa³, Marc Bijl⁴ and Johanna Westra⁵, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Internal Medicine and Rheumatology, Martini Hospital, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
High mobility group box-1 (HMGB1) affects macrophage polarization and phagocytosis in systemic lupus erythematosus patients. F Schaper, G Horst, K de Leeuw, H Bootsma, PC…
Abstract Number: 3217 • 2015 ACR/ARHP Annual Meeting
Macrophage Depletion Using a Specific CSF-1R Kinase Inhibitor Ameliorates Kidney and Skin Disease in a Mouse Model of Systemic Lupus Erythematosus
Jessica Doerner¹, Samantha Chalmers² and Chaim Putterman³, ¹Albert Einstein College of Medicine, Bronx, NY, ²Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ³The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Kidney and skin involvement are common in systemic lupus erythematosus (SLE). Nephritis is seen in up to 60% of patients, and contributes significantly to…
Abstract Number: 935 • 2015 ACR/ARHP Annual Meeting
Microrna-146a Provides Feedback Regulation of Monosodium Urate-Induced Gouty Arthritis in Mice By Targeting Tumor Necrosis Factor Receptor Associated Factor 6 and Interleukin-1 Receptor-Associated Kinase 1
Quan-Bo Zhang^1,2, Jing-Guo Zhou³, Cong-Cong Yin¹, Yu-Feng Qing⁴, Chang-Gui Li⁵, Li Zhou¹ and Qing-Sheng Mi⁶, ¹Immunology Program, Department of Dermatology, Henry Ford Health System, Detroit, MI, ²Geriatrics, Affliated hospital of North Sichuan Medical College, Nanchong, China, ³Department of Rheumatology and Immunology, Affliated hospital of North Sichuan Medical College, Nanchong, China, ⁴Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China, Nanchong, China, ⁵Affiliated Hospital of Qingdao University, Qingdao, China, ⁶Immunology, Dermatology, Henry Ford Health System, Detroit, MI
Background/Purpose: MicroRNAs (miRNAs) have been shown to serve as important regulators for inflammatory and immune responses and are implicated in several immune disorders including gouty…
Abstract Number: 1160 • 2015 ACR/ARHP Annual Meeting
DNA Hydroxylmethylation Regulates Pro-Inflammatory Cytokine Expression in Macrophages
Fangfang Sun^1,2, Renate E. Gay¹, Beat A. Michel¹, Shuang Ye², Steffen Gay¹, Michel Neidhart¹ and Emmanuel Karouzakis¹, ¹University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ²Department of Rheumatology, South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China
Background/Purpose: Activated macrophages are found in the inflamed and hyperplasic synovial RA tissues. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…
Abstract Number: 1169 • 2015 ACR/ARHP Annual Meeting
Crossregulatory Mechanisms Between Synovial Fibroblasts and Macrophages Relevant in RA Pathogenesis
Jennifer Ding¹, Lionel B. Ivashkiv² and Laura T. Donlin¹, ¹Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ²Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Macrophages and synovial fibroblasts function as key drivers of inflammation in rheumatoid arthritis (RA). We have developed a co-culture system that aims to define…
Abstract Number: 1401 • 2015 ACR/ARHP Annual Meeting
Is There Any Difference Between Autoimmune or Hemato-Oncology Etiology of Macrophage Activation Syndrome?
César Antonio Egües Dubuc, Miren Uriarte Ecenarro, Nerea Errazquin Aguirre, Olga Maiz Alonso, Iñaki Hernando Rubio and Joaquin Maria Belzunegui Otano, Rheumatology, Donostia University Hospital, Donostia, Spain
Background/Purpose: Macrophage activation syndrome (MAS) is a group of diseases, especially autoimmune (AI) and hemato-oncology (HO). So it will be interesting to find any clinical…
Abstract Number: 1402 • 2015 ACR/ARHP Annual Meeting
Development of Systemic Juvenile Idiopathic Arthritis Manifestations Following Remission of Hemophagocytic Lymphohistiocytosis
Baruch Goldberg¹, Eyal Muscal², Marietta De Guzman³ and Carl Allen⁴, ¹Pediatric Rheumatology, Texas Children's Hospital, Houston, TX, ²Pediatric Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ³Pediatric Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁴Pediatric Hematology and Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal pathologic inflammatory process resulting from impaired immune function due to inherited gene mutations or secondary to…
Abstract Number: 1625 • 2015 ACR/ARHP Annual Meeting
Role of Macrophages in the Cardiovascular Disease Associated to Rheumatoid Arthritis: Effects of ANTI-CCPS in the Phenotypic Switching and the Insulin Signalling
Patricia Ruiz-Limon, Yolanda Jiménez Gómez, Carlos Perez-Sanchez, MariCarmen Abalos-Aguilera, M.Ángeles Aguirre Zamorano, Jerusalem Calvo-Gutierrez, Rafaela Ortega, Eduardo Collantes-Estévez, Alejandro Escudero-Contreras, Chary Lopez-Pedrera and Nuria Barbarroja, IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain
Background/Purpose: Macrophages play a key role in the pathogenesis of the rheumatoid arthritis (RA). Under certain stimulus conditions these cells are able to switch their…
Abstract Number: 1679 • 2015 ACR/ARHP Annual Meeting
Vicm Is a Novel Biomarker of Macrophage Activity Evaluated in a Phase IIb Clinical Trial of Mavrilimumab
Anne C. Bay-Jensen¹, Xiang Guo², Joachim Høg Mortensen¹, Morten Asser Karsdal¹ and Wendy White², ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease driven by chronic inflammation, upheld by sustained recruitment and infiltration of leucocytes, especially macrophages. Mavrilimumab is a…

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