Abstracts tagged "Lupus"

Abstract Number: 1849 • 2019 ACR/ARP Annual Meeting
Cost-related Prescription Non-adherence Is Associated with Patient-reported Outcomes of Systemic Lupus Erythematosus Activity and Damage: The Michigan Lupus Epidemiology & Surveillance (MILES) Cohort
Deeba Minhas¹, Wendy Marder ², Sioban Harlow ³, Hanna Saltzman ³, Afton Hassett ³, Suzanna Zick ³, Lu Wang ³, Kamil Barbour ⁴, Charles Helmick ⁵, Caroline Gordon ⁶, W. Joseph McCune ¹ and Emily Somers ³, ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, ³University of Michigan, Ann Arbor, ⁴Centers for Disease Control and Prevention, Atlanta, ⁵Centers for Disease Control and Prevention, Division of Population Health, Atlanta, GA, ⁶University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Medication access and adherence play key roles in determining patient outcomes. We investigated whether cost-related non-adherence (CRNA) to prescription medications was associated with worse…
Abstract Number: 706 • 2019 ACR/ARP Annual Meeting
Neuronal BC RNAs: Systemic Lupus Erythematosus Autoantibodies Cause Dendritic Transport Impairments
ILHAM MUSLIMOV¹, ANNA IACOANGELI ², TAESUN EOM ³, ANNE RUIZ ³, MADISEN LEE ³, STACY STEPHENSON ³ and Ellen M Ginzler ⁴, ¹SUNY DOWNSTATE MEDICAL CENTER Center, BROOKLYN, NY, ²Tisch MS Research Center of New York, NEW YORK, NY, ³SUNY DOWNSTATE MEDICAL CENTER, BROOKLYN, NY, ⁴State University of New York Downstate Medical Center, Brooklyn, NY
Background/Purpose: In systemic lupus erythematosus (SLE), autoantibodies are often directed against nucleic acids or their binding proteins. Regulatory Brain-specific Cytoplasmic (BC) RNAs operate as translational…
Abstract Number: 1589 • 2019 ACR/ARP Annual Meeting
Prevalence of Cognitive Impairment in an Inception Lupus Cohort as Assessed by a Comprehensive Neuropsychological Battery
Bahar Moghaddam¹, Dorcas Beaton ², Robin Green ³, Maria Tartaglia ⁴, Lesley Ruttan ³, Mahta Kakvan ⁵, Marvin Fritzler ⁶, May Choi ⁶, Moe Zandy ⁵, Jiandong Su ⁵, Michelle Vitti ⁷, Dennisse Bonilla ⁵, Joan Wither ⁸, Sabrina Lombardi ³ and Zahi Touma ⁵, ¹University of Toronto, Toronto, ON, Canada, ²St. Michael's Hospital, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada, ⁴University Health Network, University of Toronto, Toronto, ON, Canada, ⁵University Health Network, University of Toronto, Toronto, ON, Canada, ⁶Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷University Health Network/University of Toronto, Toronto, NU, Canada, ⁸University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Systemic Lupus Erythematosus (SLE) can lead to a number of neuropsychiatric manifestations including cognitive impairment (CI). Previous meta-analyses have reported the prevalence of CI…
Abstract Number: 1959 • 2019 ACR/ARP Annual Meeting
Pleiotropy of Systemic Lupus Erythematosus (SLE) Risk Alleles: Association with Increased Risk for Type 1 Diabetes (T1D) Complications Through a PTPN22 Polymorphism
Vivian Kawai¹, Mingjian Shi ¹, Qiping Feng ², Cecilia Chung ¹, Ge Liu ², Nancy Cox ², Dan Roden ², C. Michael Stein ¹ and Jonathan Mosley ², ¹Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville
Background/Purpose: Patients with SLE have increased risk of cardiovascular events and a higher prevalence of metabolic conditions compared to the general population. Inflammation is a…
Abstract Number: 61 • 2019 ACR/ARP Annual Meeting
Lyn-Deficient Murine Lupus Is Exacerbated by Glucocorticoid-Induced Leucine Zipper (GILZ) Deficiency
Champa Nataraja¹, Jacqueline Flynn ¹, Wendy Dankers ¹, James Harris ¹, Sarah Jones ¹ and Eric Morand ¹, ¹Monash University, Melbourne, Victoria, Australia
Background/Purpose: Lyn-deficient mice develop hyperactive B cells, excess IL-6 production, and nephritis. Mice deficient in glucocorticoid-induced leucine zipper (GILZ), an intracellular protein involved in glucocorticoid…
Abstract Number: 883 • 2019 ACR/ARP Annual Meeting
B Cell-specific MyD88 Regulates Pathology After Disease Onset in Murine Lupus
Jeremy Tilstra¹, Minjung Kim ¹, Claire Leibler ¹ and Mark Shlomchik ¹, ¹University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease defined by immune dysregulation, antibody formation, followed by end-organ damage. MyD88 is a central immune…
Abstract Number: 1593 • 2019 ACR/ARP Annual Meeting
Heart Rate Visit-to-Visit Variability in Patients with Systemic Lupus Erythematosus Is Associated with Increased Mortality
Tyler Reese¹, Alyson Dickson ¹, Jocelyn Gandelman ¹, Sarah Bayefsky ¹, April Barnado ¹, Katherine Barker ¹, C. Michael Stein ¹, Vivian Kawai ¹ and Cecilia Chung ¹, ¹Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased mortality compared to the general population. Heart rate visit-to-visit variability (HRVVV) has emerged as an adverse…
Abstract Number: 2031 • 2019 ACR/ARP Annual Meeting
Interferon Alpha Promotes Caspase-Dependent Apoptosis Independently of Reactive Oxygen Species in Ultraviolet B-Exposed Keratinocytes
Shannon Estadt¹ and J. Michelle Kahlenberg ¹, ¹University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by increased sensitivity to ultraviolet radiation (UVR). UVR can trigger cutaneous and systemic disease fares,…
Abstract Number: 72 • 2019 ACR/ARP Annual Meeting
The Single-cell Transcriptomic Landscape of NZB/W Murine Lupus at Early and Late Stages of Disease
Paul Hoover¹, Tom Eisenhaure ², David Lieb ², Anne Davidson ³ and Nir Hacohen ², ¹Brigham and Women's Hospital, Boston, MA, ²Broad Institute, Cambridge, MA, ³Feinstein Institutes for Medical Research, Manhasset
Background/Purpose: Lupus nephritis is a complex and heterogeneous disease characterized by infiltrating immune cells in damaged kidney tissue. While mouse models have enabled mechanistic studies…
Abstract Number: 884 • 2019 ACR/ARP Annual Meeting
Interferon-Alpha Disrupts Multiple B Cell Tolerance Mechanisms in 3H9 Mice
Dario Ferri ¹, Yuriy Baglaenko ², Kieran Manion ³, Carolina Munoz-Grajales ⁴ and Joan Wither⁵, ¹University Health Network, Toronto, ON, Canada, ²Brigham Woman's Hospital, Boston, ³Krembil Research Institute, Toronto, ON, Canada, ⁴University Health Network, Toronto, Canada, ⁵University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Interferon-alpha (IFNα) is elevated in Systemic Lupus Erythematosus (SLE) and is thought to play a central role in its pathogenesis. Amongst IFNα’s many effects…
Abstract Number: 1594 • 2019 ACR/ARP Annual Meeting
High Expression of CD38 on CD8 T Cells Predicts Increased Burden of Infections in Patients with SLE
Lama Mulki¹, Abel Suarez-Fueyo ², Eri Katsuyama ², Vasileios Kyttaris ² and George Tsokos ², ¹Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: We have previously reported that CD38 gene expression in the peripheral blood T cell from patients with SLE is increased. CD8+CD38+ T cells have…
Abstract Number: 2037 • 2019 ACR/ARP Annual Meeting
Understanding Langerhans Cell ADAM17 Levels in Systemic Lupus Erythematosus: Potential Contributor to Photosensitivity
Theresa Lu ¹, Noa Schwartz ², Thomas Li ², William Shipman ³, Dragos Dasoveanu ³, Yong Liu ⁴, Niroshana Anandasabapathy ⁴, Henry Lee ⁴, Ali Jabbari ⁵, James Krueger ⁵, Bebak Mehrara ⁶, Keila Veiga², Kira Minkis ⁴ and David Oliver ², ¹Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery; Weill Cornell Medicine, New York, ⁴Weill Cornell Medicine (Dermatology), New York, ⁵Rockefeller University, New York, ⁶Memorial Sloan Kettering Cancer Center, New York
Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus. Lesions can be disfiguring and have a negative impact on patients’ quality…
Abstract Number: 94 • 2018 ACR/ARHP Annual Meeting
Circulating Soluble MICA Is Associated to Lupus Nephritis and to a TLR/IFN-I Signature in T Cells in a Cohort of Adult SLE Patients
Maria Perez-Ferro¹, Fredeswinda I. Romero-Bueno¹, Cristina Serrano del Castillo², Raquel Largo³, Gabriel Herrero-Beaumont³ and Olga Sanchez-Pernaute⁴, ¹Section for Autoimmune Diseases, Rheumatology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ²Immunology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ³Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ⁴Rheumatology Division. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
Background/Purpose: The MHC class I-related chain A (MICA) is a major ligand for the NKG2D receptor of NK and CD8 T cells. MICA expression at…
Abstract Number: 717 • 2018 ACR/ARHP Annual Meeting
The Burden of Chronic Kidney Disease in Systemic Lupus Erythematosus (SLE): A Nationwide Epidemiologic Study
Arthur Mageau¹, Jean Francois Timsit¹, Anne Perozziello¹, Stephane Ruckly¹, Claire Dupuis¹, Lila Bouadma¹, Thomas Papo¹ and Karim Sacre², ¹Université Paris-Diderot, Paris, France, ²Bichat Hospital, Paris Diderot University, Paris, France
Background/Purpose: Lupus nephritis occurs in about 50% of SLE patients. We aimed to analyze the impact of chronic kidney disease (CKD) on major clinical outcomes…
Abstract Number: 1096 • 2018 ACR/ARHP Annual Meeting
Unexpected Association between Health-Related Quality of Life and the Blood Interferon Modular Transcriptional Signatures in Patients with Systemic Lupus Erythematosus
Laurent Chiche¹, julie seguier², stephanie gentile², stephane burtey², bertrand dussol², philippe halfon³, wahiba bidaut³, elisabeth jouve² and Noémie Jourde-Chiche⁴, ¹Internal medicine, Hopital europeen, Marseille, France, ²aphm, marseille, France, ³hopital europeen, marseille, France, ⁴Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France
Background/Purpose: SLE has important effects on health-related quality of life (HRQOL) and is not well correlated to disease activity. As most SLE patients in remission…

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