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Abstracts tagged "lymph node and rheumatoid arthritis"

  • Abstract Number: 967 • ACR/ARHP Annual Meeting 2017

    NF-κb-Inducing Kinase Regulates LTβR-Driven NF-κb Signaling and Inflammatory Activation of Endothelium

    Paulina Kucharzewska1, Chrissta Maracle2, Jan Piet van Hamburg2, Kim Jeucken2, Henric Olsson1 and Sander W. Tas3, 1Bioscience, AstraZeneca, Göteborg, Sweden, 22Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Sites of chronic inflammation, such as rheumatoid arthritis synovial tissue, are characterized by neovascularization and often contain tertiary lymphoid structures with characteristic features of…
  • Abstract Number: 1456 • ACR/ARHP Annual Meeting 2016

    Identification of a Unique Population of B220hi B-Cells in Inflamed Lymph Nodes (Bin) As a Potential Biomarker of Arthritic Progression in the Tumor Necrosis Factor Transgenic Mouse Model of Rheumatoid Arthritis

    Megan Forney1, Richard Bell2, Edward Schwarz3 and Homaira Rahimi4, 1Orthopedics, University of Rochester, Rochester, NY, 2Pathology, University of Rochester, Rochester, NY, 3Orthopedeatrics, University of Rochester, Rochester, NY, 4Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY

    Background/Purpose: Using the tumor necrosis factor transgenic (TNF-Tg) mouse model of rheumatoid arthritis (RA), we have shown that during progression of knee synovitis, popliteal lymph…
  • Abstract Number: 2448 • ACR/ARHP Annual Meeting 2014

    DNA Methylation Analysis of Lymph Node Stromal Cells of Rheumatoid Arthritis Patients

    Emmanuel Karouzakis1, Caroline Ospelt1, Janine Hähnlein2, Renate E. Gay3, Paul Peter Tak4, Danielle Marie Gerlag5, Michel Neidhart1, Steffen Gay1 and Lisa G.M. van Baarsen2, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 4University of Cambridge,Cambridge and GlaxoSmithKline, Stevenage, United Kingdom, 5GSK,Clinical Unit Cambridge,R&D Projects Clinical Platforms & Sciences, Cambridge, United Kingdom

    Background/Purpose Lymph node stromal cells (LNSC) build the scaffold that enables migration and interaction of lymphocytes in the lymph node. More recently, it has been…

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