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Abstracts tagged "lymph node and rheumatoid arthritis (RA)"

  • Abstract Number: 51 • ACR/ARHP Annual Meeting 2018

    Genetic Ablation of Inducible Nitric Oxide Synthase in TNF Transgenic Mice with Inflammatory-Erosive Arthritis Prevents Lymph Node Expansion and Decreases Synovial Infiltrates

    Richard Bell1, Emily Wu2, Lianping Xing3, Christopher T. Ritchlin4 and Edward Schwarz5, 1Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 2Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, 3University of Rochester Medical Center, Rochester, NY, 4Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 5Orthopedeatrics, University of Rochester, Rochester, NY

    Background/Purpose: Recent studies in the TNF-Tg mouse model of rheumatoid arthritis (RA) demonstrated a critical role of lymphatic vessel (LV) function in joint homeostasis and…
  • Abstract Number: 325 • ACR/ARHP Annual Meeting 2014

    Tadalafil Decreases Joint Inflammation in TNF-Tg Mice By Restoring Passive Lymphatic Transport

    Echoe M. Bouta1, Igor Kuzin2, Ronald Wood3, Christopher T. Ritchlin4, Andrea Bottaro2 and Edward M. Schwarz5, 1University of Rochester, Rochester, NY, 2Cooper Medical School, Camden, NJ, 3Department of Urology, University of Rochester Medical Center, Rochester, NY, 4Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, 5Center for Musculoskeletal Research, University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with enigmatic episodic flares.  Using longitudinal imaging, we recently demonstrated that arthritic knee flare in…
  • Abstract Number: 333 • ACR/ARHP Annual Meeting 2012

    Pressure and Blood Flow Measurements in Efferent Lymphatics As Biomarkers of Arthritic Flare

    Echoe M. Bouta1, Ronald Wood2, Christopher T. Ritchlin3, Lianping Xing4 and Edward M. Schwarz5, 1University of Rochester, Rochester, NY, 2Department of Urology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 3Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 4Pathology & Lab Medicine, University of Rochester, Rochester, NY, 5Center for Musculoskeletal Research, University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease with episodic flares in affected joints.  These flares are associated with decreased lymphatic drainage.  In TNF-Tg mice,…

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