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Abstracts tagged "lymphocytes and systemic sclerosis"

  • Abstract Number: 1122 • 2018 ACR/ARHP Annual Meeting

    Lymphocyte Immunophenotypes at Randomization on the Scleroderma: Cyclophosphamide or Transplantation Trial: Comparison of Treatment Naïve and DMARD Treated Participants with Healthy Controls

    Ankoor Shah1, Jan Storek2, Rob Woolson3, Lynette Keyes-Elstein4, Paul Wallace5, Maureen D. Mayes6, Leslie Crofford7, Daniel E. Furst8, Ellen Goldmuntz9, Richard Nash10, Peter McSweeney10 and Keith Sullivan11, 1Medicine, Duke University Medical Center, Durham, NC, 2University of Calgary, Calgary, AB, Canada, 3Rho Inc, Chapel Hill, NC, 4Clinical Statistics, Rho Federal Systems, Inc., Chapel Hill, NC, 5Roswell Park Cancer Institute, Buffalo, NY, 6Rheumatology, University of Texas McGovern Medical School, Houston, TX, 7Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 8Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 9NIH, Bethesda, MD, 10Colorado Blood Cancer Institute, Denver, CO, 11Duke University Medical Center, Durham, NC

    Background/Purpose: The Scleroderma:Cyclophosphamide or Transplantation Trial (SCOT) study compared stem cell transplant to monthly cyclophosphamide (CYC) in patients with scleroderma (SSc). We studied baseline lymphocyte…
  • Abstract Number: 2068 • 2016 ACR/ARHP Annual Meeting

    Type 2 Innate Lymphoid Cells – Cellular Source of Profibrotic Mediators Rapidly and Persistently Recruited in Experimental Fibrosis and Systemic Sclerosis

    Stefanie Weber1, Thomas Wohlfahrt1, Simon Rauber1, Markus Luber1, Matthias Englbrecht2, Clara Dees3, Christian Beyer4, Oliver Distler5, Georg Schett3, Joerg HW Distler3 and Andreas Ramming4, 1Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, Rheumatology & Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 4Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose:  We aimed to profile ILC2s in fibrotic tissues and to evaluate the functional impact of IC2s in the pathogenesis of systemic sclerosis (SSc). Methods:…
  • Abstract Number: 773 • 2014 ACR/ARHP Annual Meeting

    Functional Autoantibodies from Patients with Systemic Sclerosis Reactive to Angiotensin II Type 1 and Endothelin-1 Type a Receptor Induce Inflammatory Lymphocyte Infiltration into Lungs of Mice

    Angela Kill1, Clement Braesch1, Anja Kühl2, Jeannine Guenther3, Mike O. Becker4, Gerd Burmester5, Thomas Walther6 and Gabriela Riemekasten7, 1Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, 2Department of Internal Medicine, Charité University Hospital, Berlin, Germany, 3Rheumatology and Clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, 4Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, 5Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 6Pharmacology & Therapeutics, University College Cork, Cork, Ireland, 7Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany

    Background/Purpose Functional autoantibodies reactive to the angiotensin II type 1 receptor (AT1R) and endothelin 1 type A receptor (ETAR) were found in elevated levels in…
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