Abstracts tagged "Lupus"

Abstract Number: 895 • 2019 ACR/ARP Annual Meeting
A Spatial-temporal Analysis of Organ-specific Lupus Flares in Relation to Fine Particulate Matter Pollution and Temperature
George Stojan¹, Anton Kvit ², Frank Curriero ² and Michelle Petri ³, ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins Bloomberg School of Public Health, Baltimore, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: We performed a spatial-time cluster analysis of the Hopkins Lupus Cohort with the goal of identifying potential clusters of SLE organ specific flares and…
Abstract Number: 1599 • 2019 ACR/ARP Annual Meeting
The Impact of Body Mass Index Variability in Systemic Lupus Erythematosus
Xuan Gao¹, Tejal Vashi ¹ and S Sam Lim ², ¹Emory University School of Medicine, Atlanta, GA, ²Emory University, Atlanta, GA
Background/Purpose: SLE is a chronic illness that carries both a physical and psychosocial burden, where the cumulative impact can lead to worse global outcomes. One…
Abstract Number: 2252 • 2019 ACR/ARP Annual Meeting
The #Worldlupusday 2019 Across Twitter: An Explorative Analysis of Spreading Concepts and Sentiment Perceptions on Social Media
Salvatore Pirri¹, Valentina Lorenzoni ², Leopoldo Trieste ³, Rosaria Talarico ⁴, Ilaria Palla ³, Chiara Tani ⁵, Elena Elefante ⁵, Sara Cannizzo ¹, Isotta Triulzi ³, Simone Ticciati ⁶, Giuseppe Turchetti ³ and Marta Mosca ⁵, ¹Institute of Management, Scuola Superiore Sant'Anna, Pisa, Toscana, Italy, ²Institute of Management , Scuola Superiore Sant'Anna, Pisa, Italy, ³Institute of Management, Scuola Superiore Sant'Anna, Pisa, Italy, ⁴Università di Pisa, Pisa, Italy, ⁵Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, ⁶Rheumatology Unit, Azienda Ospedaliero Universitaria Pisana, Italy, Pisa, Italy
Background/Purpose: Social media nowadays has the capacity to disclose sentiments and opinions difficult to obtain elsewhere. This is of valuable importance in the healthcare sector…
Abstract Number: 79 • 2019 ACR/ARP Annual Meeting
Unique Primed Status of Microglia Under the Systemic Autoimmune Condition of Lupus-Prone Mice
Atsushi Nomura¹, Daisuke Noto ², Goh Murayama ³, Asako Chiba ¹ and Sachiko Miyake ¹, ¹Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the…
Abstract Number: 897 • 2019 ACR/ARP Annual Meeting
Mortality Rates After Coronary Revascularization Procedures Among Systemic Lupus Erythematosus Compared to Diabetes Mellitus and General Population Medicaid Patients
Medha Barbhaiya¹, Sarah Chen ², Candace Feldman ³, Hongshu Guan ³, Brendan Everett ⁴ and Karen Costenbader ⁴, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Brigham and Women's Hospital and Harvard Medical School, Boston, ³Brigham and Women's Hospital, Boston, ⁴Brigham and Women's Hospital, Boston, MA
Background/Purpose: Despite similar myocardial infarction risks in SLE and diabetes mellitus (DM) patients, individuals with SLE enrolled in Medicaid had substantially higher rates of coronary…
Abstract Number: 1611 • 2019 ACR/ARP Annual Meeting
Systemic Lupus Erythematosus Registries: Are the Measures Captured in the Real World Similar to Those in Clinical Trials?
Jennifer Lofland¹, Eric Wan ², Pamela Berry ³ and Chetan Karyekar ⁴, ¹Janssen Scientific Affairs, LLC, Spring House, PA, ²Johns Hopkins Bloomberg School of Public Health, Spring House, PA, ³Janssen Scientific Affairs, LLC, Horsham, PA, ⁴Janssen Global Services, LLC, Horsham, PA
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that causes connective tissue inflammation and can result in multiple organ damage. Registries may be…
Abstract Number: 2530 • 2019 ACR/ARP Annual Meeting
Safety, Pharmacokinetics, and Pharmacodynamics of a Lyophilized Drug Product of KZR-616, a Selective Inhibitor of the Immunoproteasome
Ben Snyder ¹, Darrin Bomba ², Ken Harvey ², Janet Anderl ², Christopher Kirk ², Jinhai Wang ², R Andrea Fan ² and Niti Goel³, ¹Nucleus Network Pty Ltd, Melbourne, Australia, ²Kezar Life Sciences, SOUTH SAN FRANCISCO, CA, ³Kezar Life Sciences, Duke University School of Medicine, South San Francisco, CA
Background/Purpose: KZR-616, a first-in-class selective inhibitor of the immunoproteasome, is being evaluated for the treatment of multiple autoimmune diseases, including LN and PM/DM. At 30…
Abstract Number: 81 • 2019 ACR/ARP Annual Meeting
UV Light Stimulates a Systemic Neutrophil Response Associated with Transient Kidney Injury
Sladjana Skopelja-Gardner¹, Joyce Tai ², Xizhang Sun ², Lena Tanaka ², Payton Hermanson ² and Keith Elkon ², ¹University of Washington, Seattle, WA, ²University of Washington, Seattle
Background/Purpose: Sensitivity to ultraviolet B (UVB) light affects ~70% of SLE patients and exacerbates both skin disease and systemic flares, including lupus nephritis (LN). Our…
Abstract Number: 1022 • 2019 ACR/ARP Annual Meeting
Single Cell Transcriptome Analysis of Circulating Plasmacytoid Dendritic Cells and Switched Memory B-cells in SLE Patients Reveals Transcriptional Subsets Within the Classical Cell Lineages
Amrutesh Puranik¹, Yogita Ghodke-Puranik ², Regine Tipon ², Mark Jensen ¹, Auroni Gupta ³, Jacqueline Paredes ³, Uma Sankaramanchi ⁴, Ilona Nln ³, Amit Saxena ⁵, H. Michael Belmont ⁶, Peter Izmirly ⁷, Robert Clancy ⁷, Jill Buyon ⁵ and Timothy Niewold ², ¹Colton Center for Autoimmunity, NYU School of Medicine, New York, NY, ²Colton Center for Autoimmunity, NYU School of Medicine, New York, ³Colton Center for Autoimmunity, NYU School of Medicine, ny, ⁴Colton Center for Autoimmunity, NYU Langone Medical Center, NY, ⁵New York University School of Medicine, New York, NY, ⁶New York University School of Medicine, Ney York, ⁷New York University School of Medicine, New York
Background/Purpose: Both plasmacytoid dendritic cells (pDCs) and switched memory B cells (SMBCs) are considered to be key effector cells in systemic lupus erythematosus. It seems…
Abstract Number: 1613 • 2019 ACR/ARP Annual Meeting
LDL-cholesterol as a Risk Factor of Progression to ESRD in Patients with Lupus Nephritis
Ji-Hyoun Kang¹, Seong-Eun Choi ¹, Haimuzi Xu ¹, Dong-Jin Park ¹ and Shin-Seok Lee ², ¹Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea, ²Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: There are few data on the effect of dyslipidemia in patients with lupus nephritis (LN). Thus, we investigated the effect of low-density lipoprotein-cholesterol (LDL-C)…
Abstract Number: 2550 • 2019 ACR/ARP Annual Meeting
Impact of Pathogenic and Protective Environmental Exposures on Autoimmune Disease—The Microbiome Effects on Lupus (MEL) Study
Hayley Walter¹, Trevor Faith ², Alexander Alekseyenko ³, Ali Bakhtiari ³, Paula Ramos ² and Diane Kamen ⁴, ¹Division of Rheumatology/Medical University South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, ³Medical University South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic and often severe multi-organ autoimmune disease characterized by the production of autoantibodies and heterogeneous clinical manifestations. African…
Abstract Number: 168 • 2019 ACR/ARP Annual Meeting
Development and Usability Testing of Take Charge: An Email Series to Increase Knowledge of Self-Management Skills in People with Lupus
Karin Tse ¹, Lauren Metelski ¹, Reid Dossinger ¹, Mike Donnelly ¹ and Latifa Boyce¹, ¹Lupus Foundation of America, Washington, DC
Background/Purpose: Email may be a promising approach to expose people with lupus, especially newly diagnosed patients, to educational information, tools, and resources on lupus self-management…
Abstract Number: 1026 • 2019 ACR/ARP Annual Meeting
Interferon Lambda Promotes Age-Associated B Cells
Jennifer Barnas¹, Nida Meednu ¹, Andrew McDavid ¹, Jennifer Albrecht ¹, Christopher Richardson ¹, R. John Looney ² and Jennifer Anolik ¹, ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester Medical Center, Rochester
Background/Purpose: Age-associated B cells (ABC), defined as CD11c+ T-bet+ or CD11c+CD21-, represent a subset of B lymphocytes that are increased in systemic lupus erythematosus (SLE)…
Abstract Number: 1617 • 2019 ACR/ARP Annual Meeting
Platelet Bound Complement Split Product (PC4d) May Be a Marker of Platelet Activation and Cardiovascular Events in Systemic Lupus Erythematosus
Yevgeniya Gartshteyn¹, Adam Mor ², Laura Geraldino ², Teja Kapoor ², Tommy Chen ², Thierry Dervieux ³ and Anca Askanase ⁴, ¹Columbia University School of Medicine, Glen Rock, NJ, ²Columbia University School of Medicine, New York, NY, ³Exagen, Vista, CA, ⁴Columbia University, New York
Background/Purpose: Cell-bound complement activation products (CB-CAPs), including platelet bound C4d (PC4d), are sensitive markers for diagnosis and evaluation of lupus activity. Presence of PC4d is…
Abstract Number: 2552 • 2019 ACR/ARP Annual Meeting
Design and Development of an Online Intervention for Lupus Self-Management Based on the Transtheoretical Model of Change
Sarah Gilman ¹, Deborah Levesque ², Carol Cummins ³, Daniel Wallace ⁴, Victoria Werth ⁵ and Patricia Davidson⁶, ¹Wayfinder Health Strategies, Washington, DC, ²Pro-Change Behavior Systems, Providence, RI, ³Pro-Change Behavior Systems, Inc.,, Providence, ⁴Cedars-Sinai Medical Center/University California at Los Angeles, Los Angeles, CA, ⁵Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA and Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, ⁶Lupus Foundation of America, Washington, DC
Background/Purpose: The Lupus Foundation of America is in Year 4 of a 6-year cooperative agreement with the Centers for Disease Control and Prevention to develop…

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